Genetic analysis of a new mouse model for non-insulin-dependent diabetes

Genomics

Volumn 74, Issue 3, 2001, Pages 273-286

  Kim, Jung Han ^a   Sen , Aunak ^a   Avery, Cindy S ^a   Simpson, Elizabeth ^b   Chandler, Phillip ^c   Nishina, Patsy M ^a   Churchill, Gary A ^a   Naggert, Jürgen K ^a  

^a JACKSON LABORATORY   (United States)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Gene gene interaction; Genetics; Hyperglycemia; Mice; NIDDM; QTL

Indexed keywords

CHOLESTEROL; FATTY ACID; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHROMOSOME 16; CHROMOSOME 18; CHROMOSOME 19; CHROMOSOME MAP; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC PREDISPOSITION; GENOTYPE; HYPERGLYCEMIA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; PROTEIN PROTEIN INTERACTION; QUANTITATIVE TRAIT;

EID: 0035874913     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2001.6569     Document Type: Article

References (43)

1. Diabetes in identical twins: A study of 200 pairs
2. Epidemiology of diabetes mellitus
3. A review of methods for identifying QTLs in experimental crosses
4. Relationship of prevalence of non-insulin-dependent diabetes mellitus to Amerindian admixture in the Mexican Americans of San Antonio
5. Empirical threshold values for quantitative trait mapping
6. fa associated with variability in insulin production and susceptibility to NIDDM
7. Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
8. Genetic and metabolic heterogeneity of maturity-onset diabetes of the young
9. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
10. Pathophysiological and genetic characterization of the major diabetes locus in GK rats
11. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
12. Non-insulin-dependent diabetes mellitus-A collision between thrifty genes and an affluent society
13. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
14. Genetic analysis of obese diabetes in the TSOD mouse
15. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
16. Improved method for determination of high-density-lipoprotein cholesterol. I. Isolation of high-density lipoproteins by use of polyethylene glycol 6000
17. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
18. Genetic dissection of "OLETF", a rat model for non-insulin dependent diabetes mellitus
19. Multiple interval mapping for quantitative trait loci
20. Genetic models for non-insulin dependent diabetes mellitus in rodents
21. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults
22. Impact of obesity on metabolism in men and women
23. 1H NMP spectroscopy study
24. Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat
25. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
26. NIDDM genes in mice
27. Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus
28. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
29. Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins
30. Characterization of plasma lipids in genetically obese mice: The mutants obese, diabetes, fat, tubby, and lethal yellow
31. A statistical framework for quantitative trait mapping
32. Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci
33. Preparation of genomic DNA from mammalian tissue
34. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci
35. y allele on quantitative regulation
36. A new mouse model of spontaneous diabetes derived from ddY strain
37. Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling
38. Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain
39. Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait
40. Characterization of the two nonallelic genes encoding mouse preproinsulin
41. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model
42. Prevention of complications in non-insulin-dependent diabetes mellitus (NIDDM)
43. The prevalence of diabetes mellitus and impaired glucose tolerance in Melanesians and part-Polynesians in rural New Caledonia and Ouvea (Loyalty Islands)