-
1
-
-
0032563201
-
Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription
-
DOI 10.1074/jbc.273.30.18751
-
Agati JM, Yeagley D, Quinn PG. Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem 273: 18751-18759, 1998. (Pubitemid 28366259)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.30
, pp. 18751-18759
-
-
Agati, J.M.1
Yeagley, D.2
Quinn, P.G.3
-
2
-
-
0029913340
-
Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain
-
Antonetti DA, Algenstaedt P, Kahn CR. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol Cell Biol 16: 2195-2203, 1996. (Pubitemid 26123740)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.5
, pp. 2195-2203
-
-
Antonetti, D.A.1
Algenstaedt, P.2
Kahn, C.R.3
-
3
-
-
11144356264
-
Dehydroepiandrosterone decreases elevated hepatic glucose production in C57BL/KsJ-db/db mice
-
DOI 10.1016/j.lfs.2003.10.031, PII S0024320504001663
-
Aoki K, Taniguchi H, Ito Y, Satoh S, Nakamura S, Muramatsu K, Yamashita R, Ito S, Mori Y, Sekihara H. Dehydroepiandrosterone decreases elevated hepatic glucose production in C57BL/KsJ-db/db mice. Life Sci 74: 3075-3084, 2004. (Pubitemid 38470100)
-
(2004)
Life Sciences
, vol.74
, Issue.25
, pp. 3075-3084
-
-
Aoki, K.1
Taniguchi, H.2
Ito, Y.3
Satoh, S.4
Nakamura, S.5
Muramatsu, K.6
Yamashita, R.7
Ito, S.8
Mori, Y.9
Sekihara, H.10
-
4
-
-
0000328713
-
-
Weinheim, Germany: Verlag Chimie, 342-250, 555-561
-
Bergmeyer J, Graszl M. Methods of Enzymatic Analysis (3rd ed.). Weinheim, Germany: Verlag Chimie, 1984, vo. VI, pp. 185-198, 342-250, 555-561.
-
(1984)
Methods of Enzymatic Analysis (3rd Ed.)
, vol.6
, pp. 185-198
-
-
Bergmeyer, J.1
Graszl, M.2
-
5
-
-
0347624591
-
P50α/p55α Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity
-
DOI 10.1128/MCB.24.1.320-329.2004
-
Chen D, Mauvais-Jarvis F, Bluher M, Fisher SJ, Jozsi A, Goodyear LJ, Ueki K, Kahn CR. p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol 24: 320-329, 2004. (Pubitemid 38010057)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.1
, pp. 320-329
-
-
Chen, D.1
Mauvais-Jarvis, F.2
Bluher, M.3
Fisher, S.J.4
Jozsi, A.5
Goodyear, L.J.6
Ueki, K.7
Kahn, C.R.8
-
6
-
-
0033645342
-
Paradoxical effect of troglitazone in normal animals: Enhancement of adipocyte but reduction of liver insulin sensitivity
-
Dea MK, Van Citters GW, Ader M, Mittelman SD, Sunehag AL, Bergman RN. Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity. Diabetes 49: 2087-2093, 2000.
-
(2000)
Diabetes
, vol.49
, pp. 2087-2093
-
-
Dea, M.K.1
Van Citters, G.W.2
Ader, M.3
Mittelman, S.D.4
Sunehag, A.L.5
Bergman, R.N.6
-
7
-
-
0032493725
-
Central role for phosphatidylinositide 3-kinase in the repression of glucose'6-phosphatase gene transcription by insulin
-
DOI 10.1074/jbc.273.32.20144
-
Dickens M, Svitek CA, Culbert AA, O'Brien RM, Tavaré JM. Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin. J Biol Chem 273: 20144-20149, 1998. (Pubitemid 28377571)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.32
, pp. 20144-20149
-
-
Dickens, M.1
Svitek, C.A.2
Culbert, A.A.3
O'Brien, R.M.4
Tavare, J.M.5
-
8
-
-
0030271565
-
Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene
-
Fruman DA, Cantley LC, Carpenter CL. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics 37: 113-121, 1996.
-
(1996)
Genomics
, vol.37
, pp. 113-121
-
-
Fruman, D.A.1
Cantley, L.C.2
Carpenter, C.L.3
-
9
-
-
0033556333
-
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
-
Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science 283: 393-397, 1999. (Pubitemid 129501102)
-
(1999)
Science
, vol.283
, Issue.5400
, pp. 393-397
-
-
Fruman, D.A.1
Snapper, S.B.2
Yballe, C.M.3
Davidson, L.4
Yu, J.Y.5
Alt, F.W.6
Cantley, L.C.7
-
10
-
-
0028937422
-
Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and C57BL/KsJ-db/db mice
-
Fujiwara T, Okuno A, Yoshioka S, Horikoshi H. Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and C57BL/KsJ-db/db mice. Metabolism 44: 486-490, 1995.
-
(1995)
Metabolism
, vol.44
, pp. 486-490
-
-
Fujiwara, T.1
Okuno, A.2
Yoshioka, S.3
Horikoshi, H.4
-
11
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao T, Tanabe M, Terauchi Y, Ota T, Matsuda S, Asano T, Kadowaki T, Takeuchi T, Koyasu S. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 3: 875-881, 2002.
-
(2002)
Nat Immunol
, vol.3
, pp. 875-881
-
-
Fukao, T.1
Tanabe, M.2
Terauchi, Y.3
Ota, T.4
Matsuda, S.5
Asano, T.6
Kadowaki, T.7
Takeuchi, T.8
Koyasu, S.9
-
12
-
-
34249931118
-
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
-
DOI 10.1073/pnas.0700373104
-
Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B. Class 1A phosphoinositide 3-kinases are obligate p85-p110 heterodimers. Proc Natl Acad Sci USA 104: 7809-7814, 2007. (Pubitemid 47185833)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.19
, pp. 7809-7814
-
-
Geering, B.1
Cutillas, P.R.2
Nock, G.3
Gharbi, S.I.4
Vanhaesebroeck, B.5
-
13
-
-
0030867766
-
From receptor to transporter: Insulin signalling to glucose transport
-
DOI 10.1007/s001250050780
-
Holman GD, Kasuga M. From receptor to transporter: insulin signalling to glucose transport. Diabetologia 40: 991-1003, 1997. (Pubitemid 27381961)
-
(1997)
Diabetologia
, vol.40
, Issue.9
, pp. 991-1003
-
-
Holman, G.D.1
Kasuga, M.2
-
14
-
-
56749171368
-
Regulation of pancreatic beta cell mass by neuronal signals from the liver
-
Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y. Regulation of pancreatic beta cell mass by neuronal signals from the liver. Science 322: 1250-1254, 2008.
-
(2008)
Science
, vol.322
, pp. 1250-1254
-
-
Imai, J.1
Katagiri, H.2
Yamada, T.3
Ishigaki, Y.4
Suzuki, T.5
Kudo, H.6
Uno, K.7
Hasegawa, Y.8
Gao, J.9
Kaneko, K.10
Ishihara, H.11
Niijima, A.12
Nakazato, M.13
Asano, T.14
Minokoshi, Y.15
Oka, Y.16
-
15
-
-
0029920935
-
A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85α gene
-
DOI 10.1074/jbc.271.10.5317
-
Inukai K, Anai M, Van Breda E, Hosaka T, Katagiri H, Funaki M, Fukushima Y, Ogihara T, Yazaki Y, Kikuchi Oka Y, Asano T. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. J Biol Chem 271: 5317-5320, 1996. (Pubitemid 26083862)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.10
, pp. 5317-5320
-
-
Inukai, K.1
Anai, M.2
Van Breda, E.3
Hosaka, T.4
Katagiri, H.5
Funaki, M.6
Fukushima, Y.7
Ogihara, T.8
Yazaki, Y.9
Kikuchi, M.10
Oka, Y.11
Asano, T.12
-
16
-
-
0030615068
-
P85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin
-
DOI 10.1074/jbc.272.12.7873
-
Inukai K, Funaki M, Ogihara T, Katagiri H, Kanda A, Anai M, Fukushima Y, Hosaka T, Suzuki M, Shin BC, Takata K, Yazaki Y, Kikuchi M, Oka Y, Asano T. p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. J Biol Chem 272: 7873-7882, 1997. (Pubitemid 27137347)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.12
, pp. 7873-7882
-
-
Inukai, K.1
Funaki, M.2
Ogihara, T.3
Katagiri, H.4
Kanda, A.5
Anai, M.6
Fukushima, Y.7
Hosaka, T.8
Suzuki, M.9
Shin, B.-C.10
Takata, K.11
Yazaki, Y.12
Kikuchi, M.13
Oka, Y.14
Asano, T.15
-
17
-
-
0030443613
-
Signal transduction mechanism of insulin and insulin-like growth factor- 1
-
Kadowaki T, Tobe K, Honda-Yamamoto R, Tamemoto H, Kaburagi Y, Momomura K, Ueki K, Takahashi Y, Yamauchi T, Akanuma Y, Yazaki Y. Signal transduction mechanism of insulin and insulin-like growth factor-1. Endocr J 43: 33-41, 1996. (Pubitemid 27014286)
-
(1996)
Endocrine Journal
, vol.43
, Issue.SUPPL.
-
-
Kadowaki, T.1
Tobe, K.2
Honda-Yamamoto, R.3
Tamemoto, H.4
Kaburagi, Y.5
Momomura, K.6
Ueki, K.7
Takahashi, Y.8
Yamauchi, T.9
Akanuma, Y.10
Yazaki, Y.11
-
18
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
-
Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 19: 733-747, 2006.
-
(2006)
Cell
, vol.19
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
Zunder, E.R.4
Goldenberg, D.D.5
Williams, O.6
Loewith, R.7
Stokoe, D.8
Balla, A.9
Toth, B.10
Balla, T.11
Weiss, W.A.12
Williams, R.L.13
Shokat, K.M.14
-
19
-
-
45549087567
-
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding
-
Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T. Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab 8: 49-64, 2008.
-
(2008)
Cell Metab
, vol.8
, pp. 49-64
-
-
Kubota, N.1
Kubota, T.2
Itoh, S.3
Kumagai, H.4
Kozono, H.5
Takamoto, I.6
Mineyama, T.7
Ogata, H.8
Tokuyama, K.9
Ohsugi, M.10
Sasako, T.11
Moroi, M.12
Sugi, K.13
Kakuta, S.14
Iwakura, Y.15
Noda, T.16
Ohnishi, S.17
Nagai, R.18
Tobe, K.19
Terauchi, Y.20
Ueki, K.21
Kadowaki, T.22
more..
-
20
-
-
33646852805
-
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways
-
DOI 10.1074/jbc.M505649200
-
Kubota N, Terauchi Y, Kubota T, Kumagai H, Itoh S, Satoh H, Yano W, Ogata H, Tokuyama K, Takamoto I, Mineyama T, Ishikawa M, Moroi M, Sugi K, Yamauchi T, Ueki K, Tobe K, Noda T, Nagai R, Kadowaki T. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem 281: 8748-8755, 2006. (Pubitemid 43847980)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.13
, pp. 8748-8755
-
-
Kubota, N.1
Terauchi, Y.2
Kubota, T.3
Kumagai, H.4
Itoh, S.5
Satoh, H.6
Yano, W.7
Ogata, H.8
Tokuyama, K.9
Takamoto, I.10
Mineyama, T.11
Ishikawa, M.12
Moroi, M.13
Sugi, K.14
Yamauchi, T.15
Ueki, K.16
Tobe, K.17
Noda, T.18
Nagai, R.19
Kadowaki, T.20
more..
-
21
-
-
9644260562
-
Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
-
DOI 10.1172/JCI200421484
-
Kubota N, Terauchi Y, Tobe K, Yano W, Suzuki R, Ueki K, Takamoto I, Satoh H, Maki T, Kubota T, Moroi M, Okada-Iwabu M, Ezaki O, Nagai R, Ueta Y, Kadowaki T, Noda T. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 114: 917-927, 2004. (Pubitemid 39578719)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.7
, pp. 917-927
-
-
Kubota, N.1
Terauchi, Y.2
Tobe, K.3
Yano, W.4
Suzuki, R.5
Ueki, K.6
Takamoto, I.7
Satoh, H.8
Maki, T.9
Kubota, T.10
Moroi, M.11
Okada-Iwabu, M.12
Ezaki, O.13
Nagai, R.14
Ueta, Y.15
Kadowaki, T.16
Noda, T.17
-
22
-
-
0033755408
-
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
-
Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI, Kadowaki T. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49: 1880-1889, 2000.
-
(2000)
Diabetes
, vol.49
, pp. 1880-1889
-
-
Kubota, N.1
Tobe, K.2
Terauchi, Y.3
Eto, K.4
Yamauchi, T.5
Suzuki, R.6
Tsubamoto, Y.7
Komeda, K.8
Nakano, R.9
Miki, H.10
Satoh, S.11
Sekihara, H.12
Sciacchitano, S.13
Lesniak, M.14
Aizawa, S.15
Nagai, R.16
Kimura, S.17
Akanuma, Y.18
Taylor, S.I.19
Kadowaki, T.20
more..
-
23
-
-
34347255023
-
Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
-
DOI 10.1016/j.cmet.2007.06.003, PII S1550413107001593
-
Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 6: 55-68, 2007. (Pubitemid 47007437)
-
(2007)
Cell Metabolism
, vol.6
, Issue.1
, pp. 55-68
-
-
Kubota, N.1
Yano, W.2
Kubota, T.3
Yamauchi, T.4
Itoh, S.5
Kumagai, H.6
Kozono, H.7
Takamoto, I.8
Okamoto, S.9
Shiuchi, T.10
Suzuki, R.11
Satoh, H.12
Tsuchida, A.13
Moroi, M.14
Sugi, K.15
Noda, T.16
Ebinuma, H.17
Ueta, Y.18
Kondo, T.19
Araki, E.20
Ezaki, O.21
Nagai, R.22
Tobe, K.23
Terauchi, Y.24
Ueki, K.25
Minokoshi, Y.26
Kadowaki, T.27
more..
-
24
-
-
0030995946
-
The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family
-
Lavan BE, Lane WS, Lienhard GE. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J Biol Chem 272: 11439-11443, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 11439-11443
-
-
Lavan, B.E.1
Lane, W.S.2
Lienhard, G.E.3
-
25
-
-
0036142957
-
Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
-
DOI 10.1172/JCI200213305
-
Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest 109: 141-149, 2002. (Pubitemid 34052550)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.1
, pp. 141-149
-
-
Mauvais-Jarvis, F.1
Ueki, K.2
Fruman, D.A.3
Hirshman, M.F.4
Sakamoto, K.5
Goodyear, L.J.6
Iannacone, M.7
Accili, D.8
Cantley, L.C.9
Ronald Kahn, C.10
-
26
-
-
0031982799
-
Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol 3-kinase
-
DOI 10.1074/jbc.273.1.17
-
Mithieux G, Daniele N, Payrastre B, Zitoun C. Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol 3-kinase. J Biol Chem 273: 17-19, 1998. (Pubitemid 28042168)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.1
, pp. 17-19
-
-
Mithieux, G.1
Daniele, N.2
Payrastre, B.3
Zitoun, C.4
-
28
-
-
66049147672
-
-
Philadelphia, PA: Lippincott-Raven, edited by DK LeRoith, D, Taylor, and SI Olefsky
-
O'Brien RM, Granner JM. Gene Regulation in Diabetes Mellitus. Philadelphia, PA: Lippincott-Raven, edited by DK LeRoith, D, Taylor, and SI Olefsky. 2000, pp. 291-304.
-
(2000)
Gene Regulation in Diabetes Mellitus
, pp. 291-304
-
-
O'Brien, R.M.1
Granner, J.M.2
-
29
-
-
0035895375
-
New responsibilities for the PI3K regulatory subunit p85 alpha
-
Okkenhaug K, Vanhaesebroeck B. New responsibilities for the PI3K regulatory subunit p85 alpha. Sci STKE 16: PE1, 2001.
-
(2001)
Sci STKE
, vol.16
-
-
Okkenhaug, K.1
Vanhaesebroeck, B.2
-
31
-
-
0017986551
-
14C-labeled pyruvates and bicarbonate into blood glucose of fasted mice
-
14C-labeled pyruvates and bicarbonate into blood glucose of fasted mice. Am J Physiol Endocrinol Metab 235: E22-E26, 1978.
-
(1978)
Am J Physiol Endocrinol Metab
, vol.235
-
-
Rous, S.1
-
32
-
-
0032787346
-
Signaling pathways mediating insulin-stimulated glucose transport
-
Summers SA, Yin VP, Whiteman EL, Garza LA, Cho H, Tuttle RL, Birnbaum MJ. Signaling pathways mediating insulin-stimulated glucose transport. Ann NY Acad Sci 892: 169-186, 1999.
-
(1999)
Ann NY Acad Sci
, vol.892
, pp. 169-186
-
-
Summers, S.A.1
Yin, V.P.2
Whiteman, E.L.3
Garza, L.A.4
Cho, H.5
Tuttle, R.L.6
Birnbaum, M.J.7
-
33
-
-
0025813375
-
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
-
Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352: 73-77, 1991. (Pubitemid 21896701)
-
(1991)
Nature
, vol.352
, Issue.6330
, pp. 73-77
-
-
Sun, X.J.1
Rothenberg, P.2
Kahn, C.R.3
Backer, J.M.4
Araki, E.5
Wilden, P.A.6
Cahill, D.A.7
Goldstein, B.J.8
White, M.F.9
-
34
-
-
0029148591
-
Role of IRS-2 in insulin and cytokine signalling
-
Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG Jr, Glasheen E, Lane WS, Pierce JH, White MF. Role of IRS-2 in insulin and cytokine signalling. Nature 377: 173-177, 1995.
-
(1995)
Nature
, vol.377
, pp. 173-177
-
-
Sun, X.J.1
Wang, L.M.2
Zhang, Y.3
Yenush, L.4
Myers Jr., M.G.5
Glasheen, E.6
Lane, W.S.7
Pierce, J.H.8
White, M.F.9
-
35
-
-
0028982829
-
Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression
-
Sutherland C, O'Brien RM, Granner DK. Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression. J Biol Chem 270: 15501-15506, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 15501-15506
-
-
Sutherland, C.1
O'Brien, R.M.2
Granner, D.K.3
-
36
-
-
2942530440
-
-/- mice
-
DOI 10.1074/jbc.M311956200
-
Suzuki R, Tobe K, Aoyama M, Inoue A, Sakamoto K, Yamauchi T, Kamon J, Kubota N, Terauchi Y, Yoshimatsu H, Matsuhisa M, Nagasaka S, Ogata H, Tokuyama K, Nagai R, Kadowaki T. Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice. J Biol Chem 279: 25039-25049, 2004. (Pubitemid 38756752)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.24
, pp. 25039-25049
-
-
Suzuki, R.1
Tobe, H.2
Aoyama, M.3
Inoue, A.4
Sakamoto, K.5
Yamauchi, T.6
Kamon, J.7
Kubota, N.8
Terauchi, Y.9
Yoshimatsu, H.10
Matsuhisa, M.11
Nagasaka, S.12
Ogata, H.13
Tokuyama, K.14
Nagai, R.15
Kadowaki, T.16
-
37
-
-
33646148946
-
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta
-
Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab 3: 343-353, 2006.
-
(2006)
Cell Metab
, vol.3
, pp. 343-353
-
-
Taniguchi, C.M.1
Kondo, T.2
Sajan, M.3
Luo, J.4
Bronson, R.5
Asano, T.6
Farese, R.7
Cantley, L.C.8
Kahn, C.R.9
-
38
-
-
33747072874
-
Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN
-
DOI 10.1073/pnas.0604628103
-
Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR. Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proc Natl Acad Sci USA 103: 12093-12097, 2006. (Pubitemid 44215816)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.32
, pp. 12093-12097
-
-
Taniguchi, C.M.1
Tran, T.T.2
Kondo, T.3
Luo, J.4
Ueki, K.5
Cantley, L.C.6
Kahn, C.R.7
-
39
-
-
0033515429
-
Deconstructing type 2 diabetes
-
Taylor SI. Deconstructing type 2 diabetes. Cell 97: 9-12, 1999.
-
(1999)
Cell
, vol.97
, pp. 9-12
-
-
Taylor, S.I.1
-
40
-
-
0030961962
-
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and β cell glucokinase genes: Genetic reconstitution of diabetes as a polygenic disease
-
Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T. Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest 99: 861-866, 1997. (Pubitemid 27123622)
-
(1997)
Journal of Clinical Investigation
, vol.99
, Issue.5
, pp. 861-866
-
-
Terauchi, Y.1
Iwamoto, K.2
Tamemoto, H.3
Komeda, K.4
Ishii, C.5
Kanazawa, Y.6
Asanuma, N.7
Aizawa, T.8
Akanuma, Y.9
Yasuda, K.10
Kodama, T.11
Tobe, K.12
Yazaki, Y.13
Kadowaki, T.14
-
41
-
-
4344566155
-
Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85α phosphoinositide 3-kinase
-
DOI 10.2337/diabetes.53.9.2261
-
Terauchi Y, Matsui J, Kamon J, Yamauchi T, Kubota N, Komeda K, Aizawa S, Akanuma Y, Tomita M, Kadowaki T. Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase. Diabetes 53: 2261-2270, 2004. (Pubitemid 39145579)
-
(2004)
Diabetes
, vol.53
, Issue.9
, pp. 2261-2270
-
-
Terauchi, Y.1
Matsui, J.2
Kamon, J.3
Yamauchi, T.4
Kubota, N.5
Komeda, K.6
Aizawa, S.7
Akanuma, Y.8
Tomita, M.9
Kadowaki, T.10
-
42
-
-
33846024011
-
Glucokinase and IRS-2 are required for compensatory β cell hyperplasia in response to high-fat diet-induced insulin resistance
-
DOI 10.1172/JCI17645
-
Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T. Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest 117: 246-257, 2007. (Pubitemid 46048470)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.1
, pp. 246-257
-
-
Terauchi, Y.1
Takamoto, I.2
Kubota, N.3
Matsui, J.4
Suzuki, R.5
Komeda, K.6
Hara, A.7
Toyoda, Y.8
Miwa, I.9
Aizawa, S.10
Tsutsumi, S.11
Tsubamoto, Y.12
Hashimoto, S.13
Eto, K.14
Nakamura, A.15
Noda, M.16
Tobe, K.17
Aburatani, H.18
Nagai, R.19
Kadowaki, T.20
more..
-
43
-
-
0032909703
-
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3-kinase
-
DOI 10.1038/6023
-
Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A, Inukai K, Asano T, Kaburagi Y, Ueki K, Nakajima H, Hanafusa T, Matsuzawa Y, Sekihara H, Yin Y, Barrett JC, Oda H, Ishikawa T, Akanuma Y, Komuro I, Suzuki M, Yamamura K, Kodama T, Suzuki H, Yamamura K, Kodama T, Suzuki H, Koyasu S, Aizawa S, Tobe K, Fukui Y, Yazaki Y, Kadowaki T. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet 21: 230-235, 1999. (Pubitemid 29070374)
-
(1999)
Nature Genetics
, vol.21
, Issue.2
, pp. 230-235
-
-
Terauchi, Y.1
Tsuji, Y.2
Satoh, S.3
Minoura, H.4
Murakami, K.5
Okuno, A.6
Inukai, K.7
Asano, T.8
Kaburagi, Y.9
Ueki, K.10
Nakajima, H.11
Hanafusa, T.12
Matsuzawa, Y.13
Sekihara, H.14
Yin, Y.15
Barrett, J.C.16
Oda, H.17
Ishikawa, T.18
Akanuma, Y.19
Komuro, I.20
Suzuki, M.21
Yamamura, K.-I.22
Kodama, T.23
Suzuki, H.24
Koyasu, S.25
Aizawa, S.26
Tobe, K.27
Fukui, Y.28
Yazaki, Y.29
Kadowaki, T.30
more..
-
44
-
-
0033780412
-
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit
-
Ueki K, Algenstaedt P, Mauvais-Jarvis F, Kahn CR. Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit. Mol Cell Biol 20: 8035-8046, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8035-8046
-
-
Ueki, K.1
Algenstaedt, P.2
Mauvais-Jarvis, F.3
Kahn, C.R.4
-
45
-
-
0036143774
-
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
-
Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol 22: 965-977, 2002. (Pubitemid 34053073)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.3
, pp. 965-977
-
-
Ueki, K.1
Fruman, D.A.2
Brachmann, S.M.3
Tseng, Y.-H.4
Cantley, L.C.5
Kahn, C.R.6
-
46
-
-
33745151403
-
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity
-
DOI 10.1126/science.1126010
-
Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y. Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science 312: 1656-1659, 2006. (Pubitemid 43902665)
-
(2006)
Science
, vol.312
, Issue.5780
, pp. 1656-1659
-
-
Uno, K.1
Katagiri, H.2
Yamada, T.3
Ishigaki, Y.4
Ogihara, T.5
Imai, J.6
Hasegawa, Y.7
Gao, J.8
Kaneko, K.9
Iwasaki, H.10
Ishihara, H.11
Sasano, H.12
Inukai, K.13
Mizuguchi, H.14
Asano, T.15
Shiota, M.16
Nakazato, M.17
Oka, Y.18
-
47
-
-
0034455274
-
Perspective: The insulin signaling system - A common link in the pathogenesis of type 2 diabetes
-
DOI 10.1210/en.141.6.1917
-
Withers DJ, White M. Perspective: the insulin signaling system-a common link in the pathogenesis of type 2 diabetes. Endocrinology 141: 1917-1921, 2000. (Pubitemid 32274336)
-
(2000)
Endocrinology
, vol.141
, Issue.6
, pp. 1917-1921
-
-
Withers, D.J.1
White, M.2
-
48
-
-
0029897280
-
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mices
-
Yamauchi T, Tobe K, Tamemoto H, Ueki K, Kaburagi Y, Yamamoto- Honda R, Takahashi Y, Yoshizawa F, Aizawa S, Akanuma Y, Sonenberg N, Yazaki Y, Kadowaki T. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol 16: 3074-3084, 1996. (Pubitemid 26163377)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.6
, pp. 3074-3084
-
-
Yamauchi, T.1
Tobe, K.2
Tamemoto, H.3
Ueki, K.4
Kaburagi, Y.5
Yamamoto-Honda, R.6
Takahashi, Y.7
Yoshizawa, F.8
Aizawa, S.9
Akanuma, Y.10
Sonenberg, N.11
Yazaki, Y.12
Kadowaki, T.13
|