메뉴 건너뛰기




Volumn 34, Issue 1, 2008, Pages 42-53

A meta-analysis of QTL for diabetes-related traits in rodents

Author keywords

Diabesity; Genomewide scan; Hidden Markov model; Quantitative trait loci; Truncated product method

Indexed keywords

GLUCOSE; INSULIN;

EID: 47249120899     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00267.2007     Document Type: Article
Times cited : (38)

References (87)
  • 1
    • 25444441171 scopus 로고    scopus 로고
    • Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice
    • Allan MF, Eisen EJ, Pomp D. Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice. Genetics 170: 1863-1877, 2005.
    • (2005) Genetics , vol.170 , pp. 1863-1877
    • Allan, M.F.1    Eisen, E.J.2    Pomp, D.3
  • 2
    • 9644260361 scopus 로고    scopus 로고
    • Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice
    • Almind K, Kahn CR. Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 53: 3274-3285, 2004.
    • (2004) Diabetes , vol.53 , pp. 3274-3285
    • Almind, K.1    Kahn, C.R.2
  • 3
    • 0038659916 scopus 로고    scopus 로고
    • Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance
    • Almind K, Kulkarni RN, Lannon SM, Kahn CR. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 52: 1535-1543, 2003.
    • (2003) Diabetes , vol.52 , pp. 1535-1543
    • Almind, K.1    Kulkarni, R.N.2    Lannon, S.M.3    Kahn, C.R.4
  • 4
    • 0038352163 scopus 로고    scopus 로고
    • Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J X A/J)F2 mice
    • Anunciado RV, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T. Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J X A/J)F2 mice. Exp Anim 52: 37-42, 2003.
    • (2003) Exp Anim , vol.52 , pp. 37-42
    • Anunciado, R.V.1    Nishimura, M.2    Mori, M.3    Ishikawa, A.4    Tanaka, S.5    Horio, F.6    Ohno, T.7    Namikawa, T.8
  • 5
    • 0034220290 scopus 로고    scopus 로고
    • Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis
    • Anunciado RV, Ohno T, Mori M, Ishikawa A, Tanaka S, Horio F, Nishimura M, Namikawa T. Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis. Exp Anim 49: 217-224, 2000.
    • (2000) Exp Anim , vol.49 , pp. 217-224
    • Anunciado, R.V.1    Ohno, T.2    Mori, M.3    Ishikawa, A.4    Tanaka, S.5    Horio, F.6    Nishimura, M.7    Namikawa, T.8
  • 6
    • 0034523871 scopus 로고    scopus 로고
    • Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F2 variance of growth and obesity in DU6i X DBA/2 mice
    • Brockmann GA, Kratzsch J, Haley CS, Renne U, Schwerin M, Karle S. Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F2 variance of growth and obesity in DU6i X DBA/2 mice. Genome Res 10: 1941-1957, 2000.
    • (2000) Genome Res , vol.10 , pp. 1941-1957
    • Brockmann, G.A.1    Kratzsch, J.2    Haley, C.S.3    Renne, U.4    Schwerin, M.5    Karle, S.6
  • 7
    • 31344437783 scopus 로고    scopus 로고
    • Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein
    • Chang BH, Li L, Paul A, Taniguchi S, Nannegari V, Heird WC, Chan L. Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Mol Cell Biol 26: 1063-1076, 2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 1063-1076
    • Chang, B.H.1    Li, L.2    Paul, A.3    Taniguchi, S.4    Nannegari, V.5    Heird, W.C.6    Chan, L.7
  • 9
    • 33846892749 scopus 로고    scopus 로고
    • The genetic landscape of type 2 diabetes in mice
    • Clee SM, Attie AD. The genetic landscape of type 2 diabetes in mice. Endocr Rev 28: 48-83, 2007.
    • (2007) Endocr Rev , vol.28 , pp. 48-83
    • Clee, S.M.1    Attie, A.D.2
  • 10
    • 0015864927 scopus 로고
    • The influence of genetic background on the expression of the obese (Ob) gene in the mouse
    • Coleman DL, Hummel KP. The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 9: 287-293, 1973.
    • (1973) Diabetologia , vol.9 , pp. 287-293
    • Coleman, D.L.1    Hummel, K.P.2
  • 13
    • 19444384341 scopus 로고    scopus 로고
    • Haplotype-based genetics in mice and rats
    • Cuppen E. Haplotype-based genetics in mice and rats. Trends Genet 21: 318-322, 2005.
    • (2005) Trends Genet , vol.21 , pp. 318-322
    • Cuppen, E.1
  • 14
    • 1242342709 scopus 로고    scopus 로고
    • Meta-analysis of linkage studies for complex diseases: An overview of methods and a simulation study
    • Dempfle A, Loesgen S. Meta-analysis of linkage studies for complex diseases: an overview of methods and a simulation study. Ann Hum Genet 68: 69-83, 2004.
    • (2004) Ann Hum Genet , vol.68 , pp. 69-83
    • Dempfle, A.1    Loesgen, S.2
  • 15
  • 16
    • 1242284367 scopus 로고    scopus 로고
    • Multiple linked mouse chromosome 7 loci influence body fat mass
    • Diament AL, Warden CH. Multiple linked mouse chromosome 7 loci influence body fat mass. Int J Obes Relat Metab Disord 28: 199-210, 2004.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 199-210
    • Diament, A.L.1    Warden, C.H.2
  • 17
    • 27744519434 scopus 로고    scopus 로고
    • Bioinformatics toolbox for narrowing rodent quantitative trait loci
    • DiPetrillo K, Wang X, Stylianou IM, Paigen B. Bioinformatics toolbox for narrowing rodent quantitative trait loci. Trends Genet 21: 683-692, 2005.
    • (2005) Trends Genet , vol.21 , pp. 683-692
    • DiPetrillo, K.1    Wang, X.2    Stylianou, I.M.3    Paigen, B.4
  • 18
    • 0031743421 scopus 로고    scopus 로고
    • Profile hidden Markov models
    • Eddy SR. Profile hidden Markov models. Bioinformatics 14: 755-763, 1998.
    • (1998) Bioinformatics , vol.14 , pp. 755-763
    • Eddy, S.R.1
  • 20
    • 0242524453 scopus 로고    scopus 로고
    • The inherited basis of diabetes mellitus: Implications for the genetic analysis of complex traits
    • Florez JC, Hirschhorn J, Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 4: 257-291, 2003.
    • (2003) Annu Rev Genomics Hum Genet , vol.4 , pp. 257-291
    • Florez, J.C.1    Hirschhorn, J.2    Altshuler, D.3
  • 21
    • 34248594090 scopus 로고    scopus 로고
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894, 2007.
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894, 2007.
  • 22
    • 4444329913 scopus 로고    scopus 로고
    • Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome
    • Frazer KA, Wade CM, Hinds DA, Patil N, Cox DR, Daly MJ. Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome. Genome Res 14: 1493-1500, 2004.
    • (2004) Genome Res , vol.14 , pp. 1493-1500
    • Frazer, K.A.1    Wade, C.M.2    Hinds, D.A.3    Patil, N.4    Cox, D.R.5    Daly, M.J.6
  • 25
    • 32544451924 scopus 로고    scopus 로고
    • Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38: 320-323, 2006.
    • Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38: 320-323, 2006.
  • 28
    • 21344446108 scopus 로고    scopus 로고
    • Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes
    • Hiukka A, Fruchart-Najib J, Leinonen E, Hilden H, Fruchart JC, Taskinen MR. Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes. Diabetologia 48: 1207-1215, 2005.
    • (2005) Diabetologia , vol.48 , pp. 1207-1215
    • Hiukka, A.1    Fruchart-Najib, J.2    Leinonen, E.3    Hilden, H.4    Fruchart, J.C.5    Taskinen, M.R.6
  • 29
    • 0015381515 scopus 로고
    • The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains
    • Hummel KP, Coleman DL, Lane PW. The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains. Biochem Genet 7: 1-13, 1972.
    • (1972) Biochem Genet , vol.7 , pp. 1-13
    • Hummel, K.P.1    Coleman, D.L.2    Lane, P.W.3
  • 30
    • 0029022716 scopus 로고
    • Multiple trait analysis of genetic mapping for quantitative trait loci
    • Jiang C, Zeng ZB. Multiple trait analysis of genetic mapping for quantitative trait loci. Genetics 140: 1111-1127, 1995.
    • (1995) Genetics , vol.140 , pp. 1111-1127
    • Jiang, C.1    Zeng, Z.B.2
  • 31
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846, 2006.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 32
    • 0034201736 scopus 로고    scopus 로고
    • Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain
    • Kayo T, Fujita H, Nozaki J, E X, Koizumi A. Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain. Comp Med 50: 296-302, 2000.
    • (2000) Comp Med , vol.50 , pp. 296-302
    • Kayo, T.1    Fujita, H.2    Nozaki, J.E.X.3    Koizumi, A.4
  • 33
    • 0034079629 scopus 로고    scopus 로고
    • Genetic modifiers of the insulin resistance phenotype in mice
    • Kido Y, Philippe N, Schaffer AA, Accili D. Genetic modifiers of the insulin resistance phenotype in mice. Diabetes 49: 589-596, 2000.
    • (2000) Diabetes , vol.49 , pp. 589-596
    • Kido, Y.1    Philippe, N.2    Schaffer, A.A.3    Accili, D.4
  • 35
    • 0038303164 scopus 로고    scopus 로고
    • Mapping of genetic loci predisposing to hypertriglyceridaemia in the hereditary hypertriglyceridaemic rat: Analysis of genetic association with related traits of the insulin resistance syndrome
    • Klimes I, Weston K, Kovacs P, Gasperikova D, Jezova D, Kvetnansky R, Thompson JR, Sebokova E, Samani NJ. Mapping of genetic loci predisposing to hypertriglyceridaemia in the hereditary hypertriglyceridaemic rat: analysis of genetic association with related traits of the insulin resistance syndrome. Diabetologia 46: 352-358, 2003.
    • (2003) Diabetologia , vol.46 , pp. 352-358
    • Klimes, I.1    Weston, K.2    Kovacs, P.3    Gasperikova, D.4    Jezova, D.5    Kvetnansky, R.6    Thompson, J.R.7    Sebokova, E.8    Samani, N.J.9
  • 36
    • 0034806108 scopus 로고    scopus 로고
    • Quantitative trait loci for body weight, blood pressure, blood glucose, and serum lipids: Linkage analysis with wild rats (Rattus norvegicus)
    • Kloting I, Kovacs P, van den Brandt J. Quantitative trait loci for body weight, blood pressure, blood glucose, and serum lipids: linkage analysis with wild rats (Rattus norvegicus). Biochem Biophys Res Commun 284: 1126-1133, 2001.
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 1126-1133
    • Kloting, I.1    Kovacs, P.2    van den Brandt, J.3
  • 37
    • 33244465359 scopus 로고    scopus 로고
    • Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains
    • Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F. Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains. Diabetologia 49: 486-495, 2006.
    • (2006) Diabetologia , vol.49 , pp. 486-495
    • Kobayashi, M.1    Io, F.2    Kawai, T.3    Kumazawa, M.4    Ikegami, H.5    Nishimura, M.6    Ohno, T.7    Horio, F.8
  • 38
    • 0037222392 scopus 로고    scopus 로고
    • Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains
    • Kobayashi M, Ohno T, Tsuji A, Nishimura M, Horio F. Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains. Diabetes 52: 180-186, 2003.
    • (2003) Diabetes , vol.52 , pp. 180-186
    • Kobayashi, M.1    Ohno, T.2    Tsuji, A.3    Nishimura, M.4    Horio, F.5
  • 41
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11: 241-247, 1995.
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 43
    • 0024448693 scopus 로고
    • The genetics of diabetes susceptibility in mice
    • Leiter EH. The genetics of diabetes susceptibility in mice. FASEB J 3: 2231-2241, 1989.
    • (1989) FASEB J , vol.3 , pp. 2231-2241
    • Leiter, E.H.1
  • 44
    • 0031823493 scopus 로고    scopus 로고
    • NIDDM genes in mice: Deleterious synergism by both parental genomes contributes to diabetogenic thresholds
    • Leiter EH, Reifsnyder PC, Flurkey K, Partke HJ, Junger E, Herberg L. NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 47: 1287-1295, 1998.
    • (1998) Diabetes , vol.47 , pp. 1287-1295
    • Leiter, E.H.1    Reifsnyder, P.C.2    Flurkey, K.3    Partke, H.J.4    Junger, E.5    Herberg, L.6
  • 47
    • 0031560443 scopus 로고    scopus 로고
    • Genetic analysis of non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat
    • Nara Y, Gao M, Ikeda K, Sato T, Sawamura M, Kawano K, Yamori Y. Genetic analysis of non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat. Biochem Biophys Res Commun 241: 200-204, 1997.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 200-204
    • Nara, Y.1    Gao, M.2    Ikeda, K.3    Sato, T.4    Sawamura, M.5    Kawano, K.6    Yamori, Y.7
  • 48
    • 0033015835 scopus 로고    scopus 로고
    • Identification of possible quantitative trait loci responsible for hyperglycaemia after 70% pancreatectomy using a spontaneously diabetogenic rat
    • Ogino T, Moralejo DH, Zhu M, Toide K, Wei S, Wei K, Yamada T, Mizuno A, Matsumoto K, Shima K. Identification of possible quantitative trait loci responsible for hyperglycaemia after 70% pancreatectomy using a spontaneously diabetogenic rat. Genet Res 73: 29-36, 1999.
    • (1999) Genet Res , vol.73 , pp. 29-36
    • Ogino, T.1    Moralejo, D.H.2    Zhu, M.3    Toide, K.4    Wei, S.5    Wei, K.6    Yamada, T.7    Mizuno, A.8    Matsumoto, K.9    Shima, K.10
  • 50
    • 20444502520 scopus 로고    scopus 로고
    • Genetic epidemiology of diabetes
    • Permutt MA, Wasson J, Cox N. Genetic epidemiology of diabetes. J Clin Invest 115: 1431-1439, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 1431-1439
    • Permutt, M.A.1    Wasson, J.2    Cox, N.3
  • 51
    • 0036599146 scopus 로고    scopus 로고
    • Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: Islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat
    • Plum L, Giesen K, Kluge R, Junger E, Linnartz K, Schurmann A, Becker W, Joost HG. Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia 45: 823-830, 2002.
    • (2002) Diabetologia , vol.45 , pp. 823-830
    • Plum, L.1    Giesen, K.2    Kluge, R.3    Junger, E.4    Linnartz, K.5    Schurmann, A.6    Becker, W.7    Joost, H.G.8
  • 52
    • 0033863051 scopus 로고    scopus 로고
    • Type 2 diabetes-like hyperglycemia in a backcross model of NZO and SJL mice: Characterization of a susceptibility locus on chromosome 4 and its relation with obesity
    • Plum L, Kluge R, Giesen K, Altmuller J, Ortlepp JR, Joost HG. Type 2 diabetes-like hyperglycemia in a backcross model of NZO and SJL mice: characterization of a susceptibility locus on chromosome 4 and its relation with obesity. Diabetes 49: 1590-1596, 2000.
    • (2000) Diabetes , vol.49 , pp. 1590-1596
    • Plum, L.1    Kluge, R.2    Giesen, K.3    Altmuller, J.4    Ortlepp, J.R.5    Joost, H.G.6
  • 53
  • 54
    • 0024610919 scopus 로고
    • A tutorial on hidden Markov models and selected applications in speech recognition
    • Rabiner LR. A tutorial on hidden Markov models and selected applications in speech recognition. Proc IEEE 77: 257-286, 1989.
    • (1989) Proc IEEE , vol.77 , pp. 257-286
    • Rabiner, L.R.1
  • 55
    • 0033787384 scopus 로고    scopus 로고
    • Maternal environment and genotype interact to establish diabesity in mice
    • Reifsnyder PC, Churchill G, Leiter EH. Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10: 1568-1578, 2000.
    • (2000) Genome Res , vol.10 , pp. 1568-1578
    • Reifsnyder, P.C.1    Churchill, G.2    Leiter, E.H.3
  • 56
    • 0036317545 scopus 로고    scopus 로고
    • Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice
    • Reifsnyder PC, Leiter EH. Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 51: 825-832, 2002.
    • (2002) Diabetes , vol.51 , pp. 825-832
    • Reifsnyder, P.C.1    Leiter, E.H.2
  • 57
    • 34249888775 scopus 로고    scopus 로고
    • Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Rastam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjogren M, Sterner M, Surti A, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336, 2007
    • Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Rastam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjogren M, Sterner M, Surti A, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336, 2007.
  • 58
    • 57049188077 scopus 로고    scopus 로고
    • Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 222: 222-223, 2007.
    • Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 222: 222-223, 2007.
  • 59
    • 11144222672 scopus 로고    scopus 로고
    • Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: Identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4
    • Seidelmann SB, De Luca C, Leibel RL, Breslow JL, Tall AR, Welch CL. Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol 25: 204-210, 2005.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 204-210
    • Seidelmann, S.B.1    De Luca, C.2    Leibel, R.L.3    Breslow, J.L.4    Tall, A.R.5    Welch, C.L.6
  • 60
    • 0029988850 scopus 로고    scopus 로고
    • Development and consequences of insulin resistance: Lessons from animals with hyperinsulinaemia
    • Shafrir E. Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia. Diabetes Metab 22: 122-131, 1996.
    • (1996) Diabetes Metab , vol.22 , pp. 122-131
    • Shafrir, E.1
  • 62
    • 0035432057 scopus 로고    scopus 로고
    • Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model
    • Shike T, Hirose S, Kobayashi M, Funabiki K, Shirai T, Tomino Y. Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model. Diabetes 50: 1943-1948, 2001.
    • (2001) Diabetes , vol.50 , pp. 1943-1948
    • Shike, T.1    Hirose, S.2    Kobayashi, M.3    Funabiki, K.4    Shirai, T.5    Tomino, Y.6
  • 66
    • 34249828965 scopus 로고    scopus 로고
    • Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39: 770-775, 2007.
    • Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39: 770-775, 2007.
  • 68
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365: 1333-1346, 2005.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    van Haeften, T.W.3
  • 69
    • 0032699475 scopus 로고    scopus 로고
    • Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method
    • Sugiura K, Miyake T, Taniguchi Y, Yamada T, Moralejo DH, Wei S, Wei K, Sasaki Y, Matsumoto K. Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method. Mamm Genome 10: 1126-1131, 1999.
    • (1999) Mamm Genome , vol.10 , pp. 1126-1131
    • Sugiura, K.1    Miyake, T.2    Taniguchi, Y.3    Yamada, T.4    Moralejo, D.H.5    Wei, S.6    Wei, K.7    Sasaki, Y.8    Matsumoto, K.9
  • 70
    • 0032420530 scopus 로고    scopus 로고
    • Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice
    • Suto J, Matsuura S, Imamura K, Yamanaka H, Sekikawa K. Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice. Eur J Endocrinol 139: 654-661, 1998.
    • (1998) Eur J Endocrinol , vol.139 , pp. 654-661
    • Suto, J.1    Matsuura, S.2    Imamura, K.3    Yamanaka, H.4    Sekikawa, K.5
  • 72
    • 33748980248 scopus 로고    scopus 로고
    • Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice
    • Takeshita S, Moritani M, Kunika K, Inoue H, Itakura M. Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice. Mamm Genome 17: 927-940, 2006.
    • (2006) Mamm Genome , vol.17 , pp. 927-940
    • Takeshita, S.1    Moritani, M.2    Kunika, K.3    Inoue, H.4    Itakura, M.5
  • 73
    • 0031214118 scopus 로고    scopus 로고
    • Obesity QTLs on mouse chromosomes 2 and 17
    • Taylor BA, Phillips SJ. Obesity QTLs on mouse chromosomes 2 and 17. Genomics 43: 249-257, 1997.
    • (1997) Genomics , vol.43 , pp. 249-257
    • Taylor, B.A.1    Phillips, S.J.2
  • 74
    • 29644441804 scopus 로고    scopus 로고
    • Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice
    • Togawa K, Moritani M, Yaguchi H, Itakura M. Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice. Hum Mol Genet 15: 113-128, 2006.
    • (2006) Hum Mol Genet , vol.15 , pp. 113-128
    • Togawa, K.1    Moritani, M.2    Yaguchi, H.3    Itakura, M.4
  • 75
    • 20944448234 scopus 로고    scopus 로고
    • Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48: 675-686, 2005.
    • Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48: 675-686, 2005.
  • 76
    • 0035874933 scopus 로고    scopus 로고
    • Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat
    • Tsuji A, Nishikawa T, Mori M, Suda K, Nishimori I, Nishimura M. Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat. Genomics 74: 365-369, 2001.
    • (2001) Genomics , vol.74 , pp. 365-369
    • Tsuji, A.1    Nishikawa, T.2    Mori, M.3    Suda, K.4    Nishimori, I.5    Nishimura, M.6
  • 78
    • 34250197180 scopus 로고    scopus 로고
    • A Markov chain model for haplotype assembly from SNP fragments
    • Wang RS, Wu LY, Zhang XS, Chen L. A Markov chain model for haplotype assembly from SNP fragments. Genome Inform 17: 162-171, 2006.
    • (2006) Genome Inform , vol.17 , pp. 162-171
    • Wang, R.S.1    Wu, L.Y.2    Zhang, X.S.3    Chen, L.4
  • 80
    • 0032805994 scopus 로고    scopus 로고
    • Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat
    • Wei S, Wei K, Moralejo DH, Ogino T, Koike G, Jacob HJ, Sugiura K, Sasaki Y, Yamada T, Matsumoto K. Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Mamm Genome 10: 249-258, 1999.
    • (1999) Mamm Genome , vol.10 , pp. 249-258
    • Wei, S.1    Wei, K.2    Moralejo, D.H.3    Ogino, T.4    Koike, G.5    Jacob, H.J.6    Sugiura, K.7    Sasaki, Y.8    Yamada, T.9    Matsumoto, K.10
  • 83
    • 34247471241 scopus 로고    scopus 로고
    • A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice
    • Wuschke S, Dahm S, Schmidt C, Joost HG, Al-Hasani H. A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice. Int J Obes 31: 829-841, 2007.
    • (2007) Int J Obes , vol.31 , pp. 829-841
    • Wuschke, S.1    Dahm, S.2    Schmidt, C.3    Joost, H.G.4    Al-Hasani, H.5
  • 84
    • 16244378266 scopus 로고    scopus 로고
    • Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL
    • Yaguchi H, Togawa K, Moritani M, Itakura M. Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL. Genomics 85: 591-599, 2005.
    • (2005) Genomics , vol.85 , pp. 591-599
    • Yaguchi, H.1    Togawa, K.2    Moritani, M.3    Itakura, M.4
  • 85
    • 21744434038 scopus 로고    scopus 로고
    • Evaluation of apolipoprotein E secretion by macrophages in type 2 diabetic patients: Role of HDL and apolipoprotein A-I
    • Yamato K, Tamasawa N, Murakami H, Matsui J, Tanabe J, Suda T, Yasujima M. Evaluation of apolipoprotein E secretion by macrophages in type 2 diabetic patients: role of HDL and apolipoprotein A-I. Diabetes Res Clin Pract 69: 124-128, 2005.
    • (2005) Diabetes Res Clin Pract , vol.69 , pp. 124-128
    • Yamato, K.1    Tamasawa, N.2    Murakami, H.3    Matsui, J.4    Tanabe, J.5    Suda, T.6    Yasujima, M.7
  • 87
    • 34249895023 scopus 로고    scopus 로고
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316: 1336-1341, 2007.
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316: 1336-1341, 2007.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.