Selective deletion of the Hnf1β (MODY5) gene in β-cells leads to altered gene expression and defective insulin release

Endocrinology

Volumn 145, Issue 8, 2004, Pages 3941-3949

  Wang, Li ^a,d   Coffinier, Catherine ^c,e   Thomas, Melissa K ^b   Gresh, Lionel ^c   Eddu, Ganiu ^a   Manor, Tal ^a   Levitsky, Lynne L ^a   Yaniv, Moshe ^c   Rhoads, David B ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c INSTITUT PASTEUR   (France)

^d Eli Lilly and Company   (China)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 4; INSULIN; MESSENGER RNA; NUCLEAR FACTOR I; NUCLEAR FACTOR IALPHA; NUCLEAR FACTOR IBETA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1BETA; TCF2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FERTILITY; GENE DELETION; GENE EXPRESSION; GENETIC RECOMBINATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GROWTH RATE; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; DBA MOUSE; GENETICS; GLUCOSE TOLERANCE TEST; METABOLISM; MOUSE MUTANT; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY; SECRETION;

ANIMALS; ARGININE; BLOOD GLUCOSE; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HEPATOCYTE NUCLEAR FACTOR 1-BETA; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; TRANSCRIPTION FACTORS;

EID: 3843127483     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0281     Document Type: Article

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