메뉴 건너뛰기




Volumn 11, Issue 3, 2011, Pages 218-235

Current insights into the role of HIF-1 in cutaneous wound healing

Author keywords

Aging; Angiogenesis; Dermal wound healing; Diabetes; Hypoxia; Hypoxia Inducible Factor 1

Indexed keywords

ACYLTRANSFERASE; ANGIOPOIETIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN 4; ANGIOTENSIN II; CARDIAC GLYCOSIDE; CICLOPIROXOLAMINE; DIGOXIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR 2; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; LIFICIGUAT; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN P53; RAPAMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SOMATOMEDIN C; THROMBIN; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 79953310118     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652411795243414     Document Type: Article
Times cited : (63)

References (237)
  • 1
    • 0027159666 scopus 로고
    • Effects of hypothermia in hypercapnia and hypercapnic hypoxemia
    • Wetterberg T, Sjoberg T, Steen S. Effects of hypothermia in hypercapnia and hypercapnic hypoxemia. Acta Anaesthesiol Scand 1993; 37(3): 296-302.
    • (1993) Acta Anaesthesiol Scand , vol.37 , Issue.3 , pp. 296-302
    • Wetterberg, T.1    Sjoberg, T.2    Steen, S.3
  • 2
    • 0025939093 scopus 로고
    • Severe hypoxemia secondary to acute sternal infarction in sickle cell anemia
    • Ballas SK, Park CH. Severe hypoxemia secondary to acute sternal infarction in sickle cell anemia. J Nucl Med 1991; 32(8): 1617-8.
    • (1991) J Nucl Med , vol.32 , Issue.8 , pp. 1617-1618
    • Ballas, S.K.1    Park, C.H.2
  • 4
    • 58649103319 scopus 로고    scopus 로고
    • Wound healing essentials: Let there be oxygen
    • Sen CK. Wound healing essentials: let there be oxygen. Wound Repair Regen 2009; 17(1): 1-18.
    • (2009) Wound Repair Regen , vol.17 , Issue.1 , pp. 1-18
    • Sen, C.K.1
  • 5
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010; 29(5): 625-34.
    • (2010) Oncogene , vol.29 , Issue.5 , pp. 625-634
    • Semenza, G.L.1
  • 6
    • 0030583293 scopus 로고    scopus 로고
    • In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    • Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun 1996; 225(2): 485-8.
    • (1996) Biochem Biophys Res Commun , vol.225 , Issue.2 , pp. 485-488
    • Wiener, C.M.1    Booth, G.2    Semenza, G.L.3
  • 7
    • 0033435198 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain
    • Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci 1999; 11(12): 4159-70.
    • (1999) Eur J Neurosci , vol.11 , Issue.12 , pp. 4159-4170
    • Bergeron, M.1    Yu, A.Y.2    Solway, K.E.3    Semenza, G.L.4    Sharp, F.R.5
  • 8
    • 0034326273 scopus 로고    scopus 로고
    • Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
    • Elson DA, Ryan HE, Snow JW, Johnson R, Arbeit JM. Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res 2000; 60(21): 6189-95.
    • (2000) Cancer Res , vol.60 , Issue.21 , pp. 6189-6195
    • Elson, D.A.1    Ryan, H.E.2    Snow, J.W.3    Johnson, R.4    Arbeit, J.M.5
  • 9
    • 0035476509 scopus 로고    scopus 로고
    • Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha
    • Elson DA, Thurston G, Huang LE, et al. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev 2001; 15(19): 2520-32.
    • (2001) Genes Dev , vol.15 , Issue.19 , pp. 2520-2532
    • Elson, D.A.1    Thurston, G.2    Huang, L.E.3
  • 10
    • 33947117494 scopus 로고    scopus 로고
    • Extracellular heat shock protein-90alpha: Linking hypoxia to skin cell motility and wound healing
    • Li W, Li Y, Guan S, et al. Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J 2007; 26(5): 1221-33.
    • (2007) EMBO J , vol.26 , Issue.5 , pp. 1221-1233
    • Li, W.1    Li, Y.2    Guan, S.3
  • 11
    • 0037340247 scopus 로고    scopus 로고
    • Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease
    • Giatromanolaki A, Sivridis E, Maltezos E, et al. Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease. J Clin Pathol 2003; 56(3): 209-13.
    • (2003) J Clin Pathol , vol.56 , Issue.3 , pp. 209-213
    • Giatromanolaki, A.1    Sivridis, E.2    Maltezos, E.3
  • 12
    • 61449231910 scopus 로고    scopus 로고
    • Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: Implications for the treatment of inflammatory bowel disease
    • Hirota SA, Beck PL, MacDonald JA. Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: implications for the treatment of inflammatory bowel disease. Recent Pat Inflamm Allergy Drug Discov 2009; 3(1): 1-16.
    • (2009) Recent Pat Inflamm Allergy Drug Discov , vol.3 , Issue.1 , pp. 1-16
    • Hirota, S.A.1    Beck, P.L.2    Macdonald, J.A.3
  • 13
    • 18444380862 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys
    • Rosenberger C, Mandriota S, Jurgensen JS, et al. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 2002; 13(7): 1721-1732.
    • (2002) J Am Soc Nephrol , vol.13 , Issue.7 , pp. 1721-1732
    • Rosenberger, C.1    Mandriota, S.2    Jurgensen, J.S.3
  • 14
    • 0037530588 scopus 로고    scopus 로고
    • Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats
    • Matsumoto M, Makino Y, Tanaka T, et al. Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol 2003; 14(7): 1825-32.
    • (2003) J Am Soc Nephrol , vol.14 , Issue.7 , pp. 1825-1832
    • Matsumoto, M.1    Makino, Y.2    Tanaka, T.3
  • 15
    • 0033104847 scopus 로고    scopus 로고
    • Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha
    • Yu AY, Shimoda LA, Iyer NV, et al. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest 1999; 103(5): 691-6.
    • (1999) J Clin Invest , vol.103 , Issue.5 , pp. 691-696
    • Yu, A.Y.1    Shimoda, L.A.2    Iyer, N.V.3
  • 16
    • 0028199835 scopus 로고
    • Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis
    • Koch AE, Harlow LA, Haines GK, et al. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol 1994; 152(8): 4149-56.
    • (1994) J Immunol , vol.152 , Issue.8 , pp. 4149-4156
    • Koch, A.E.1    Harlow, L.A.2    Haines, G.K.3
  • 17
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 2000; 88(4): 1474-80.
    • (2000) J Appl Physiol , vol.88 , Issue.4 , pp. 1474-1480
    • Semenza, G.L.1
  • 18
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995; 270(3): 1230-7.
    • (1995) J Biol Chem , vol.270 , Issue.3 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 19
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92(12): 5510-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.12 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 20
    • 0030585761 scopus 로고    scopus 로고
    • Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q
    • Semenza GL, Rue EA, Iyer NV, Pang MG, Kearns WG. Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q. Genomics 1996; 34(3): 437-9.
    • (1996) Genomics , vol.34 , Issue.3 , pp. 437-439
    • Semenza, G.L.1    Rue, E.A.2    Iyer, N.V.3    Pang, M.G.4    Kearns, W.G.5
  • 21
    • 0027317967 scopus 로고
    • The Ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3
    • Johnson B, Brooks BA, Heinzmann C, et al. The Ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3. Genomics 1993; 17(3): 592-8.
    • (1993) Genomics , vol.17 , Issue.3 , pp. 592-598
    • Johnson, B.1    Brooks, B.A.2    Heinzmann, C.3
  • 22
    • 8044253996 scopus 로고    scopus 로고
    • Structural and functional analysis of hypoxia-inducible factor 1
    • Semenza GL, Agani F, Booth G, et al. Structural and functional analysis of hypoxia-inducible factor 1. Kidney Int 1997; 51(2): 553-5.
    • (1997) Kidney Int , vol.51 , Issue.2 , pp. 553-555
    • Semenza, G.L.1    Agani, F.2    Booth, G.3
  • 23
    • 67349277998 scopus 로고    scopus 로고
    • HIF-1 in the inflammatory microenvironment
    • Dehne N, Brune B. HIF-1 in the inflammatory microenvironment. Exp Cell Res 2009; 315(11): 1791-7.
    • (2009) Exp Cell Res , vol.315 , Issue.11 , pp. 1791-1797
    • Dehne, N.1    Brune, B.2
  • 24
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 1996; 271(30): 17771-8.
    • (1996) J Biol Chem , vol.271 , Issue.30 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 25
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394(6692): 485-90.
    • (1998) Nature , vol.394 , Issue.6692 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3
  • 26
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy AP, Levy NS, Wegner S, Goldberg MA. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 1995; 270(22): 13333-40.
    • (1995) J Biol Chem , vol.270 , Issue.22 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 27
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996; 16(9): 4604-13.
    • (1996) Mol Cell Biol , vol.16 , Issue.9 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3
  • 28
    • 0030751493 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
    • Gerber HP, Condorelli F, Park J, Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem 1997; 272(38): 23659-67.
    • (1997) J Biol Chem , vol.272 , Issue.38 , pp. 23659-23667
    • Gerber, H.P.1    Condorelli, F.2    Park, J.3    Ferrara, N.4
  • 29
    • 0344874751 scopus 로고    scopus 로고
    • Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
    • Kelly BD, Hackett SF, Hirota K, et al. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 2003; 93(11): 1074-81.
    • (2003) Circ Res , vol.93 , Issue.11 , pp. 1074-1081
    • Kelly, B.D.1    Hackett, S.F.2    Hirota, K.3
  • 30
    • 24344433563 scopus 로고    scopus 로고
    • Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia
    • Patel TH, Kimura H, Weiss CR, Semenza GL, Hofmann LV. Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia. Cardiovasc Res 2005; 68(1): 144-154.
    • (2005) Cardiovasc Res , vol.68 , Issue.1 , pp. 144-154
    • Patel, T.H.1    Kimura, H.2    Weiss, C.R.3    Semenza, G.L.4    Hofmann, L.V.5
  • 31
    • 4043184065 scopus 로고    scopus 로고
    • Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    • Ceradini DJ, Kulkarni AR, Callaghan MJ, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004; 10(8): 858-864.
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 858-864
    • Ceradini, D.J.1    Kulkarni, A.R.2    Callaghan, M.J.3
  • 32
    • 0344436031 scopus 로고    scopus 로고
    • Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice
    • Kappel A, Ronicke V, Damert A, Flamme I, Risau W, Breier G. Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice. Blood 1999; 93(12): 4284-92.
    • (1999) Blood , vol.93 , Issue.12 , pp. 4284-4292
    • Kappel, A.1    Ronicke, V.2    Damert, A.3    Flamme, I.4    Risau, W.5    Breier, G.6
  • 33
    • 0030792094 scopus 로고    scopus 로고
    • Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1
    • Rolfs A, Kvietikova I, Gassmann M, Wenger RH. Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J Biol Chem 1997; 272(32): 20055-62.
    • (1997) J Biol Chem , vol.272 , Issue.32 , pp. 20055-20062
    • Rolfs, A.1    Kvietikova, I.2    Gassmann, M.3    Wenger, R.H.4
  • 34
    • 0033588021 scopus 로고    scopus 로고
    • Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation
    • Tacchini L, Bianchi L, Bernelli-Zazzera A, Cairo G. Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J Biol Chem 1999; 274(34): 24142-6.
    • (1999) J Biol Chem , vol.274 , Issue.34 , pp. 24142-24146
    • Tacchini, L.1    Bianchi, L.2    Bernelli-Zazzera, A.3    Cairo, G.4
  • 35
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    • Iyer NV, Kotch LE, Agani F, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998; 12(2): 149-62.
    • (1998) Genes Dev , vol.12 , Issue.2 , pp. 149-162
    • Iyer, N.V.1    Kotch, L.E.2    Agani, F.3
  • 36
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan HE, Lo J, Johnson RS. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998; 17(11): 3005-15.
    • (1998) EMBO J , vol.17 , Issue.11 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 37
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    • Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 1999; 59(16): 3915-8.
    • (1999) Cancer Res , vol.59 , Issue.16 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Ferreira, G.5    Semenza, G.L.6
  • 38
    • 0032576971 scopus 로고    scopus 로고
    • Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand
    • Hu J, Discher DJ, Bishopric NH, Webster KA. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun 1998; 245(3): 894-9.
    • (1998) Biochem Biophys Res Commun , vol.245 , Issue.3 , pp. 894-899
    • Hu, J.1    Discher, D.J.2    Bishopric, N.H.3    Webster, K.A.4
  • 39
    • 0030611360 scopus 로고    scopus 로고
    • Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle
    • Eckhart AD, Yang N, Xin X, Faber JE. Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle. Proc Natl Acad Sci USA 1997; 94(17): 9487-92.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.17 , pp. 9487-9492
    • Eckhart, A.D.1    Yang, N.2    Xin, X.3    Faber, J.E.4
  • 40
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo G, Musso T, Sica A, Taylor LS, Cox GW, Varesio L. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 1995; 182(6): 1683-93.
    • (1995) J Exp Med , vol.182 , Issue.6 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 41
    • 33845604971 scopus 로고    scopus 로고
    • HIF-dependent induction of adenosine A2B receptor in hypoxia
    • Kong T, Westerman KA, Faigle M, Eltzschig HK, Colgan SP. HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J 2006; 20(13): 2242-50.
    • (2006) FASEB J , vol.20 , Issue.13 , pp. 2242-2250
    • Kong, T.1    Westerman, K.A.2    Faigle, M.3    Eltzschig, H.K.4    Colgan, S.P.5
  • 42
    • 36148988817 scopus 로고    scopus 로고
    • HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells
    • Maxwell PJ, Gallagher R, Seaton A, et al. HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells. Oncogene 2007; 26(52): 7333-45.
    • (2007) Oncogene , vol.26 , Issue.52 , pp. 7333-7345
    • Maxwell, P.J.1    Gallagher, R.2    Seaton, A.3
  • 43
    • 3142752573 scopus 로고    scopus 로고
    • Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression
    • Kong T, Eltzschig HK, Karhausen J, Colgan SP, Shelley CS. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci U S A 2004; 101(28): 10440-5.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.28 , pp. 10440-10445
    • Kong, T.1    Eltzschig, H.K.2    Karhausen, J.3    Colgan, S.P.4    Shelley, C.S.5
  • 44
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S, Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997; 272(36): 22642-7.
    • (1997) J Biol Chem , vol.272 , Issue.36 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 45
    • 0029859510 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
    • Jiang BH, Semenza GL, Bauer C, Marti HH. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol 1996; 271(4 Pt 1): C1172-80.
    • (1996) Am J Physiol , vol.271 , Issue.4 Pt 1
    • Jiang, B.H.1    Semenza, G.L.2    Bauer, C.3    Marti, H.H.4
  • 46
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
    • Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998; 95(14): 7987-92.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.14 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 47
    • 0032538797 scopus 로고    scopus 로고
    • Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
    • Kallio PJ, Okamoto K, O'Brien S, et al. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J 1998; 17(22): 6573-86.
    • (1998) EMBO J , vol.17 , Issue.22 , pp. 6573-6586
    • Kallio, P.J.1    Okamoto, K.2    O'Brien, S.3
  • 48
    • 0030787469 scopus 로고    scopus 로고
    • Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
    • Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem 1997; 272(31): 19253-60.
    • (1997) J Biol Chem , vol.272 , Issue.31 , pp. 19253-19260
    • Jiang, B.H.1    Zheng, J.Z.2    Leung, S.W.3    Roe, R.4    Semenza, G.L.5
  • 49
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001; 292(5516): 468-72.
    • (2001) Science , vol.292 , Issue.5516 , pp. 468-472
    • Jaakkola, P.1    Mole, D.R.2    Tian, Y.M.3
  • 50
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107(1): 43-54.
    • (2001) Cell , vol.107 , Issue.1 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3
  • 51
    • 0035917313 scopus 로고    scopus 로고
    • HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
    • Ivan M, Kondo K, Yang H, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001; 292(5516): 464-8.
    • (2001) Science , vol.292 , Issue.5516 , pp. 464-468
    • Ivan, M.1    Kondo, K.2    Yang, H.3
  • 52
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • Yu F, White SB, Zhao Q, Lee FS. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 2001; 98(17): 9630-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.17 , pp. 9630-9635
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4
  • 53
    • 0043234538 scopus 로고    scopus 로고
    • Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
    • Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 2003; 278(33): 30772-80.
    • (2003) J Biol Chem , vol.278 , Issue.33 , pp. 30772-30780
    • Hirsila, M.1    Koivunen, P.2    Gunzler, V.3    Kivirikko, K.I.4    Myllyharju, J.5
  • 54
    • 33749410367 scopus 로고    scopus 로고
    • The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases
    • Koivunen P, Hirsila M, Kivirikko KI, Myllyharju J. The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. J Biol Chem 2006; 281(39): 28712-20.
    • (2006) J Biol Chem , vol.281 , Issue.39 , pp. 28712-28720
    • Koivunen, P.1    Hirsila, M.2    Kivirikko, K.I.3    Myllyharju, J.4
  • 55
    • 5644240828 scopus 로고    scopus 로고
    • Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes
    • Stolze IP, Tian YM, Appelhoff RJ, et al. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes. J Biol Chem 2004; 279(41): 42719-25.
    • (2004) J Biol Chem , vol.279 , Issue.41 , pp. 42719-42725
    • Stolze, I.P.1    Tian, Y.M.2    Appelhoff, R.J.3
  • 56
    • 0037180452 scopus 로고    scopus 로고
    • Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
    • Dann CE 3rd, Bruick RK, Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci USA 2002; 99(24): 15351-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.24 , pp. 15351-15356
    • Dann 3rd., C.E.1    Bruick, R.K.2    Deisenhofer, J.3
  • 57
  • 58
    • 0038386022 scopus 로고    scopus 로고
    • Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2
    • Braganca J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem 2003; 278(18): 16021-9.
    • (2003) J Biol Chem , vol.278 , Issue.18 , pp. 16021-16029
    • Braganca, J.1    Eloranta, J.J.2    Bamforth, S.D.3    Ibbitt, J.C.4    Hurst, H.C.5    Bhattacharya, S.6
  • 59
    • 0035969508 scopus 로고    scopus 로고
    • Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
    • Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001; 414(6863): 550-4.
    • (2001) Nature , vol.414 , Issue.6863 , pp. 550-554
    • Makino, Y.1    Cao, R.2    Svensson, K.3    Bertilsson, G.4    Asman, M.5    Tanaka, H.6
  • 60
    • 18744375998 scopus 로고    scopus 로고
    • Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
    • Jeong JW, Bae MK, Ahn MY, et al. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell 2002; 111(5): 709-20.
    • (2002) Cell , vol.111 , Issue.5 , pp. 709-720
    • Jeong, J.W.1    Bae, M.K.2    Ahn, M.Y.3
  • 61
    • 70349696534 scopus 로고    scopus 로고
    • Identification of a novel small molecule HIF-1alpha translation inhibitor
    • Narita T, Yin S, Gelin CF, et al. Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res 2009; 15(19): 6128-36.
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6128-6136
    • Narita, T.1    Yin, S.2    Gelin, C.F.3
  • 62
    • 58149374576 scopus 로고    scopus 로고
    • Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
    • Zhang H, Qian DZ, Tan YS, et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci USA 2008; 105(50): 19579-86.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.50 , pp. 19579-19586
    • Zhang, H.1    Qian, D.Z.2    Tan, Y.S.3
  • 63
    • 0036789574 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    • Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002; 22(20): 7004-7014.
    • (2002) Mol Cell Biol , vol.22 , Issue.20 , pp. 7004-7014
    • Hudson, C.C.1    Liu, M.2    Chiang, G.G.3
  • 64
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia- inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia- inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60(6): 1541-5.
    • (2000) Cancer Res , vol.60 , Issue.6 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3
  • 65
    • 0037119415 scopus 로고    scopus 로고
    • Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
    • Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 2002; 277(33): 29936-44.
    • (2002) J Biol Chem , vol.277 , Issue.33 , pp. 29936-29944
    • Isaacs, J.S.1    Jung, Y.J.2    Mimnaugh, E.G.3    Martinez, A.4    Cuttitta, F.5    Neckers, L.M.6
  • 66
    • 0032749463 scopus 로고    scopus 로고
    • Hypoxia-induced activation of HIF-1: Role of HIF-1alpha-Hsp90 interaction
    • Minet E, Mottet D, Michel G, et al. Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. FEBS Lett 1999; 460(2): 251-6.
    • (1999) FEBS Lett , vol.460 , Issue.2 , pp. 251-256
    • Minet, E.1    Mottet, D.2    Michel, G.3
  • 67
    • 0037414180 scopus 로고    scopus 로고
    • YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
    • Yeo EJ, Chun YS, Cho YS, et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 2003; 95(7): 516-525.
    • (2003) J Natl Cancer Inst , vol.95 , Issue.7 , pp. 516-525
    • Yeo, E.J.1    Chun, Y.S.2    Cho, Y.S.3
  • 68
    • 0035871942 scopus 로고    scopus 로고
    • Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells
    • Chun YS, Yeo EJ, Choi E, et al. Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochem Pharmacol 2001; 61(8): 947-54.
    • (2001) Biochem Pharmacol , vol.61 , Issue.8 , pp. 947-954
    • Chun, Y.S.1    Yeo, E.J.2    Choi, E.3
  • 69
    • 33846990665 scopus 로고    scopus 로고
    • A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent
    • Kim HL, Yeo EJ, Chun YS, Park JW. A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent. Int J Oncol 2006; 29(1): 255-60.
    • (2006) Int J Oncol , vol.29 , Issue.1 , pp. 255-260
    • Kim, H.L.1    Yeo, E.J.2    Chun, Y.S.3    Park, J.W.4
  • 70
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
    • Ravi R, Mookerjee B, Bhujwalla ZM, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 2000; 14(1): 34-44.
    • (2000) Genes Dev , vol.14 , Issue.1 , pp. 34-44
    • Ravi, R.1    Mookerjee, B.2    Bhujwalla, Z.M.3
  • 71
    • 0035958932 scopus 로고    scopus 로고
    • The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits HIF-1-mediated transcription
    • Fatyol K, Szalay AA. The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits HIF-1-mediated transcription. J Biol Chem 2001; 276(30): 28421-9.
    • (2001) J Biol Chem , vol.276 , Issue.30 , pp. 28421-28429
    • Fatyol, K.1    Szalay, A.A.2
  • 72
    • 0034925041 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    • Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 2001; 12(7): 363-9.
    • (2001) Cell Growth Differ , vol.12 , Issue.7 , pp. 363-369
    • Jiang, B.H.1    Jiang, G.2    Zheng, J.Z.3    Lu, Z.4    Hunter, T.5    Vogt, P.K.6
  • 73
    • 0034050050 scopus 로고    scopus 로고
    • Loss of PTEN facilitates HIF-1-mediated gene expression
    • Zundel W, Schindler C, Haas-Kogan D, et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 2000; 14(4): 391-6.
    • (2000) Genes Dev , vol.14 , Issue.4 , pp. 391-396
    • Zundel, W.1    Schindler, C.2    Haas-Kogan, D.3
  • 74
    • 0043234256 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells
    • Mottet D, Dumont V, Deccache Y, et al. Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. J Biol Chem 2003; 278(33): 31277-85.
    • (2003) J Biol Chem , vol.278 , Issue.33 , pp. 31277-31285
    • Mottet, D.1    Dumont, V.2    Deccache, Y.3
  • 75
    • 0042029755 scopus 로고    scopus 로고
    • The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism
    • Tang TT, Lasky LA. The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism. J Biol Chem 2003; 278(32): 30125-35.
    • (2003) J Biol Chem , vol.278 , Issue.32 , pp. 30125-30135
    • Tang, T.T.1    Lasky, L.A.2
  • 76
    • 33845403070 scopus 로고    scopus 로고
    • Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha
    • Mylonis I, Chachami G, Samiotaki M, et al. Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha. J Biol Chem 2006; 281(44): 33095-106.
    • (2006) J Biol Chem , vol.281 , Issue.44 , pp. 33095-33106
    • Mylonis, I.1    Chachami, G.2    Samiotaki, M.3
  • 77
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    • Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999; 274(46): 32631-7.
    • (1999) J Biol Chem , vol.274 , Issue.46 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 78
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001; 21(12): 3995-4004.
    • (2001) Mol Cell Biol , vol.21 , Issue.12 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 79
    • 0035816732 scopus 로고    scopus 로고
    • Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase
    • Gorlach A, Diebold I, Schini-Kerth VB, et al. Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res 2001; 89(1): 47-54.
    • (2001) Circ Res , vol.89 , Issue.1 , pp. 47-54
    • Gorlach, A.1    Diebold, I.2    Schini-Kerth, V.B.3
  • 80
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002; 277(41): 38205-11.
    • (2002) J Biol Chem , vol.277 , Issue.41 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 81
    • 0033181324 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
    • Hellwig-Burgel T, Rutkowski K, Metzen E, Fandrey J, Jelkmann W. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 1999; 94(5): 1561-7.
    • (1999) Blood , vol.94 , Issue.5 , pp. 1561-1567
    • Hellwig-Burgel, T.1    Rutkowski, K.2    Metzen, E.3    Fandrey, J.4    Jelkmann, W.5
  • 82
    • 0021969522 scopus 로고
    • Ciclopirox olamine 1% cream. A preliminary review of its antimicrobial activity and therapeutic use
    • Jue SG, Dawson GW, Brogden RN. Ciclopirox olamine 1% cream. A preliminary review of its antimicrobial activity and therapeutic use. Drugs 1985; 29(4): 330-41.
    • (1985) Drugs , vol.29 , Issue.4 , pp. 330-341
    • Jue, S.G.1    Dawson, G.W.2    Brogden, R.N.3
  • 83
    • 0034663153 scopus 로고    scopus 로고
    • Epolones induce erythropoietin expression via hypoxia-inducible factor-1 alpha activation
    • Wanner RM, Spielmann P, Stroka DM, et al. Epolones induce erythropoietin expression via hypoxia-inducible factor-1 alpha activation. Blood 2000; 96(4): 1558-65.
    • (2000) Blood , vol.96 , Issue.4 , pp. 1558-1565
    • Wanner, R.M.1    Spielmann, P.2    Stroka, D.M.3
  • 84
    • 0037390915 scopus 로고    scopus 로고
    • The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis
    • Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH. The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis. FASEB J 2003; 17(6): 761-3.
    • (2003) FASEB J , vol.17 , Issue.6 , pp. 761-763
    • Linden, T.1    Katschinski, D.M.2    Eckhardt, K.3    Scheid, A.4    Pagel, H.5    Wenger, R.H.6
  • 85
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription
    • Arsham AM, Plas DR, Thompson CB, Simon MC. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem 2002; 277(17): 15162-70.
    • (2002) J Biol Chem , vol.277 , Issue.17 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 86
    • 0035477438 scopus 로고    scopus 로고
    • Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway
    • Blancher C, Moore JW, Robertson N, Harris AL. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. Cancer Res 2001; 61(19): 7349-55.
    • (2001) Cancer Res , vol.61 , Issue.19 , pp. 7349-7355
    • Blancher, C.1    Moore, J.W.2    Robertson, N.3    Harris, A.L.4
  • 88
    • 0034682786 scopus 로고    scopus 로고
    • Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
    • Chandel NS, McClintock DS, Feliciano CE, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 2000; 275(33): 25130-8.
    • (2000) J Biol Chem , vol.275 , Issue.33 , pp. 25130-25138
    • Chandel, N.S.1    McClintock, D.S.2    Feliciano, C.E.3
  • 89
    • 11144356447 scopus 로고    scopus 로고
    • Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species
    • Goyal P, Weissmann N, Grimminger F, et al. Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species. Free Radic Biol Med 2004; 36(10): 1279-88.
    • (2004) Free Radic Biol Med , vol.36 , Issue.10 , pp. 1279-1288
    • Goyal, P.1    Weissmann, N.2    Grimminger, F.3
  • 90
    • 0035860375 scopus 로고    scopus 로고
    • A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha
    • Haddad JJ, Land SC. A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. FEBS Lett 2001; 505(2): 269-74.
    • (2001) FEBS Lett , vol.505 , Issue.2 , pp. 269-274
    • Haddad, J.J.1    Land, S.C.2
  • 91
    • 0037073695 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms
    • Page EL, Robitaille GA, Pouyssegur J, Richard DE. Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms. J Biol Chem 2002; 277(50): 48403-9.
    • (2002) J Biol Chem , vol.277 , Issue.50 , pp. 48403-48409
    • Page, E.L.1    Robitaille, G.A.2    Pouyssegur, J.3    Richard, D.E.4
  • 92
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
    • Moeller BJ, Cao Y, Li CY, Dewhirst MW. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004; 5(5): 429-41.
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 93
    • 0036400865 scopus 로고    scopus 로고
    • Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells
    • Enomoto N, Koshikawa N, Gassmann M, Hayashi J, Takenaga K. Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells. Biochem Biophys Res Commun 2002; 297(2): 346-52.
    • (2002) Biochem Biophys Res Commun , vol.297 , Issue.2 , pp. 346-352
    • Enomoto, N.1    Koshikawa, N.2    Gassmann, M.3    Hayashi, J.4    Takenaga, K.5
  • 95
    • 0033118983 scopus 로고    scopus 로고
    • Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
    • Ema M, Hirota K, Mimura J, et al. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 1999; 18(7): 1905-1914.
    • (1999) EMBO J , vol.18 , Issue.7 , pp. 1905-1914
    • Ema, M.1    Hirota, K.2    Mimura, J.3
  • 96
    • 0042469448 scopus 로고    scopus 로고
    • Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases
    • Metzen E, Zhou J, Jelkmann W, Fandrey J, Brune B. Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell 2003; 14(8): 3470-81.
    • (2003) Mol Biol Cell , vol.14 , Issue.8 , pp. 3470-3481
    • Metzen, E.1    Zhou, J.2    Jelkmann, W.3    Fandrey, J.4    Brune, B.5
  • 98
    • 1642453685 scopus 로고    scopus 로고
    • Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
    • Kasuno K, Takabuchi S, Fukuda K, et al. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem 2004; 279(4): 2550-8.
    • (2004) J Biol Chem , vol.279 , Issue.4 , pp. 2550-2558
    • Kasuno, K.1    Takabuchi, S.2    Fukuda, K.3
  • 99
    • 0141640863 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
    • Yamakawa M, Liu LX, Date T, et al. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ Res 2003; 93(7): 664-73.
    • (2003) Circ Res , vol.93 , Issue.7 , pp. 664-673
    • Yamakawa, M.1    Liu, L.X.2    Date, T.3
  • 100
    • 33645504221 scopus 로고    scopus 로고
    • Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
    • Calvani M, Rapisarda A, Uranchimeg B, Shoemaker RH, Melillo G. Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood 2006; 107(7): 2705-12.
    • (2006) Blood , vol.107 , Issue.7 , pp. 2705-2712
    • Calvani, M.1    Rapisarda, A.2    Uranchimeg, B.3    Shoemaker, R.H.4    Melillo, G.5
  • 101
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9(6): 653-60.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 653-660
    • Carmeliet, P.1
  • 102
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9(6): 669-76.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 103
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146(5): 1029-39.
    • (1995) Am J Pathol , vol.146 , Issue.5 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 104
    • 0032560844 scopus 로고    scopus 로고
    • VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development
    • Larcher F, Murillas R, Bolontrade M, Conti CJ, Jorcano JL. VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development. Oncogene 1998; 17(3): 303-11.
    • (1998) Oncogene , vol.17 , Issue.3 , pp. 303-311
    • Larcher, F.1    Murillas, R.2    Bolontrade, M.3    Conti, C.J.4    Jorcano, J.L.5
  • 105
    • 0033601357 scopus 로고    scopus 로고
    • Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    • Thurston G, Suri C, Smith K, et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 1999; 286(5449): 2511-4.
    • (1999) Science , vol.286 , Issue.5449 , pp. 2511-2514
    • Thurston, G.1    Suri, C.2    Smith, K.3
  • 106
    • 0035476508 scopus 로고    scopus 로고
    • Building better vasculature
    • Bruick RK, McKnight SL. Building better vasculature. Genes Dev 2001; 15(19): 2497-502.
    • (2001) Genes Dev , vol.15 , Issue.19 , pp. 2497-2502
    • Bruick, R.K.1    McKnight, S.L.2
  • 107
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277(5322): 55-60.
    • (1997) Science , vol.277 , Issue.5322 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 108
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999; 18(38): 5356-62.
    • (1999) Oncogene , vol.18 , Issue.38 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 109
    • 0036558290 scopus 로고    scopus 로고
    • Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites
    • Li J, Shworak NW, Simons M. Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites. J Cell Sci 2002; 115(Pt 9): 1951-9.
    • (2002) J Cell Sci , vol.115 , Issue.Pt 9 , pp. 1951-1959
    • Li, J.1    Shworak, N.W.2    Simons, M.3
  • 110
    • 52449108643 scopus 로고    scopus 로고
    • FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha
    • Conte C, Riant E, Toutain C, et al. FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha. PLoS One 2008; 3(8): e3078.
    • (2008) PLoS One , vol.3 , Issue.8
    • Conte, C.1    Riant, E.2    Toutain, C.3
  • 111
    • 37349115260 scopus 로고    scopus 로고
    • Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia
    • Bosch-Marce M, Okuyama H, Wesley JB, et al. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 2007; 101(12): 1310-8.
    • (2007) Circ Res , vol.101 , Issue.12 , pp. 1310-1318
    • Bosch-Marce, M.1    Okuyama, H.2    Wesley, J.B.3
  • 112
    • 0038363443 scopus 로고    scopus 로고
    • Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
    • Cao R, Brakenhielm E, Pawliuk R, et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 2003; 9(5): 604-13.
    • (2003) Nat Med , vol.9 , Issue.5 , pp. 604-613
    • Cao, R.1    Brakenhielm, E.2    Pawliuk, R.3
  • 113
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet P, Moons L, Luttun A, et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 2001; 7(5): 575-83.
    • (2001) Nat Med , vol.7 , Issue.5 , pp. 575-583
    • Carmeliet, P.1    Moons, L.2    Luttun, A.3
  • 114
    • 0036344495 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    • Luttun A, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 2002; 8(8): 831-40.
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 831-840
    • Luttun, A.1    Tjwa, M.2    Moons, L.3
  • 115
    • 0037423858 scopus 로고    scopus 로고
    • VEGFR-1-selective VEGF homologue PlGF is arteriogenic: Evidence for a monocyte-mediated mechanism
    • Pipp F, Heil M, Issbrucker K, et al. VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism. Circ Res 2003; 92(4): 378-85.
    • (2003) Circ Res , vol.92 , Issue.4 , pp. 378-385
    • Pipp, F.1    Heil, M.2    Issbrucker, K.3
  • 116
    • 33847615147 scopus 로고    scopus 로고
    • Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation
    • Takeda K, Fong GH. Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation. Hypertension 2007; 49(1): 178-84.
    • (2007) Hypertension , vol.49 , Issue.1 , pp. 178-184
    • Takeda, K.1    Fong, G.H.2
  • 117
    • 69549120060 scopus 로고    scopus 로고
    • Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor
    • An X, Jin Y, Guo H, et al. Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation 2009; 120(7): 617-27.
    • (2009) Circulation , vol.120 , Issue.7 , pp. 617-627
    • An, X.1    Jin, Y.2    Guo, H.3
  • 118
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
    • OReilly MS. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997; 88(2): 277-85.
    • (1997) Cell , vol.88 , Issue.2 , pp. 277-285
    • Oreilly, M.S.1
  • 119
    • 0036831302 scopus 로고    scopus 로고
    • The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
    • Hajitou A, Grignet C, Devy L, et al. The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells. FASEB J 2002; 16(13): 1802-4.
    • (2002) FASEB J , vol.16 , Issue.13 , pp. 1802-1804
    • Hajitou, A.1    Grignet, C.2    Devy, L.3
  • 120
    • 0034307327 scopus 로고    scopus 로고
    • Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase
    • Kim YM, Jang JW, Lee OH, et al. Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase. Cancer Res 2000; 60(19): 5410-3.
    • (2000) Cancer Res , vol.60 , Issue.19 , pp. 5410-5413
    • Kim, Y.M.1    Jang, J.W.2    Lee, O.H.3
  • 121
    • 0642379684 scopus 로고    scopus 로고
    • Anti-angiogenic activity of human endostatin is HIF-1-independent in vitro and sensitive to timing of treatment in a human saphenous vein assay
    • Macpherson GR, Ng SS, Forbes SL, et al. Anti-angiogenic activity of human endostatin is HIF-1-independent in vitro and sensitive to timing of treatment in a human saphenous vein assay. Mol Cancer Ther 2003; 2(9): 845-54.
    • (2003) Mol Cancer Ther , vol.2 , Issue.9 , pp. 845-854
    • Macpherson, G.R.1    Ng, S.S.2    Forbes, S.L.3
  • 122
    • 33746123520 scopus 로고    scopus 로고
    • Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
    • Kaidi A, Qualtrough D, Williams AC, Paraskeva C. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res 2006; 66(13): 6683-91.
    • (2006) Cancer Res , vol.66 , Issue.13 , pp. 6683-6691
    • Kaidi, A.1    Qualtrough, D.2    Williams, A.C.3    Paraskeva, C.4
  • 123
    • 1642307340 scopus 로고    scopus 로고
    • Endostatin's antiangiogenic signaling network
    • Abdollahi A, Hahnfeldt P, Maercker C, et al. Endostatin's antiangiogenic signaling network. Mol Cell 2004; 13(5): 649-63.
    • (2004) Mol Cell , vol.13 , Issue.5 , pp. 649-663
    • Abdollahi, A.1    Hahnfeldt, P.2    Maercker, C.3
  • 124
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
    • Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 2000; 275(35): 26765-71.
    • (2000) J Biol Chem , vol.275 , Issue.35 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 125
    • 33744944257 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells
    • Schultz K, Fanburg BL, Beasley D. Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2006; 290(6): H2528-34.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.6
    • Schultz, K.1    Fanburg, B.L.2    Beasley, D.3
  • 126
    • 0028228645 scopus 로고
    • Hypoxia stimulates human endothelial cells to release smooth muscle cell mitogens: Role of prostaglandins and bFGF
    • Michiels C, De Leener F, Arnould T, Dieu M, Remacle J. Hypoxia stimulates human endothelial cells to release smooth muscle cell mitogens: role of prostaglandins and bFGF. Exp Cell Res 1994; 213(1): 43-54.
    • (1994) Exp Cell Res , vol.213 , Issue.1 , pp. 43-54
    • Michiels, C.1    de Leener, F.2    Arnould, T.3    Dieu, M.4    Remacle, J.5
  • 127
    • 67049115821 scopus 로고    scopus 로고
    • Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms
    • Schultz K, Murthy V, Tatro JB, Beasley D. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol 2009; 296(6): L921-7.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296 , Issue.6
    • Schultz, K.1    Murthy, V.2    Tatro, J.B.3    Beasley, D.4
  • 128
    • 50249128071 scopus 로고    scopus 로고
    • Hypoxia stimulates the autocrine regulation of migration of vascular smooth muscle cells via HIF-1alpha-dependent expression of thrombospondin-1
    • Osada-Oka M, Ikeda T, Akiba S, Sato T. Hypoxia stimulates the autocrine regulation of migration of vascular smooth muscle cells via HIF-1alpha-dependent expression of thrombospondin-1. J Cell Biochem 2008; 104(5): 1918-26.
    • (2008) J Cell Biochem , vol.104 , Issue.5 , pp. 1918-1926
    • Osada-Oka, M.1    Ikeda, T.2    Akiba, S.3    Sato, T.4
  • 129
    • 40449107626 scopus 로고    scopus 로고
    • Role of thrombospondin-1 in hypoxia-induced migration of human vascular smooth muscle cells
    • Takahashi M, Oka M, Ikeda T, Akiba S, Sato T. Role of thrombospondin-1 in hypoxia-induced migration of human vascular smooth muscle cells. Yakugaku Zasshi 2008; 128(3): 377-83.
    • (2008) Yakugaku Zasshi , vol.128 , Issue.3 , pp. 377-383
    • Takahashi, M.1    Oka, M.2    Ikeda, T.3    Akiba, S.4    Sato, T.5
  • 130
  • 131
    • 0020313151 scopus 로고
    • Synthesis and secretion of thrombospondin by cultured human endothelial cells
    • Mosher DF, Doyle MJ, Jaffe EA. Synthesis and secretion of thrombospondin by cultured human endothelial cells. J Cell Biol 1982; 93(2): 343-8.
    • (1982) J Cell Biol , vol.93 , Issue.2 , pp. 343-348
    • Mosher, D.F.1    Doyle, M.J.2    Jaffe, E.A.3
  • 133
    • 0032770860 scopus 로고    scopus 로고
    • Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas
    • Streit M, Velasco P, Brown LF, et al. Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. Am J Pathol 1999; 155(2): 441-52.
    • (1999) Am J Pathol , vol.155 , Issue.2 , pp. 441-452
    • Streit, M.1    Velasco, P.2    Brown, L.F.3
  • 134
    • 0025147371 scopus 로고
    • A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
    • Good DJ, Polverini PJ, Rastinejad F, et al. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc Natl Acad Sci USA 1990; 87(17): 6624-8.
    • (1990) Proc Natl Acad Sci USA , vol.87 , Issue.17 , pp. 6624-6628
    • Good, D.J.1    Polverini, P.J.2    Rastinejad, F.3
  • 135
    • 0033514927 scopus 로고    scopus 로고
    • Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization
    • Bleuel K, Popp S, Fusenig NE, Stanbridge EJ, Boukamp P. Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization. Proc Natl Acad Sci USA 1999; 96(5): 2065-70.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.5 , pp. 2065-2070
    • Bleuel, K.1    Popp, S.2    Fusenig, N.E.3    Stanbridge, E.J.4    Boukamp, P.5
  • 136
    • 58149169164 scopus 로고    scopus 로고
    • Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/-mice
    • Moura R, Tjwa M, Vandervoort P, Van Kerckhoven S, Holvoet P, Hoylaerts MF. Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/-mice. Circ Res 2008; 103(10): 1181-9.
    • (2008) Circ Res , vol.103 , Issue.10 , pp. 1181-1189
    • Moura, R.1    Tjwa, M.2    Vandervoort, P.3    van Kerckhoven, S.4    Holvoet, P.5    Hoylaerts, M.F.6
  • 137
    • 0031845732 scopus 로고    scopus 로고
    • Thrombospondin-1 is elevated with both intimal hyperplasia and hypercholesterolemia
    • Roth JJ, Gahtan V, Brown JL, et al. Thrombospondin-1 is elevated with both intimal hyperplasia and hypercholesterolemia. J Surg Res 1998; 74(1): 11-6.
    • (1998) J Surg Res , vol.74 , Issue.1 , pp. 11-16
    • Roth, J.J.1    Gahtan, V.2    Brown, J.L.3
  • 138
    • 0031911316 scopus 로고    scopus 로고
    • Immunolocalization of thrombospondin-1 in human atherosclerotic and restenotic arteries
    • Riessen R, Kearney M, Lawler J, Isner JM. Immunolocalization of thrombospondin-1 in human atherosclerotic and restenotic arteries. Am Heart J 1998; 135(2 Pt 1): 357-64.
    • (1998) Am Heart J , vol.135 , Issue.2 Pt 1 , pp. 357-364
    • Riessen, R.1    Kearney, M.2    Lawler, J.3    Isner, J.M.4
  • 140
    • 0023182022 scopus 로고
    • Thrombospondin promotes cell-substratum adhesion
    • Tuszynski GP, Rothman V, Murphy A, et al. Thrombospondin promotes cell-substratum adhesion. Science 1987; 236(4808): 1570-3.
    • (1987) Science , vol.236 , Issue.4808 , pp. 1570-1573
    • Tuszynski, G.P.1    Rothman, V.2    Murphy, A.3
  • 141
    • 0023875603 scopus 로고
    • Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation
    • Majack RA, Goodman LV, Dixit VM. Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol 1988; 106(2): 415-22.
    • (1988) J Cell Biol , vol.106 , Issue.2 , pp. 415-422
    • Majack, R.A.1    Goodman, L.V.2    Dixit, V.M.3
  • 142
    • 0025370524 scopus 로고
    • Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: A potential angiogenesis regulatory factor
    • Taraboletti G, Roberts D, Liotta LA, Giavazzi R. Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J Cell Biol 1990; 111(2): 765-72.
    • (1990) J Cell Biol , vol.111 , Issue.2 , pp. 765-772
    • Taraboletti, G.1    Roberts, D.2    Liotta, L.A.3    Giavazzi, R.4
  • 143
    • 51449105857 scopus 로고    scopus 로고
    • Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
    • Liu L, Marti GP, Wei X, et al. Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol 2008; 217(2): 319-27.
    • (2008) J Cell Physiol , vol.217 , Issue.2 , pp. 319-327
    • Liu, L.1    Marti, G.P.2    Wei, X.3
  • 144
    • 0033565540 scopus 로고    scopus 로고
    • VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
    • Asahara T, Takahashi T, Masuda H, et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J 1999; 18(14): 3964-72.
    • (1999) EMBO J , vol.18 , Issue.14 , pp. 3964-3972
    • Asahara, T.1    Takahashi, T.2    Masuda, H.3
  • 145
    • 0037418213 scopus 로고    scopus 로고
    • Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors
    • Rehman J, Li J, Orschell CM, March KL. Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003; 107(8): 1164-9.
    • (2003) Circulation , vol.107 , Issue.8 , pp. 1164-1169
    • Rehman, J.1    Li, J.2    Orschell, C.M.3    March, K.L.4
  • 146
    • 0036281597 scopus 로고    scopus 로고
    • Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization
    • Grant MB, May WS, Caballero S, et al. Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization. Nat Med 2002; 8(6): 607-12.
    • (2002) Nat Med , vol.8 , Issue.6 , pp. 607-612
    • Grant, M.B.1    May, W.S.2    Caballero, S.3
  • 147
    • 1842486565 scopus 로고    scopus 로고
    • Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    • Kinnaird T, Stabile E, Burnett MS, et al. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 2004; 109(12): 1543-9.
    • (2004) Circulation , vol.109 , Issue.12 , pp. 1543-1549
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3
  • 148
    • 0035383801 scopus 로고    scopus 로고
    • Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells
    • Hattori K, Heissig B, Tashiro K, et al. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood 2001; 97(11): 3354-60.
    • (2001) Blood , vol.97 , Issue.11 , pp. 3354-3360
    • Hattori, K.1    Heissig, B.2    Tashiro, K.3
  • 149
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003; 425(6955): 307-11.
    • (2003) Nature , vol.425 , Issue.6955 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 150
    • 38149035012 scopus 로고    scopus 로고
    • Angiogenesis by transplantation of HIF-1 alpha modified EPCs into ischemic limbs
    • Jiang M, Wang B, Wang C, et al. Angiogenesis by transplantation of HIF-1 alpha modified EPCs into ischemic limbs. J Cell Biochem 2008; 103(1): 321-34.
    • (2008) J Cell Biochem , vol.103 , Issue.1 , pp. 321-334
    • Jiang, M.1    Wang, B.2    Wang, C.3
  • 151
    • 0032820711 scopus 로고    scopus 로고
    • Proteolysis and cell migration: Creating a path?
    • Murphy G, Gavrilovic J. Proteolysis and cell migration: creating a path? Curr Opin Cell Biol 1999; 11(5): 614-21.
    • (1999) Curr Opin Cell Biol , vol.11 , Issue.5 , pp. 614-621
    • Murphy, G.1    Gavrilovic, J.2
  • 152
    • 1242314761 scopus 로고    scopus 로고
    • Regulation of angiogenesis by extracellular matrix
    • Sottile J. Regulation of angiogenesis by extracellular matrix. Biochim Biophys Acta 2004; 1654(1): 13-22.
    • (2004) Biochim Biophys Acta , vol.1654 , Issue.1 , pp. 13-22
    • Sottile, J.1
  • 153
    • 0033679623 scopus 로고    scopus 로고
    • Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle
    • Haas TL, Milkiewicz M, Davis SJ, et al. Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle. Am J Physiol Heart Circ Physiol 2000; 279(4): H1540-7.
    • (2000) Am J Physiol Heart Circ Physiol , vol.279 , Issue.4
    • Haas, T.L.1    Milkiewicz, M.2    Davis, S.J.3
  • 154
    • 9444274032 scopus 로고    scopus 로고
    • MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix
    • Chun TH, Sabeh F, Ota I, et al. MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix. J Cell Biol 2004; 167(4): 757-67.
    • (2004) J Cell Biol , vol.167 , Issue.4 , pp. 757-767
    • Chun, T.H.1    Sabeh, F.2    Ota, I.3
  • 155
    • 22344437713 scopus 로고    scopus 로고
    • Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
    • Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol 2005; 169(4): 681-91.
    • (2005) J Cell Biol , vol.169 , Issue.4 , pp. 681-691
    • Lee, S.1    Jilani, S.M.2    Nikolova, G.V.3    Carpizo, D.4    Iruela-Arispe, M.L.5
  • 156
    • 0029999603 scopus 로고    scopus 로고
    • Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin
    • Senger DR, Ledbetter SR, Claffey KP, Papadopoulos-Sergiou A, Peruzzi CA, Detmar M. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. Am J Pathol 1996; 149(1): 293-305.
    • (1996) Am J Pathol , vol.149 , Issue.1 , pp. 293-305
    • Senger, D.R.1    Ledbetter, S.R.2    Claffey, K.P.3    Papadopoulos-Sergiou, A.4    Peruzzi, C.A.5    Detmar, M.6
  • 157
    • 0031459892 scopus 로고    scopus 로고
    • Angiogenesis promoted by vascular endothelial growth factor: Regulation through alpha1beta1 and alpha2beta1 integrins
    • Senger DR, Claffey KP, Benes JE, Perruzzi CA, Sergiou AP, Detmar M. Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins. Proc Natl Acad Sci USA 1997; 94(25): 13612-7.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.25 , pp. 13612-13617
    • Senger, D.R.1    Claffey, K.P.2    Benes, J.E.3    Perruzzi, C.A.4    Sergiou, A.P.5    Detmar, M.6
  • 159
    • 0025976838 scopus 로고
    • Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
    • Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991; 64(4): 841-8.
    • (1991) Cell , vol.64 , Issue.4 , pp. 841-848
    • Yayon, A.1    Klagsbrun, M.2    Esko, J.D.3    Leder, P.4    Ornitz, D.M.5
  • 160
    • 0022477372 scopus 로고
    • Heparin protects basic and acidic FGF from inactivation
    • Gospodarowicz D, Cheng J. Heparin protects basic and acidic FGF from inactivation. J Cell Physiol 1986; 128(3): 475-84.
    • (1986) J Cell Physiol , vol.128 , Issue.3 , pp. 475-484
    • Gospodarowicz, D.1    Cheng, J.2
  • 161
    • 0023687871 scopus 로고
    • Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation
    • Saksela O, Moscatelli D, Sommer A, Rifkin DB. Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. J Cell Biol 1988; 107(2): 743-751.
    • (1988) J Cell Biol , vol.107 , Issue.2 , pp. 743-751
    • Saksela, O.1    Moscatelli, D.2    Sommer, A.3    Rifkin, D.B.4
  • 162
    • 0020574001 scopus 로고
    • Human endothelial cells: Use of heparin in cloning and long-term serial cultivation
    • Thornton SC, Mueller SN, Levine EM. Human endothelial cells: use of heparin in cloning and long-term serial cultivation. Science 1983; 222(4624): 623-5.
    • (1983) Science , vol.222 , Issue.4624 , pp. 623-625
    • Thornton, S.C.1    Mueller, S.N.2    Levine, E.M.3
  • 163
    • 0018936563 scopus 로고
    • Mast cell heparin stimulates migration of capillary endothelial cells in vitro
    • Azizkhan RG, Azizkhan JC, Zetter BR, Folkman J. Mast cell heparin stimulates migration of capillary endothelial cells in vitro. J Exp Med 1980; 152(4): 931-44.
    • (1980) J Exp Med , vol.152 , Issue.4 , pp. 931-944
    • Azizkhan, R.G.1    Azizkhan, J.C.2    Zetter, B.R.3    Folkman, J.4
  • 164
    • 0019949388 scopus 로고
    • Protamine is an inhibitor of angiogenesis
    • Taylor S, Folkman J. Protamine is an inhibitor of angiogenesis. Nature 1982; 297(5864): 307-12.
    • (1982) Nature , vol.297 , Issue.5864 , pp. 307-312
    • Taylor, S.1    Folkman, J.2
  • 165
    • 23844540031 scopus 로고    scopus 로고
    • Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells
    • Sasabe E, Tatemoto Y, Li D, Yamamoto T, Osaki T. Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells. Cancer Sci 2005; 96(7): 394-402.
    • (2005) Cancer Sci , vol.96 , Issue.7 , pp. 394-402
    • Sasabe, E.1    Tatemoto, Y.2    Li, D.3    Yamamoto, T.4    Osaki, T.5
  • 166
    • 72949099284 scopus 로고    scopus 로고
    • Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis
    • Huang CH, Yang WH, Chang SY, et al. Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis. Neoplasia 2009; 11(12): 1371-82.
    • (2009) Neoplasia , vol.11 , Issue.12 , pp. 1371-1382
    • Huang, C.H.1    Yang, W.H.2    Chang, S.Y.3
  • 167
    • 77953647350 scopus 로고    scopus 로고
    • Interference of HIF-1alpha by RNA reduces the expression of matrix metalloproteinase-2 in human cervical carcinoma HeLa cells
    • Xie T, Yuan XL, Yu SY, Yang B, Dong LL. Interference of HIF-1alpha by RNA reduces the expression of matrix metalloproteinase-2 in human cervical carcinoma HeLa cells. Ai Zheng 2008; 27(6): 600-5.
    • (2008) Ai Zheng , vol.27 , Issue.6 , pp. 600-605
    • Xie, T.1    Yuan, X.L.2    Yu, S.Y.3    Yang, B.4    Dong, L.L.5
  • 168
    • 0037374289 scopus 로고    scopus 로고
    • Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
    • Krishnamachary B, Berg-Dixon S, Kelly B, et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res 2003; 63(5): 1138-43.
    • (2003) Cancer Res , vol.63 , Issue.5 , pp. 1138-1143
    • Krishnamachary, B.1    Berg-Dixon, S.2    Kelly, B.3
  • 169
  • 170
    • 35248891427 scopus 로고    scopus 로고
    • The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: An animal experiment study in the mouse model
    • Sun B, Zhang S, Zhang D, Gu Y, Zhang W, Zhao X. The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse model. J Cancer Res Clin Oncol 2007; 133(12): 979-85.
    • (2007) J Cancer Res Clin Oncol , vol.133 , Issue.12 , pp. 979-985
    • Sun, B.1    Zhang, S.2    Zhang, D.3    Gu, Y.4    Zhang, W.5    Zhao, X.6
  • 171
    • 34247847903 scopus 로고    scopus 로고
    • Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas
    • Fujiwara S, Nakagawa K, Harada H, et al. Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas. Int J Oncol 2007; 30(4): 793-802.
    • (2007) Int J Oncol , vol.30 , Issue.4 , pp. 793-802
    • Fujiwara, S.1    Nakagawa, K.2    Harada, H.3
  • 172
    • 36348949677 scopus 로고    scopus 로고
    • Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma
    • Kleinman ME, Greives MR, Churgin SS, et al. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol 2007; 27(12): 2664-70.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.12 , pp. 2664-2670
    • Kleinman, M.E.1    Greives, M.R.2    Churgin, S.S.3
  • 173
    • 13944252559 scopus 로고    scopus 로고
    • Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma
    • Petrella BL, Lohi J, Brinckerhoff CE. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005; 24(6): 1043-52.
    • (2005) Oncogene , vol.24 , Issue.6 , pp. 1043-1052
    • Petrella, B.L.1    Lohi, J.2    Brinckerhoff, C.E.3
  • 174
    • 44849126662 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor-1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes
    • Ahn JK, Koh EM, Cha HS, et al. Role of hypoxia-inducible factor-1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes. Rheumatology (Oxford) 2008; 47(6): 834-9.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.6 , pp. 834-839
    • Ahn, J.K.1    Koh, E.M.2    Cha, H.S.3
  • 175
    • 33947302545 scopus 로고    scopus 로고
    • Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner
    • Miyoshi A, Kitajima Y, Ide T, et al. Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner. Int J Oncol 2006; 29(6): 1533-9.
    • (2006) Int J Oncol , vol.29 , Issue.6 , pp. 1533-1539
    • Miyoshi, A.1    Kitajima, Y.2    Ide, T.3
  • 176
    • 34948827102 scopus 로고    scopus 로고
    • Hypoxia down-regulates secretion of MMP-2, MMP-9 in porcine pulmonary artery endothelial and smooth muscle cells and the role of HIF-1
    • Ye H, Zheng Y, Ma W, et al. Hypoxia down-regulates secretion of MMP-2, MMP-9 in porcine pulmonary artery endothelial and smooth muscle cells and the role of HIF-1. J Huazhong Univ Sci Technolog Med Sci 2005; 25(4): 382-4, 407.
    • (2005) J Huazhong Univ Sci Technolog Med Sci , vol.25 , Issue.4 , pp. 382-384
    • Ye, H.1    Zheng, Y.2    Ma, W.3
  • 177
    • 23744479831 scopus 로고    scopus 로고
    • Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
    • Kim SJ, Rabbani ZN, Dewhirst MW, et al. Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer 2005; 49(3): 325-35.
    • (2005) Lung Cancer , vol.49 , Issue.3 , pp. 325-335
    • Kim, S.J.1    Rabbani, Z.N.2    Dewhirst, M.W.3
  • 178
    • 39649085541 scopus 로고    scopus 로고
    • Extracellular matrix and HIF-1 signaling: The role of prolidase
    • Surazynski A, Donald SP, Cooper SK, et al. Extracellular matrix and HIF-1 signaling: the role of prolidase. Int J Cancer 2008; 122(6): 1435-40.
    • (2008) Int J Cancer , vol.122 , Issue.6 , pp. 1435-1440
    • Surazynski, A.1    Donald, S.P.2    Cooper, S.K.3
  • 179
    • 0026601915 scopus 로고
    • Wound repair, keratinocyte activation and integrin modulation
    • Grinnell F. Wound repair, keratinocyte activation and integrin modulation. J Cell Sci 1992; 101 (Pt 1): 1-5.
    • (1992) J Cell Sci , vol.101 , Issue.Pt 1 , pp. 1-5
    • Grinnell, F.1
  • 180
    • 12944260524 scopus 로고    scopus 로고
    • Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes
    • Savagner P, Kusewitt DF, Carver EA, et al. Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol 2005; 202(3): 858-66.
    • (2005) J Cell Physiol , vol.202 , Issue.3 , pp. 858-866
    • Savagner, P.1    Kusewitt, D.F.2    Carver, E.A.3
  • 181
    • 0027092936 scopus 로고
    • Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion
    • Reichmann E, Schwarz H, Deiner EM, Leitner I, Eilers M, Berger J, et al. Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell 1992; 71(7): 1103-16.
    • (1992) Cell , vol.71 , Issue.7 , pp. 1103-1116
    • Reichmann, E.1    Schwarz, H.2    Deiner, E.M.3    Leitner, I.4    Eilers, M.5    Berger, J.6
  • 182
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Perez-Moreno MA, Rodrigo I, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2(2): 76-83.
    • (2000) Nat Cell Biol , vol.2 , Issue.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3
  • 183
    • 33750358078 scopus 로고    scopus 로고
    • Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition
    • Moreno-Bueno G, Cubillo E, Sarrio D, et al. Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res 2006; 66(19): 9543-56.
    • (2006) Cancer Res , vol.66 , Issue.19 , pp. 9543-9556
    • Moreno-Bueno, G.1    Cubillo, E.2    Sarrio, D.3
  • 184
    • 69049106307 scopus 로고    scopus 로고
    • Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2)
    • Hudson LG, Newkirk KM, Chandler HL, et al. Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2). J Dermatol Sci 2009; 56(1): 19-26.
    • (2009) J Dermatol Sci , vol.56 , Issue.1 , pp. 19-26
    • Hudson, L.G.1    Newkirk, K.M.2    Chandler, H.L.3
  • 185
    • 0031005659 scopus 로고    scopus 로고
    • The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
    • Savagner P, Yamada KM, Thiery JP. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 1997; 137(6): 1403-19.
    • (1997) J Cell Biol , vol.137 , Issue.6 , pp. 1403-1419
    • Savagner, P.1    Yamada, K.M.2    Thiery, J.P.3
  • 186
    • 55049118220 scopus 로고    scopus 로고
    • HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration
    • Fitsialos G, Bourget I, Augier S, et al. HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration. J Cell Sci 2008; 121(Pt 18): 2992-3001.
    • (2008) J Cell Sci , vol.121 , Issue.Pt 18 , pp. 2992-3001
    • Fitsialos, G.1    Bourget, I.2    Augier, S.3
  • 187
    • 0032489876 scopus 로고    scopus 로고
    • Processing of laminin-5 and its functional consequences: Role of plasmin and tissue-type plasminogen activator
    • Goldfinger LE, Stack MS, Jones JC. Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator. J Cell Biol 1998; 141(1): 255-65.
    • (1998) J Cell Biol , vol.141 , Issue.1 , pp. 255-265
    • Goldfinger, L.E.1    Stack, M.S.2    Jones, J.C.3
  • 188
    • 0033813105 scopus 로고    scopus 로고
    • Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion
    • Nguyen BP, Ryan MC, Gil SG, Carter WG. Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion. Curr Opin Cell Biol 2000; 12(5): 554-62.
    • (2000) Curr Opin Cell Biol , vol.12 , Issue.5 , pp. 554-562
    • Nguyen, B.P.1    Ryan, M.C.2    Gil, S.G.3    Carter, W.G.4
  • 189
    • 67649950623 scopus 로고    scopus 로고
    • Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration
    • Woodley DT, Fan J, Cheng CF, et al. Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration. J Cell Sci 2009; 122(Pt 10): 1495-8.
    • (2009) J Cell Sci , vol.122 , Issue.Pt 10 , pp. 1495-1498
    • Woodley, D.T.1    Fan, J.2    Cheng, C.F.3
  • 190
    • 38349058266 scopus 로고    scopus 로고
    • HIF-1alpha controls keratinocyte proliferation by up-regulating p21(WAF1/Cip1)
    • Cho YS, Bae JM, Chun YS, et al. HIF-1alpha controls keratinocyte proliferation by up-regulating p21(WAF1/Cip1). Biochim Biophys Acta 2008; 1783(2): 323-33.
    • (2008) Biochim Biophys Acta , vol.1783 , Issue.2 , pp. 323-333
    • Cho, Y.S.1    Bae, J.M.2    Chun, Y.S.3
  • 191
    • 77951043486 scopus 로고    scopus 로고
    • Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds
    • Biswas S, Roy S, Banerjee J, et al. Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds. Proc Natl Acad Sci USA 2010; 107(15): 6976-81.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.15 , pp. 6976-6981
    • Biswas, S.1    Roy, S.2    Banerjee, J.3
  • 192
    • 10944251346 scopus 로고    scopus 로고
    • The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification
    • Chang WY, Bryce DM, D'Souza SJ, Dagnino L. The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification. J Biol Chem 2004; 279(49): 51343-53.
    • (2004) J Biol Chem , vol.279 , Issue.49 , pp. 51343-51353
    • Chang, W.Y.1    Bryce, D.M.2    D'souza, S.J.3    Dagnino, L.4
  • 193
    • 0030875640 scopus 로고    scopus 로고
    • E2F as a regulator of keratinocyte proliferation: Implications for skin tumor development
    • Jones SJ, Dicker AJ, Dahler AL, Saunders NA. E2F as a regulator of keratinocyte proliferation: implications for skin tumor development. J Invest Dermatol 1997; 109(2): 187-93.
    • (1997) J Invest Dermatol , vol.109 , Issue.2 , pp. 187-193
    • Jones, S.J.1    Dicker, A.J.2    Dahler, A.L.3    Saunders, N.A.4
  • 194
    • 67649442743 scopus 로고    scopus 로고
    • Micromanaging vascular biology: Tiny microRNAs play big band
    • Sen CK, Gordillo GM, Khanna S, Roy S. Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res 2009; 46(6): 527-40.
    • (2009) J Vasc Res , vol.46 , Issue.6 , pp. 527-540
    • Sen, C.K.1    Gordillo, G.M.2    Khanna, S.3    Roy, S.4
  • 195
    • 75149150770 scopus 로고    scopus 로고
    • Selective deficiency of HIF-1alpha in myeloid cells influences secondary intention wound healing in mouse skin
    • Owings RA, Boerma M, Wang J, et al. Selective deficiency of HIF-1alpha in myeloid cells influences secondary intention wound healing in mouse skin. In vivo 2009; 23(6): 879-84.
    • (2009) In Vivo , vol.23 , Issue.6 , pp. 879-884
    • Owings, R.A.1    Boerma, M.2    Wang, J.3
  • 196
    • 0033547805 scopus 로고    scopus 로고
    • Age-dependent impairment of angiogenesis
    • Rivard A, Fabre JE, Silver M, et al. Age-dependent impairment of angiogenesis. Circulation 1999; 99(1): 111-20.
    • (1999) Circulation , vol.99 , Issue.1 , pp. 111-120
    • Rivard, A.1    Fabre, J.E.2    Silver, M.3
  • 197
    • 0032748767 scopus 로고    scopus 로고
    • The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice
    • Frenkel-Denkberg G, Gershon D, Levy AP. The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice. FEBS Lett 1999; 462(3): 341-4.
    • (1999) FEBS Lett , vol.462 , Issue.3 , pp. 341-344
    • Frenkel-Denkberg, G.1    Gershon, D.2    Levy, A.P.3
  • 198
    • 0034703017 scopus 로고    scopus 로고
    • Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity
    • Rivard A, Berthou-Soulie L, Principe N, et al. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J Biol Chem 2000; 275(38): 29643-7.
    • (2000) J Biol Chem , vol.275 , Issue.38 , pp. 29643-29647
    • Rivard, A.1    Berthou-Soulie, L.2    Principe, N.3
  • 199
    • 37349021749 scopus 로고    scopus 로고
    • Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia
    • Chang EI, Loh SA, Ceradini DJ, et al. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation 2007; 116(24): 2818-29.
    • (2007) Circulation , vol.116 , Issue.24 , pp. 2818-2829
    • Chang, E.I.1    Loh, S.A.2    Ceradini, D.J.3
  • 200
    • 61749087539 scopus 로고    scopus 로고
    • SDF-1 alpha expression during wound healing in the aged is HIF dependent
    • Loh SA, Chang EI, Galvez MG, et al. SDF-1 alpha expression during wound healing in the aged is HIF dependent. Plast Reconstr Surg 2009; 123(2 Suppl): 65S-75S.
    • (2009) Plast Reconstr Surg , vol.123 , Issue.2 SUPPL.
    • Loh, S.A.1    Chang, E.I.2    Galvez, M.G.3
  • 201
    • 33644620740 scopus 로고    scopus 로고
    • NO restores HIF-1alpha hydroxylation during hypoxia: Role of reactive oxygen species
    • Callapina M, Zhou J, Schmid T, Kohl R, Brune B. NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species. Free Radic Biol Med 2005; 39(7): 925-36.
    • (2005) Free Radic Biol Med , vol.39 , Issue.7 , pp. 925-936
    • Callapina, M.1    Zhou, J.2    Schmid, T.3    Kohl, R.4    Brune, B.5
  • 202
    • 0028004471 scopus 로고
    • Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse
    • Werner S, Breeden M, Hubner G, Greenhalgh DG, Longaker MT. Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. J Invest Dermatol 1994; 103(4): 469-73.
    • (1994) J Invest Dermatol , vol.103 , Issue.4 , pp. 469-473
    • Werner, S.1    Breeden, M.2    Hubner, G.3    Greenhalgh, D.G.4    Longaker, M.T.5
  • 203
    • 0029045246 scopus 로고
    • Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing
    • Frank S, Hubner G, Breier G, Longaker MT, Greenhalgh DG, Werner S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem 1995; 270(21): 12607-13.
    • (1995) J Biol Chem , vol.270 , Issue.21 , pp. 12607-12613
    • Frank, S.1    Hubner, G.2    Breier, G.3    Longaker, M.T.4    Greenhalgh, D.G.5    Werner, S.6
  • 204
    • 0025359279 scopus 로고
    • PDGF and FGF stimulate wound healing in the genetically diabetic mouse
    • Greenhalgh DG, Sprugel KH, Murray MJ, Ross R. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol 1990; 136(6): 1235-46.
    • (1990) Am J Pathol , vol.136 , Issue.6 , pp. 1235-1246
    • Greenhalgh, D.G.1    Sprugel, K.H.2    Murray, M.J.3    Ross, R.4
  • 205
    • 0028334260 scopus 로고
    • PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse
    • Brown RL, Breeden MP, Greenhalgh DG. PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse. J Surg Res 1994; 56(6): 562-70.
    • (1994) J Surg Res , vol.56 , Issue.6 , pp. 562-570
    • Brown, R.L.1    Breeden, M.P.2    Greenhalgh, D.G.3
  • 206
    • 34447325570 scopus 로고    scopus 로고
    • Placenta growth factor in diabetic wound healing: Altered expression and therapeutic potential
    • Cianfarani F, Zambruno G, Brogelli L, et al. Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am J Pathol 2006; 169(4): 1167-82.
    • (2006) Am J Pathol , vol.169 , Issue.4 , pp. 1167-1182
    • Cianfarani, F.1    Zambruno, G.2    Brogelli, L.3
  • 207
    • 0037154304 scopus 로고    scopus 로고
    • Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: A possible explanation for impaired collateral formation in cardiac tissue
    • Chou E, Suzuma I, Way KJ, et al. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation 2002; 105(3): 373-379.
    • (2002) Circulation , vol.105 , Issue.3 , pp. 373-379
    • Chou, E.1    Suzuma, I.2    Way, K.J.3
  • 208
    • 0035085050 scopus 로고    scopus 로고
    • Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: A comparative study of normal and impaired repair
    • Kampfer H, Pfeilschifter J, Frank S. Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair. Lab Invest 2001; 81(3): 361-73.
    • (2001) Lab Invest , vol.81 , Issue.3 , pp. 361-373
    • Kampfer, H.1    Pfeilschifter, J.2    Frank, S.3
  • 209
    • 0036020282 scopus 로고    scopus 로고
    • Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients
    • Lobmann R, Ambrosch A, Schultz G, Waldmann K, Schiweck S, Lehnert H. Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients. Diabetologia 2002; 45(7): 1011-6.
    • (2002) Diabetologia , vol.45 , Issue.7 , pp. 1011-1016
    • Lobmann, R.1    Ambrosch, A.2    Schultz, G.3    Waldmann, K.4    Schiweck, S.5    Lehnert, H.6
  • 210
    • 0033795456 scopus 로고    scopus 로고
    • Gelatinase activities in wounds of healing-impaired mice versus wounds of non-healing-impaired mice
    • Neely AN, Clendening CE, Gardner J, Greenhalgh DG. Gelatinase activities in wounds of healing-impaired mice versus wounds of non-healing-impaired mice. J Burn Care Rehabil 2000; 21(5): 395-402.
    • (2000) J Burn Care Rehabil , vol.21 , Issue.5 , pp. 395-402
    • Neely, A.N.1    Clendening, C.E.2    Gardner, J.3    Greenhalgh, D.G.4
  • 211
    • 0031010192 scopus 로고    scopus 로고
    • Diabetes-impaired healing and reduced wound nitric oxide synthesis: A possible pathophysiologic correlation
    • Schaffer MR, Tantry U, Efron PA, Ahrendt GM, Thornton FJ, Barbul A. Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery 1997; 121(5): 513-519.
    • (1997) Surgery , vol.121 , Issue.5 , pp. 513-519
    • Schaffer, M.R.1    Tantry, U.2    Efron, P.A.3    Ahrendt, G.M.4    Thornton, F.J.5    Barbul, A.6
  • 212
    • 0032031678 scopus 로고    scopus 로고
    • Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer
    • Yamasaki K, Edington HD, McClosky C, et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1998; 101(5): 967-71.
    • (1998) J Clin Invest , vol.101 , Issue.5 , pp. 967-971
    • Yamasaki, K.1    Edington, H.D.2    McClosky, C.3
  • 213
    • 34848879004 scopus 로고    scopus 로고
    • Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair
    • Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM. Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen 2007; 15(5): 636-45.
    • (2007) Wound Repair Regen , vol.15 , Issue.5 , pp. 636-645
    • Mace, K.A.1    Yu, D.H.2    Paydar, K.Z.3    Boudreau, N.4    Young, D.M.5
  • 214
    • 0037220689 scopus 로고    scopus 로고
    • Cellular dysfunction in the diabetic fibroblast: Impairment in migration, vascular endothelial growth factor production, and response to hypoxia
    • Lerman OZ, Galiano RD, Armour M, Levine JP, Gurtner GC. Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol 2003; 162(1): 303-12.
    • (2003) Am J Pathol , vol.162 , Issue.1 , pp. 303-312
    • Lerman, O.Z.1    Galiano, R.D.2    Armour, M.3    Levine, J.P.4    Gurtner, G.C.5
  • 215
    • 9444296528 scopus 로고    scopus 로고
    • Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function
    • Catrina SB, Okamoto K, Pereira T, Brismar K, Poellinger L. Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes 2004; 53(12): 3226-32.
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3226-3232
    • Catrina, S.B.1    Okamoto, K.2    Pereira, T.3    Brismar, K.4    Poellinger, L.5
  • 216
    • 69449108536 scopus 로고    scopus 로고
    • The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues
    • Thangarajah H, Yao D, Chang EI, et al. The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc Natl Acad Sci USA 2009; 106(32): 13505-10.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.32 , pp. 13505-13510
    • Thangarajah, H.1    Yao, D.2    Chang, E.I.3
  • 217
    • 33845241195 scopus 로고    scopus 로고
    • Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    • Norgren L, Hiatt WR, Dormandy JA, et al. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). Eur J Vasc Endovasc Surg 2007; 33 Suppl 1: S1-75.
    • (2007) Eur J Vasc Endovasc Surg , vol.33 , Issue.SUPPL. 1
    • Norgren, L.1    Hiatt, W.R.2    Dormandy, J.A.3
  • 218
    • 0037265253 scopus 로고    scopus 로고
    • Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model
    • Rissanen TT, Markkanen JE, Arve K, et al. Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model. FASEB J 2003; 17(1): 100-02.
    • (2003) FASEB J , vol.17 , Issue.1 , pp. 100-102
    • Rissanen, T.T.1    Markkanen, J.E.2    Arve, K.3
  • 219
    • 0037714018 scopus 로고    scopus 로고
    • VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses
    • Rissanen TT, Markkanen JE, Gruchala M, et al. VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses. Circ Res 2003; 92(10): 1098-106.
    • (2003) Circ Res , vol.92 , Issue.10 , pp. 1098-1106
    • Rissanen, T.T.1    Markkanen, J.E.2    Gruchala, M.3
  • 220
    • 0036665610 scopus 로고    scopus 로고
    • Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study
    • Makinen K, Manninen H, Hedman M, et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol Ther 2002; 6(1): 127-33.
    • (2002) Mol Ther , vol.6 , Issue.1 , pp. 127-133
    • Makinen, K.1    Manninen, H.2    Hedman, M.3
  • 221
    • 19044389402 scopus 로고    scopus 로고
    • Naked plasmid DNA encoding fibroblast growth factor type 1 for the treatment of end-stage unreconstructible lower extremity ischemia: Preliminary results of a phase I trial
    • Comerota AJ, Throm RC, Miller KA, et al. Naked plasmid DNA encoding fibroblast growth factor type 1 for the treatment of end-stage unreconstructible lower extremity ischemia: preliminary results of a phase I trial. J Vasc Surg 2002; 35(5): 930-36.
    • (2002) J Vasc Surg , vol.35 , Issue.5 , pp. 930-936
    • Comerota, A.J.1    Throm, R.C.2    Miller, K.A.3
  • 222
    • 0037097035 scopus 로고    scopus 로고
    • Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): A randomised trial
    • Lederman RJ, Mendelsohn FO, Anderson RD, et al. Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial. Lancet 2002; 359(9323): 2053-8.
    • (2002) Lancet , vol.359 , Issue.9323 , pp. 2053-2058
    • Lederman, R.J.1    Mendelsohn, F.O.2    Anderson, R.D.3
  • 223
    • 0037055666 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: A pilot study and a randomised controlled trial
    • Tateishi-Yuyama E, Matsubara H, Murohara T, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 2002; 360(9331): 427-35.
    • (2002) Lancet , vol.360 , Issue.9331 , pp. 427-435
    • Tateishi-Yuyama, E.1    Matsubara, H.2    Murohara, T.3
  • 224
    • 0035852662 scopus 로고    scopus 로고
    • Augmentation of postnatal neovascularization with autologous bone marrow transplantation
    • Shintani S, Murohara T, Ikeda H, et al. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation 2001; 103(6): 897-903.
    • (2001) Circulation , vol.103 , Issue.6 , pp. 897-903
    • Shintani, S.1    Murohara, T.2    Ikeda, H.3
  • 225
    • 33845802110 scopus 로고    scopus 로고
    • Critical limb ischemia and stem cell research: Anchoring hope with informed adverse event reporting
    • Hirsch AT. Critical limb ischemia and stem cell research: anchoring hope with informed adverse event reporting. Circulation 2006; 114(24): 2581-3.
    • (2006) Circulation , vol.114 , Issue.24 , pp. 2581-2583
    • Hirsch, A.T.1
  • 226
    • 2942572769 scopus 로고    scopus 로고
    • Therapeutic angiogenesis and vasculogenesis for ischemic disease: Part II: Cell-based therapies
    • Losordo DW, Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies. Circulation 2004; 109(22): 2692-7.
    • (2004) Circulation , vol.109 , Issue.22 , pp. 2692-2697
    • Losordo, D.W.1    Dimmeler, S.2
  • 227
    • 2642565248 scopus 로고    scopus 로고
    • Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: Angiogenic cytokines
    • Losordo DW, Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines. Circulation 2004; 109(21): 2487-91.
    • (2004) Circulation , vol.109 , Issue.21 , pp. 2487-2491
    • Losordo, D.W.1    Dimmeler, S.2
  • 228
    • 73249140173 scopus 로고    scopus 로고
    • Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice
    • Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marce M, Semenza GL. Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proc Natl Acad Sci USA 2009; 106(44): 18769-74.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.44 , pp. 18769-18774
    • Sarkar, K.1    Fox-Talbot, K.2    Steenbergen, C.3    Bosch-Marce, M.4    Semenza, G.L.5
  • 229
    • 2342628400 scopus 로고    scopus 로고
    • HIF-VEGF-VEGFR-2, TNF-alpha and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array
    • Tuomisto TT, Rissanen TT, Vajanto I, Korkeela A, Rutanen J, Yla-Herttuala S. HIF-VEGF-VEGFR-2, TNF-alpha and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array. Atherosclerosis 2004; 174(1): 111-20.
    • (2004) Atherosclerosis , vol.174 , Issue.1 , pp. 111-120
    • Tuomisto, T.T.1    Rissanen, T.T.2    Vajanto, I.3    Korkeela, A.4    Rutanen, J.5    Yla-Herttuala, S.6
  • 230
    • 77957791211 scopus 로고    scopus 로고
    • Polymorphisms of the hypoxia-inducible factor 1 gene and peripheral artery disease
    • Bahadori B, Uitz E, Mayer A, et al. Polymorphisms of the hypoxia-inducible factor 1 gene and peripheral artery disease. Vasc Med 2010; 15(5): 371-4.
    • (2010) Vasc Med , vol.15 , Issue.5 , pp. 371-374
    • Bahadori, B.1    Uitz, E.2    Mayer, A.3
  • 231
    • 23744461969 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease
    • Resar JR, Roguin A, Voner J, et al. Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease. Chest 2005; 128(2): 787-791.
    • (2005) Chest , vol.128 , Issue.2 , pp. 787-791
    • Resar, J.R.1    Roguin, A.2    Voner, J.3
  • 232
    • 36148973202 scopus 로고    scopus 로고
    • Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease
    • Hlatky MA, Quertermous T, Boothroyd DB, et al. Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. Am Heart J 2007; 154(6): 1035-42.
    • (2007) Am Heart J , vol.154 , Issue.6 , pp. 1035-1042
    • Hlatky, M.A.1    Quertermous, T.2    Boothroyd, D.B.3
  • 233
    • 0038380432 scopus 로고    scopus 로고
    • Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure: Impairment of the HIF-1alpha/VEGF pathway
    • Michaud SE, Menard C, Guy LG, Gennaro G, Rivard A. Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure: impairment of the HIF-1alpha/VEGF pathway. FASEB J 2003; 17(9): 1150-2.
    • (2003) FASEB J , vol.17 , Issue.9 , pp. 1150-1152
    • Michaud, S.E.1    Menard, C.2    Guy, L.G.3    Gennaro, G.4    Rivard, A.5
  • 235
    • 0037345994 scopus 로고    scopus 로고
    • Is revascularization and limb salvage always the best treatment for critical limb ischemia?
    • Nehler MR, Hiatt WR, Taylor LM, Jr. Is revascularization and limb salvage always the best treatment for critical limb ischemia? J Vasc Surg 2003;37(3): 704-8.
    • (2003) J Vasc Surg , vol.37 , Issue.3 , pp. 704-708
    • Nehler, M.R.1    Hiatt, W.R.2    Taylor Jr., L.M.3
  • 236
    • 33745647191 scopus 로고    scopus 로고
    • Natural history of limbs with arterial insufficiency and chronic ulceration treated without revascularization
    • Marston WA, Davies SW, Armstrong B, et al. Natural history of limbs with arterial insufficiency and chronic ulceration treated without revascularization. J Vasc Surg 2006; 44(1): 108-14.
    • (2006) J Vasc Surg , vol.44 , Issue.1 , pp. 108-114
    • Marston, W.A.1    Davies, S.W.2    Armstrong, B.3
  • 237
    • 78049448196 scopus 로고    scopus 로고
    • Management of lower extremity wounds in patients with peripheral arterial disease: A stratified conservative approach
    • Chiriano J, Bianchi C, Teruya TH, Mills B, Bishop V, Abou-Zamzam AM, Jr. Management of lower extremity wounds in patients with peripheral arterial disease: a stratified conservative approach. Ann Vasc Surg 2010; 24(8): 1110-6.
    • (2010) Ann Vasc Surg , vol.24 , Issue.8 , pp. 1110-1116
    • Chiriano, J.1    Bianchi, C.2    Teruya, T.H.3    Mills, B.4    Bishop, V.5    Abou-Zamzam Jr., A.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.