메뉴 건너뛰기




Volumn 9, Issue 6, 2003, Pages 669-676

The biology of VEGF and its receptors

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; APTAMER; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN MONOCLONAL ANTIBODY; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

EID: 0037699954     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0603-669     Document Type: Review
Times cited : (8266)

References (137)
  • 2
    • 0034648793 scopus 로고    scopus 로고
    • Vascular-specific growth factors and blood vessel formation
    • Yancopoulos, G.D. et al. Vascular-specific growth factors and blood vessel formation. Nature 407, 242-248 (2000).
    • (2000) Nature , vol.407 , pp. 242-248
    • Yancopoulos, G.D.1
  • 3
    • 0036782278 scopus 로고    scopus 로고
    • VEGF the quest for tumour angiogenesis factors
    • Ferrara, N. VEGF and the quest for tumour angiogenesis factors. Nat. Rev. Cancer 2, 795-803 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 4
    • 0032710319 scopus 로고    scopus 로고
    • Clinical applications of angiogenic growth factors and their inhibitors
    • Ferrara, N. & Alitalo, K. Clinical applications of angiogenic growth factors and their inhibitors. Nat. Med. 5, 1359-1364 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 1359-1364
    • Ferrara, N.1    Alitalo, K.2
  • 5
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nat. Med. 6, 389-395 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 6
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara, N. & Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr. Rev. 18, 4-25 (1997).
    • (1997) Endocr. Rev. , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 7
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld, G., Cohen, T., Gengrinovitch, S. & Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9-22 (1999).
    • (1999) FASEB J. , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 8
    • 0036144374 scopus 로고    scopus 로고
    • Lymphatic endothelium: A new frontier of metastasis research
    • Karkkainen, M.J., Makinen, T. & Alitalo, K. Lymphatic endothelium: a new frontier of metastasis research. Nat. Cell Biol. 4, E2-E5 (2002).
    • (2002) Nat. Cell Biol. , vol.4
    • Karkkainen, M.J.1    Makinen, T.2    Alitalo, K.3
  • 9
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung, D.W., Cachianes, G., Kuang, W.J., Goeddel, D.V. & Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306-1309 (1989).
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 10
    • 0024816246 scopus 로고
    • Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT 20 cells
    • Plouet, J., Schilling, J. & Gospodarowicz, D. Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT20 cells. EMBO J. 8, 3801-3808 (1989).
    • (1989) EMBO J. , vol.8 , pp. 3801-3808
    • Plouet, J.1    Schilling, J.2    Gospodarowicz, D.3
  • 11
    • 0037011070 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis
    • Nagy, J.A. et al. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J. Exp. Med. 196, 1497-1506 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 1497-1506
    • Nagy, J.A.1
  • 12
    • 4244078727 scopus 로고    scopus 로고
    • VEGF receptor signal transduction
    • Matsumoto, T. & Claesson-Welsh, L. VEGF receptor signal transduction. Science STKE 112 (RE21), 1-17 (2001).
    • (2001) Science STKE , vol.112 , Issue.RE21 , pp. 1-17
    • Matsumoto, T.1    Claesson-Welsh, L.2
  • 13
    • 0035983324 scopus 로고    scopus 로고
    • Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    • Compernolle, V. et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat. Med. 8, 702-710 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 702-710
    • Compernolle, V.1
  • 14
    • 0032557564 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
    • Gerber, H.P., Dixit, V. & Ferrara, N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem. 273, 13313-13316 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 13313-13316
    • Gerber, H.P.1    Dixit, V.2    Ferrara, N.3
  • 15
    • 0000615805 scopus 로고    scopus 로고
    • VEGF regulates endothelial cell survival by the PI3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber, H.P. et al. VEGF regulates endothelial cell survival by the PI3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273, 30366-30343 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 30366-30343
    • Gerber, H.P.1
  • 16
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin, L.E., Golijanin, D., Itin, A., Pode, D. & Keshet, E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103, 159-165 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 17
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan, F. et al. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl. Acad. Sci. USA 93, 14765-14770 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14765-14770
    • Yuan, F.1
  • 18
    • 0032931234 scopus 로고    scopus 로고
    • VEGF is required for growth and survival in neonatal mice
    • Gerber, H.P. et al. VEGF is required for growth and survival in neonatal mice. Development 126, 1149-1159 (1999).
    • (1999) Development , vol.126 , pp. 1149-1159
    • Gerber, H.P.1
  • 19
    • 0025688912 scopus 로고
    • Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
    • Clauss, M. et al. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 172, 1535-1545 (1990).
    • (1990) J. Exp. Med. , vol.172 , pp. 1535-1545
    • Clauss, M.1
  • 20
    • 0029583080 scopus 로고
    • Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor
    • Broxmeyer, H.E. et al. Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor. Int. J. Hematol. 62, 203-215 (1995).
    • (1995) Int. J. Hematol. , vol.62 , pp. 203-215
    • Broxmeyer, H.E.1
  • 21
    • 0029842830 scopus 로고    scopus 로고
    • Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
    • Gabrilovich, D.I. et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2, 1096-1103 (1996).
    • (1996) Nat. Med. , vol.2 , pp. 1096-1103
    • Gabrilovich, D.I.1
  • 22
    • 0035821293 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells
    • Hattori, K. et al. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. J. Exp Med. 193, 1005-1014 (2001).
    • (2001) J. Exp Med. , vol.193 , pp. 1005-1014
    • Hattori, K.1
  • 23
    • 0037182861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates hematopoietic stem cell survival by an internal autocrine loop mechanism
    • Gerber, H.-P. et al. Vascular endothelial growth factor regulates hematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417, 954-958 (2002).
    • (2002) Nature , vol.417 , pp. 954-958
    • Gerber, H.-P.1
  • 24
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger, D.R. et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, 983-985 (1983).
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1
  • 25
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak, H.F., Brown, L.F., Detmar, M. & Dvorak, A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029-1039 (1995).
    • (1995) Am. J. Pathol. , vol.146 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 26
    • 0030865278 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway
    • Bates, D.O. & Curry, F.E. Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway. Am. J. Physiol. 273, H687-H694 (1997).
    • (1997) Am. J. Physiol. , vol.273
    • Bates, D.O.1    Curry, F.E.2
  • 27
    • 0029010434 scopus 로고
    • Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
    • Roberts, W.G. & Palade, G.E. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci. 108, 2369-2379 (1995).
    • (1995) J. Cell Sci. , vol.108 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 28
    • 0027217832 scopus 로고
    • Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries
    • Ku, D.D., Zaleski, J.K., Liu, S. & Brock, T.A. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am. J. Physiol. 265, H586-H592 (1993).
    • (1993) Am. J. Physiol. , vol.265
    • Ku, D.D.1    Zaleski, J.K.2    Liu, S.3    Brock, T.A.4
  • 29
    • 0030022917 scopus 로고    scopus 로고
    • Effects of vascular endothelial growth factor on hemodynamics and cardiac performance
    • Yang, R. et al. Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J. Cardiovasc. Pharmacol. 27, 838-844 (1996).
    • (1996) J. Cardiovasc. Pharmacol. , vol.27 , pp. 838-844
    • Yang, R.1
  • 30
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
    • Houck, K.A. et al, The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol. 5, 1806-1814 (1991).
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1806-1814
    • Houck, K.A.1
  • 31
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • Tischer, E. et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 266, 11947-11954 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 11947-11954
    • Tischer, E.1
  • 32
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara, N. & Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161, 851-858 (1989).
    • (1989) Biochem. Biophys. Res. Commun. , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 33
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck, K.A., Leung, D.W., Rowland, A.M., Winer, J. & Ferrara, N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 267, 26031-26037 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 34
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor isoforms (VEGF): Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park, J.E., Keller, H.-A. & Ferrara, N. The vascular endothelial growth factor isoforms (VEGF): differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4, 1317-1326 (1993).
    • (1993) Mol. Biol. Cell , vol.4 , pp. 1317-1326
    • Park, J.E.1    Keller, H.-A.2    Ferrara, N.3
  • 35
    • 0029937679 scopus 로고    scopus 로고
    • The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency
    • Keyt, B.A et al. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem. 271, 7788-7795 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 7788-7795
    • Keyt, B.A.1
  • 36
    • 0032925156 scopus 로고    scopus 로고
    • Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelila growth factor isoforms VEGF 164 and VEGF188
    • Carmeliet, P. et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelila growth factor isoforms VEGF164 and VEGF188. Nat. Med. 5, 495-502 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 495-502
    • Carmeliet, P.1
  • 37
    • 0037108152 scopus 로고    scopus 로고
    • Spatially restricted patterning cues provided by heparin-binding VEGFA control blood vessel branching morphogenesis
    • Ruhrberg, C. et al. Spatially restricted patterning cues provided by heparin-binding VEGFA control blood vessel branching morphogenesis. Genes Dev. 16, 2684-2698 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2684-2698
    • Ruhrberg, C.1
  • 38
    • 0034979159 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis
    • Dor, Y., Porat, R. & Keshet, E. Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am. J. Physiol. 280, C1367-C1374 (2001).
    • (2001) Am. J. Physiol. , vol.280
    • Dor, Y.1    Porat, R.2    Keshet, E.3
  • 39
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • Semenza, G. Signal transduction to hypoxia-inducible factor 1. Biochem. Pharmacol. 64, 993-998 (2002).
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 993-998
    • Semenza, G.1
  • 40
    • 0036138398 scopus 로고    scopus 로고
    • Regulation of HIF by the von Hippel-Lindau tumour suppressor: Implications for cellular oxygen sensing
    • Mole, D.R., Maxwell, P.H., Pugh, C.W. & Ratcliffe, P.J. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. IUBMB Life 52, 43-47 (2001).
    • (2001) IUBMB Life , vol.52 , pp. 43-47
    • Mole, D.R.1    Maxwell, P.H.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 41
    • 0029920054 scopus 로고    scopus 로고
    • Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein
    • Siemeister, G. et al. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res. 56, 2299-2301 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 2299-2301
    • Siemeister, G.1
  • 43
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell, P.H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275 (1999).
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1
  • 45
    • 0037362890 scopus 로고    scopus 로고
    • HIF hydroxylation and the mammalian oxygen-sensing pathway
    • Safran, M. & Kaelin, W.J. HIF hydroxylation and the mammalian oxygen-sensing pathway. J. Clin Invest. 111, 779-783 (2003).
    • (2003) J. Clin Invest. , vol.111 , pp. 779-783
    • Safran, M.1    Kaelin, W.J.2
  • 46
    • 0028834638 scopus 로고
    • Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • Grugel, S., Finkenzeller, G., Weindel, K., Barleon, B. & Marme, D. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J. Biol. Chem. 270, 25915-25919 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marme, D.5
  • 47
    • 0032584108 scopus 로고    scopus 로고
    • Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
    • Okada, F. et al. Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc. Natl. Acad. Sci. USA 95, 3609-3614 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3609-3614
    • Okada, F.1
  • 48
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptortype tyrosine kinase (flt) closely related to the fms family
    • Shibuya, M. et al. Nucleotide sequence and expression of a novel human receptortype tyrosine kinase (flt) closely related to the fms family. Oncogene 8, 519-527 (1990).
    • (1990) Oncogene , vol.8 , pp. 519-527
    • Shibuya, M.1
  • 49
    • 0025739016 scopus 로고
    • Identification of a new endothelial cell growth factor receptor tyrosine kinase
    • Terman, B.I. et al. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6, 1677-1683 (1991).
    • (1991) Oncogene , vol.6 , pp. 1677-1683
    • Terman, B.I.1
  • 50
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • de Vries, C. et al. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255, 989-991 (1992).
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1
  • 51
    • 0030751493 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the two VEGF receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
    • Gerber, H.P., Condorelli, F., Park, J. & Ferrara, N. Differential transcriptional regulation of the two VEGF receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272, 23659-23667 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 23659-23667
    • Gerber, H.P.1    Condorelli, F.2    Park, J.3    Ferrara, N.4
  • 52
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park, J.E., Chen, H.H., Winer, J., Houck, K.A. & Ferrara, N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 269, 25646-25654 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 53
    • 13144266696 scopus 로고    scopus 로고
    • Vascular endothelial growth factor B (VEGFB) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
    • Olofsson, B. et al. Vascular endothelial growth factor B (VEGFB) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc. Natl. Acad. Sci. USA 95, 11709-11714 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11709-11714
    • Olofsson, B.1
  • 54
    • 0027421333 scopus 로고
    • Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
    • Kendall, R.L. & Thomas, K.A. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. USA 90, 10705-10709 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10705-10709
    • Kendall, R.L.1    Thomas, K.A.2
  • 55
    • 0029790466 scopus 로고    scopus 로고
    • The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade
    • Davis-Smyth, T., Chen, H., Park, J., Presta, L. G. & Ferrara, N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 15, 4919-4927 (1996).
    • (1996) EMBO J. , vol.15 , pp. 4919-4927
    • Davis-Smyth, T.1    Chen, H.2    Park, J.3    Presta, L.G.4    Ferrara, N.5
  • 56
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt 1, two receptors for vascular endothelial growth factor
    • Waltenberger, J., Claesson Welsh, L., Siegbahn, A., Shibuya, M. & Heldin, C.H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269, 26988-26995 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 26988-26995
    • Waltenberger, J.1    Claesson Welsh, L.2    Siegbahn, A.3    Shibuya, M.4    Heldin, C.H.5
  • 57
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7, 575-583 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 575-583
    • Carmeliet, P.1
  • 58
    • 0034254273 scopus 로고    scopus 로고
    • A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits VEGF-dependent PI 3 kinase activation and endothelial cell migration
    • Gille, H. et al. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits VEGF-dependent PI 3 kinase activation and endothelial cell migration. EMBO J. 19, 4064-4073 (2000).
    • (2000) EMBO J. , vol.19 , pp. 4064-4073
    • Gille, H.1
  • 59
    • 0032554778 scopus 로고    scopus 로고
    • Flt-1, a receptor for vascular endothelial growth factor, has transforming and morphogenic potentials
    • Maru, Y., Yamaguchi, S. & Shibuya, M. Flt-1, a receptor for vascular endothelial growth factor, has transforming and morphogenic potentials. Oncogene 16, 2585-2595 (1998).
    • (1998) Oncogene , vol.16 , pp. 2585-2595
    • Maru, Y.1    Yamaguchi, S.2    Shibuya, M.3
  • 60
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong, G.H., Rossant, J., Gertsenstein, M. & Breitman, M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66-70 (1995).
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 61
    • 0032764427 scopus 로고    scopus 로고
    • Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
    • Fong, G.H., Zhang, L., Bryce, D.M. & Peng, J. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development 126, 3015-3025 (1999).
    • (1999) Development , vol.126 , pp. 3015-3025
    • Fong, G.H.1    Zhang, L.2    Bryce, D.M.3    Peng, J.4
  • 62
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka, S., Minowa, O., Kuno, J., Noda, T. & Shibuya, M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 4, 9349-9354 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.4 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 63
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon, B. et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87, 3336-3343 (1996).
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1
  • 64
    • 0036782035 scopus 로고    scopus 로고
    • MMP9 induction by vascular endothelial growth factor receptor1 is involved in lung-specific metastasis
    • Hiratsuka, S. et al. MMP9 induction by vascular endothelial growth factor receptor1 is involved in lung-specific metastasis. Cancer Cell 2, 289-300 (2002).
    • (2002) Cancer Cell , vol.2 , pp. 289-300
    • Hiratsuka, S.1
  • 65
    • 0036344496 scopus 로고    scopus 로고
    • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    • Hattori, K. et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat. Med. 8, 841-849 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 841-849
    • Hattori, K.1
  • 66
    • 0036344495 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by PLGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt 1
    • Luttun, A. et al. Revascularization of ischemic tissues by PLGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8, 831-840 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 831-840
    • Luttun, A.1
  • 67
    • 0037423321 scopus 로고    scopus 로고
    • Angiogenesis-independent endothelial protection of liver: Role of VEGFR-1
    • LeCouter, J. et al. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 299, 890-893 (2003).
    • (2003) Science , vol.299 , pp. 890-893
    • LeCouter, J.1
  • 68
    • 0026702970 scopus 로고
    • Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
    • Terman, B.I. et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187, 1579-1586 (1992).
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 1579-1586
    • Terman, B.I.1
  • 69
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-l-deficient mice
    • Shalaby, F. et al. Failure of blood-island formation and vasculogenesis in Flk-l-deficient mice. Nature 376, 62-66 (1995).
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1
  • 70
    • 0028899424 scopus 로고
    • Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation
    • Guo, D., Jia, Q., Song, H.Y., Warren, R.S. & Donner, D.B. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. J. Biol. Chem. 270, 6729-6733 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 6729-6733
    • Guo, D.1    Jia, Q.2    Song, H.Y.3    Warren, R.S.4    Donner, D.B.5
  • 71
    • 0033393771 scopus 로고    scopus 로고
    • Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
    • Eliceiri, B.P. et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell 4, 915-924 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 915-924
    • Eliceiri, B.P.1
  • 72
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi, T., Ueno, H. & Shibuya, M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18, 2221-2230 (1999).
    • (1999) Oncogene , vol.18 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 73
    • 0035793623 scopus 로고    scopus 로고
    • Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific VEGF mutants
    • Gille, H. et al. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific VEGF mutants. J. Biol. Chem. 276, 3222-3230 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 3222-3230
    • Gille, H.1
  • 74
    • 0037093078 scopus 로고    scopus 로고
    • Placental growth factor is a survival factor for tumor endothelial cells and macrophages
    • Adini, A., Kornaga, T., Firoozbakht, F. & Benjamin, L.E. Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res. 62, 2749-2752 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 2749-2752
    • Adini, A.1    Kornaga, T.2    Firoozbakht, F.3    Benjamin, L.E.4
  • 75
    • 0029965081 scopus 로고    scopus 로고
    • Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain
    • Soker, S., Fidder, H., Neufeld, G. & Klagsbrun, M. Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J. Biol. Chem. 271, 5761-5767 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 5761-5767
    • Soker, S.1    Fidder, H.2    Neufeld, G.3    Klagsbrun, M.4
  • 76
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker, S., Takashima, S., Miao, H.Q., Neufeld, G. & Klagsbrun, M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92, 735-745 (1998).
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 77
    • 0036139515 scopus 로고    scopus 로고
    • The neuropilins: Multifunctional semaphorin and VEGF receptors that modulate axon guidance and angio genesis
    • Neufeld, G. et al. The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc. Med. 12, 13-19 (2002).
    • (2002) Trends Cardiovasc. Med. , vol.12 , pp. 13-19
    • Neufeld, G.1
  • 78
    • 0032707249 scopus 로고    scopus 로고
    • A requirement for neuropilin-1 in embryonic vessel formation
    • Kawasaki, T. et al. A requirement for neuropilin-1 in embryonic vessel formation. Development 126, 4895-4902 (1999).
    • (1999) Development , vol.126 , pp. 4895-4902
    • Kawasaki, T.1
  • 79
    • 0036678171 scopus 로고    scopus 로고
    • Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish
    • Lee, P. et al. Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc. Natl. Acad. Sci. USA 99, 10470-10475 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10470-10475
    • Lee, P.1
  • 80
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439 (1996).
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1
  • 81
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442 (1996).
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1
  • 82
    • 18844473540 scopus 로고    scopus 로고
    • Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia
    • Bellomo, D. et al. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ. Res. 86, E29-E35 (2000).
    • (2000) Circ. Res. , vol.86
    • Bellomo, D.1
  • 83
    • 0030927017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an essential molecule for mouse kidney development: Glomerulogenesis and nephrogenesis
    • Kitamoto, Y., Tokunaga, H. & Tomita, K. Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis. J. Clin. Invest. 99, 2351-2357 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 2351-2357
    • Kitamoto, Y.1    Tokunaga, H.2    Tomita, K.3
  • 84
    • 0037370325 scopus 로고    scopus 로고
    • Glomerular-specific alterations of VEGFA expression lead to distinct congenital and acquired renal diseases
    • Eremina, V. et al. Glomerular-specific alterations of VEGFA expression lead to distinct congenital and acquired renal diseases. J. Clin. Invest. 111, 707-716 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 707-716
    • Eremina, V.1
  • 85
    • 0032979775 scopus 로고    scopus 로고
    • Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody
    • Ryan, A.M. et al. Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody. Toxicol. Pathol. 27, 78-86 (1999).
    • (1999) Toxicol. Pathol. , vol.27 , pp. 78-86
    • Ryan, A.M.1
  • 86
    • 0001786414 scopus 로고
    • The growth plate: Cellular physiology, cartilage assembly and mineralization
    • eds. Hall, B.K. & Newman, S.A. (CRC Press, Boca Raton, Florida)
    • Poole, A.R. The growth plate: cellular physiology, cartilage assembly and mineralization. in Cartilage: Molecular Aspects (eds. Hall, B.K. & Newman, S.A.) 179-211 (CRC Press, Boca Raton, Florida, 1991).
    • (1991) Cartilage: Molecular Aspects , pp. 179-211
    • Poole, A.R.1
  • 87
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber, H.P. et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. 5, 623-628 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 623-628
    • Gerber, H.P.1
  • 88
    • 0034097594 scopus 로고    scopus 로고
    • Conditional inactivation of VEGFA in areas of collagen 2a1 expression results in embryonic lethality in the heterozygous state
    • Haigh, J.J., Gerber, H.P., Ferrara, N. & Wagner, E.F. Conditional inactivation of VEGFA in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development 127, 1445-1453 (2000).
    • (2000) Development , vol.127 , pp. 1445-1453
    • Haigh, J.J.1    Gerber, H.P.2    Ferrara, N.3    Wagner, E.F.4
  • 89
    • 0036339867 scopus 로고    scopus 로고
    • Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis
    • Zelzer, E. et al. Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development 129, 1893-1904 (2002).
    • (2002) Development , vol.129 , pp. 1893-1904
    • Zelzer, E.1
  • 90
    • 0031729982 scopus 로고    scopus 로고
    • Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis
    • Goede, V., Schmidt, T., Kimmina, S., Kozian, D. & Augustin, H.G. Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Lab. Invest. 78, 1385-1394 (1998).
    • (1998) Lab. Invest. , vol.78 , pp. 1385-1394
    • Goede, V.1    Schmidt, T.2    Kimmina, S.3    Kozian, D.4    Augustin, H.G.5
  • 91
    • 0025002792 scopus 로고
    • Vascular endothelial growth factor is expressed in rat corpus luteum
    • Phillips, H.S., Hains, J., Leung, D.W. & Ferrara, N. Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology 127, 965-967 (1990).
    • (1990) Endocrinology , vol.127 , pp. 965-967
    • Phillips, H.S.1    Hains, J.2    Leung, D.W.3    Ferrara, N.4
  • 92
    • 0031940839 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is essential for corpus luteum angiogenesis
    • Ferrara, N. et al. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat. Med. 4, 336-340 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 336-340
    • Ferrara, N.1
  • 93
    • 0034463242 scopus 로고    scopus 로고
    • Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor
    • Fraser, H. M. et al. Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor. Endocrinology 141, 995-1000 (2000).
    • (2000) Endocrinology , vol.141 , pp. 995-1000
    • Fraser, H.M.1
  • 94
    • 0035096105 scopus 로고    scopus 로고
    • Short-term administration of antivascular endothelial growth factor antibody in the late follicular phase delays follicular development in the rhesus monkey
    • Zimmermann, R.C. et al. Short-term administration of antivascular endothelial growth factor antibody in the late follicular phase delays follicular development in the rhesus monkey. J. Clin. Endocrinol. Metab. 86, 768-772 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 768-772
    • Zimmermann, R.C.1
  • 95
    • 0035974803 scopus 로고    scopus 로고
    • Identification of an angiogenic mitogen selective for endocrine gland endothelium
    • LeCouter, J. et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature 412, 877-884 (2001).
    • (2001) Nature , vol.412 , pp. 877-884
    • LeCouter, J.1
  • 96
    • 0036732411 scopus 로고    scopus 로고
    • Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis
    • LeCouter, J., Lin, R. & Ferrara, N. Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis. Nat. Med. 8, 913-917 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 913-917
    • LeCouter, J.1    Lin, R.2    Ferrara, N.3
  • 97
    • 0038363403 scopus 로고    scopus 로고
    • Differential expression of the angiogenic factor genes VEGF and EG-VEGF in normal and polycystic human ovaries
    • Ferrara, N. et al. Differential expression of the angiogenic factor genes VEGF and EG-VEGF in normal and polycystic human ovaries. Am. J. Path. 162, 1881-1893 (2003).
    • (2003) Am. J. Path. , vol.162 , pp. 1881-1893
    • Ferrara, N.1
  • 98
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Kim, K.J. et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362, 841-844 (1993).
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1
  • 99
    • 0032544686 scopus 로고    scopus 로고
    • Tumor induction of VEGF promoter activity in stromal cells
    • Fukumura, D. et al. Tumor induction of VEGF promoter activity in stromal cells. Cell 94, 715-725 (1998).
    • (1998) Cell , vol.94 , pp. 715-725
    • Fukumura, D.1
  • 100
    • 0033708398 scopus 로고    scopus 로고
    • Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor
    • Gerber, H.P., Kowalski, J., Sherman, D., Eberhard, D.A. & Ferrara, N. Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res. 60, 6253-6258 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 6253-6258
    • Gerber, H.P.1    Kowalski, J.2    Sherman, D.3    Eberhard, D.A.4    Ferrara, N.5
  • 101
    • 0033693293 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α→ hypoxia response element→ VEGF cascade differ entially regulates vascular response and growth rate in tumors
    • Tsuzuki, Y. et al. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α→ hypoxia response element→ VEGF cascade differ entially regulates vascular response and growth rate in tumors. Cancer Res. 60, 6248-6252 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 6248-6252
    • Tsuzuki, Y.1
  • 102
    • 0036491615 scopus 로고    scopus 로고
    • VEGFA has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis
    • Inoue, M., Hager, J.H., Ferrara, N., Gerber, H.P. & Hanahan, D. VEGFA has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis. Cancer Cell. 1, 193-202 (2002).
    • (2002) Cancer Cell. , vol.1 , pp. 193-202
    • Inoue, M.1    Hager, J.H.2    Ferrara, N.3    Gerber, H.P.4    Hanahan, D.5
  • 103
    • 0000391746 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
    • Bergers, G. et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell Biol. 2, 737-744 (2000).
    • (2000) Nat. Cell Biol. , vol.2 , pp. 737-744
    • Bergers, G.1
  • 104
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor 2 antibody induces sustained tumor regression without overt toxicity
    • Klement, G. et al. Continuous low-dose therapy with vinblastine and VEGF receptor2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 105, R15-R24 (2000).
    • (2000) J. Clin. Invest. , vol.105
    • Klement, G.1
  • 105
    • 0034306974 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
    • Lee, C.G. et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 60, 5565-5570 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 5565-5570
    • Lee, C.G.1
  • 106
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta, L.G. et al. Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 57, 4593-4599 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 4593-4599
    • Presta, L.G.1
  • 107
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis
    • Prewett, M. et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis. Cancer Res. 59, 5209-5218 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5209-5218
    • Prewett, M.1
  • 108
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood, J.M. et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60, 2178-2189 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 2178-2189
    • Wood, J.M.1
  • 109
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash, J. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc. Natl. Acad. Sci. USA 99, 11393-11398 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11393-11398
    • Holash, J.1
  • 110
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar, F. et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. 21, 60-65 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 60-65
    • Kabbinavar, F.1
  • 111
    • 0037705602 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab (anti-VEGF antibody) in metastatic renal cancer
    • in the press
    • Yang, J. C. et al. A randomized trial of bevacizumab (anti-VEGF antibody) in metastatic renal cancer. N. Engl. J. Med. (in the press).
    • N. Engl. J. Med.
    • Yang, J.C.1
  • 112
    • 0037280306 scopus 로고    scopus 로고
    • The role of VEGF in normal and neoplastic hematopoiesis
    • Gerber, H.P. & Ferrara, N. The role of VEGF in normal and neoplastic hematopoiesis. J. Mol. Med. 81, 20-31 (2003).
    • (2003) J. Mol. Med. , vol.81 , pp. 20-31
    • Gerber, H.P.1    Ferrara, N.2
  • 113
    • 0035282940 scopus 로고    scopus 로고
    • The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemi blasts
    • Smolich, B.D. et al. The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemi blasts. Blood 97, 1413-1421 (2001).
    • (2001) Blood , vol.97 , pp. 1413-1421
    • Smolich, B.D.1
  • 114
    • 0033861874 scopus 로고    scopus 로고
    • Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration
    • Dias, S. et al. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J. Clin. Invest. 106, 511-521 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 511-521
    • Dias, S.1
  • 115
    • 0002418099 scopus 로고
    • Vascular diseases
    • eds. Garner, A. & Klintworth, G.K. (Marcel Dekker, New York)
    • Garner, A. Vascular diseases. in Pathobiology of Ocular Disease 2nd edn. (eds. Garner, A. & Klintworth, G.K.) 1625-1710 (Marcel Dekker, New York, 1994).
    • (1994) Pathobiology of Ocular Disease 2nd Edn. , pp. 1625-1710
    • Garner, A.1
  • 116
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello, L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480-1487 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1480-1487
    • Aiello, L.P.1
  • 117
    • 0027962667 scopus 로고
    • Detection of vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy
    • Malecaze, F. et al. Detection of vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch. Ophthalmol. 112, 1476-1482 (1994).
    • (1994) Arch. Ophthalmol. , vol.112 , pp. 1476-1482
    • Malecaze, F.1
  • 118
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello, L.P. et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. USA 92, 10457-10461 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10457-10461
    • Aiello, L.P.1
  • 119
    • 0030067257 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate
    • Adamis, A.P. et al. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch. Ophthalmol. 114, 66-71 (1996).
    • (1996) Arch. Ophthalmol. , vol.114 , pp. 66-71
    • Adamis, A.P.1
  • 120
    • 0029879849 scopus 로고    scopus 로고
    • Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degenerationrelated choroidal neovascular membranes
    • Lopez, P.F., Sippy, B.D., Lambert, H.M., Thach, A.B. & Hinton, D.R. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degenerationrelated choroidal neovascular membranes. Invest. Ophthalmol. Vis. Sci. 37, 855-868 (1996).
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 855-868
    • Lopez, P.F.1    Sippy, B.D.2    Lambert, H.M.3    Thach, A.B.4    Hinton, D.R.5
  • 121
    • 0033527584 scopus 로고    scopus 로고
    • Selection and analysis of an optimized anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen
    • Chen, Y. et al. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J. Mol. Biol. 293, 865-881 (1999).
    • (1999) J. Mol. Biol. , vol.293 , pp. 865-881
    • Chen, Y.1
  • 122
    • 0032493654 scopus 로고    scopus 로고
    • 165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain
    • 165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. J. Biol. Chem. 273, 20556-20567 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 20556-20567
    • Ruckman, J.1
  • 123
    • 0036129304 scopus 로고    scopus 로고
    • Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
    • Krzystolik, M.G. et al. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch. Ophthalmol. 120, 338-346 (2002).
    • (2002) Arch. Ophthalmol. , vol.120 , pp. 338-346
    • Krzystolik, M.G.1
  • 124
    • 0029129814 scopus 로고
    • Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells
    • Detmar, M. et al. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J. Invest. Dermatol. 105, 44-50 (1995).
    • (1995) J. Invest. Dermatol. , vol.105 , pp. 44-50
    • Detmar, M.1
  • 125
    • 7144264398 scopus 로고    scopus 로고
    • Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
    • Detmar, M. et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J. Invest. Dermatol. 111, 1-6 (1998).
    • (1998) J. Invest. Dermatol. , vol.111 , pp. 1-6
    • Detmar, M.1
  • 126
    • 0037423948 scopus 로고    scopus 로고
    • HIF1α is essential for myeloid cell-mediated inflammation
    • Cramer, T. HIF1α is essential for myeloid cell-mediated inflammation. Cell 112, 645-657 (2003).
    • (2003) Cell , vol.112 , pp. 645-657
    • Cramer, T.1
  • 127
    • 0029745025 scopus 로고    scopus 로고
    • VEGF and flt. Expression time kinetics in rat brain infarct
    • Kovacs, Z., Ikezaki, K., Samoto, K., Inamura, T. & Fukui, M. VEGF and flt. Expression time kinetics in rat brain infarct. Stroke 27, 1865-1872 (1996).
    • (1996) Stroke , vol.27 , pp. 1865-1872
    • Kovacs, Z.1    Ikezaki, K.2    Samoto, K.3    Inamura, T.4    Fukui, M.5
  • 128
    • 0033404669 scopus 로고    scopus 로고
    • VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain
    • van Bruggen, N. et al. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J. Clin. Invest. 104, 1613-1620 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1613-1620
    • Van Bruggen, N.1
  • 129
    • 0035129504 scopus 로고    scopus 로고
    • Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke
    • Paul, R. et al. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat. Med. 7, 222-227 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 222-227
    • Paul, R.1
  • 130
    • 0002062198 scopus 로고    scopus 로고
    • Polycystic ovary syndrome (hyperandrogenic chronic anovulation
    • eds. Yen, S.S.C., Jaffe, R.B. & Barbieri, R.L. (W.B. Saunders, Philadelphia)
    • Yen, S.S.C. Polycystic ovary syndrome (hyperandrogenic chronic anovulation). in Reproductive Endocrinology (eds. Yen, S.S.C., Jaffe, R.B. & Barbieri, R.L.) 436-478 (W.B. Saunders, Philadelphia, 1999).
    • (1999) Reproductive Endocrinology , pp. 436-478
    • Yen, S.S.C.1
  • 131
    • 0030035755 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids
    • McLaren, J. et al. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. J. Clin. Invest. 98, 482-489 (1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 482-489
    • McLaren, J.1
  • 132
    • 0037373006 scopus 로고    scopus 로고
    • Excess placental soluble fms-like tyrosine kinase 1 (sflt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    • Maynard, S.E. et al. Excess placental soluble fms-like tyrosine kinase 1 (sflt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 111, 649-658 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 649-658
    • Maynard, S.E.1
  • 133
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel, R. & Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727-739 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 134
    • 0037453099 scopus 로고    scopus 로고
    • The VIVA trial: Vascular endothelial growth factor in ischemia for vascular angiogenesis
    • Henry, T.D. et al. The VIVA trial: Vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation 107, 1359-1365 (2003).
    • (2003) Circulation , vol.107 , pp. 1359-1365
    • Henry, T.D.1
  • 135
    • 0036665610 scopus 로고    scopus 로고
    • Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study
    • Makinen, K. et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol. Ther. 6, 127-133 (2002).
    • (2002) Mol. Ther. , vol.6 , pp. 127-133
    • Makinen, K.1
  • 136
    • 0037090776 scopus 로고    scopus 로고
    • Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy
    • Dor, Y. et al. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J. 21, 1939-1947 (2002).
    • (2002) EMBO J. , vol.21 , pp. 1939-1947
    • Dor, Y.1
  • 137
    • 0037162547 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover
    • Street, J. et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc. Natl. Acad. Sci. USA 99, 9656-9661 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9656-9661
    • Street, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.