Hypoxia inducible factor 1α and 2α overexpression in inflammatory bowel disease

Journal of Clinical Pathology

Volumn 56, Issue 3, 2003, Pages 209-213

  Giatromanolaki, A ^a,b   Sivridis, E ^b   Maltezos, E ^b   Papazoglou, D ^b   Simopoulos, C ^b   Gatter, K C ^c   Harris, A L ^c   Koukourakis, M I ^b  

^a Department of Pathology ^*  (Greece)

^b DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; THYMIDINE PHOSPHORYLASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; EPITHELIUM CELL; FEMALE; FIBROBLAST; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE OVEREXPRESSION; GLYCOLYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATORY CELL; MALE; MUSCLE CELL; PRIORITY JOURNAL; TISSUE REGENERATION; ULCERATIVE COLITIS;

ADULT; AGED; ANGIOGENESIS INDUCING AGENTS; ANTIBODIES, MONOCLONAL; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; DNA-BINDING PROTEINS; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOENZYME TECHNIQUES; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0037340247     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.56.3.209     Document Type: Article

References (34)

1. Maini RN. Autoimmunity in rheumatoid arthritis. An approach via a study of B lymphocytes. Rheum Dis Clin North Am 1987;13:319.
2. Kanazawa S, Tsunoda T, Onuma E, et al. VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterol 2001;96:822-8.
3. Bousvaros A, Leichtner A, Zurakowski D, et al. Elevated serum vascular endothelial growth factor in children and young adults with Crohn's disease. Dig Dis Sci 1999;44:424-30.
4. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-54.
5. Wiesener MS, Turley H, Allen WE, et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α. Blood 1998;92:2260-8.
6. 2-dependent degradation domain via the ubiquitine-proteasome pathway. Proc Natl Acad Sci U S A 1998;95:7987-92.
7. 2 homeostasis. Curr Opin Genet Dev 1998;8:588-94.
8. Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia inducible factors HIF-1α and HIF-2α in normal human tissues, cancers and tumor associated macrophages. Am J Pathol 2000;157:2411-21.
9. Zhang L, Scott P, Turley H, et al. Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections: expression of VEGF in the human endometrium. J Pathol 1998;185:402-8.
10. Brekken RA, Huang X, King SW, et al. Vascular endothelial growth factor as a marker of tumor endothelium. Cancer Res 1998;58:1952-9.
11. Fox SB, Moghaddam A, Westwood M, et al. Platelet derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues an immunohistochemical study. J Pathol 1995;176:183-90.
12. Parums DV, Cordell JL, Micklem K, et al. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol 1990;43:752-7.
13. Griga T, Voigt E, Gretzer B, et al. Increased production of vascular endothelial growth factor by intestinal mucosa of patients with inflammatory bowel disease. Hepatogastroenterology 1999;46:920-3.
14. Brown NS, Bicknell R. Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis. Biochem J 1998;334:1-8.
15. Brown NS, Jones A, Fujiyama C, et al. Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res 2002;60:6298-302.
16. Gunsilius E, Petzer A, Stockhammer G, et al. Thrombocytes are the major source for soluble vascular endothelial growth factor in peripheral blood. Oncology 2000;58:169-74.
17. Verheul HM, Hoekman K, Luykx-de Bakker S, et al. Platelet transporter of vascular endothelial growth factor. Clin Cancer Res 1997;3:2187-90.
18. Maloney JP, Silliman CC, Ambruso DR, et al. In vitro release of vascular endothelial growth factor during platelet aggregation. Am J Physiol 1998;275:1054-61.
19. Webb NJ, Bottomley MJ, Watson CJ, et al. Vascular endothelial growth factor (VEGF) is released from platelets during blood clotting: implications for measurement of circulating VEGF levels in clinical disease. Clin Sci (Colch) 1998;94:395-404.
20. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776-81.
21. Kapsoritakis AN, Potamianos SP, Sfiridaki Al, et al. Elevated thrombopoietin serum levels in patients with inflammatory bowel disease. Am J Gastroenterol 2000;95:3478-81.
22. Thornton RD, Lane P, Borghaei RC, et al. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem J 2000;1:307-12.
23. Braybrooke JP, Propper DJ, O'Byrne KJ, et al. Induction of thymidine phosphorylase as a pharmacodynamic end point in patients with advanced carcinoma treated with 5-fluorouracil, folinic acid and interferon-alpha. Br J Cancer 2000;83:219-24.
24. Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001;85:881-90.
25. Sivridis E, Giatromanolaki A, Gatter KC, et al. Hypoxia inducible factor (1-alpha and 2-alpha) expression in endometrial cancer relates with angiogenesis and prognosis. Cancer 2002;95:1055-63.
26. Ema M, Taya S, Yokotani N, et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 1997;94:4273-8.
27. Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604-13.
28. Makino Y, Cao R, Svensson K, et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001;414:550-4.
29. Watson CJ, Webb NJ, Bottomley MJ, et al. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine 2000;12:1232-5.
30. Abu-Ghazaleh R, Kabir J, Jia H, et al. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem J 2001;360:255-64.
31. Bachelder RE, Crago A, Chung J, et al. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res 2001;61:5736-40.
32. Brown KR, England KM, Goss KL, et al. VEGF induces airway epithelial cell proliferation in human fetal lung in vitro. Am J Physiol 2001;281:1001-10.
33. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000;106:1311-19.
34. Koukourakis MI, Flordellis CS, Giatromanolaki A, et al. Oral administration of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) in the management of radiotherapy induced esophagitis. Clin Cancer Res 1999;5:3970-6.