The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1α by a von Hippel-Lindau protein-independent mechanism

Journal of Biological Chemistry

Volumn 278, Issue 32, 2003, Pages 30125-30135

  Tang, Tracy Tzu Ling ^b   Lasky, Laurence A ^a  

^a GENENTECH INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GENES; HYDROXYLATION; METABOLISM; PROTEINS;

FORKHEAD TRANSCRIPTION FACTOR;

BIOCHEMISTRY;

ERYTHROPOIETIN; GLUCOSE TRANSPORTER 1; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEASOME; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXO4; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; ERYTHROPOIESIS; GENE ACTIVATION; GENE CONTROL; GENE MUTATION; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; HOMEOSTASIS; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR GROWTH;

ANOXIA; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; DNA; DOWN-REGULATION; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIGASES; LUCIFERASES; MULTIENZYME COMPLEXES; OXYGEN; PLASMIDS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0042029755     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302042200     Document Type: Article

References (66)

1. Toker, A., and Cantley, L. C. (1997) Nature 387, 673-676
2. Toker, A., and Newton, A. C. (2000) Cell 103, 185-188
3. Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., and Ruvkun, G. (1997) Nature 389, 994-999
4. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Cell 96, 857-868
5. Kops, G. J., de Ruiter, N. D., De Vries-Smits, A. M., Powell, D. R., Bos, J. L., and Burgering, B. M. (1999) Nature 398, 630-634
6. Tang, E. D., Nunez, G., Barr, F. G., and Guan, K. L. (1999) J. Biol. Chem. 274, 16741-16746
7. Takaishi, H., Konishi, H., Matsuzaki, H., Ono, Y., Shirai, Y., Saito, N., Kitamura, T., Ogawa, W., Kasuga, M., Kikkawa, U., and Nishizuka, Y. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11836-11841
8. Nakamura, N., Ramaswamy, S., Vazquez, F., Signoretti, S., Loda, M., and Sellers, W. R. (2000) Mol. Cell. Biol. 20, 8969-8982
9. Tang, T. T., Dowbenko, D., Jackson, A., Toney, L., Lewin, D. A., Dent, A. L., and Lasky, L. A. (2002) J. Biol. Chem. 277, 14255-14265
10. Biggs III, W. H., Meisenhelder, J., Hunter, T., Cavenee, W. K., and Arden, K. C. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 7421-7426
11. Cichy, S. B., Uddin, S., Danilkovich, A., Guo, S., Klippel, A., and Unterman, T. G. (1998) J. Biol. Chem. 273, 6482-6487
12. Medema, R. H., Kops, G. J., Bos, J. L., and Burgering, B. M. (2000) Nature 404, 782-787
13. Dijkers, P. F., Medema, R. H., Pals, C., Banerji, L., Thomas, N. S., Lam, E. W., Burgering, B. M., Raaijmakers, J. A., Lammers, J. W., Koenderman, L., and Coffer, P. J. (2000) Mol. Cell. Biol. 20, 9138-9148
14. Dijkers, P. F., Medema, R. H., Lammers, J. W., Koenderman, L., and Coffer, P. J. (2000) Curr. Biol. 10, 1201-1204
15. Modur, V., Nagarajan, R., Evers, B. M., and Milbrandt, J. (2002) J. Biol. Chem. 277, 47928-47937
16. Schmidt, M., de Mattos, S. F., van der Horst, A., Klompmaker, R., Kops, G. J., Lam, E. W., Burgering, B. M., and Medema, R. H. (2002) Mol. Cell. Biol. 22, 7842-7852
17. Ramaswamy, S., Nakamura, N., Sansal, I., Bergeron, L., and Sellers, W. R. (2002) Cancer Cell. 2, 81-91
18. Li, D. M., and Sun, H. (1997) Cancer Res. 57, 2124-2129
19. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H., and Tavtigian, S. V. (1997) Nat. Genet. 15, 356-362
20. Maehama, T., and Dixon, J. E. (1998) J. Biol. Chem. 273, 13375-13378
21. Wu, X., Senechal, K., Neshat, M. S., Whang, Y. E., and Sawyers, C. L. (1998) Proc. Natl. Acad, Sci. U. S. A. 95, 15587-15591
22. Haas-Kogan, D., Shalev, N., Wong, M., Mills, G., Yount, G., and Stokoe, D. (1998) Curr. Biol. 8, 1195-1198
23. Semenza, G. L. (2000) J. Appl. Physiol. 88, 1474-1480
24. Semenza, G. L. (2001) Curr. Opin. Cell Biol. 13, 167-171
25. Semenza, G. L. (2002) Biochem. Pharmacol. 64, 993-998
26. Salceda, S., and Caro, J. (1997) J. Biol. Chem. 272, 22642-22647
27. Huang, L. E., Gu, J., Schau, M., and Bunn, H. F. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7987-7992
28. Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. (1999) Nature 399, 271-275
29. Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G. W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J., and Maxwell, P. H. (2000) J. Biol. Chem. 275, 25733-25741
30. Kamura, T., Sato, S., Iwai, K., Czyzyk-Krzeska, M., Conaway, R. C., and Conaway, J. W. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10430-10435
31. Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T. Y., Huang, L. E., Pavletich, N., Chau, V., and Kaelin, W. G. (2000) Nat. Cell Biol. 2, 423-427
32. Tanimoto, K., Makino, Y., Pereira, T., and Poellinger, L. (2000) EMBO J. 19, 4298-4309
33. Berra, E., Roux, D., Richard, D. E., and Pouyssegur, J. (2001) EMBO Rep. 2, 615-620
34. Maranchie, J. K., Vasselli, J. R., Riss, J., Bonifacino, J. S., Linehan, W. M., and Klausner, R. D. (2002) Cancer Cell. 1, 247-255
35. Kondo, K., Klco, J., Nakamura, E., Lechpammer, M., and Kaelin, W. G. (2002) Cancer Cell. 1, 237-246
36. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., and Kaelin, W. G. (2001) Science 292, 464-468
37. Jaakkola, P., Mole, D. R., Tian, Y. M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A., Hebestreit, H. F., Mukherji, M., Schofield, C. J., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Science 292, 468-472
38. Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W., and Ratchffe, P. J. (2001) EMBO J. 20, 5197-5206
39. Bruick, R. K., and McKnight, S. L. (2001) Science 294, 1337-1340
40. Epstein, A. C., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., Tian, Y. M., Masson, N., Hamilton, D. L., Jaakkola, P., Barstead, R., Hodgkin, J., Maxwell, P. H., Pugh, C. W., Schofield, C. J., and Ratcliffe, P. J. (2001) Cell 107, 43-54
41. Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C., and Semenza, G. L. (2001) Mol. Cell. Biol. 21, 3995-4004
42. Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., Stokoe, D., and Giaccia, A. J. (2000) Genes Dev. 14, 391-396
43. Jiang, B. H., Zheng, J. Z., Aoki, M., and Vogt, P. K. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1749-1753
44. Jiang, B. H., Jiang, G., Zheng, J. Z., Lu, Z., Hunter, T., and Vogt, P. K. (2001) Cell Growth & Differ. 12, 363-369
45. Mazure, N. M., Chen, E. Y., Laderoute, K. R., and Giaccia, A. J. (1997) Blood 90, 3322-3331
46. Blancher, C., Moore, J. W., Robertson, N., and Harris, A. L. (2001) Cancer Res. 61, 7349-7355
47. Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M. M., Simons, J. W., and Semenza, G. L. (2000) Cancer Res. 60, 1541-1545
48. Chen, E. Y., Mazure, N. M., Cooper, J. A., and Giaccia, A. J. (2001) Cancer Res. 61, 2429-2433
49. Lin, X., Liang, M., and Feng, X. H. (2000) J. Biol. Chem. 275, 36818-36822
50. Zhang, Y., Chang, C., Gehling, D. J., Hemmati-Brivanlou, A., and Derynck, R. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 974-979
51. Kavsak, P., Rasmussen, R. K., Causing, C. G., Bonni, S., Zhu, H., Thomsen, G. H., and Wrana, J. L. (2000) Mol. Cell. 6, 1365-1375
52. Bonni, S., Wang, H. R., Causing, C. G., Kavsak, P., Stroschein, S. L., Luo, K., and Wrana, J. L. (2001) Nat. Cell Biol. 3, 587-595
53. Arora, K., and Warrior, R. (2001) Dev Cell. 1, 441-442
54. Podos, S. D., Hanson, K. K., Wang, Y. C., and Ferguson, E. L. (2001) Dev Cell. 1, 567-578
55. Neumann, F., and Krawinkel, U. (1997) Exp. Cell Res. 230, 252-261
56. Swanson, H. I., and Bradfield, C. A. (1993) Pharmacogenetics 3, 213-230
57. Hankinson, O. (1995) Annu. Rev. Pharmacol. Toxicol. 35, 307-340
58. Park, H. (1999) Mol. Cell 9, 172-178
59. Bhattacharya, S., Michels, C. L., Leung, M.-K., Arany, Z. P., Kung, A. L., and Livingston, D. M. (1999) Genes Dev. 13, 64-75
60. Arany, Z., Huang, L. E., Eckner, R., Bhattacharya, S., Jiang, C., Goldberg, M. A., Bunn, H. F., and Livingston, D. M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12969-12973
61. Chan, W. K., Yao, G., Gu, Y.-Z., and Bradfield, C. A. (1999) J. Biol. Chem. 274, 12115-12123
62. Benezra, R., Rafii, S., and Lyden, D. (2001) Oncogene 20, 8334-8341
63. Lyden, D., Young, A. Z., Zagzag, D., Yan, W., Gerald, W., O'Reilly, R., Bader, B. L., Hynes, R. O., Zhuang, Y., Manova, K., and Benezra, R. (1999) Nature 401, 670-677
64. Volpert, O. V., Pili, R., Sikder, H. A., Nelius, T., Zaichuk, T., Morris, C., Shiflett, C. B., Devhn, M. K., Conant, K., and Alani, R. M. (2002) Cancer Cell. 2, 473-483
65. Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., and Bedi, A. (2000) Genes Dev. 14, 34-44
66. Jeong, J. W., Bae, M. K., Ahn, M. Y., Kim, S. H., Sohn, T. K., Bae, M. H., Yoo, M. A., Song, E. J., Lee, K. J., and Kim, K. W. (2002) Cell 111, 709-720