메뉴 건너뛰기




Volumn 296, Issue 6, 2009, Pages

Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1α-dependent mechanisms

Author keywords

Cyclin A; Fibroblast growth factor; Oxygen; Platelet derived growth factor

Indexed keywords

CYCLIN A; FIBROBLAST GROWTH FACTOR 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYLHYDROXYLASE 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 67049115821     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90393.2008     Document Type: Article
Times cited : (24)

References (46)
  • 3
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
    • DOI 10.1093/emboj/cdg392
    • Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22: 4082-4090, 2003. (Pubitemid 37021737)
    • (2003) EMBO Journal , vol.22 , Issue.16 , pp. 4082-4090
    • Berra, E.1    Benizri, E.2    Ginouves, A.3    Volmat, V.4    Roux, D.5    Pouyssegur, J.6
  • 5
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • DOI 10.1126/science.1066373
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340, 2001. (Pubitemid 33063099)
    • (2001) Science , vol.294 , Issue.5545 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 6
    • 27844472745 scopus 로고    scopus 로고
    • Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of Hypoxia-Inducible Factor-α/Sima
    • DOI 10.1038/sj.embor.7400528, PII 7400528
    • Centanin L, Ratcliffe PJ, Wappner P. Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima. EMBO Rep 6: 1070-1075, 2005. (Pubitemid 41637653)
    • (2005) EMBO Reports , vol.6 , Issue.11 , pp. 1070-1075
    • Centanin, L.1    Ratcliffe, P.J.2    Wappner, P.3
  • 8
    • 0031830048 scopus 로고    scopus 로고
    • Hypoxic growth of bovine pulmonary artery smooth muscle cells: Dependence on synergy, heterogeneity, and injury-induced phenotypic change
    • Dempsey EC, Ditas M, Frid MG, Xu Y, Stenmark KR. Hypoxic growth of bovine pulmonary artery smooth muscle cells. Dependence on synergy, heterogeneity, and injury-induced phenotypic change. Chest 114: 29S-30S, 1998. (Pubitemid 28334846)
    • (1998) Chest , vol.114 , Issue.1 SUPPL.
    • Dempsey, E.C.1    Das, M.2    Frid, M.G.3    Xu, Y.4    Stenmark, K.R.5
  • 9
    • 57349100797 scopus 로고    scopus 로고
    • Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: Role of NFkappaB-dependent hypoxia-inducible factor-1alpha transcription
    • Diebold I, Djordjevic T, Hess J, Gorlach A. Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: role of NFkappaB-dependent hypoxia-inducible factor-1alpha transcription. Thromb Haemost 100: 1021-1028, 2008.
    • (2008) Thromb Haemost , vol.100 , pp. 1021-1028
    • Diebold, I.1    Djordjevic, T.2    Hess, J.3    Gorlach, A.4
  • 11
    • 40949114950 scopus 로고    scopus 로고
    • Role and regulation of prolyl hydroxylase domain proteins
    • Fong GH, Takeda K. Role and regulation of prolyl hydroxylase domain proteins. Cell Death Differ 15: 635-641, 2008.
    • (2008) Cell Death Differ , vol.15 , pp. 635-641
    • Fong, G.H.1    Takeda, K.2
  • 12
    • 0442278330 scopus 로고    scopus 로고
    • Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth
    • DOI 10.1016/S1534-5807(03)00409-X, PII S153458070300409X
    • Frei C, Edgar BA. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. Dev Cell 6: 241-251, 2004. (Pubitemid 38190364)
    • (2004) Developmental Cell , vol.6 , Issue.2 , pp. 241-251
    • Frei, C.1    Edgar, B.A.2
  • 13
    • 0042763564 scopus 로고    scopus 로고
    • HIF-1 in cell cycle regulation, apoptosis, and tumor progression
    • Goda N, Dozier SJ, Johnson RS. HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxid Redox Signal 5: 467-473, 2003. (Pubitemid 37087407)
    • (2003) Antioxidants and Redox Signaling , vol.5 , Issue.4 , pp. 467-473
    • Goda, N.1    Dozier, S.J.2    Johnson, R.S.3
  • 14
    • 0032568481 scopus 로고    scopus 로고
    • Nitric oxide-induced downregulation of cdk2 activity and cyclin a gene transcription in vascular smooth muscle cells
    • Guo K, Andres V, Walsh K. Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Circulation 97: 2066-2072, 1998. (Pubitemid 28243670)
    • (1998) Circulation , vol.97 , Issue.20 , pp. 2066-2072
    • Guo, K.1    Andres, V.2    Walsh, K.3
  • 15
    • 0022383183 scopus 로고
    • Pulmonary hypertension: Vasoconstriction and vascular remodeling
    • Hales CA. Pulmonary hypertension: vasoconstriction and vascular remodeling. Semin Resp Med 7: 136-140, 1985. (Pubitemid 16241425)
    • (1985) Seminars in Respiratory Medicine , vol.7 , Issue.2 , pp. 136-140
    • Hales, C.A.1
  • 16
    • 0043234538 scopus 로고    scopus 로고
    • Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
    • DOI 10.1074/jbc.M304982200
    • Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278: 30772-30780, 2003. (Pubitemid 36994584)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.33 , pp. 30772-30780
    • Hirsila, M.1    Koivunen, P.2    Gunzler, V.3    Kivirikko, K.I.4    Myllyharju, J.5
  • 17
    • 0037131159 scopus 로고    scopus 로고
    • Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
    • DOI 10.1074/jbc.M206955200
    • Huang J, Zhao Q, Mooney SM, Lee FS. Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J Biol Chem 277: 39792-39800, 2002. (Pubitemid 35190963)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.42 , pp. 39792-39800
    • Huang, J.1    Zhao, Q.2    Mooney, S.M.3    Lee, F.S.4
  • 18
    • 40949108800 scopus 로고    scopus 로고
    • Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation
    • Huang LE. Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation. Cell Death Differ 15: 672-677, 2008.
    • (2008) Cell Death Differ , vol.15 , pp. 672-677
    • Huang, L.E.1
  • 19
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR) -dependent signaling
    • DOI 10.1096/fj.01-0658com
    • Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 16: 771-780, 2002. (Pubitemid 34615125)
    • (2002) FASEB Journal , vol.16 , Issue.8 , pp. 771-780
    • Humar, R.O.K.1    Kiefer, F.N.2    Berns, H.3    Resink, T.J.4    Battegay, E.J.5
  • 23
    • 33749410367 scopus 로고    scopus 로고
    • The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases
    • DOI 10.1074/jbc.M604628200
    • Koivunen P, Hirsila M, Kivirikko KI, Myllyharju J. The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. J Biol Chem 281: 28712-28720, 2006. (Pubitemid 44507013)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.39 , pp. 28712-28720
    • Koivunen, P.1    Hirsila, M.2    Kivirikko, K.I.3    Myllyharju, J.4
  • 24
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF
    • DOI 10.1074/jbc.M610415200
    • Koivunen P, Hirsila M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J Biol Chem 282: 4524-4532, 2007. (Pubitemid 47100953)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.7 , pp. 4524-4532
    • Koivunen, P.1    Hirsila, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5    Myllyharju, J.6
  • 25
    • 3142631736 scopus 로고    scopus 로고
    • HIF-1α induces cell cycle arrest by functionally counteracting Myc
    • DOI 10.1038/sj.emboj.7600196
    • Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J 23: 1949-1956, 2004. (Pubitemid 38902073)
    • (2004) EMBO Journal , vol.23 , Issue.9 , pp. 1949-1956
    • Koshiji, M.1    Kageyama, Y.2    Pete, E.A.3    Horikawa, I.4    Barrett, J.C.5    Huang, L.E.6
  • 26
    • 29644442625 scopus 로고    scopus 로고
    • Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
    • DOI 10.1074/jbc.M508718200
    • Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem 280: 41928-41939, 2005. (Pubitemid 43023162)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.51 , pp. 41928-41939
    • Lu, H.1    Dalgard, C.L.2    Mohyeldin, A.3    McFate, T.4    Tait, A.S.5    Verma, A.6
  • 29
    • 33644837102 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury
    • DOI 10.1161/01.RES.0000197816.63513.27, PII 0000301220060106000020
    • Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA 3rd. Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury. Circ Res 98: 133-140, 2006. (Pubitemid 43970213)
    • (2006) Circulation Research , vol.98 , Issue.1 , pp. 133-140
    • Natarajan, R.1    Salloum, F.N.2    Fisher, B.J.3    Kukreja, R.C.4    Fowler III, A.A.5
  • 31
    • 34848842419 scopus 로고    scopus 로고
    • Three autocrine feedback loops determine HIF1α expression in chronic hypoxia
    • DOI 10.1016/j.bbamcr.2007.07.004, PII S0167488907001681
    • Qutub AA, Popel AS. Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia. Biochim Biophys Acta 1773: 1511-1525, 2007. (Pubitemid 47500174)
    • (2007) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1773 , Issue.10 , pp. 1511-1525
    • Qutub, A.A.1    Popel, A.S.2
  • 32
    • 0018340698 scopus 로고
    • The pulmonary circulation: Remodeling in growth and disease
    • Reid LM. The pulmonary circulation: remodeling in growth and disease. Am Rev Respir Dis 119: 531-546, 1979.
    • (1979) Am Rev Respir Dis , vol.119 , pp. 531-546
    • Reid, L.M.1
  • 33
    • 0032725554 scopus 로고    scopus 로고
    • P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
    • Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 274: 32631-32637, 1999. (Pubitemid 129535289)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.46 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 34
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells
    • DOI 10.1074/jbc.M003325200
    • Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 275: 26765-26771, 2000. (Pubitemid 30688019)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.35 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 35
    • 0029917858 scopus 로고    scopus 로고
    • Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells
    • DOI 10.1074/jbc.271.14.8345
    • Sasaguri T, Ishida A, Kosaka C, Nojima H, Ogata J. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. J Biol Chem 271: 8345-8351, 1996. (Pubitemid 26108669)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.14 , pp. 8345-8351
    • Sasaguri, T.1    Ishida, A.2    Kosaka, C.3    Nojima, H.4    Ogata, J.5
  • 36
    • 33744944257 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1α promote growth factor-induced proliferation of human vascular smooth muscle cells
    • DOI 10.1152/ajpheart.01077.2005
    • Schultz K, Fanburg BL, Beasley D. Hypoxia and hypoxia-inducible factor-1α promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 290: H2528-H2534, 2006. (Pubitemid 43846084)
    • (2006) American Journal of Physiology - Heart and Circulatory Physiology , vol.290 , Issue.6
    • Schultz, K.1    Fanburg, B.L.2    Beasley, D.3
  • 38
    • 35148828429 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 (HIF-1) pathway
    • Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007: cm8, 2007.
    • (2007) Sci STKE , vol.2007
    • Semenza, G.L.1
  • 39
    • 0033564697 scopus 로고    scopus 로고
    • 1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512, 1999. (Pubitemid 29297917)
    • (1999) Genes and Development , vol.13 , Issue.12 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 40
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • DOI 10.1101/gad.1256504
    • Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 18: 2699-2711, 2004. (Pubitemid 39507762)
    • (2004) Genes and Development , vol.18 , Issue.22 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 41
    • 0035884701 scopus 로고    scopus 로고
    • HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
    • Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 61: 6669-6673, 2001. (Pubitemid 32896483)
    • (2001) Cancer Research , vol.61 , Issue.18 , pp. 6669-6673
    • Sowter, H.M.1    Ratcliffe, P.J.2    Watson, P.3    Greenberg, A.H.4    Harris, A.L.5
  • 43
    • 34547905406 scopus 로고    scopus 로고
    • Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
    • DOI 10.1161/CIRCULATIONAHA.107.701516, PII 0000301720070814000016
    • Takeda K, Cowan A, Fong GH. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 116: 774-781, 2007. (Pubitemid 47255995)
    • (2007) Circulation , vol.116 , Issue.7 , pp. 774-781
    • Takeda, K.1    Cowan, A.2    Fong, G.-H.3
  • 44
    • 33750976389 scopus 로고    scopus 로고
    • Placental but not heart defects are associated with elevated hypoxia-inducible factor α levels in mice lacking prolyl hydroxylase domain protein 2
    • DOI 10.1128/MCB.00425-06
    • Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol 26: 8336-8346, 2006. (Pubitemid 44748568)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.22 , pp. 8336-8346
    • Takeda, K.1    Ho, V.C.2    Takeda, H.3    Duan, L.-J.4    Nagy, A.5    Fong, G.-H.6
  • 45
    • 0031043721 scopus 로고    scopus 로고
    • Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty
    • Wei GL, Krasinski K, Kearney M, Isner JM, Walsh K, Andres V. Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty. Circ Res 80: 418-426, 1997. (Pubitemid 27093357)
    • (1997) Circulation Research , vol.80 , Issue.3 , pp. 418-426
    • Wei, G.L.1    Krasinski, K.2    Kearney, M.3    Isner, J.M.4    Walsh, K.5    Andres, V.6
  • 46
    • 60849118110 scopus 로고    scopus 로고
    • Role of HIF-1α and VEGF in human mesenchymal stem cell proliferation by 17β-estradiol: Involvement of PKC, PI3K/Akt, and MAPKs
    • Yun SP, Lee MY, Ryu JM, Song CH, Han HJ. Role of HIF-1α and VEGF in human mesenchymal stem cell proliferation by 17β-estradiol: involvement of PKC, PI3K/Akt, and MAPKs. Am J Physiol Cell Physiol 296: C317-C326, 2009.
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Yun, S.P.1    Lee, M.Y.2    Ryu, J.M.3    Song, C.H.4    Han, H.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.