Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

Science

Volumn 286, Issue 5449, 1999, Pages 2511-2514

  Thurston, G ^a   Suri, C ^b   Smith, K ^a   McClain, J ^b   Sato, T N ^c   Yancopoulos, G D ^b   McDonald, D M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL PERMEABILITY; GENE OVEREXPRESSION; HISTOPATHOLOGY; INFLAMMATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANGIOPOIETIN-1; ANIMALS; ARTERIOLES; BINDING SITES; CAPILLARIES; CAPILLARY PERMEABILITY; EAR; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; INFLAMMATION; INFLAMMATION MEDIATORS; LYMPHOKINES; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; MICROCIRCULATION; MUSTARD PLANT; NEOVASCULARIZATION, PHYSIOLOGIC; PLANT EXTRACTS; PLANT LECTINS; PLANT OILS; PLANTS, MEDICINAL; PLATELET ACTIVATING FACTOR; RICIN; SEROTONIN; SKIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VENULES;

ANIMALIA; MUS MUSCULUS;

EID: 0033601357     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5449.2511     Document Type: Article

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39. Supported in part by NIH grants HL-59157 and HL-24136. We thank P. Baluk and J. W. McLean for helpful discussions; M. Simmons, T. Murphy, and N. Glazer for technical assistance; and C. Murphy and E. Burrows for help with graphics.