-
1
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumor growth
-
A.L. Harris, Hypoxia-a key regulatory factor in tumor growth, Nat. Rev. Cancer 2 (2002) 38-47.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
2
-
-
0036187999
-
Oxygen sensing, HIF-1a stabilization and potential therapeutic strategies
-
T. Hofer, R.H. Wenger, M. Gassmann, Oxygen sensing, HIF-1a stabilization and potential therapeutic strategies, Eur. J. Physiol. 443 (2002) 503-507.
-
(2002)
Eur. J. Physiol.
, vol.443
, pp. 503-507
-
-
Hofer, T.1
Wenger, R.H.2
Gassmann, M.3
-
3
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
G.L. Semenza, G.L. Wang, A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation, Mol. Cell. Biol. 12 (1992) 5447-5454.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
5
-
-
0035183438
-
Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression
-
G. Camenisch, D.M. Stroka, M. Gassmann, R.H. Wenger, Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression, Eur. J. Physiol. 443 (2001) 240-249.
-
(2001)
Eur. J. Physiol.
, vol.443
, pp. 240-249
-
-
Camenisch, G.1
Stroka, D.M.2
Gassmann, M.3
Wenger, R.H.4
-
6
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
P.H. Maxwell, M.S. Wiesener, G.W. Chang, S.C. Clifford, E.C. Vaux, M.E. Cockman, C.C. Wykoff, C.W. Pugh, E.R. Maher, P.J. Ratcliffe, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature 399 (1999) 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
7
-
-
0034682783
-
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
M.E. Cockman, N. Masson, D.R. Mole, P. Jaakkola, G.W. Chang, S.C. Clifford, E.R. Maher, C.W. Pugh, P.J. Ratcliffe, P.H. Maxwell, Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein, J. Biol. Chem. 275 (2000) 25733-25741.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakkola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
8
-
-
0035347260
-
Induction of HIF-1a in response to hypoxia is instantaneous
-
U.R. Jewell, I. Kvietikova, A. Scheid, C. Bauer, R.H. Wenger, M. Gassmann, Induction of HIF-1a in response to hypoxia is instantaneous, FASEB J. 15 (2001) 1312-1314.
-
(2001)
FASEB J.
, vol.15
, pp. 1312-1314
-
-
Jewell, U.R.1
Kvietikova, I.2
Scheid, A.3
Bauer, C.4
Wenger, R.H.5
Gassmann, M.6
-
9
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
-
R. Ravi, B. Mookerjee, Z.M. Bhujwalla, C.H. Sutter, D. Artemov, Q. Zeng, L.E. Dillehay, A. Manda, G.L. Semenza, A. Bedi, Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α, Genes Dev. 14 (2000) 34-44.
-
(2000)
Genes Dev.
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Manda, A.8
Semenza, G.L.9
Bedi, A.10
-
10
-
-
0035917313
-
2 sensing
-
2 sensing, Science 292 (2001) 464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin W.G., Jr.10
-
11
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation, Science 292 (2001) 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.V.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratclife, P.J.13
-
12
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
R.K. Bruick, S.L. Mcknight, A conserved family of prolyl-4-hydroxylases that modify HIF, Science 294 (2001) 1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
Mcknight, S.L.2
-
13
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit
-
L.E. Huang, Z. Arany, D.M. Livingston, H.F. Bunn, Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit, J. Biol. Chem. 271 (1996) 32253-32259.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
14
-
-
0027970536
-
Role of hydrogen peroxide in hypoxia-induced erythropoietin production
-
J. Fandrey, S. Frede, W. Jelkmann, Role of hydrogen peroxide in hypoxia-induced erythropoietin production, Biochem. J. 303 (1994) 507-510.
-
(1994)
Biochem. J.
, vol.303
, pp. 507-510
-
-
Fandrey, J.1
Frede, S.2
Jelkmann, W.3
-
15
-
-
0029123437
-
Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1
-
G.L. Wang, B.H. Jiang, G.L. Semenza, Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1, Biochem. Biophys. Res. Commun. 212 (1995) 550-556.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.212
, pp. 550-556
-
-
Wang, G.L.1
Jiang, B.H.2
Semenza, G.L.3
-
16
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
S. Salceda, J. Caro, Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes, J. Biol. Chem. 272 (1997) 22642-22647.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
17
-
-
0031038417
-
Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species
-
J. Fandrey, S. Frede, W. Ehleben, T. Porwol, H. Acker, W. Jelkmann, Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species, Kidney Int. 51 (1997) 492-496.
-
(1997)
Kidney Int.
, vol.51
, pp. 492-496
-
-
Fandrey, J.1
Frede, S.2
Ehleben, W.3
Porwol, T.4
Acker, H.5
Jelkmann, W.6
-
18
-
-
0031791118
-
Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis
-
O. Canbolat, J. Fandrey, W. Jelkmann, Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis, Respir. Physiol. 114 (1998) 175-183.
-
(1998)
Respir. Physiol.
, vol.114
, pp. 175-183
-
-
Canbolat, O.1
Fandrey, J.2
Jelkmann, W.3
-
19
-
-
0030076791
-
Hydrogen peroxide in the regulation of erythropoietin (Epo) gene expression in hepatocellular carcinoma cells
-
J.K. Ndele, K. Yoshioka, J.W. Fisher, Hydrogen peroxide in the regulation of erythropoietin (Epo) gene expression in hepatocellular carcinoma cells, East Afr. Med. J. 73 (1996) 143-146.
-
(1996)
East Afr. Med. J.
, vol.73
, pp. 143-146
-
-
Ndele, J.K.1
Yoshioka, K.2
Fisher, J.W.3
-
20
-
-
10144222652
-
Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo
-
M. Kuroki, E.E. Voest, S. Amano, L.V. Beerepoot, S. Takashima, M. Tolentino, R.Y. Kim, R.M. Rohan, K.A. Colby, K.-T. Yeo, A.P. Adamis, Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo, J. Clin. Invest. 98 (1996) 1667-1675.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1667-1675
-
-
Kuroki, M.1
Voest, E.E.2
Amano, S.3
Beerepoot, L.V.4
Takashima, S.5
Tolentino, M.6
Kim, R.Y.7
Rohan, R.M.8
Colby, K.A.9
Yeo, K.-T.10
Adamis, A.P.11
-
21
-
-
0032578458
-
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
-
N.S. Chandel, E. Maltepe, E. Goldwasser, C.E. Mathieu, M.C. Simon, P.T. Schumacker, Mitochondrial reactive oxygen species trigger hypoxia-induced transcription, Proc. Natl. Acad. Sci. USA 95 (1998) 11715-11720.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11715-11720
-
-
Chandel, N.S.1
Maltepe, E.2
Goldwasser, E.3
Mathieu, C.E.4
Simon, M.C.5
Schumacker, P.T.6
-
22
-
-
0034682786
-
Reactive oxygen species generated at mitochondria complex III stabilize hypoxia-inducible factor-1α during hypoxia
-
N.S. Chandel, D.S. McClintock, C.E. Feliciano, T.M. Wood, A.M. Melendez, P.T. Schumacker, Reactive oxygen species generated at mitochondria complex III stabilize hypoxia-inducible factor-1α during hypoxia, J. Biol. Chem. 275 (2000) 25130-25138.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25130-25138
-
-
Chandel, N.S.1
McClintock, D.S.2
Feliciano, C.E.3
Wood, T.M.4
Melendez, A.M.5
Schumacker, P.T.6
-
23
-
-
0035933716
-
Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway
-
V. Srinivas, I. Leshchinsky, N. Sang, M.P. King, A. Minchenko, J. Caro, Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway, J. Biol. Chem. 276 (2001) 21995-21998.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21995-21998
-
-
Srinivas, V.1
Leshchinsky, I.2
Sang, N.3
King, M.P.4
Minchenko, A.5
Caro, J.6
-
24
-
-
0035880239
-
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
-
E.C. Vaux, E. Metzen, K.M. Yeates, P.J. Ratcliffe, Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain, Blood 98 (2001) 296-302.
-
(2001)
Blood
, vol.98
, pp. 296-302
-
-
Vaux, E.C.1
Metzen, E.2
Yeates, K.M.3
Ratcliffe, P.J.4
-
25
-
-
0028365120
-
Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes
-
J. Hayashi, S. Ohta, Y. Kagawa, D. Takai, S. Miyabayashi, K. Tada, H. Fukushima, K. Inui, S. Okada, Y. Goto, I. Nonaka, Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes, J. Biol. Chem. 269 (1994) 19060-19066.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19060-19066
-
-
Hayashi, J.1
Ohta, S.2
Kagawa, Y.3
Takai, D.4
Miyabayashi, S.5
Tada, K.6
Fukushima, H.7
Inui, K.8
Okada, S.9
Goto, Y.10
Nonaka, I.11
-
26
-
-
0028262917
-
Human mitochondria and mitochondrial genome function as a single dynamic cellular unit
-
J. Hayashi, M. Takemitsu, Y. Goto, I. Nonaka, Human mitochondria and mitochondrial genome function as a single dynamic cellular unit, J. Cell Biol. 125 (1994) 43-50.
-
(1994)
J. Cell Biol.
, vol.125
, pp. 43-50
-
-
Hayashi, J.1
Takemitsu, M.2
Goto, Y.3
Nonaka, I.4
-
27
-
-
0034213449
-
Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells
-
N. Koshikawa, K. Takenaga, M. Tagawa, S. Sakiyama, Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells, Cancer Res. 60 (2000) 2936-2941.
-
(2000)
Cancer Res.
, vol.60
, pp. 2936-2941
-
-
Koshikawa, N.1
Takenaga, K.2
Tagawa, M.3
Sakiyama, S.4
-
28
-
-
0028008584
-
Characterization of 2′, 7′-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: Estimation on intracellular content of hydrogen peroxide
-
Y. Oyama, A. Hayashi, T. Ueha, K. Maekawa, Characterization of 2′, 7′-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide, Brain Res. 635 (1994) 113-117.
-
(1994)
Brain Res.
, vol.635
, pp. 113-117
-
-
Oyama, Y.1
Hayashi, A.2
Ueha, T.3
Maekawa, K.4
-
29
-
-
0004136246
-
-
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
-
J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning: A Laboratory Manual, second ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
-
(1989)
Molecular Cloning: A Laboratory Manual, Second Ed.
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
30
-
-
0033975850
-
Hypoxia response element of human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide; control of hypoxia-inducible factor-1 activity by nitric oxide
-
H. Kimura, A. Werisz, Y. Kurashima, K. Hashimoto, T. Ogura, F. DAcquisto, R. Addeo, H. Esumi, Hypoxia response element of human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide; control of hypoxia-inducible factor-1 activity by nitric oxide, Blood 95 (2000) 189-197.
-
(2000)
Blood
, vol.95
, pp. 189-197
-
-
Kimura, H.1
Werisz, A.2
Kurashima, Y.3
Hashimoto, K.4
Ogura, T.5
DAcquisto, F.6
Addeo, R.7
Esumi, H.8
-
31
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
G.L. Wang, G.L. Semenza, Purification and characterization of hypoxia-inducible factor 1, J. Biol. Chem. 270 (1995) 1230-1237.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
32
-
-
0032905578
-
General applicability of chicken egg yolk antibodies: The performance of IgY immunoglobulins raised against the hypoxia-inducible factor 1α
-
G. Camenisch, M. Tini, D. Chilov, I. Kvietikova, V. Srinivas, J. Caro, P. Spielmann, R.H. Wenger, M. Gassmann, General applicability of chicken egg yolk antibodies: the performance of IgY immunoglobulins raised against the hypoxia-inducible factor 1α, FASEB J. 13 (1999) 81-88.
-
(1999)
FASEB J.
, vol.13
, pp. 81-88
-
-
Camenisch, G.1
Tini, M.2
Chilov, D.3
Kvietikova, I.4
Srinivas, V.5
Caro, J.6
Spielmann, P.7
Wenger, R.H.8
Gassmann, M.9
-
33
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
M.M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72 (1976) 248-254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
34
-
-
0032541173
-
Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes
-
T.L.V. Hoek, L.B. Becker, Z. Shao, C. Li, P.T. Schumacker, Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes, J. Biol. Chem. 273 (1998) 18092-18098.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18092-18098
-
-
Hoek, T.L.V.1
Becker, L.B.2
Shao, Z.3
Li, C.4
Schumacker, P.T.5
-
35
-
-
0032496159
-
Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes
-
J. Duranteau, N.S. Chandel, A. Kulisz, Z. Shao, P.T. Schumacker, Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes, J. Biol. Chem. 273 (1998) 11619-11624.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11619-11624
-
-
Duranteau, J.1
Chandel, N.S.2
Kulisz, A.3
Shao, Z.4
Schumacker, P.T.5
-
36
-
-
0037188928
-
Diversity in mitochondrial function explains differences in vascular oxygen sensing
-
E.D. Michelakis, V. Hampl, A. Nsair, X. Wu, G. Harry, A. Haromy, R. Gurtu, S.L. Archer, Diversity in mitochondrial function explains differences in vascular oxygen sensing, Circ. Res. 90 (2002) 1307-1315.
-
(2002)
Circ. Res.
, vol.90
, pp. 1307-1315
-
-
Michelakis, E.D.1
Hampl, V.2
Nsair, A.3
Wu, X.4
Harry, G.5
Haromy, A.6
Gurtu, R.7
Archer, S.L.8
-
37
-
-
0345672740
-
Hypoxic upregulation of tyrosine hydroxylase gene expression is paralleled, but not induced by increased generation of reactive oxygen species in PC12 cells
-
B. Höhler, B. Lange, B. Holzapfel, A. Goldenberg, J. Hänze, A. Sell, H. Testan, W. Möller, W. Kummer, Hypoxic upregulation of tyrosine hydroxylase gene expression is paralleled, but not induced by increased generation of reactive oxygen species in PC12 cells, FEBS Lett. 457 (1999) 53-56.
-
(1999)
FEBS Lett.
, vol.457
, pp. 53-56
-
-
Höhler, B.1
Lange, B.2
Holzapfel, B.3
Goldenberg, A.4
Hänze, J.5
Sell, A.6
Testan, H.7
Möller, W.8
Kummer, W.9
-
38
-
-
0029922167
-
Isolation of human cell lines lacking mitochondrial DNA
-
M.P. King, G. Attardi, Isolation of human cell lines lacking mitochondrial DNA, Methods Enzymol. 264 (1996) 304-313.
-
(1996)
Methods Enzymol.
, vol.264
, pp. 304-313
-
-
King, M.P.1
Attardi, G.2
|