The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 32, 2009, Pages 13505-13510

  Thangarajah, Hariharan ^a   Yao, Dachun ^a   Chang, Edward I ^a   Shi, Yubin ^a   Jazayeri, Leila ^a   Vial, Ivan N ^a   Galiano, Robert D ^a   Du, Xue Liang ^b   Grogan, Raymon ^a   Galvez, Michael G ^a   Januszyk, Michael ^a   Brownlee, Michael ^b   Gurtner, Geoffrey C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Deferoxamine; HIF 1; Hyperglycemia; Ischemia

Indexed keywords

DEFEROXAMINE; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METHYLGLYOXAL; PROTEIN P300; REACTIVE OXYGEN METABOLITE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONJUGATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPOXIA; IN VIVO STUDY; ISCHEMIA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; SKIN; SKIN FIBROBLAST; TRANSACTIVATION; UPREGULATION; WOUND; WOUND HEALING;

ANIMALS; ANOXIA; CELLS, CULTURED; DEFEROXAMINE; DIABETES COMPLICATIONS; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; NEOVASCULARIZATION, PATHOLOGIC; P300-CBP TRANSCRIPTION FACTORS; PROTEIN BINDING; PYRUVALDEHYDE; REACTIVE OXYGEN SPECIES; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

ANIMALIA; MUS;

EID: 69449108536     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906670106     Document Type: Article

References (35)

1. Caro JJ, Ward AJ, O'Brien JA (2002) Lifetime costs of complications resulting from type 2 diabetes in the U.S. Diabetes Care 25:476-481. (Pubitemid 41103339)
2. Norhammar A, et al. (2002) Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: A prospective study. Lancet 359:2140-2144. (Pubitemid 34694020)
3. Abaci A, et al. (1999) Effect of diabetes mellitus on formation of coronary collateral vessels. Circulation 99:2239-2242. (Pubitemid 29201128)
4. Wilson PW (1998) Diabetes mellitus and coronary heart disease. Am J Kidney Dis 32(Suppl 3):S89-S100. (Pubitemid 28527266)
5. Yla-Herttuala S, Rissanen TT, Vajanto I, Hartikainen J (2007) Vascular endothelial growth factors: Biology and current status of clinical applications in cardiovascular medicine. J Am Coll Cardiol 49:1015-1026. (Pubitemid 46349500)
6. Chou E, et al. (2002) Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: A possible explanation for impaired collateral formation in cardiac tissue. Circulation 105:373-379. (Pubitemid 34106188)
7. Lerman OZ, Galiano RD, Armour M, Levine JP, Gurtner GC (2003) Cellular dysfunction in the diabetic fibroblast: Impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol 162:303-312. (Pubitemid 36042012)
8. Frank S, et al. (1995) Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem 270:12607-12613.
9. Forsythe JA, et al. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613. (Pubitemid 26272112)
10. Covello KL, Simon MC (2004) HIFs, hypoxia, and vascular development. Curr Top Dev Biol 62:37-54.
11. Brownlee M (2005) The pathobiology of diabetic complications: A unifying mechanism. Diabetes 54:1615-1625. (Pubitemid 40770750)
12. Strohmeyer G, et al. (1988) Abnormalities in estrogen, androgen, and insulin metabolism in idiopathic hemochromatosis. Ann NY Acad Sci 526:209-223. (Pubitemid 18201693)
13. Trivin F, Beaumont C, Emerit J (2001) Iron metabolism, free radicals, and oxidative injury. Biomed Pharmacother 55:333-339. (Pubitemid 32595478)
14. Galiano RD, Michaels J, Dobryansky M, Levine JP, Gurtner GC (2004) Quantitative and reproducible murine model of excisional wound healing. Wound Repair Regen 12:485-492. (Pubitemid 39007049)
15. Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820. (Pubitemid 34000785)
16. Tepper OM, et al. (2002) Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106:2781-2786.
17. Semenza GL, et al. (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271:32529-32537. (Pubitemid 27008669)
18. Arany Z, et al. (1996) An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 93:12969-12973. (Pubitemid 26382753)
19. Ema M, et al. (1999) Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 18:1905-1914. (Pubitemid 29158534)
20. Kung AL, Wang S, Klco JM, Kaelin WG, Livingston DM (2000) Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med 6:1335-1340. (Pubitemid 32001016)
21. Ahmed N, Thornalley PJ (2003) Quantitative screening of protein biomarkers of early glycation, advanced glycation, oxidation and nitrosation in cellular and extracellular proteins by tandem mass spectrometry multiple reaction monitoring. Biochem Soc Trans 31:1417-1422. (Pubitemid 38030990)
22. Ceradini DJ, et al. (2008) Decreasing intracellular superoxide corrects defective ischemia- induced new vessel formation in diabetic mice. J Biol Chem 283:10930-10938.
23. Appelhoff RJ, et al. (2004) Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279:38458-38465.
24. Hirsila M, et al. (2005) Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. Faseb J 19:1308-1310. (Pubitemid 41113732)
25. Shibata T, Giaccia AJ, Brown JM (2000) Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther 7:493-498. (Pubitemid 30156563)
26. Schofield CJ, Ratcliffe PJ (2004) Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5:343-354.
27. Martin A, Komada MR, Sane DC (2003) Abnormal angiogenesis in diabetes mellitus. Med Res Rev 23:117-145.
28. Walters DP, Gatling W, Mullee MA, Hill RD (1992) The distribution and severity of diabetic foot disease: A community study with comparison to a non-diabetic group. Diabet Med 9:354-358.
29. Takahashi T, et al. (1999) Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 5:434-438. (Pubitemid 29180584)
30. Ceradini DJ, et al. (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10:858-864.
31. Capla JM, et al. (2007) Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia. Plast Reconstr Surg 119:59-70.
32. Gallagher KA, et al. (2007) Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest 117:1249-1259.
33. Botusan IR, et al. (2008) Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Proc Natl Acad Sci USA 105:19426-19431.
34. Hinchliffe RJ, et al. (2008) A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes. Diabetes Metab Res Rev 24(Suppl 1):S119-S144. (Pubitemid 351802785)
35. Gu J, Milligan J, Huang LE (2001) Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine. J Biol Chem 276:3550-3554. (Pubitemid 37411656)