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Volumn 96, Issue 7, 2005, Pages 394-402

Mechanism of HIF-1α-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CASPASE 3; CASPASE 9; CYTOCHROME C; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; AKT1 PROTEIN, HUMAN; BAK1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; CALCIUM; HIF1A PROTEIN, HUMAN; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN BCL X; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR;

EID: 23844540031     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2005.00065.x     Document Type: Article
Times cited : (115)

References (42)
  • 2
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions
    • Salceda S, Caro J. Hypoxia-inducible factor-1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. J Biol Chem 1997; 272: 22642-7.
    • (1997) J. Biol. Chem. , vol.272 , pp. 22642-22667
    • Salceda, S.1    Caro, J.2
  • 4
    • 0034712939 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
    • Sutter CH, Laughner E, Semenza GL. Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 2000; 97: 4748-53.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4748-4753
    • Sutter, C.H.1    Laughner, E.2    Semenza, G.L.3
  • 5
    • 0030963616 scopus 로고    scopus 로고
    • The hypoxic response: Huffing HIFing
    • Guillemin K, Krasnow MA. The hypoxic response: huffing HIFing. Cell 1997; 89: 9-12.
    • (1997) Cell , vol.89 , pp. 9-12
    • Guillemin, K.1    Krasnow, M.A.2
  • 6
    • 0031823016 scopus 로고    scopus 로고
    • The molecular basis of the hypoxia response pathway: Tumor hypoxia as a therapy target
    • Blancher C, Harris AL. The molecular basis of the hypoxia response pathway: tumor hypoxia as a therapy target. Cancer Metastasis Rev 1998; 17: 187-94.
    • (1998) Cancer Metastasis. Rev. , vol.17 , pp. 187-194
    • Blancher, C.1    Harris, A.L.2
  • 8
    • 0033991530 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1: Mechanisms and consequences
    • Semenza GL. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol 2000; 59: 47-53.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 47-53
    • Semenza, G.L.1
  • 9
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989; 49: 6449-65.
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 10
    • 0030968939 scopus 로고    scopus 로고
    • Targeting gene expression to hypoxic tumor cells
    • Dachs GU, Patterson AV, Firth JD et al. Targeting gene expression to hypoxic tumor cells. Nat Med 1997; 3: 515-20.
    • (1997) Nat. Med. , vol.3 , pp. 515-520
    • Dachs, G.U.1    Patterson, A.V.2    Firth, J.D.3
  • 12
    • 0030816109 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    • Maxwell PH, Dachs GU, Gleadle JM et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 1997; 94: 8104-9.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8104-8109
    • Maxwell, P.H.1    Dachs, G.U.2    Gleadle, J.M.3
  • 13
    • 0033870727 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α is a positive factor in solid tumor growth
    • Ryan HE, Poloni M, McNulty W et al. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res 2000; 60: 4010-5.
    • (2000) Cancer Res. , vol.60 , pp. 4010-4015
    • Ryan, H.E.1    Poloni, M.2    McNulty, W.3
  • 14
    • 0034989311 scopus 로고    scopus 로고
    • Biological consequences of tumor hypoxia
    • Hockel M, Vaupel P. Biological consequences of tumor hypoxia. Semin Oncol 2001; 28: 36-41.
    • (2001) Semin. Oncol. , vol.28 , pp. 36-41
    • Hockel, M.1    Vaupel, P.2
  • 15
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 1999; 59: 5830-5.
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 16
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157: 411-21.
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 17
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 2000; 60: 4693-6.
    • (2000) Cancer Res. , vol.60 , pp. 4693-4696
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Plank, C.4    Breitenecker, G.5    Oberhuber, G.6
  • 18
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebersold DM, Burri P, Beer KT et al. Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001; 61: 2911-6.
    • (2001) Cancer Res. , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1    Burri, P.2    Beer, K.T.3
  • 19
    • 0036680153 scopus 로고    scopus 로고
    • Hypoxia inducible factor (HIF-1α and HIF-2α), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer
    • Koukourakis MI, Giatromanolaki A, Sivridis E et al. Hypoxia inducible factor (HIF-1α and HIF-2α), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys 2002; 53: 1192-202.
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.53 , pp. 1192-1202
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3
  • 20
    • 0036569941 scopus 로고    scopus 로고
    • Hypoxia-inducible factors HIF-1α and HIF-2α in head and neck cancer: Relationship to tumor biology and treatment outcome in surgically resected patients
    • Beasley NJ, Leek R, Alam M et al. Hypoxia-inducible factors HIF-1α and HIF-2α in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res 2002; 62: 2493-7.
    • (2002) Cancer Res. , vol.62 , pp. 2493-2497
    • Beasley, N.J.1    Leek, R.2    Alam, M.3
  • 21
    • 1842861767 scopus 로고    scopus 로고
    • 2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: A possible anti-apoptotic role for HIF-1α
    • 2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1α. Exp Cell Res 2004; 295: 340-9.
    • (2004) Exp. Cell Res. , vol.295 , pp. 340-349
    • Piret, J.P.1    Lecocq, C.2    Toffoli, S.3    Ninane, N.4    Raes, M.5    Michiels, C.6
  • 22
    • 12144287046 scopus 로고    scopus 로고
    • Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
    • Erler JT, Cawthorne CJ, Williams KJ et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol 2004; 24: 2875-89.
    • (2004) Mol. Cell Biol. , vol.24 , pp. 2875-2889
    • Erler, J.T.1    Cawthorne, C.J.2    Williams, K.J.3
  • 23
    • 0345276414 scopus 로고    scopus 로고
    • Bcl-2-family proteins and the role of mitochondria in apoptosis
    • Kuwana T, Newmeyer DD. Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 2003; 15: 691-9.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 691-699
    • Kuwana, T.1    Newmeyer, D.D.2
  • 24
    • 1442335318 scopus 로고    scopus 로고
    • Control of mitochondrial permeability by Bcl-2 family members
    • Sharpe JC, Arnoult D, Youle RJ. Control of mitochondrial permeability by Bcl-2 family members. Biochem Biophys Acta 2004; 1644: 107-13.
    • (2004) Biochem. Biophys. Acta , vol.1644 , pp. 107-113
    • Sharpe, J.C.1    Arnoult, D.2    Youle, R.J.3
  • 25
    • 0344629380 scopus 로고    scopus 로고
    • Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death
    • Festjens N, van Gurp M, van Loo G, Saelens X, Vandenabeele P. Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death. Acta Haematol 2004; 111: 7-27.
    • (2004) Acta Haematol. , vol.111 , pp. 7-27
    • Festjens, N.1    van Gurp, M.2    van Loo, G.3    Saelens, X.4    Vandenabeele, P.5
  • 26
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Detta SR, Dudek H, Tao X et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-41.
    • (1997) Cell , vol.91 , pp. 231-241
    • Detta, S.R.1    Dudek, H.2    Tao, X.3
  • 27
    • 0034735569 scopus 로고    scopus 로고
    • Akt regulates cell survival and apoptosis at a postmitochondial level
    • Zhou H, Li XM, Meinkoth J, Pittman RN. Akt regulates cell survival and apoptosis at a postmitochondial level. J Cell Biol 2000; 151: 483-94.
    • (2000) J. Cell Biol. , vol.151 , pp. 483-494
    • Zhou, H.1    Li, X.M.2    Meinkoth, J.3    Pittman, R.N.4
  • 28
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone MH, Roy N, Stennicke HR et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-21.
    • (1998) Science , vol.282 , pp. 1318-1321
    • Cardone, M.H.1    Roy, N.2    Stennicke, H.R.3
  • 29
    • 0031787083 scopus 로고    scopus 로고
    • p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation
    • Yoneda K, Yamamoto T, Osaki T. p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation. Oral Oncol 1998; 34: 529-37.
    • (1998) Oral Oncol. , vol.34 , pp. 529-537
    • Yoneda, K.1    Yamamoto, T.2    Osaki, T.3
  • 30
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • Bruick RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA 2000; 97: 9082-7.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 31
    • 0035884701 scopus 로고    scopus 로고
    • HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
    • Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 2001; 61: 6669-73.
    • (2001) Cancer Res. , vol.61 , pp. 6669-6673
    • Sowter, H.M.1    Ratcliffe, P.J.2    Watson, P.3    Greenberg, A.H.4    Harris, A.L.5
  • 32
    • 0033538057 scopus 로고    scopus 로고
    • The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling
    • Thakker GD, Hajjar DP, Muller WA, Rosengart TK. The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling. J Biol Chem 1999; 274: 100027.
    • (1999) J. Biol. Chem. , vol.274 , pp. 100027
    • Thakker, G.D.1    Hajjar, D.P.2    Muller, W.A.3    Rosengart, T.K.4
  • 33
    • 0031466232 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells
    • Kroll J, Waltenberger J. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem 1997; 272: 32521-7.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32521-32527
    • Kroll, J.1    Waltenberger, J.2
  • 34
    • 0033981845 scopus 로고    scopus 로고
    • ERK activation upon hypoxia: Involvement in HIF-1 activation
    • Minet E, Arnould T, Michel G et al. ERK activation upon hypoxia: involvement in HIF-1 activation. FEBS Lett 2000; 468: 53-8.
    • (2000) FEBS Lett. , vol.468 , pp. 53-58
    • Minet, E.1    Arnould, T.2    Michel, G.3
  • 35
    • 0035478294 scopus 로고    scopus 로고
    • Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation
    • Minet E, Michel G, Mottet D, Raes M, Michiels C. Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation. Free Radic Biol Med 2001; 31: 847-55.
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 847-855
    • Minet, E.1    Michel, G.2    Mottet, D.3    Raes, M.4    Michiels, C.5
  • 37
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells. Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D et al. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells. Implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60: 1541-5.
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3
  • 38
    • 0034925041 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    • Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 2001; 12: 363-9.
    • (2001) Cell Growth Differ. , vol.12 , pp. 363-369
    • Jiang, B.H.1    Jiang, G.2    Zheng, J.Z.3    Lu, Z.4    Hunter, T.5    Vogt, P.K.6
  • 39
    • 0037134442 scopus 로고    scopus 로고
    • Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
    • Alvarez-Tejado M, Alfranca A, Aragones J, Vara A, Landazuri MO, del Peso L. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem 2002; 277: 13508-17.
    • (2002) J. Biol. Chem. , vol.277 , pp. 13508-13517
    • Alvarez-Tejado, M.1    Alfranca, A.2    Aragones, J.3    Vara, A.4    Landazuri, M.O.5    del Peso, L.6
  • 40
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 α nor sufficient for HIF-1-dependent target gene transcription
    • Arsham AM, Plas DR, Thompson CB, Simon MC. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 α nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem 2002; 277: 15162-70.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 41
    • 0043234256 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β pathway in HepG2 cells
    • Mottet D, Dumont V, Deccache Y et al. Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β pathway in HepG2 cells. J Biol Chem 2003; 278: 31277-85.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31277-31285
    • Mottet, D.1    Dumont, V.2    Deccache, Y.3
  • 42
    • 0032541677 scopus 로고    scopus 로고
    • Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis
    • Porter AC, Vaillancourt RR. Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis. Oncogene 1998; 17: 1343-52.
    • (1998) Oncogene , vol.17 , pp. 1343-1352
    • Porter, A.C.1    Vaillancourt, R.R.2


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