Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer

Journal of Clinical Investigation

Volumn 101, Issue 5, 1998, Pages 967-971

  Yamasaki, Kokushi ^a   Edington, Howard D J ^a   McClosky, Carol ^a   Tzeng, Edith ^a   Lizonova, Alena ^b   Kovesdi, Imre ^b   Steed, David L ^a   Billiar, Timothy R ^a,c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b GENVEC INC   (United States)

^c PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

Gene therapy; iNOS; iNOS knockout; Nitric oxide; Wound repair

Indexed keywords

NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE TRANSFER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WOUND HEALING;

EID: 0032031678     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2067     Document Type: Article

References (26)

1. Albina, J.E., C.D. Mills, W.L. Henry, Jr., and M.D. Caldwell. 1990. Temporal expression of different pathways of L-arginine metabolism in healing wounds. J. Immunol. 144:3877-3880.
2. Smith, D.J., M.J. Dunphy, L.N. Strag, and M.A. Marletta. 1991. The influence of wound healing on urinary nitrate levels in rats. Wounds. 3:50-58.
3. Becker, W.K., R.L Shippee, A.T. McManus, A.D. Mason, Jr., and B.A. Pruitt, Jr. 1993. Kinetics of nitrogen oxide production following experimental thermal injury in rats. J. Trauma. 34:855-862.
4. Carter, E.A., T. Derojas-Walker, S. Tamir, S.R. Tannenbaum, Y.M. Yu, and R.G. Tompkins. 1994. Nitric oxide production is intensely and persistently increased in tissue by thermal injury. Biochem. J. 304:201-204.
5. Barbul, A., S.A. Lazarou, D.T. Efron, H.L. Wasserkrug, and G. Efron. 1990. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 108:331-337.
6. Kirk, S.J., M. Hurson, M.C. Regan, D.R. Holt, H.L. Wasserkrug, and A. Barbul. 1993. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 114:155-160.
7. Leibovich, S.J., P.J. Polverini, T.W. Fong, L.A. Harlow, and A.E. Koch. 1994. Production of angiogenic activity by human monocytes requires an L-argininc/nitric oxide-synthase-dependent effector mechanism. Proc. Natl. Acad. Sci. USA. 91:4190-4194.
8. Ziche, M., L. Morbidelli, E. Masini, S. Amerini, H.J. Granger, C.A. Maggi, P. Geppetti, and F. Ledda. 1994. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J. Clin. Invest. 94:2036-2044.
9. Morbidelli, L., C.H. Chang, J.G. Douglas, H.J. Granger, F. Ledda, and M. Ziche. 1996. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am. J. Physiol. 270:H411-H415.
10. Benrath, J., M. Zimmerman, and F. Gillardon. 1995. Substance P and nitric oxide mediate wound healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation. Neurosci. Lett. 200:17-20.
11. Noiri, E., T. Peresleni, N. Srivastava, P. Weber, W.F. Bahou, N. Peunova, and M.S. Goligorsky. 1996. Nitric oxide is necessary for a switch from stationary to locomoting phenotype in epithelial cells. Am. J. Physiol. 170:C794-C802.
12. Bulgrin, J.P., M. Shabani, D. Chakravarthy, and D.J. Smith. 1995. Nitric oxide synthesis is suppressed in steroid-impaired and diabetic wounds. Wounds. 7:48-57.
13. Schaffer, M.R., U. Tantry, P.A. Efron, G.M. Ahrendt, F.J. Thornton, and A. Barbul. 1997. Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery. 121:513-519.
14. Schaffer, M.R., U. Tantry, S.S. Gross, H.L. Wasserkrug, and A. Barbul. 1996. Nitric oxide regulates wound healing. J. Surg. Res. 63:237-240.
15. Shabani, M., S.K. Pulfer, J.P. Bulgrin, and D.J. Smith. 1996. Enhancement of wound repair with a topically applied nitric oxide-releasing polymer. Wound Repair Regen. 4:353-362.
16. Morris, S.M., Jr., and T.R. Billiar. 1994. New insights into the regulation of inducible nitric oxide synthesis. Am. J. Physiol. 266:E829-E839.
17. MacMicking, J.D., C. Nathan, G. Hom, N. Chartrain, D.S. Fletcher, M. Trumbauer, K. Stevens, Q.W. Xie, K. Sokol, N. Hutchinson, et al. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 81:641-650.
18. Geller, D.A., C.J. Lowenstein, R.A. Shapiro, A.K. Nussler, M. Di Silvio, S.C. Wang, D.K. Nakayama, S.H. Snyder, R.L. Simmons, and T.R. Billiar. 1993. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. USA. 90:3491-3495.
19. Graham, F.L., J. Smiley, W.C. Russell, and R. Nairn. 1977. Characteristics of a human cell line transformed by DNA from a human adenovirus type 5. J. Gen. Virol. 36:59-72.
20. Chinnadurai, G., S. Chinnadurai, and J. Brusca. 1979. Physical mapping of a large-plaque mutation of adenovirus type 2. J. Virol. 32:623-628.
21. Geller, D.A., A.K. Nussler, M. Di Silvio, C.J. Lowenstein, R.A. Shapiro, S.C. Wang, R.L. Simmons, and T.R. Billiar. 1993. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. USA. 90:522-526.
22. Tzeng, E., L.L. Shears, P.D. Robbins, B.R. Pitt, D.A. Geller, S.C. Watkins, R.L. Simmons, and T.R. Billiar. 1996. Vascular gene transfer of the human inducible nitric oxide synthase: characterization of activity and effects on myointimal hyperplasia. Mol. Med. 2:211-225.
23. Connor, J.R., P.T. Manning. S.L. Settle, W.M. Moore, G.M. Jerome, R.K. Webber, F.S. Tjoeng, and M.G. Currie, 1995. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur. J. Pharmacol. 273:15-24.
24. Tzeng, E., T.R. Billiar, P.D. Robbins, M. Loftus, and D.J. Stuehr. 1995. Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin-deficient cell line: tetrahydrobiopterin promotes assembly of enzyme subunits into an active dimer. Proc. Natl. Acad. Sci. USA. 92:11771-11775.
25. Heck, D.E., D.L. Laskin, C.R. Gardner, and J.D. Laskin. 1992. Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. J. Biol. Chem. 267:21277-21280.
26. Schaffer, M.R., P.A. Efron, F.J. Thornton, K. Klingel, S.S. Gross, and A. Barbul. 1997. Nitric oxide, an autocrine regulator of wound fibroblast synthetic function. J. Immunol. 158:2382-2389.