-
1
-
-
64249114545
-
Telomere length maintenance in stem cell populations
-
Allen ND, Baird DM. 2009. Telomere length maintenance in stem cell populations. Biochim Biophys Acta 1792: 324- 328.
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 324-328
-
-
Allen, N.D.1
Baird, D.M.2
-
2
-
-
0037480961
-
Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
-
Allsopp RC, Morin GB, DePinho R, et al. 2003a. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102: 517-520.
-
(2003)
Blood
, vol.102
, pp. 517-520
-
-
Allsopp, R.C.1
Morin, G.B.2
DePinho, R.3
-
3
-
-
0345636016
-
Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
-
Allsopp RC, Morin GB, Horner JW, et al. 2003b. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med 9: 369-371.
-
(2003)
Nat Med
, vol.9
, pp. 369-371
-
-
Allsopp, R.C.1
Morin, G.B.2
Horner, J.W.3
-
4
-
-
76549104441
-
Evolution in health and medicine Sackler colloquium: genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
-
Atzmon G, Cho M, Cawthon RM, et al. 2010. Evolution in health and medicine Sackler colloquium: genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci USA 107 (Suppl 1): 1710-1717.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.SUPPL. 1
, pp. 1710-1717
-
-
Atzmon, G.1
Cho, M.2
Cawthon, R.M.3
-
5
-
-
0026576937
-
Isolation of a candidate human hematopoietic stem-cell population
-
Baum CM, Weissman IL, Tsukamoto AS, et al. 1992. Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA 89: 2804-2808.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2804-2808
-
-
Baum, C.M.1
Weissman, I.L.2
Tsukamoto, A.S.3
-
6
-
-
77950418688
-
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
-
Beerman I, Bhattacharya D, Zandi S, et al. 2010. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci USA 107: 5465-5470.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 5465-5470
-
-
Beerman, I.1
Bhattacharya, D.2
Zandi, S.3
-
7
-
-
70349559751
-
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
-
Begus-Nahrmann Y, Lechel A, Obenauf AC, et al. 2009. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet 41: 1138-1143.
-
(2009)
Nat Genet
, vol.41
, pp. 1138-1143
-
-
Begus-Nahrmann, Y.1
Lechel, A.2
Obenauf, A.C.3
-
8
-
-
0022375359
-
Multiparameter analysis of transplantable hemopoietic stem cells. I. The separation and enrichment of stem cells homing to marrow and spleen on the basis of rhodamine-123 fluorescence
-
Bertoncello I, Hodgson GS, Bradley TR. 1985. Multiparameter analysis of transplantable hemopoietic stem cells. I. The separation and enrichment of stem cells homing to marrow and spleen on the basis of rhodamine-123 fluorescence. Exp Hematol 13: 999-1006.
-
(1985)
Exp Hematol
, vol.13
, pp. 999-1006
-
-
Bertoncello, I.1
Hodgson, G.S.2
Bradley, T.R.3
-
9
-
-
0035929353
-
Switching and signaling at the telomere
-
Blackburn EH. 2001. Switching and signaling at the telomere. Cell 106: 661-673.
-
(2001)
Cell
, vol.106
, pp. 661-673
-
-
Blackburn, E.H.1
-
10
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, et al. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
-
11
-
-
70349782798
-
BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration
-
Brack AS, Murphy-Seiler F, Hanifi J, et al. 2009. BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Dev Biol 335: 93-105.
-
(2009)
Dev Biol
, vol.335
, pp. 93-105
-
-
Brack, A.S.1
Murphy-Seiler, F.2
Hanifi, J.3
-
12
-
-
0030609861
-
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
-
Brown JP, Wei W, Sedivy JM. 1997. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277: 831-834.
-
(1997)
Science
, vol.277
, pp. 831-834
-
-
Brown, J.P.1
Wei, W.2
Sedivy, J.M.3
-
13
-
-
0029051426
-
Oxidative DNA damage and senescence of human diploid fibroblast cells
-
Chen Q, Fischer A, Reagan JD, et al. 1995. Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 92: 4337-4341.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4337-4341
-
-
Chen, Q.1
Fischer, A.2
Reagan, J.D.3
-
14
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
-
Cheng T, Rodrigues N, Shen H, et al. 2000. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287: 1804-1808.
-
(2000)
Science
, vol.287
, pp. 1804-1808
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
-
15
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin L, Artandi SE, Shen Q, et al. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97: 527-538.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
-
16
-
-
47049099198
-
A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells
-
Cho RH, Sieburg HB, Muller-Sieburg CE. 2008. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 111: 5553-5561.
-
(2008)
Blood
, vol.111
, pp. 5553-5561
-
-
Cho, R.H.1
Sieburg, H.B.2
Muller-Sieburg, C.E.3
-
17
-
-
33845892109
-
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
-
Choudhury AR, Ju Z, Djojosubroto MW, et al. 2007. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 39: 99-105.
-
(2007)
Nat Genet
, vol.39
, pp. 99-105
-
-
Choudhury, A.R.1
Ju, Z.2
Djojosubroto, M.W.3
-
18
-
-
35848954274
-
Probing ATR activation with model DNA templates
-
Cimprich KA. 2007. Probing ATR activation with model DNA templates. Cell Cycle 6: 2348-2354.
-
(2007)
Cell Cycle
, vol.6
, pp. 2348-2354
-
-
Cimprich, K.A.1
-
19
-
-
34447543913
-
Cellular senescence in cancer and aging
-
Collado M, Blasco MA, Serrano M. 2007. Cellular senescence in cancer and aging. Cell 130: 223-233.
-
(2007)
Cell
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
20
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
Conboy IM, Conboy MJ, Wagers AJ, et al. 2005. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433: 760-764.
-
(2005)
Nature
, vol.433
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
-
21
-
-
0028913739
-
A p53-dependent mouse spindle checkpoint
-
Cross SM, Sanchez CA, Morgan CA, et al. 1995. A p53-dependent mouse spindle checkpoint. Science 267: 1353-1356.
-
(1995)
Science
, vol.267
, pp. 1353-1356
-
-
Cross, S.M.1
Sanchez, C.A.2
Morgan, C.A.3
-
22
-
-
24944460598
-
Shelterin: the protein complex that shapes and safeguards human telomeres
-
de Lange T. 2005. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 19: 2100-2110.
-
(2005)
Genes Dev
, vol.19
, pp. 2100-2110
-
-
de Lange, T.1
-
23
-
-
0028978183
-
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
-
Deng C, Zhang P, Harper JW, et al. 1995. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684.
-
(1995)
Cell
, vol.82
, pp. 675-684
-
-
Deng, C.1
Zhang, P.2
Harper, J.W.3
-
24
-
-
0037928721
-
Telomeres and telomerase in aging, regeneration and cancer
-
Djojosubroto MW, Choi YS, Lee HW, Rudolph KL. 2003. Telomeres and telomerase in aging, regeneration and cancer. Mol Cells 15: 164-175.
-
(2003)
Mol Cells
, vol.15
, pp. 164-175
-
-
Djojosubroto, M.W.1
Choi, Y.S.2
Lee, H.W.3
Rudolph, K.L.4
-
25
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower LA, Harvey M, Slagle BL, et al. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
-
26
-
-
34548414281
-
Adult mouse hematopoietic stem cells: purification and single-cell assays
-
Ema H, Morita Y, Yamazaki S, et al. 2006. Adult mouse hematopoietic stem cells: purification and single-cell assays. Nat Protoc 1: 2979-2987.
-
(2006)
Nat Protoc
, vol.1
, pp. 2979-2987
-
-
Ema, H.1
Morita, Y.2
Yamazaki, S.3
-
27
-
-
4644294031
-
Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination
-
Enwere E, Shingo T, Gregg C, et al. 2004. Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. J Neurosci 24: 8354-8365.
-
(2004)
J Neurosci
, vol.24
, pp. 8354-8365
-
-
Enwere, E.1
Shingo, T.2
Gregg, C.3
-
28
-
-
66149115277
-
IFNalpha activates dormant haematopoietic stem cells in vivo
-
Essers MA, Offner S, Blanco-Bose WE, et al. 2009. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 458: 904-908.
-
(2009)
Nature
, vol.458
, pp. 904-908
-
-
Essers, M.A.1
Offner, S.2
Blanco-Bose, W.E.3
-
29
-
-
0037280096
-
SOD2 functions downstream of Sch9 to extend longevity in yeast
-
Fabrizio P, Liou LL, Moy VN, et al. 2003. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163: 35-46.
-
(2003)
Genetics
, vol.163
, pp. 35-46
-
-
Fabrizio, P.1
Liou, L.L.2
Moy, V.N.3
-
30
-
-
1642491749
-
Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae
-
Fabrizio P, Pletcher SD, Minois N, et al. 2004. Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett 557: 136-142.
-
(2004)
FEBS Lett
, vol.557
, pp. 136-142
-
-
Fabrizio, P.1
Pletcher, S.D.2
Minois, N.3
-
31
-
-
70949100121
-
Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis
-
Ferron SR, Marques-Torrejon MA, Mira H, et al. 2009. Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J Neurosci 29: 14394-14407.
-
(2009)
J Neurosci
, vol.29
, pp. 14394-14407
-
-
Ferron, S.R.1
Marques-Torrejon, M.A.2
Mira, H.3
-
32
-
-
34547941973
-
The common biology of cancer and ageing
-
Finkel T, Serrano M, Blasco MA. 2007. The common biology of cancer and ageing. Nature 448: 767-774.
-
(2007)
Nature
, vol.448
, pp. 767-774
-
-
Finkel, T.1
Serrano, M.2
Blasco, M.A.3
-
33
-
-
77955842046
-
The role of telomeres and telomerase in stem cell aging
-
Flores I, Blasco MA. 2010. The role of telomeres and telomerase in stem cell aging. FEBS Lett 584: 3826-3830.
-
(2010)
FEBS Lett
, vol.584
, pp. 3826-3830
-
-
Flores, I.1
Blasco, M.A.2
-
34
-
-
23844540299
-
Effects of telomerase and telomere length on epidermal stem cell behavior
-
Flores I, Cayuela ML, Blasco MA. 2005. Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309: 1253-1256.
-
(2005)
Science
, vol.309
, pp. 1253-1256
-
-
Flores, I.1
Cayuela, M.L.2
Blasco, M.A.3
-
35
-
-
40349085766
-
The longest telomeres: a general signature of adult stem cell compartments
-
Flores I, Canela A, Vera E, et al. 2008. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev 22: 654-667.
-
(2008)
Genes Dev
, vol.22
, pp. 654-667
-
-
Flores, I.1
Canela, A.2
Vera, E.3
-
36
-
-
0025373259
-
Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine
-
Fraga CG, Shigenaga MK, Park JW, et al. 1990. Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87: 4533-4537.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 4533-4537
-
-
Fraga, C.G.1
Shigenaga, M.K.2
Park, J.W.3
-
37
-
-
0035896748
-
Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant
-
Friedman JS, Rebel VI, Derby R, et al. 2001. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. J Exp Med 193: 925-934.
-
(2001)
J Exp Med
, vol.193
, pp. 925-934
-
-
Friedman, J.S.1
Rebel, V.I.2
Derby, R.3
-
38
-
-
4944225788
-
SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness
-
Friedman JS, Lopez MF, Fleming MD, et al. 2004. SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood 104: 2565-2573.
-
(2004)
Blood
, vol.104
, pp. 2565-2573
-
-
Friedman, J.S.1
Lopez, M.F.2
Fleming, M.D.3
-
39
-
-
0029881977
-
Abnormal centrosome amplification in the absence of p53
-
Fukasawa K, Choi T, Kuriyama R, et al. 1996. Abnormal centrosome amplification in the absence of p53. Science 271: 1744-1747.
-
(1996)
Science
, vol.271
, pp. 1744-1747
-
-
Fukasawa, K.1
Choi, T.2
Kuriyama, R.3
-
40
-
-
40549103466
-
Epidermal stem cells are retained in vivo throughout skin aging
-
Giangreco A, Qin M, Pintar JE, Watt FM. 2008. Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell 7: 250-259.
-
(2008)
Aging Cell
, vol.7
, pp. 250-259
-
-
Giangreco, A.1
Qin, M.2
Pintar, J.E.3
Watt, F.M.4
-
41
-
-
22744447211
-
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
-
Giorgio M, Migliaccio E, Orsini F, et al. 2005. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122: 221-233.
-
(2005)
Cell
, vol.122
, pp. 221-233
-
-
Giorgio, M.1
Migliaccio, E.2
Orsini, F.3
-
42
-
-
0029958876
-
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
-
Goodell MA, Brose K, Paradis G, et al. 1996. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 183: 1797-1806.
-
(1996)
J Exp Med
, vol.183
, pp. 1797-1806
-
-
Goodell, M.A.1
Brose, K.2
Paradis, G.3
-
43
-
-
0031435428
-
Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
-
Goodell MA, Rosenzweig M, Kim H, et al. 1997. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 3: 1337-1345.
-
(1997)
Nat Med
, vol.3
, pp. 1337-1345
-
-
Goodell, M.A.1
Rosenzweig, M.2
Kim, H.3
-
44
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer EL, Brunet A. 2005. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24: 7410-7425.
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
45
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
-
Greider CW, Blackburn EH. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43 (2, Part 1): 405-413.
-
(1985)
Cell
, vol.43
, Issue.2 PART 1
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
46
-
-
77954682347
-
Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice
-
Guachalla LM, Ju Z, Koziel R, et al. 2009. Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice. Aging (Albany, NY) 1: 303-315.
-
(2009)
Aging (Albany, NY)
, vol.1
, pp. 303-315
-
-
Guachalla, L.M.1
Ju, Z.2
Koziel, R.3
-
48
-
-
77049308856
-
Aging: a theory based on free radical and radiation chemistry
-
Harman D. 1956. Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298-300.
-
(1956)
J Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
49
-
-
36048947606
-
Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
-
Hattiangady B, Shetty AK. 2008. Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus. Neurobiol Aging 29: 129-147.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 129-147
-
-
Hattiangady, B.1
Shetty, A.K.2
-
50
-
-
0032434055
-
How and why we age
-
Hayflick L. 1998. How and why we age. Exp Gerontol 33: 639-653.
-
(1998)
Exp Gerontol
, vol.33
, pp. 639-653
-
-
Hayflick, L.1
-
51
-
-
0037214382
-
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1
-
Itahana K, Zou Y, Itahana Y, et al. 2003. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol 23: 389-401.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 389-401
-
-
Itahana, K.1
Zou, Y.2
Itahana, Y.3
-
52
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
Ito K, Hirao A, Arai F, et al. 2004. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431: 997-1002.
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
-
53
-
-
33645730667
-
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
-
Ito K, Hirao A, Arai F, et al. 2006. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 12: 446-451.
-
(2006)
Nat Med
, vol.12
, pp. 446-451
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
-
54
-
-
0028118111
-
Tumor spectrum analysis in p53-mutant mice
-
Jacks T, Remington L, Williams BO, et al. 1994. Tumor spectrum analysis in p53-mutant mice. Curr Biol 4: 1-7.
-
(1994)
Curr Biol
, vol.4
, pp. 1-7
-
-
Jacks, T.1
Remington, L.2
Williams, B.O.3
-
55
-
-
35548936968
-
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
-
Jang YY, Sharkis SJ. 2007. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 110: 3056-3063.
-
(2007)
Blood
, vol.110
, pp. 3056-3063
-
-
Jang, Y.Y.1
Sharkis, S.J.2
-
56
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
-
Janzen V, Forkert R, Fleming HE, et al. 2006. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443: 421-426.
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.E.3
-
57
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers JR, Parganas E, Lee Y, et al. 2003. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321-328.
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
-
58
-
-
33646408788
-
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
-
Kakoki M, Kizer CM, Yi X, et al. 2006. Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest 116: 1302-1309.
-
(2006)
J Clin Invest
, vol.116
, pp. 1302-1309
-
-
Kakoki, M.1
Kizer, C.M.2
Yi, X.3
-
59
-
-
0028168643
-
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
-
Kemp CJ, Wheldon T, Balmain A. 1994. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet 8: 66-69.
-
(1994)
Nat Genet
, vol.8
, pp. 66-69
-
-
Kemp, C.J.1
Wheldon, T.2
Balmain, A.3
-
60
-
-
21244463426
-
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
-
Kiel MJ, Yilmaz OH, Iwashita T, et al. 2005. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121: 1109-1121.
-
(2005)
Cell
, vol.121
, pp. 1109-1121
-
-
Kiel, M.J.1
Yilmaz, O.H.2
Iwashita, T.3
-
61
-
-
0032100452
-
Rhodamine-123 staining in hematopoietic stem cells of young mice indicates mitochondrial activation rather than dye efflux
-
Kim M, Cooper DD, Hayes SF, Spangrude GJ. 1998. Rhodamine-123 staining in hematopoietic stem cells of young mice indicates mitochondrial activation rather than dye efflux. Blood 91: 4106-4117.
-
(1998)
Blood
, vol.91
, pp. 4106-4117
-
-
Kim, M.1
Cooper, D.D.2
Hayes, S.F.3
Spangrude, G.J.4
-
62
-
-
15444377643
-
p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
-
Kippin TE, Martens DJ, van der Kooy D. 2005. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev 19: 756-767.
-
(2005)
Genes Dev
, vol.19
, pp. 756-767
-
-
Kippin, T.E.1
Martens, D.J.2
van der Kooy, D.3
-
63
-
-
33748850636
-
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
-
Kirstetter P, Anderson K, Porse BT, et al. 2006. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7: 1048-1056.
-
(2006)
Nat Immunol
, vol.7
, pp. 1048-1056
-
-
Kirstetter, P.1
Anderson, K.2
Porse, B.T.3
-
64
-
-
0035496909
-
Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age
-
Kollman C, Howe CW, Anasetti C, et al. 2001. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 98: 2043-2051.
-
(2001)
Blood
, vol.98
, pp. 2043-2051
-
-
Kollman, C.1
Howe, C.W.2
Anasetti, C.3
-
65
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops GJ, Dansen TB, Polderman PE, et al. 2002. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419: 316-321.
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
-
66
-
-
33749187810
-
p16INK4a induces an age-dependent decline in islet regenerative potential
-
Krishnamurthy J, Ramsey MR, Ligon KL, et al. 2006. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443: 453-457.
-
(2006)
Nature
, vol.443
, pp. 453-457
-
-
Krishnamurthy, J.1
Ramsey, M.R.2
Ligon, K.L.3
-
67
-
-
0028033027
-
Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice
-
Lee JM, Abrahamson JL, Kandel R, et al. 1994. Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice. Oncogene 9: 3731-3736.
-
(1994)
Oncogene
, vol.9
, pp. 3731-3736
-
-
Lee, J.M.1
Abrahamson, J.L.2
Kandel, R.3
-
68
-
-
0032499210
-
Essential role of mouse telomerase in highly proliferative organs
-
Lee HW, Blasco MA, Gottlieb GJ, et al. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature 392: 569-574.
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Lee, H.W.1
Blasco, M.A.2
Gottlieb, G.J.3
-
69
-
-
0037673984
-
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
-
Lessard J, Sauvageau G. 2003. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423: 255-260.
-
(2003)
Nature
, vol.423
, pp. 255-260
-
-
Lessard, J.1
Sauvageau, G.2
-
70
-
-
1642633053
-
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
-
Leung C, Lingbeek M, Shakhova O, et al. 2004. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428: 337-341.
-
(2004)
Nature
, vol.428
, pp. 337-341
-
-
Leung, C.1
Lingbeek, M.2
Shakhova, O.3
-
72
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin MT, Beal MF. 2006. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787-795.
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
73
-
-
1142275269
-
Age-related changes in lymphocyte development and function
-
Linton PJ, Dorshkind K. 2004. Age-related changes in lymphocyte development and function. Nat Immunol 5: 133-139.
-
(2004)
Nat Immunol
, vol.5
, pp. 133-139
-
-
Linton, P.J.1
Dorshkind, K.2
-
74
-
-
10944240539
-
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
-
Liu D, O'Connor MS, Qin J, Songyang Z. 2004. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem 279: 51338-51342.
-
(2004)
J Biol Chem
, vol.279
, pp. 51338-51342
-
-
Liu, D.1
O'Connor, M.S.2
Qin, J.3
Songyang, Z.4
-
75
-
-
34547908461
-
Augmented Wnt signaling in a mammalian model of accelerated aging
-
Liu H, Fergusson MM, Castilho RM, et al. 2007. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-806.
-
(2007)
Science
, vol.317
, pp. 803-806
-
-
Liu, H.1
Fergusson, M.M.2
Castilho, R.M.3
-
76
-
-
67349156082
-
Bmi1 regulates mitochondrial function and the DNA damage response pathway
-
Liu J, Cao L, Chen J, et al. 2009. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 459: 387-392.
-
(2009)
Nature
, vol.459
, pp. 387-392
-
-
Liu, J.1
Cao, L.2
Chen, J.3
-
77
-
-
0036682516
-
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants
-
Maringele L, Lydall D. 2002. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev 16: 1919-1933.
-
(2002)
Genes Dev
, vol.16
, pp. 1919-1933
-
-
Maringele, L.1
Lydall, D.2
-
78
-
-
69749092744
-
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
-
Martinez P, Thanasoula M, Munoz P, et al. 2009. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev 23: 2060-2075.
-
(2009)
Genes Dev
, vol.23
, pp. 2060-2075
-
-
Martinez, P.1
Thanasoula, M.2
Munoz, P.3
-
79
-
-
1242341960
-
Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice
-
Maslov AY, Barone TA, Plunkett RJ, Pruitt SC. 2004. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci 24: 1726-1733.
-
(2004)
J Neurosci
, vol.24
, pp. 1726-1733
-
-
Maslov, A.Y.1
Barone, T.A.2
Plunkett, R.J.3
Pruitt, S.C.4
-
80
-
-
44049095767
-
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
-
Michalak EM, Villunger A, Adams JM, Strasser A. 2008. In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ 15: 1019-1029.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1019-1029
-
-
Michalak, E.M.1
Villunger, A.2
Adams, J.M.3
Strasser, A.4
-
81
-
-
34249882777
-
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
-
Miyamoto K, Araki KY, Naka K, et al. 2007. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1: 101-112.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 101-112
-
-
Miyamoto, K.1
Araki, K.Y.2
Naka, K.3
-
82
-
-
0242667922
-
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
-
Molofsky AV, Pardal R, Iwashita T, et al. 2003. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425: 962-967.
-
(2003)
Nature
, vol.425
, pp. 962-967
-
-
Molofsky, A.V.1
Pardal, R.2
Iwashita, T.3
-
83
-
-
33749171885
-
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
-
Molofsky AV, Slutsky SG, Joseph NM, et al. 2006. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443: 448-452.
-
(2006)
Nature
, vol.443
, pp. 448-452
-
-
Molofsky, A.V.1
Slutsky, S.G.2
Joseph, N.M.3
-
84
-
-
77953512588
-
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
-
Morita Y, Ema H, Nakauchi H. 2010. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med 207: 1173-1182.
-
(2010)
J Exp Med
, vol.207
, pp. 1173-1182
-
-
Morita, Y.1
Ema, H.2
Nakauchi, H.3
-
85
-
-
0028534860
-
The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
-
Morrison SJ, Weissman IL. 1994. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1: 661-673.
-
(1994)
Immunity
, vol.1
, pp. 661-673
-
-
Morrison, S.J.1
Weissman, I.L.2
-
86
-
-
58049202768
-
Stem cell aging: survival of the laziest?
-
Muller-Sieburg C, Sieburg HB. 2008. Stem cell aging: survival of the laziest? Cell Cycle 7: 3798-3804.
-
(2008)
Cell Cycle
, vol.7
, pp. 3798-3804
-
-
Muller-Sieburg, C.1
Sieburg, H.B.2
-
87
-
-
54949122449
-
Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use?
-
Nalapareddy K, Jiang H, Guachalla Gutierrez LM, Rudolph KL. 2008. Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use? Exp Gerontol 43: 998-1004.
-
(2008)
Exp Gerontol
, vol.43
, pp. 998-1004
-
-
Nalapareddy, K.1
Jiang, H.2
Guachalla Gutierrez, L.M.3
Rudolph, K.L.4
-
88
-
-
34250001450
-
DNA repair is limiting for haematopoietic stem cells during ageing
-
Nijnik A, Woodbine L, Marchetti C, et al. 2007. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447: 686-690.
-
(2007)
Nature
, vol.447
, pp. 686-690
-
-
Nijnik, A.1
Woodbine, L.2
Marchetti, C.3
-
89
-
-
67650660751
-
Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study
-
Njajou OT, Hsueh WC, Blackburn EH, et al. 2009. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci 64: 860-864.
-
(2009)
J Gerontol A Biol Sci Med Sci
, vol.64
, pp. 860-864
-
-
Njajou, O.T.1
Hsueh, W.C.2
Blackburn, E.H.3
-
90
-
-
0023181066
-
Age-related changes in oxidized proteins
-
Oliver CN, Ahn BW, Moerman EJ, et al. 1987. Age-related changes in oxidized proteins. J Biol Chem 262: 5488- 5491.
-
(1987)
J Biol Chem
, vol.262
, pp. 5488-5491
-
-
Oliver, C.N.1
Ahn, B.W.2
Moerman, E.J.3
-
91
-
-
0029796633
-
Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
-
Osawa M, Hanada K, Hamada H, Nakauchi H. 1996. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273: 242-245.
-
(1996)
Science
, vol.273
, pp. 242-245
-
-
Osawa, M.1
Hanada, K.2
Hamada, H.3
Nakauchi, H.4
-
92
-
-
70350497348
-
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
-
Paik JH, Ding Z, Narurkar R, et al. 2009. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5: 540-553.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 540-553
-
-
Paik, J.H.1
Ding, Z.2
Narurkar, R.3
-
93
-
-
34249028642
-
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
-
Passos JF, Saretzki G, Ahmed S, et al. 2007. Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol 5: e110.
-
(2007)
PLoS Biol
, vol.5
-
-
Passos, J.F.1
Saretzki, G.2
Ahmed, S.3
-
94
-
-
77954857354
-
Potential and pitfalls of stem cell therapy in old age
-
Piccin D, Morshead CM. 2010. Potential and pitfalls of stem cell therapy in old age. Dis Model Mech 3: 421-425.
-
(2010)
Dis Model Mech
, vol.3
, pp. 421-425
-
-
Piccin, D.1
Morshead, C.M.2
-
95
-
-
66649109663
-
Antioxidants prevent health-promoting effects of physical exercise in humans
-
Ristow M, Zarse K, Oberbach A, et al. 2009. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci USA 106: 8665-8670.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8665-8670
-
-
Ristow, M.1
Zarse, K.2
Oberbach, A.3
-
96
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi DJ, Bryder D, Seita J, et al. 2007. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447: 725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
-
97
-
-
39149086121
-
Stems cells and the pathways to aging and cancer
-
Rossi DJ, Jamieson CH, Weissman IL. 2008. Stems cells and the pathways to aging and cancer. Cell 132: 681-696.
-
(2008)
Cell
, vol.132
, pp. 681-696
-
-
Rossi, D.J.1
Jamieson, C.H.2
Weissman, I.L.3
-
98
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph KL, Chang S, Lee HW, et al. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96: 701-712.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
-
99
-
-
34249885603
-
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
-
Ruzankina Y, Pinzon-Guzman C, Asare A, et al. 2007. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 1: 113-126.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 113-126
-
-
Ruzankina, Y.1
Pinzon-Guzman, C.2
Asare, A.3
-
100
-
-
70349559919
-
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
-
Ruzankina Y, Schoppy DW, Asare A, et al. 2009. Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet 41: 1144-1149.
-
(2009)
Nat Genet
, vol.41
, pp. 1144-1149
-
-
Ruzankina, Y.1
Schoppy, D.W.2
Asare, A.3
-
101
-
-
0037089438
-
Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells
-
Samper E, Fernandez P, Eguia R, et al. 2002. Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood 99: 2767-2775.
-
(2002)
Blood
, vol.99
, pp. 2767-2775
-
-
Samper, E.1
Fernandez, P.2
Eguia, R.3
-
102
-
-
46249128798
-
Bmi1 is expressed in vivo in intestinal stem cells
-
Sangiorgi E, Capecchi MR. 2008. Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 40: 915-920.
-
(2008)
Nat Genet
, vol.40
, pp. 915-920
-
-
Sangiorgi, E.1
Capecchi, M.R.2
-
103
-
-
2942529456
-
Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling
-
Satyanarayana A, Greenberg RA, Schaetzlein S, et al. 2004. Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Mol Cell Biol 24: 5459-5474.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5459-5474
-
-
Satyanarayana, A.1
Greenberg, R.A.2
Schaetzlein, S.3
-
104
-
-
34548259806
-
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice
-
Schaetzlein S, Kodandaramireddy NR, Ju Z, et al. 2007. Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell 130: 863-877.
-
(2007)
Cell
, vol.130
, pp. 863-877
-
-
Schaetzlein, S.1
Kodandaramireddy, N.R.2
Ju, Z.3
-
105
-
-
33748859509
-
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
-
Scheller M, Huelsken J, Rosenbauer F, et al. 2006. Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol 7: 1037-1047.
-
(2006)
Nat Immunol
, vol.7
, pp. 1037-1047
-
-
Scheller, M.1
Huelsken, J.2
Rosenbauer, F.3
-
106
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, et al. 2005. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308: 1909-1911.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
-
107
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz TJ, Zarse K, Voigt A, et al. 2007. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 6: 280-293.
-
(2007)
Cell Metab
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
-
108
-
-
0021234973
-
DNA sequences of telomeres maintained in yeast
-
Shampay J, Szostak JW, Blackburn EH. 1984. DNA sequences of telomeres maintained in yeast. Nature 310: 154-157.
-
(1984)
Nature
, vol.310
, pp. 154-157
-
-
Shampay, J.1
Szostak, J.W.2
Blackburn, E.H.3
-
109
-
-
34548153747
-
How stem cells age and why this makes us grow old
-
Sharpless NE, DePinho RA. 2007. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8: 703-713.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 703-713
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
110
-
-
0034117954
-
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
-
Sitte N, Merker K, von Zglinicki T, Grune T. 2000. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radic Biol Med 28: 701-708.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 701-708
-
-
Sitte, N.1
Merker, K.2
von Zglinicki, T.3
Grune, T.4
-
111
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R. 1996. Oxidative stress, caloric restriction, and aging. Science 273: 59-63.
-
(1996)
Science
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
112
-
-
0025016163
-
Resting and activated subsets of mouse multipotent hematopoietic stem cells
-
Spangrude GJ, Johnson GR. 1990. Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc Natl Acad Sci USA 87: 7433-7437.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 7433-7437
-
-
Spangrude, G.J.1
Johnson, G.R.2
-
113
-
-
0023922373
-
Purification and characterization of mouse hematopoietic stem cells
-
Spangrude GJ, Heimfeld S, Weissman IL. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241: 58-62.
-
(1988)
Science
, vol.241
, pp. 58-62
-
-
Spangrude, G.J.1
Heimfeld, S.2
Weissman, I.L.3
-
114
-
-
0019949718
-
Cloning yeast telomeres on linear plasmid vectors
-
Szostak JW, Blackburn EH. 1982. Cloning yeast telomeres on linear plasmid vectors. Cell 29: 245-255.
-
(1982)
Cell
, vol.29
, pp. 245-255
-
-
Szostak, J.W.1
Blackburn, E.H.2
-
115
-
-
77956217067
-
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
-
Takubo K, Goda N, Yamada W, et al. 2010. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 7: 391-402.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 391-402
-
-
Takubo, K.1
Goda, N.2
Yamada, W.3
-
116
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, Kollipara R, Huntly BJ, et al. 2007. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128: 325-339.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
-
117
-
-
0142248307
-
Senescence-associated cell death of human endothelial cells: the role of oxidative stress
-
Unterluggauer H, Hampel B, Zwerschke W, Jansen-Durr P. 2003. Senescence-associated cell death of human endothelial cells: the role of oxidative stress. Exp Gerontol 38: 1149-1160.
-
(2003)
Exp Gerontol
, vol.38
, pp. 1149-1160
-
-
Unterluggauer, H.1
Hampel, B.2
Zwerschke, W.3
Jansen-Durr, P.4
-
118
-
-
0028201742
-
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
-
van der Lugt NM, Domen J, Linders K, et al. 1994. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8: 757-769.
-
(1994)
Genes Dev
, vol.8
, pp. 757-769
-
-
van der Lugt, N.M.1
Domen, J.2
Linders, K.3
-
119
-
-
34147168247
-
A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning
-
van Os R, Kamminga LM, Ausema A, et al. 2007. A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning. Stem Cells 25: 836-843.
-
(2007)
Stem Cells
, vol.25
, pp. 836-843
-
-
van Os, R.1
Kamminga, L.M.2
Ausema, A.3
-
120
-
-
12144288373
-
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
-
Van Remmen H, Ikeno Y, Hamilton M, et al. 2003. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 16: 29-37.
-
(2003)
Physiol Genomics
, vol.16
, pp. 29-37
-
-
Van Remmen, H.1
Ikeno, Y.2
Hamilton, M.3
-
121
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A, Michalak EM, Coultas L, et al. 2003. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-1038.
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
-
123
-
-
33745516977
-
Dyskeratosis congenita
-
Vulliamy T, Dokal I. 2006. Dyskeratosis congenita. Semin Hematol 43: 157-166.
-
(2006)
Semin Hematol
, vol.43
, pp. 157-166
-
-
Vulliamy, T.1
Dokal, I.2
-
124
-
-
0034614576
-
Stem cells: units of development, units of regeneration, and units in evolution
-
Weissman IL. 2000. Stem cells: units of development, units of regeneration, and units in evolution. Cell 100: 157-168.
-
(2000)
Cell
, vol.100
, pp. 157-168
-
-
Weissman, I.L.1
-
125
-
-
56549128268
-
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
-
Wilson A, Laurenti E, Oser G, et al. 2008. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135: 1118-1129.
-
(2008)
Cell
, vol.135
, pp. 1118-1129
-
-
Wilson, A.1
Laurenti, E.2
Oser, G.3
-
126
-
-
33747613351
-
Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells
-
Yamazaki S, Iwama A, Takayanagi S, et al. 2006. Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J 25: 3515-3523.
-
(2006)
EMBO J
, vol.25
, pp. 3515-3523
-
-
Yamazaki, S.1
Iwama, A.2
Takayanagi, S.3
-
127
-
-
60849093771
-
TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation
-
Yamazaki S, Iwama A, Takayanagi S, et al. 2009. TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood 113: 1250-1256.
-
(2009)
Blood
, vol.113
, pp. 1250-1256
-
-
Yamazaki, S.1
Iwama, A.2
Takayanagi, S.3
-
128
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz OH, Valdez R, Theisen BK, et al. 2006. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441: 475-482.
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
-
129
-
-
31544463261
-
Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite manners
-
Yu H, Yuan Y, Shen H, Cheng T. 2006. Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite manners. Blood 107: 1200-1206.
-
(2006)
Blood
, vol.107
, pp. 1200-1206
-
-
Yu, H.1
Yuan, Y.2
Shen, H.3
Cheng, T.4
-
130
-
-
2342601849
-
In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C
-
Yuan Y, Shen H, Franklin DS, et al. 2004. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol 6: 436-442.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 436-442
-
-
Yuan, Y.1
Shen, H.2
Franklin, D.S.3
-
131
-
-
33646351002
-
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
-
Zhang J, Grindley JC, Yin T, et al. 2006. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 441: 518-522.
-
(2006)
Nature
, vol.441
, pp. 518-522
-
-
Zhang, J.1
Grindley, J.C.2
Yin, T.3
-
132
-
-
39149107803
-
Mechanisms and functional implications of adult neurogenesis
-
Zhao C, Deng W, Gage FH. 2008. Mechanisms and functional implications of adult neurogenesis. Cell 132: 645-660.
-
(2008)
Cell
, vol.132
, pp. 645-660
-
-
Zhao, C.1
Deng, W.2
Gage, F.H.3
|