Augmented Wnt signaling in a mammalian model of accelerated aging

Science

Volumn 317, Issue 5839, 2007, Pages 803-806

  Liu, Hongjun ^a   Fergusson, Maria M ^a   Castilho, Rogerio M ^b   Liu, Jie ^a   Cao, Liu ^a   Chen, Jichun ^a   Malide, Daniela ^a   Rovira, Ilsa I ^a   Schimel, Daniel ^c   Kuo, Calvin J ^d   Gutkind, J Silvio ^b   Hwang, Paul M ^a   Finkel, Toren ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CELL PROTEIN; DNA; KLOTHO PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT PROTEIN ANTAGONIST; WNT3 PROTEIN;

AGING; GENE; MAMMAL; MODEL; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; SENESCENCE; SIGNAL TRANSDUCTION; STEM CELL;

AGING; ANIMALS; APOPTOSIS; BONE AND BONES; BONE DENSITY; CELL AGING; CELL COUNT; CELL LINE; CELL SHAPE; GLUCURONIDASE; HUMANS; MICE; MICE, TRANSGENIC; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STEM CELLS; WNT PROTEINS; WNT1 PROTEIN;

ANIMALIA; MAMMALIA; MUS;

EID: 34547908461     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1143578     Document Type: Article

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24. We thank R. Moon for the Wnt (TOP/FOP) reporter constructs, M. Kuro-o for generating the klotho mice, and H. Dietz for providing the klotho mice. The TOPGAL mouse was generated by E. Fuchs and kindly provided by Y. Yang. We also thank J. G. Kang for technical help. This work was supported by Intramural NIH funds (T.F.), a grant from the Ellison Medical Foundation (T.F.), and an NIH 1 R01 DK069989-01 to C.J.K.