메뉴 건너뛰기




Volumn 107, Issue SUPPL. 1, 2010, Pages 1710-1717

Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

Author keywords

Aging; Biomarker; Heritability; Longevity

Indexed keywords

ENZYME; HUMAN TELOMERASE RNA COMPONENT; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; LIPID; RNA; TELOMERASE RNA; TERT PROTEIN, HUMAN;

EID: 76549104441     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906191106     Document Type: Article
Times cited : (203)

References (50)
  • 1
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange T (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110.
    • (2005) Genes Dev , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 2
    • 0141763835 scopus 로고    scopus 로고
    • Telomere maintenance and disease
    • Wong JM, Collins K (2003) Telomere maintenance and disease. Lancet 362:983-988.
    • (2003) Lancet , vol.362 , pp. 983-988
    • Wong, J.M.1    Collins, K.2
  • 3
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi J, d'Adda di Fagagna F (2007) Cellular senescence: When bad things happen to good cells. Nat Rev Mol Cell 8:729-740.
    • (2007) Nat Rev Mol Cell , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 5
    • 34547546721 scopus 로고    scopus 로고
    • Telomere length is paternally inherited and is associated with parental lifespan
    • Njajou OT, et al. (2007) Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci USA 104:12135-12139.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12135-12139
    • Njajou, O.T.1
  • 6
    • 0035256310 scopus 로고    scopus 로고
    • Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity
    • Benetos A, et al. (2001) Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 37:381-385.
    • (2001) Hypertension , vol.37 , pp. 381-385
    • Benetos, A.1
  • 8
    • 1242272818 scopus 로고    scopus 로고
    • Telomere length and possible link to X chromosome
    • Nawrot TS, Staessen JA, Gardner JP, Aviv A (2004) Telomere length and possible link to X chromosome. Lancet 363:507-510.
    • (2004) Lancet , vol.363 , pp. 507-510
    • Nawrot, T.S.1    Staessen, J.A.2    Gardner, J.P.3    Aviv, A.4
  • 9
    • 0027993344 scopus 로고
    • Genetic determination of telomere size in humans: A twin study of three age groups
    • Slagboom PE, Droog S, Boomsma DI (1994) Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 55:876-882.
    • (1994) Am J Hum Genet , vol.55 , pp. 876-882
    • Slagboom, P.E.1    Droog, S.2    Boomsma, D.I.3
  • 10
    • 33747493496 scopus 로고    scopus 로고
    • Telomeres and human somatic fitness
    • Aviv A (2006) Telomeres and human somatic fitness. J Gerontol A Biol Sci Med Sci 61: 871-873.
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 871-873
    • Aviv, A.1
  • 11
    • 18044398540 scopus 로고    scopus 로고
    • Telomeres as biomarkers for ageing and agerelated diseases
    • von Zglinicki T, Martin-Ruiz CM (2005) Telomeres as biomarkers for ageing and agerelated diseases. Curr Mol Med 5:197-203.
    • (2005) Curr Mol Med , vol.5 , pp. 197-203
    • von Zglinicki, T.1    Martin-Ruiz, C.M.2
  • 12
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA (2003) Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361:393-395.
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 13
    • 27144503866 scopus 로고    scopus 로고
    • The heritability of telomere length among the elderly and oldest-old
    • Bischoff C, et al. (2005) The heritability of telomere length among the elderly and oldest-old. Twin Res Hum Genet 8:433-439.
    • (2005) Twin Res Hum Genet , vol.8 , pp. 433-439
    • Bischoff, C.1
  • 14
    • 33646794390 scopus 로고    scopus 로고
    • No association between telomere length and survival among the elderly and oldest old
    • Bischoff C, et al. (2006) No association between telomere length and survival among the elderly and oldest old. Epidemiology 17:190-194.
    • (2006) Epidemiology , vol.17 , pp. 190-194
    • Bischoff, C.1
  • 15
    • 33644822655 scopus 로고    scopus 로고
    • Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: A population-based study
    • Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RG (2005) Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: A population-based study. Aging Cell 4:287-290.
    • (2005) Aging Cell , vol.4 , pp. 287-290
    • Martin-Ruiz, C.M.1    Gussekloo, J.2    van Heemst, D.3    von Zglinicki, T.4    Westendorp, R.G.5
  • 17
    • 19944410471 scopus 로고    scopus 로고
    • Mapping of a major locus that determines telomere length in humans
    • Vasa-Nicotera M, et al. (2005) Mapping of a major locus that determines telomere length in humans. Am J Hum Genet 76:147-151.
    • (2005) Am J Hum Genet , vol.76 , pp. 147-151
    • Vasa-Nicotera, M.1
  • 18
    • 33344470218 scopus 로고    scopus 로고
    • Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs
    • Andrew T, et al. (2006) Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet 78: 480-486.
    • (2006) Am J Hum Genet , vol.78 , pp. 480-486
    • Andrew, T.1
  • 19
    • 34548667973 scopus 로고    scopus 로고
    • Telomere length, stem cells and aging
    • Blasco MA (2007) Telomere length, stem cells and aging. Nat Chem Biol 3:640-649.
    • (2007) Nat Chem Biol , vol.3 , pp. 640-649
    • Blasco, M.A.1
  • 20
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 21
    • 38049019132 scopus 로고    scopus 로고
    • Human diseases of telomerase dysfunction: Insights into tissue aging
    • Garcia CK, Wright WE, Shay JW (2007) Human diseases of telomerase dysfunction: Insights into tissue aging. Nucleic Acids Res 35:7406-7416.
    • (2007) Nucleic Acids Res , vol.35 , pp. 7406-7416
    • Garcia, C.K.1    Wright, W.E.2    Shay, J.W.3
  • 22
    • 33846703426 scopus 로고    scopus 로고
    • Hallmarks of telomeres in ageing research
    • Shay JW, Wright WE (2007) Hallmarks of telomeres in ageing research. J Pathol 211: 114-123.
    • (2007) J Pathol , vol.211 , pp. 114-123
    • Shay, J.W.1    Wright, W.E.2
  • 23
    • 0842296490 scopus 로고    scopus 로고
    • Clinical phenotype of families with longevity
    • Atzmon G, et al. (2004) Clinical phenotype of families with longevity. J Am Geriatr Soc 52:274-277.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 274-277
    • Atzmon, G.1
  • 24
    • 10744225878 scopus 로고    scopus 로고
    • Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects
    • Benetos A, et al. (2004) Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension 43:182-185.
    • (2004) Hypertension , vol.43 , pp. 182-185
    • Benetos, A.1
  • 25
    • 33846049673 scopus 로고    scopus 로고
    • Brouilette SW, et al.; West of Scotland Coronary Prevention Study Group (2007) Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study. Lancet 369:107-114.
    • Brouilette SW, et al.; West of Scotland Coronary Prevention Study Group (2007) Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study. Lancet 369:107-114.
  • 26
    • 0037213048 scopus 로고    scopus 로고
    • Telomere shortening in T cells correlates with Alzheimer's disease status
    • Panossian LA, et al. (2003) Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging 24:77-84.
    • (2003) Neurobiol Aging , vol.24 , pp. 77-84
    • Panossian, L.A.1
  • 28
    • 0033747604 scopus 로고    scopus 로고
    • Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?
    • von Zglinicki T, et al. (2000) Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor? Lab Invest 80: 1739-1747.
    • (2000) Lab Invest , vol.80 , pp. 1739-1747
    • von Zglinicki, T.1
  • 29
    • 55749092742 scopus 로고    scopus 로고
    • Genetics of the Framingham Heart Study population
    • Govindaraju DR, et al. (2008) Genetics of the Framingham Heart Study population. Adv Genet 62:33-65.
    • (2008) Adv Genet , vol.62 , pp. 33-65
    • Govindaraju, D.R.1
  • 30
    • 0043122919 scopus 로고    scopus 로고
    • SIFT: Predicting amino acid changes that affect protein function
    • Ng PC, Henikoff S (2003) SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 31:3812-3814.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3812-3814
    • Ng, P.C.1    Henikoff, S.2
  • 31
    • 0035869223 scopus 로고    scopus 로고
    • Prediction of deleterious human alleles
    • Sunyaev S, et al. (2001) Prediction of deleterious human alleles. Hum Mol Genet 10: 591-597.
    • (2001) Hum Mol Genet , vol.10 , pp. 591-597
    • Sunyaev, S.1
  • 32
    • 0036846496 scopus 로고    scopus 로고
    • Plasma HDL levels highly correlate with cognitive function in exceptional longevity
    • Atzmon G, et al. (2002) Plasma HDL levels highly correlate with cognitive function in exceptional longevity. J Gerontol A Biol Sci Med Sci 57:M712-M715.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57
    • Atzmon, G.1
  • 33
    • 33845930201 scopus 로고    scopus 로고
    • A genotype of exceptional longevity is associated with preservation of cognitive function
    • Barzilai N, Atzmon G, Derby CA, Bauman JM, Lipton RB (2006) A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology 67:2170-2175.
    • (2006) Neurology , vol.67 , pp. 2170-2175
    • Barzilai, N.1    Atzmon, G.2    Derby, C.A.3    Bauman, J.M.4    Lipton, R.B.5
  • 34
    • 0142088521 scopus 로고    scopus 로고
    • Unique lipoprotein phenotype and genotype associated with exceptional longevity
    • Barzilai N, et al. (2003) Unique lipoprotein phenotype and genotype associated with exceptional longevity. J Am Med Assoc 290:2030-2040.
    • (2003) J Am Med Assoc , vol.290 , pp. 2030-2040
    • Barzilai, N.1
  • 35
    • 33748917567 scopus 로고    scopus 로고
    • Telomeres, telomerase, and human disease
    • Artandi SE (2006) Telomeres, telomerase, and human disease. N Engl J Med 355: 1195-1197.
    • (2006) N Engl J Med , vol.355 , pp. 1195-1197
    • Artandi, S.E.1
  • 36
    • 34047134989 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis-New insights
    • Verma S, Slutsky AS (2007) Idiopathic pulmonary fibrosis-New insights. N Engl J Med 356:1370-1372.
    • (2007) N Engl J Med , vol.356 , pp. 1370-1372
    • Verma, S.1    Slutsky, A.S.2
  • 37
    • 0032961696 scopus 로고    scopus 로고
    • Validity of reported age and centenarian prevalence in New England
    • Perls TT, Bochen K, Freeman M, Alpert L, Silver MH (1999) Validity of reported age and centenarian prevalence in New England. Age Ageing 28:193-197.
    • (1999) Age Ageing , vol.28 , pp. 193-197
    • Perls, T.T.1    Bochen, K.2    Freeman, M.3    Alpert, L.4    Silver, M.H.5
  • 38
    • 34250614359 scopus 로고    scopus 로고
    • Adult-onset pulmonary fibrosis caused by mutations in telomerase
    • Tsakiri KD, et al. (2007) Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci USA 104:7552-7557.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7552-7557
    • Tsakiri, K.D.1
  • 39
    • 33846504706 scopus 로고    scopus 로고
    • A "silent" polymorphism in the MDR1 gene changes substrate specificity
    • Kimchi-Sarfaty C, et al. (2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 315:525-528.
    • (2007) Science , vol.315 , pp. 525-528
    • Kimchi-Sarfaty, C.1
  • 40
    • 33748288289 scopus 로고    scopus 로고
    • Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: Evidence for functional effects of synonymous polymorphisms
    • Qu HQ, Lawrence SG, Guo F, Majewski J, Polychronakos C (2006) Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: Evidence for functional effects of synonymous polymorphisms. BMC Genomics 7:213.
    • (2006) BMC Genomics , vol.7 , pp. 213
    • Qu, H.Q.1    Lawrence, S.G.2    Guo, F.3    Majewski, J.4    Polychronakos, C.5
  • 41
    • 0037148401 scopus 로고    scopus 로고
    • Regulation of the human telomerase reverse transcriptase gene
    • Ducrest AL, Szutorisz H, Lingner J, Nabholz M (2002) Regulation of the human telomerase reverse transcriptase gene. Oncogene 21:541-552.
    • (2002) Oncogene , vol.21 , pp. 541-552
    • Ducrest, A.L.1    Szutorisz, H.2    Lingner, J.3    Nabholz, M.4
  • 42
    • 54349098423 scopus 로고    scopus 로고
    • Increased telomerase activity and comprehensive lifestyle changes: A pilot study
    • Ornish D, et al. (2008) Increased telomerase activity and comprehensive lifestyle changes: A pilot study. Lancet Oncol 9:1048-1057.
    • (2008) Lancet Oncol , vol.9 , pp. 1048-1057
    • Ornish, D.1
  • 43
    • 30944435031 scopus 로고    scopus 로고
    • Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT
    • Matsubara Y, et al. (2006) Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT. Biochem Biophys Res Commun 341:128-131.
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 128-131
    • Matsubara, Y.1
  • 44
    • 54049136464 scopus 로고    scopus 로고
    • Mushiroda T, et al.; Pirfenidone Clinical Study Group (2008) A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. J Med Genet 45:654-656.
    • Mushiroda T, et al.; Pirfenidone Clinical Study Group (2008) A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. J Med Genet 45:654-656.
  • 46
    • 0035897696 scopus 로고    scopus 로고
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). J Am Med Assoc 285: 2486-2497.
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). J Am Med Assoc 285: 2486-2497.
  • 47
    • 0016823810 scopus 로고
    • Mini-mental state. A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 48
    • 2342419515 scopus 로고    scopus 로고
    • Telomere measurement by quantitative PCR
    • Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30:e47.
    • (2002) Nucleic Acids Res , vol.30
    • Cawthon, R.M.1
  • 49
    • 76549093571 scopus 로고    scopus 로고
    • eds Patrinos GP, Ansorge W Elsevier, Amsterdam, pp
    • Vijg J, Suh Y (2005) in Molecular Diagnostics, eds Patrinos GP, Ansorge W (Elsevier, Amsterdam), pp 95-105.
    • (2005) Molecular Diagnostics , pp. 95-105
    • Vijg, J.1    Suh, Y.2
  • 50
    • 0242691208 scopus 로고    scopus 로고
    • A comparison of bayesian methods for haplotype reconstruction from population genotype data
    • Stephens M, Donnelly P (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169.
    • (2003) Am J Hum Genet , vol.73 , pp. 1162-1169
    • Stephens, M.1    Donnelly, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.