메뉴 건너뛰기




Volumn 6, Issue 19, 2007, Pages 2348-2354

Probing ATR activation with model DNA templates

Author keywords

ATR; Check point; Chk1; DNA damage; Replication; ssDNA; Xenopus egg extracts

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; SINGLE STRANDED DNA;

EID: 35848954274     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.19.4755     Document Type: Review
Times cited : (10)

References (70)
  • 1
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004; 432:316-23.
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 2
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ. The DNA damage response: Putting checkpoints in perspective. Nature 2000; 408:433-9.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 3
    • 18244401922 scopus 로고    scopus 로고
    • Unwind and slow down: Checkpoint activation by helicase and polymerase uncoupling
    • Cortez D. Unwind and slow down: Checkpoint activation by helicase and polymerase uncoupling. Genes Dev 2005; 19:1007-12.
    • (2005) Genes Dev , vol.19 , pp. 1007-1012
    • Cortez, D.1
  • 4
    • 0037106186 scopus 로고    scopus 로고
    • A requirement for replication in activation of the ATR-dependent DNA damage checkpoint
    • Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA. A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev 2002; 16:2327-32.
    • (2002) Genes Dev , vol.16 , pp. 2327-2332
    • Lupardus, P.J.1    Byun, T.2    Yee, M.C.3    Hekmat-Nejad, M.4    Cimprich, K.A.5
  • 5
    • 0037009006 scopus 로고    scopus 로고
    • DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
    • Stokes MP, Van Hatten R, Lindsay HD, Michael WM. DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. J Cell Biol 2002; 158:863-72.
    • (2002) J Cell Biol , vol.158 , pp. 863-872
    • Stokes, M.P.1    Van Hatten, R.2    Lindsay, H.D.3    Michael, W.M.4
  • 6
    • 0034703330 scopus 로고    scopus 로고
    • Activation of the DNA replication checkpoint through RNA synthesis by primase
    • Michael WM, Ott R, Fanning E, Newport J. Activation of the DNA replication checkpoint through RNA synthesis by primase. Science 2000; 289:2133-7.
    • (2000) Science , vol.289 , pp. 2133-2137
    • Michael, W.M.1    Ott, R.2    Fanning, E.3    Newport, J.4
  • 7
    • 0033936230 scopus 로고    scopus 로고
    • Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts
    • Mimura S, Masuda T, Matsui T, Takisawa H. Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells 2000; 5:439-52.
    • (2000) Genes Cells , vol.5 , pp. 439-452
    • Mimura, S.1    Masuda, T.2    Matsui, T.3    Takisawa, H.4
  • 8
    • 0034671935 scopus 로고    scopus 로고
    • Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts
    • Walter JC. Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts. J Biol Chem 2000; 275:39773-8.
    • (2000) J Biol Chem , vol.275 , pp. 39773-39778
    • Walter, J.C.1
  • 9
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev 2005; 19:1040-52.
    • (2005) Genes Dev , vol.19 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 10
    • 0033637837 scopus 로고    scopus 로고
    • Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
    • Walter J, Newport J. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol Cell 2000; 5:617-27.
    • (2000) Mol Cell , vol.5 , pp. 617-627
    • Walter, J.1    Newport, J.2
  • 11
    • 5044236667 scopus 로고    scopus 로고
    • A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication
    • Pacek M, Walter JC. A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J 2004; 23:3667-76.
    • (2004) EMBO J , vol.23 , pp. 3667-3676
    • Pacek, M.1    Walter, J.C.2
  • 12
    • 0028822203 scopus 로고
    • Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
    • Garvik B, Carson M, Hartwell L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol 1995; 15:6128-38.
    • (1995) Mol Cell Biol , vol.15 , pp. 6128-6138
    • Garvik, B.1    Carson, M.2    Hartwell, L.3
  • 13
    • 0029791693 scopus 로고    scopus 로고
    • The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast
    • Longhese MP, Neecke H, Paciotti V, Lucchini G, Plevani P. The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast. Nucleic Acids Res 1996; 24:3533-7.
    • (1996) Nucleic Acids Res , vol.24 , pp. 3533-3537
    • Longhese, M.P.1    Neecke, H.2    Paciotti, V.3    Lucchini, G.4    Plevani, P.5
  • 14
    • 0035008609 scopus 로고    scopus 로고
    • Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae
    • Kim HS, Brill SJ. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Mol Cell Biol 2001; 21:3725-37.
    • (2001) Mol Cell Biol , vol.21 , pp. 3725-3737
    • Kim, H.S.1    Brill, S.J.2
  • 15
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300:1542-8.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 17
    • 3242887431 scopus 로고    scopus 로고
    • Dial 9-1-1 for DNA damage: The Rad9-Hus1-Rad1 (9-1-1) clamp complex
    • Parrilla-Castellar ER, Arlander SJ, Karnitz L. Dial 9-1-1 for DNA damage: The Rad9-Hus1-Rad1 (9-1-1) clamp complex. DNA Repair 2004; 3:1009-14.
    • (2004) DNA Repair , vol.3 , pp. 1009-1014
    • Parrilla-Castellar, E.R.1    Arlander, S.J.2    Karnitz, L.3
  • 18
    • 33845607102 scopus 로고    scopus 로고
    • The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
    • Majka J, Niedziela-Majka A, Burgers PM. The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell 2006; 24:891-901.
    • (2006) Mol Cell , vol.24 , pp. 891-901
    • Majka, J.1    Niedziela-Majka, A.2    Burgers, P.M.3
  • 19
    • 0037178814 scopus 로고    scopus 로고
    • The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint
    • You Z, Kong L, Newport J. The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. J Biol Chem 2002; 277:27088-93.
    • (2002) J Biol Chem , vol.277 , pp. 27088-27093
    • You, Z.1    Kong, L.2    Newport, J.3
  • 20
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 complexes
    • Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci USA 2003; 100:13827-32.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3
  • 21
    • 4243156107 scopus 로고    scopus 로고
    • Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5' recessed DNA
    • Ellison V, Stillman B. Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol 2003; 1:E33.
    • (2003) PLoS Biol , vol.1
    • Ellison, V.1    Stillman, B.2
  • 22
    • 33748780358 scopus 로고    scopus 로고
    • Replication protein A directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions
    • Majka J, Binz SK, Wold MS, Burgers PM. Replication protein A directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions. J Biol Chem 2006; 281:27855-61.
    • (2006) J Biol Chem , vol.281 , pp. 27855-27861
    • Majka, J.1    Binz, S.K.2    Wold, M.S.3    Burgers, P.M.4
  • 24
    • 85190570699 scopus 로고    scopus 로고
    • Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000; 6:839-49.
    • Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000; 6:839-49.
  • 25
    • 33645516584 scopus 로고    scopus 로고
    • Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures
    • Yoo HY, Jeong SY, Dunphy WG. Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Genes Dev 2006; 20:772-83.
    • (2006) Genes Dev , vol.20 , pp. 772-783
    • Yoo, H.Y.1    Jeong, S.Y.2    Dunphy, W.G.3
  • 26
    • 33644683073 scopus 로고    scopus 로고
    • Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP
    • Kim SM, Kumagai A, Lee J, Dunphy W. Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. J Biol Chem 2005; 280:38355-64.
    • (2005) J Biol Chem , vol.280 , pp. 38355-38364
    • Kim, S.M.1    Kumagai, A.2    Lee, J.3    Dunphy, W.4
  • 27
    • 9644275421 scopus 로고    scopus 로고
    • Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
    • Kumagai A, Kim SM, Dunphy WG. Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J Biol Chem 2004; 279:49599-608.
    • (2004) J Biol Chem , vol.279 , pp. 49599-49608
    • Kumagai, A.1    Kim, S.M.2    Dunphy, W.G.3
  • 28
    • 33646119403 scopus 로고    scopus 로고
    • Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling
    • Yan S, Lindsay HD, Michael WM. Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. J Cell Biol 2006; 173:181-6.
    • (2006) J Cell Biol , vol.173 , pp. 181-186
    • Yan, S.1    Lindsay, H.D.2    Michael, W.M.3
  • 29
    • 11144227916 scopus 로고    scopus 로고
    • Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses
    • Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG. Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem 2004; 279:53353-64.
    • (2004) J Biol Chem , vol.279 , pp. 53353-53364
    • Yoo, H.Y.1    Shevchenko, A.2    Shevchenko, A.3    Dunphy, W.G.4
  • 30
    • 34547115962 scopus 로고    scopus 로고
    • Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM
    • Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM. J Biol Chem 2007; 282:17501-6.
    • (2007) J Biol Chem , vol.282 , pp. 17501-17506
    • Yoo, H.Y.1    Kumagai, A.2    Shevchenko, A.3    Shevchenko, A.4    Dunphy, W.G.5
  • 32
    • 34247251276 scopus 로고    scopus 로고
    • Single- and double-stranded DNA: Building a trigger of ATR-mediated DNA damage response
    • Zou L. Single- and double-stranded DNA: Building a trigger of ATR-mediated DNA damage response. Genes Dev 2007; 21:879-85.
    • (2007) Genes Dev , vol.21 , pp. 879-885
    • Zou, L.1
  • 34
    • 27544460716 scopus 로고    scopus 로고
    • Identification and functional analysis of TopBP1 and its homologs
    • Garcia V, Furuya K, Carr AM. Identification and functional analysis of TopBP1 and its homologs. DNA Repair 2005; 4:1227-39.
    • (2005) DNA Repair , vol.4 , pp. 1227-1239
    • Garcia, V.1    Furuya, K.2    Carr, A.M.3
  • 35
    • 0036531901 scopus 로고    scopus 로고
    • A unified view of the DNA-damage checkpoint
    • Melo J, Toczyski D. A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol 2002; 14:237-45.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 237-245
    • Melo, J.1    Toczyski, D.2
  • 36
    • 33644757806 scopus 로고    scopus 로고
    • TopBP1 activates the ATR-ATRIP complex
    • Kumagai A, Lee J, Yoo HY, Dunphy WG. TopBP1 activates the ATR-ATRIP complex. Cell 2006; 124:943-55.
    • (2006) Cell , vol.124 , pp. 943-955
    • Kumagai, A.1    Lee, J.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 37
    • 33845330910 scopus 로고    scopus 로고
    • Replisome assembly and the direct restart of stalled replication forks
    • Heller RC, Marians KJ. Replisome assembly and the direct restart of stalled replication forks. Nat Rev Mol Cell Biol 2006; 7:932-43.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 932-943
    • Heller, R.C.1    Marians, K.J.2
  • 38
    • 33745932747 scopus 로고    scopus 로고
    • DNA replication: Keep moving and don't mind the gap
    • Langston LD, O'Donnell M. DNA replication: Keep moving and don't mind the gap. Mol Cell 2006; 23:155-60.
    • (2006) Mol Cell , vol.23 , pp. 155-160
    • Langston, L.D.1    O'Donnell, M.2
  • 39
    • 29544437558 scopus 로고    scopus 로고
    • Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions
    • Lopes M, Foiani M, Sogo JM. Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell 2006; 21:15-27.
    • (2006) Mol Cell , vol.21 , pp. 15-27
    • Lopes, M.1    Foiani, M.2    Sogo, J.M.3
  • 42
  • 43
    • 2442646547 scopus 로고    scopus 로고
    • Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
    • Furuya K, Poitelea M, Guo L, Caspari T, Carr AM. Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev 2004; 18:1154-64.
    • (2004) Genes Dev , vol.18 , pp. 1154-1164
    • Furuya, K.1    Poitelea, M.2    Guo, L.3    Caspari, T.4    Carr, A.M.5
  • 44
    • 0026508487 scopus 로고
    • Human nucleotide excision nuclease removes thymine dimers from DNA by incising the 22nd phosphodiester bond 5′ and the 6th phosphodiester bond 3' to the photodimer
    • Huang JC, Svoboda DL, Reardon JT, Sancar A. Human nucleotide excision nuclease removes thymine dimers from DNA by incising the 22nd phosphodiester bond 5′ and the 6th phosphodiester bond 3' to the photodimer. Proc Natl Acad Sci USA 1992; 89:3664-8.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3664-3668
    • Huang, J.C.1    Svoboda, D.L.2    Reardon, J.T.3    Sancar, A.4
  • 45
    • 0030908093 scopus 로고    scopus 로고
    • Replication protein A: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
    • Wold MS. Replication protein A: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem 1997; 66:61-92.
    • (1997) Annu Rev Biochem , vol.66 , pp. 61-92
    • Wold, M.S.1
  • 47
    • 0345073699 scopus 로고    scopus 로고
    • A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
    • O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet 2003; 33:497-501.
    • (2003) Nat Genet , vol.33 , pp. 497-501
    • O'Driscoll, M.1    Ruiz-Perez, V.L.2    Woods, C.G.3    Jeggo, P.A.4    Goodship, J.A.5
  • 48
    • 0037178748 scopus 로고    scopus 로고
    • Interfaces between the detection, signaling, and repair of DNA damage
    • Rouse J, Jackson SP. Interfaces between the detection, signaling, and repair of DNA damage. Science 2002; 297:547-51.
    • (2002) Science , vol.297 , pp. 547-551
    • Rouse, J.1    Jackson, S.P.2
  • 49
    • 1542320702 scopus 로고    scopus 로고
    • Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint
    • Giannattasio M, Lazzaro F, Longhese MP, Plevani P, Muzi-Falconi M. Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J 2004; 23:429-38.
    • (2004) EMBO J , vol.23 , pp. 429-438
    • Giannattasio, M.1    Lazzaro, F.2    Longhese, M.P.3    Plevani, P.4    Muzi-Falconi, M.5
  • 50
    • 0037178740 scopus 로고    scopus 로고
    • Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
    • Sogo JM, Lopes M, Foiani M. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 2002; 297:599-602.
    • (2002) Science , vol.297 , pp. 599-602
    • Sogo, J.M.1    Lopes, M.2    Foiani, M.3
  • 51
    • 85011937036 scopus 로고    scopus 로고
    • In: DePamphilis ML, ed. DNA Replication and Human Disease. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, 2006.
    • In: DePamphilis ML, ed. DNA Replication and Human Disease. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, 2006.
  • 52
    • 0037335861 scopus 로고    scopus 로고
    • Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
    • Brown EJ, Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 2003; 17:615-28.
    • (2003) Genes Dev , vol.17 , pp. 615-628
    • Brown, E.J.1    Baltimore, D.2
  • 53
    • 0034649590 scopus 로고    scopus 로고
    • Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
    • Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr Biol 2000; 10:1565-73.
    • (2000) Curr Biol , vol.10 , pp. 1565-1573
    • Hekmat-Nejad, M.1    You, Z.2    Yee, M.C.3    Newport, J.W.4    Cimprich, K.A.5
  • 54
    • 0037423308 scopus 로고    scopus 로고
    • Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints
    • Miao H, Seiler JA, Burhans WC. Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints. J Biol Chem 2003; 278:4295-304.
    • (2003) J Biol Chem , vol.278 , pp. 4295-4304
    • Miao, H.1    Seiler, J.A.2    Burhans, W.C.3
  • 55
    • 3142544855 scopus 로고    scopus 로고
    • Control of replication origin density and firing time in Xenopus egg extracts: Role of a caffeine-sensitive, ATR-dependent checkpoint
    • Marheineke K, Hyrien O. Control of replication origin density and firing time in Xenopus egg extracts: Role of a caffeine-sensitive, ATR-dependent checkpoint. J Biol Chem 2004; 279:28071-81.
    • (2004) J Biol Chem , vol.279 , pp. 28071-28081
    • Marheineke, K.1    Hyrien, O.2
  • 56
    • 3242670803 scopus 로고    scopus 로고
    • ATR and ATM regulate the timing of DNA replication origin firing
    • Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol 2004; 6:648-55.
    • (2004) Nat Cell Biol , vol.6 , pp. 648-655
    • Shechter, D.1    Costanzo, V.2    Gautier, J.3
  • 57
    • 5044224075 scopus 로고    scopus 로고
    • ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
    • Sorensen CS, Syljuasen RG, Lukas J, Bartek J. ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle 2004; 3:941-5.
    • (2004) Cell Cycle , vol.3 , pp. 941-945
    • Sorensen, C.S.1    Syljuasen, R.G.2    Lukas, J.3    Bartek, J.4
  • 59
    • 0030070356 scopus 로고    scopus 로고
    • Coupling of a replicative polymerase and helicase: A tau-DnaB interaction mediates rapid replication fork movement
    • Kim S, Dallmann HG, McHenry CS, Marians KJ. Coupling of a replicative polymerase and helicase: A tau-DnaB interaction mediates rapid replication fork movement. Cell 1996; 84:643-50.
    • (1996) Cell , vol.84 , pp. 643-650
    • Kim, S.1    Dallmann, H.G.2    McHenry, C.S.3    Marians, K.J.4
  • 60
    • 19644399070 scopus 로고    scopus 로고
    • DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase
    • Stano NM, Jeong YJ, Donmez I, Tummalapalli P, Levin MK, Patel SS. DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase. Nature 2005; 435:370-3.
    • (2005) Nature , vol.435 , pp. 370-373
    • Stano, N.M.1    Jeong, Y.J.2    Donmez, I.3    Tummalapalli, P.4    Levin, M.K.5    Patel, S.S.6
  • 61
    • 0031856520 scopus 로고    scopus 로고
    • Mutational effect of fission yeast polalpha on cell cycle events
    • Bhaumik D, Wang TS. Mutational effect of fission yeast polalpha on cell cycle events. Mol Biol Cell 1998; 9:2107-23.
    • (1998) Mol Biol Cell , vol.9 , pp. 2107-2123
    • Bhaumik, D.1    Wang, T.S.2
  • 62
    • 0034312277 scopus 로고    scopus 로고
    • Requirement for ATR in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
    • Guo Z, Kumagai A, Wang SX, Dunphy WG. Requirement for ATR in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 2000; 14:2745-56.
    • (2000) Genes Dev , vol.14 , pp. 2745-2756
    • Guo, Z.1    Kumagai, A.2    Wang, S.X.3    Dunphy, W.G.4
  • 63
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001; 21:4129-39.
    • (2001) Mol Cell Biol , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 64
    • 34147206546 scopus 로고    scopus 로고
    • Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
    • Niida H, Katsuno Y, Banerjee B, Hande MP, Nakanishi M. Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol 2007; 27:2572-81.
    • (2007) Mol Cell Biol , vol.27 , pp. 2572-2581
    • Niida, H.1    Katsuno, Y.2    Banerjee, B.3    Hande, M.P.4    Nakanishi, M.5
  • 65
    • 33745331961 scopus 로고    scopus 로고
    • Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus
    • Lupardus PJ, Cimprich KA. Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. Mol Biol Cell 2006; 17:1559-69.
    • (2006) Mol Biol Cell , vol.17 , pp. 1559-1569
    • Lupardus, P.J.1    Cimprich, K.A.2
  • 67
    • 33646503204 scopus 로고    scopus 로고
    • ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
    • Yoshioka K, Yoshioka Y, Hsieh P. ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell 2006; 22:501-10.
    • (2006) Mol Cell , vol.22 , pp. 501-510
    • Yoshioka, K.1    Yoshioka, Y.2    Hsieh, P.3
  • 68
    • 21244456772 scopus 로고    scopus 로고
    • Complicated tails: Histone modifications and the DNA damage response
    • Vidanes GM, Bonilla CY, Toczyski DP. Complicated tails: Histone modifications and the DNA damage response. Cell 2005; 121:973-6.
    • (2005) Cell , vol.121 , pp. 973-976
    • Vidanes, G.M.1    Bonilla, C.Y.2    Toczyski, D.P.3
  • 70
    • 0037291130 scopus 로고    scopus 로고
    • Lee J, Kumagai A, Dunphy WG. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell 2003; 11:329-40.
    • Lee J, Kumagai A, Dunphy WG. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell 2003; 11:329-40.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.