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Volumn 15, Issue 2, 2003, Pages 164-175

Telomeres and telomerase in aging, regeneration and cancer

Author keywords

Aging; Chronic Disease; Regeneration; Telomerase Therapy; Telomere Shortening

Indexed keywords

TELOMERASE;

EID: 0037928721     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey
Times cited : (134)

References (129)
  • 5
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocation and epithelial cancers in mice
    • Artandi, S. E., Chang, S., Lee, S. L., Alson, S., Gottlieb, G. J., Chin, L., and DePinho, R. A. (2000) Telomere dysfunction promotes non-reciprocal translocation and epithelial cancers in mice. Nature 406, 641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    Depinho, R.A.7
  • 7
    • 0029759286 scopus 로고    scopus 로고
    • Telomere reduction in scleroderma patients: A possible cause for chromosomal instability
    • Artlett, C. M., Black, C. M., Briggs, D. C., Stevens, C. O., and Welsh, K. I. (1996) Telomere reduction in scleroderma patients: a possible cause for chromosomal instability. Br. J. Rheumatol. 35, 732-737.
    • (1996) Br. J. Rheumatol. , vol.35 , pp. 732-737
    • Artlett, C.M.1    Black, C.M.2    Briggs, D.C.3    Stevens, C.O.4    Welsh, K.I.5
  • 9
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn, E. H. (1991) Structure and function of telomeres. Nature 350, 569-573.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 10
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • Blasco, M. A., Funk, W., Villeponteau, B., and Greider, C. W. (1995) Functional characterization and developmental regulation of mouse telomerase RNA. Science 269, 1267-1270.
    • (1995) Science , vol.269 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.2    Villeponteau, B.3    Greider, C.W.4
  • 14
    • 0343750701 scopus 로고    scopus 로고
    • Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry
    • Brummendorf, T. H., Holyoake, T. L., Rufer, N., Barnett, M. J., Schulzer, M., Eaves, C. J., Eaves, A. C., and Lansdorp, P. M. (2000) Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood 95, 1883-1890.
    • (2000) Blood , vol.95 , pp. 1883-1890
    • Brummendorf, T.H.1    Holyoake, T.L.2    Rufer, N.3    Barnett, M.J.4    Schulzer, M.5    Eaves, C.J.6    Eaves, A.C.7    Lansdorp, P.M.8
  • 16
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., and Reddel, R. R. (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240-4248.
    • (1995) EMBO J. , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 18
    • 0030706072 scopus 로고    scopus 로고
    • Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer
    • Engelhardt, M., Drullinsky, P., Guillem, J., and Moore, M. A. (1997a) Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer. Clin. Cancer Res. 3, 1931-1941.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1931-1941
    • Engelhardt, M.1    Drullinsky, P.2    Guillem, J.3    Moore, M.A.4
  • 19
    • 0030920228 scopus 로고    scopus 로고
    • Telomerase regulation, cell cycle, and telomerase stability in primitive hematopoietic cells
    • Engelhardt, M., Kumar, R., Albanell, J., Pettengell, R., Han, W., and Moore, M. A. (1997b) Telomerase regulation, cell cycle, and telomerase stability in primitive hematopoietic cells. Blood 90, 182-193.
    • (1997) Blood , vol.90 , pp. 182-193
    • Engelhardt, M.1    Kumar, R.2    Albanell, J.3    Pettengell, R.4    Han, W.5    Moore, M.A.6
  • 20
    • 0036566036 scopus 로고    scopus 로고
    • Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
    • Espejel, S., Franco, S., Rodriguez-Perales, S., Bouffler, S. D., Cigudosa, J. C., and Blasco, M. A. (2002) Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21, 2207-2219.
    • (2002) EMBO J. , vol.21 , pp. 2207-2219
    • Espejel, S.1    Franco, S.2    Rodriguez-Perales, S.3    Bouffler, S.D.4    Cigudosa, J.C.5    Blasco, M.A.6
  • 22
    • 0032951804 scopus 로고    scopus 로고
    • Long-term telomere dynamics: Modest increase of cell turnover in HIV-infected individuals followed for up to 14 years
    • Feng, Y. R., Biggar, R. J., Gee, D., Norwood, D., Zeichner, S. L., and Dimitrov, D. S. (1999) Long-term telomere dynamics: modest increase of cell turnover in HIV-infected individuals followed for up to 14 years. Pathobiology 67, 34-38.
    • (1999) Pathobiology , vol.67 , pp. 34-38
    • Feng, Y.R.1    Biggar, R.J.2    Gee, D.3    Norwood, D.4    Zeichner, S.L.5    Dimitrov, D.S.6
  • 23
    • 0037081078 scopus 로고    scopus 로고
    • Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres
    • Franco, S., Segura, I., Riese, H. H., and Blasco, M. A. (2002) Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res. 62, 552-559.
    • (2002) Cancer Res. , vol.62 , pp. 552-559
    • Franco, S.1    Segura, I.2    Riese, H.H.3    Blasco, M.A.4
  • 24
    • 13144305133 scopus 로고    scopus 로고
    • The rate of telomere sequence loss in human leukocytes varies with age
    • Frenck, R. W., Blackburn, E. H., and Shannon, K. M. (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. USA 95, 5607-5610.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5607-5610
    • Frenck, R.W.1    Blackburn, E.H.2    Shannon, K.M.3
  • 26
    • 0343228751 scopus 로고    scopus 로고
    • Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
    • Gonzalez-Suarez, E., Samper, E., Flores, J. M., and Blasco, M. A. (2000) Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat. Genet. 26, 114-117.
    • (2000) Nat. Genet. , vol.26 , pp. 114-117
    • Gonzalez-Suarez, E.1    Samper, E.2    Flores, J.M.3    Blasco, M.A.4
  • 27
    • 0032473931 scopus 로고    scopus 로고
    • Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation
    • Greenberg, R. A., Allsopp, R. C., Chin, L., Morin, G. B., and DePinho, R. A. (1998) Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene 16, 1723-1730.
    • (1998) Oncogene , vol.16 , pp. 1723-1730
    • Greenberg, R.A.1    Allsopp, R.C.2    Chin, L.3    Morin, G.B.4    Depinho, R.A.5
  • 28
  • 30
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider, C. W. and Blackburn, E. H. (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 31
    • 0033593814 scopus 로고    scopus 로고
    • Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
    • Hande, P., Samper, E., Lansdorp, P., and Blasco, M. A. (1999) Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144, 589-601.
    • (1999) J. Cell Biol. , vol.144 , pp. 589-601
    • Hande, P.1    Samper, E.2    Lansdorp, P.3    Blasco, M.A.4
  • 32
    • 0029901910 scopus 로고    scopus 로고
    • Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes
    • Harle-Bachor, C. and Boukamp, P. (1996) Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc. Natl. Acad. Sci. USA 93, 6476-6481.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6476-6481
    • Harle-Bachor, C.1    Boukamp, P.2
  • 33
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., Futcher, A. B., and Greider, C. W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 34
    • 0031799895 scopus 로고    scopus 로고
    • X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions
    • Heiss, N. S., Knight, S. W., Vulliamy, T. J., Klauck, S. M., Wiemann, S., Mason, P. J., Poustka, A., and Dokal, I. (1998) X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat. Genet. 19, 32-38.
    • (1998) Nat. Genet. , vol.19 , pp. 32-38
    • Heiss, N.S.1    Knight, S.W.2    Vulliamy, T.J.3    Klauck, S.M.4    Wiemann, S.5    Mason, P.J.6    Poustka, A.7    Dokal, I.8
  • 35
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann, M. T., Strong, M. A., Hao, L. Y., and Greider, C. W. (2001) The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 36
    • 0037038681 scopus 로고    scopus 로고
    • P16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
    • Herbert, B.-S., Wright, W. E., and Shay, J. W. (2002) p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells. Oncogene 21, 7897-7900.
    • (2002) Oncogene , vol.21 , pp. 7897-7900
    • Herbert, B.-S.1    Wright, W.E.2    Shay, J.W.3
  • 37
    • 0033104511 scopus 로고    scopus 로고
    • Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube
    • Herrera, E., Samper, E., and Blasco, M. A. (1999a) Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. EMBO J. 18, 1172-1181.
    • (1999) EMBO J. , vol.18 , pp. 1172-1181
    • Herrera, E.1    Samper, E.2    Blasco, M.A.3
  • 38
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
    • Herrera, E., Samper, E., Martin-Caballero, J., Flores, J. M., Lee, H.-W., and Blasco, M. A. (1999b) Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950-2960.
    • (1999) EMBO J. , vol.18 , pp. 2950-2960
    • Herrera, E.1    Samper, E.2    Martin-Caballero, J.3    Flores, J.M.4    Lee, H.-W.5    Blasco, M.A.6
  • 40
    • 0035097792 scopus 로고    scopus 로고
    • Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues
    • Hiyama, E., Hiyama, K., Yokoyama, T., and Shay, J. W. (2001) Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues. Neoplasia 3, 17-26.
    • (2001) Neoplasia , vol.3 , pp. 17-26
    • Hiyama, E.1    Hiyama, K.2    Yokoyama, T.3    Shay, J.W.4
  • 42
    • 0035867190 scopus 로고    scopus 로고
    • Telomere shortening and decreased replicative potential, contrasted by continued proliferation of telomerase-positive CD8+CD28(lo) T cells in patients with systemic lupus erythematosus
    • Honda, M., Mengesha, E., Albano, S., Nichols, W. S., Wallace, D. J., Metzger, A., Klinenberg, J. R., and Linker-Israeli, M. (2001) Telomere shortening and decreased replicative potential, contrasted by continued proliferation of telomerase-positive CD8+CD28(lo) T cells in patients with systemic lupus erythematosus. Clin. Immunol. 99, 211-221.
    • (2001) Clin. Immunol. , vol.99 , pp. 211-221
    • Honda, M.1    Mengesha, E.2    Albano, S.3    Nichols, W.S.4    Wallace, D.J.5    Metzger, A.6    Klinenberg, J.R.7    Linker-Israeli, M.8
  • 43
    • 0031747370 scopus 로고    scopus 로고
    • Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer
    • Ito, H., Kyo, S., Kanaya, T., Takakura, M., Inoue, M., and Namiki, M. (1998) Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer. Clin. Cancer Res. 4, 1603-1608.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1603-1608
    • Ito, H.1    Kyo, S.2    Kanaya, T.3    Takakura, M.4    Inoue, M.5    Namiki, M.6
  • 45
    • 0035865143 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase
    • Johnson, F. B., Marciniak, R. A., McVey, M., Stewart, S. A., Hahn, W. C., and Guarente, L. (2001) The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J. 20, 905-913.
    • (2001) EMBO J. , vol.20 , pp. 905-913
    • Johnson, F.B.1    Marciniak, R.A.2    McVey, M.3    Stewart, S.A.4    Hahn, W.C.5    Guarente, L.6
  • 46
    • 0031765619 scopus 로고    scopus 로고
    • TERT is a critical determinant of telomerase activity in renal-cell carcinoma
    • Kanaya, T., Kyo, S., Takakura, M., Ito, H., Namiki, M., and Inoue, M. (1998) hTERT is a critical determinant of telomerase activity in renal-cell carcinoma. Int. J. Cancer 78, 539-543.
    • (1998) Int. J. Cancer , vol.78 , pp. 539-543
    • Kanaya, T.1    Kyo, S.2    Takakura, M.3    Ito, H.4    Namiki, M.5    Inoue, M.6
  • 47
    • 0037204532 scopus 로고    scopus 로고
    • The telomeric length and heterogeneity decrease with age in normal human oral keratinocytes
    • Kang, M. K., Swee, J., Kim, R. H., Baluda, M. A., and Park, N. H. (2002) The telomeric length and heterogeneity decrease with age in normal human oral keratinocytes. Mech. Ageing Dev. 123, 585-592.
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 585-592
    • Kang, M.K.1    Swee, J.2    Kim, R.H.3    Baluda, M.A.4    Park, N.H.5
  • 48
    • 0031908803 scopus 로고    scopus 로고
    • A repressor function for telomerase activity in telomerase-negative immortal cells
    • Katoh, M., Katoh, M., Kameyama, M., Kugoh, H., Shimizu, M., and Oshimura, M. (1998) A repressor function for telomerase activity in telomerase-negative immortal cells. Mol. Carcinog. 21, 17-25.
    • (1998) Mol. Carcinog. , vol.21 , pp. 17-25
    • Katoh, M.1    Katoh, M.2    Kameyama, M.3    Kugoh, H.4    Shimizu, M.5    Oshimura, M.6
  • 52
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., and Klingelhutz, A. J. (1998) Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396, 84-88.
    • (1998) Nature , vol.396 , pp. 84-88
    • Kiyono, T.1    Foster, S.A.2    Koop, J.I.3    McDougall, J.K.4    Galloway, D.A.5    Klingelhutz, A.J.6
  • 54
    • 0033524343 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues
    • Kyo, S., Kanaya, T., Takakura, M., Tanaka, M., and Inoue, M. (1999) Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues. Int. J. Cancer 80, 60-63.
    • (1999) Int. J. Cancer , vol.80 , pp. 60-63
    • Kyo, S.1    Kanaya, T.2    Takakura, M.3    Tanaka, M.4    Inoue, M.5
  • 57
    • 0033561672 scopus 로고    scopus 로고
    • Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: A mechanism for rescue from replicative senescence
    • Maini, M. K., Soares, M. V., Zilch, C. F., Akbar, A. N., and Beverley, P. C. (1999) Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence. J. Immunol. 162, 4521-4526.
    • (1999) J. Immunol. , vol.162 , pp. 4521-4526
    • Maini, M.K.1    Soares, M.V.2    Zilch, C.F.3    Akbar, A.N.4    Beverley, P.C.5
  • 59
    • 0036283579 scopus 로고    scopus 로고
    • Human chondrocyte senescence and osteoarthritis
    • Martin, J. A. and Buckwalter, J. A. (2002) Human chondrocyte senescence and osteoarthritis. Biorheology 39, 145-152.
    • (2002) Biorheology , vol.39 , pp. 145-152
    • Martin, J.A.1    Buckwalter, J.A.2
  • 60
    • 0032168370 scopus 로고    scopus 로고
    • Expression of mouse telomerase catalytic subunit in embryos and adult tissues
    • Martin-Rivera, L., Herrera, E., Albar, J. P., and Blasco, M. A. (1998) Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc. Natl. Acad. Sci. USA 95, 10471-10476.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10471-10476
    • Martin-Rivera, L.1    Herrera, E.2    Albar, J.P.3    Blasco, M.A.4
  • 65
    • 0037007075 scopus 로고    scopus 로고
    • Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction
    • Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., and Komuro, I. (2002) Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105, 1541-1544.
    • (2002) Circulation , vol.105 , pp. 1541-1544
    • Minamino, T.1    Miyauchi, H.2    Yoshida, T.3    Ishida, Y.4    Yoshida, H.5    Komuro, I.6
  • 66
    • 0033518188 scopus 로고    scopus 로고
    • A telomerase component is defective in the human disease dyskeratosis congenita
    • Mitchell, J. R., Wood, E., and Collins, K. (1999) A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402, 551-555.
    • (1999) Nature , vol.402 , pp. 551-555
    • Mitchell, J.R.1    Wood, E.2    Collins, K.3
  • 69
    • 0024325562 scopus 로고
    • The human telomerase terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin, G. B. (1989) The human telomerase terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59, 521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 72
    • 0040675333 scopus 로고    scopus 로고
    • Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT gene
    • Nakamura, H., Fukami, H., Hayashi, Y., Kiyono, T., Nakatsugawa, S., Hamaguchi, M., and Ishizaki, K. (2002) Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT gene. J. Radiat. Res. 43, 167-174.
    • (2002) J. Radiat. Res. , vol.43 , pp. 167-174
    • Nakamura, H.1    Fukami, H.2    Hayashi, Y.3    Kiyono, T.4    Nakatsugawa, S.5    Hamaguchi, M.6    Ishizaki, K.7
  • 75
    • 0032522443 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase: Components and regulations
    • Nugent, C. I. and Lundbland, V. (1998) The telomerase reverse transcriptase: components and regulations. Genes Dev. 12, 1073-1085.
    • (1998) Genes Dev. , vol.12 , pp. 1073-1085
    • Nugent, C.I.1    Lundbland, V.2
  • 76
    • 0030916581 scopus 로고    scopus 로고
    • Advanced telomere shortening in respiratory chain disorders
    • Oexle, K. and Zwirner, A. (1997) Advanced telomere shortening in respiratory chain disorders. Hum. Mol. Genet. 6, 905-908.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 905-908
    • Oexle, K.1    Zwirner, A.2
  • 77
    • 0029939998 scopus 로고    scopus 로고
    • Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous livers
    • Ohashi, K., Tsutsumi, M., Nakajima, Y., Kobitsu, K., Nakano, H., and Konishi, Y. (1996a) Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous livers. Concern, 1747-1751.
    • (1996) Concern , pp. 1747-1751
    • Ohashi, K.1    Tsutsumi, M.2    Nakajima, Y.3    Kobitsu, K.4    Nakano, H.5    Konishi, Y.6
  • 78
  • 79
    • 0036379582 scopus 로고    scopus 로고
    • The polymorphism of telomerase RNA component gene in patients with systemic sclerosis
    • Ohtsuka, T., Yamakage, A., and Yamazaki, S. (2002) The polymorphism of telomerase RNA component gene in patients with systemic sclerosis. Br. J. Dermatol. 147, 250-254.
    • (2002) Br. J. Dermatol. , vol.147 , pp. 250-254
    • Ohtsuka, T.1    Yamakage, A.2    Yamazaki, S.3
  • 81
    • 0037175018 scopus 로고    scopus 로고
    • Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
    • Opresko, P. L., von Kobbe, C., Laine, J. P., Harrigan, J., Hickson, I. D., and Bohr, V. A. (2002) Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J. Biol. Chem. 277, 41110-41119.
    • (2002) J. Biol. Chem. , vol.277 , pp. 41110-41119
    • Opresko, P.L.1    Von Kobbe, C.2    Laine, J.P.3    Harrigan, J.4    Hickson, I.D.5    Bohr, V.A.6
  • 82
  • 83
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse, K. R. and Greider, C. W. (1995) Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. USA 92, 4818-4822.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 85
    • 0033953479 scopus 로고    scopus 로고
    • Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse
    • Remes, K., Norrback, K. F., Rosenquist, R., Mehle, C., Lindh, J., and Roos, G. (2000) Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse. Br. J. Cancer 82, 601-607.
    • (2000) Br. J. Cancer , vol.82 , pp. 601-607
    • Remes, K.1    Norrback, K.F.2    Rosenquist, R.3    Mehle, C.4    Lindh, J.5    Roos, G.6
  • 86
    • 0035910550 scopus 로고    scopus 로고
    • Hydroxyl radical-induced apoptosis in human tumor cells is associated with telomere shortening but not telomerase inhibition and caspase activation
    • Ren, J. G., Xia, H. L., Just, T., and Dai, Y. R. (2001) Hydroxyl radical-induced apoptosis in human tumor cells is associated with telomere shortening but not telomerase inhibition and caspase activation. FEBS Lett. 488, 123-132.
    • (2001) FEBS Lett. , vol.488 , pp. 123-132
    • Ren, J.G.1    Xia, H.L.2    Just, T.3    Dai, Y.R.4
  • 88
    • 0009760393 scopus 로고    scopus 로고
    • Telomeres and telomerase in experimental liver cirrhosis
    • Arias, I. M., Boyer, J. L., Chisari, F. V., Fausto, N., Schachter, D., and Shafritz, D. (eds.), 4th ed., Lippincott Williams and Wilkins, Philadelphia
    • Rudolph, K. L. and DePinho, R. A. (2001) Telomeres and telomerase in experimental liver cirrhosis; in The Liver: Biology and Pathology, Arias, I. M., Boyer, J. L., Chisari, F. V., Fausto, N., Schachter, D., and Shafritz, D. (eds.), 4th ed., pp. 1000-1010, Lippincott Williams and Wilkins, Philadelphia.
    • (2001) The Liver: Biology and Pathology , pp. 1000-1010
    • Rudolph, K.L.1    DePinho, R.A.2
  • 90
    • 0034681457 scopus 로고    scopus 로고
    • Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
    • Rudolph, K. L., Chang, S., Millard, M., Schreiber-Agus, N., and DePinho, R. A. (2000) Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 287, 1253-1258.
    • (2000) Science , vol.287 , pp. 1253-1258
    • Rudolph, K.L.1    Chang, S.2    Millard, M.3    Schreiber-Agus, N.4    Depinho, R.A.5
  • 91
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • Rudolph, K. L., Millard, M., Bosenberg, M. W., and DePinho, R. A. (2001) Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28, 155-159.
    • (2001) Nat. Genet. , vol.28 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    DePinho, R.A.4
  • 93
    • 0034280093 scopus 로고    scopus 로고
    • Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
    • Samper, E., Goytisolo, F. A., Slijepcevic, P., van Buul, P. P., and Blasco, M. A. (2000) Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep. 1, 244-252.
    • (2000) EMBO Rep. , vol.1 , pp. 244-252
    • Samper, E.1    Goytisolo, F.A.2    Slijepcevic, P.3    Van Buul, P.P.4    Blasco, M.A.5
  • 94
    • 0036236630 scopus 로고    scopus 로고
    • Replicative aging, telomeres, and oxidative stress
    • Saretzki, G. and Von Zglinicki, T. (2002) Replicative aging, telomeres, and oxidative stress. Ann. NY. Acad. Sci. 959, 24-29.
    • (2002) Ann. NY. Acad. Sci. , vol.959 , pp. 24-29
    • Saretzki, G.1    Von Zglinicki, T.2
  • 96
    • 0023685747 scopus 로고
    • Fanconi anemia mutation causes cellular susceptibility to ambient oxygen
    • Schindler, D. and Hoehn, H. (1988) Fanconi anemia mutation causes cellular susceptibility to ambient oxygen. Am. J. Hum. Genet. 43, 429-435.
    • (1988) Am. J. Hum. Genet. , vol.43 , pp. 429-435
    • Schindler, D.1    Hoehn, H.2
  • 97
    • 0036130252 scopus 로고    scopus 로고
    • Immortal activated human hepatic stellate cells generated by ectopic telomerase expression
    • Schnabl, B., Choi, Y. H., Olsen, J. C., Hagedorn, C. H., and Brenner, D. A. (2002) Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Lab. Invest. 82, 323-333.
    • (2002) Lab. Invest. , vol.82 , pp. 323-333
    • Schnabl, B.1    Choi, Y.H.2    Olsen, J.C.3    Hagedorn, C.H.4    Brenner, D.A.5
  • 98
    • 0029971241 scopus 로고    scopus 로고
    • Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
    • Schulz, V. P., Zakian, V. A., Ogburn, C. E., McKay, J., Jarzebowicz, A. A., Edland, S. D., and Martin, G. M. (1996) Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum. Genet. 97, 750-754.
    • (1996) Hum. Genet. , vol.97 , pp. 750-754
    • Schulz, V.P.1    Zakian, V.A.2    Ogburn, C.E.3    McKay, J.4    Jarzebowicz, A.A.5    Edland, S.D.6    Martin, G.M.7
  • 99
    • 0037067656 scopus 로고    scopus 로고
    • P53: Good cop/bad cop
    • Sharpless, N. E. and DePinho, R. A. (2002) p53: good cop/bad cop. Cell 12, 9-12.
    • (2002) Cell , vol.12 , pp. 9-12
    • Sharpless, N.E.1    DePinho, R.A.2
  • 100
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J. W. and Bacchetti, S. (1997) A survey of telomerase activity in human cancer. Eur. J. Cancer 33, 787-791.
    • (1997) Eur. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 101
    • 0027993344 scopus 로고
    • Genetic determination of telomere size in humans: A twin study of three age groups
    • Slagboom, P. E., Droog, S., and Boomsma, D. I. (1994) Genetic determination of telomere size in humans: a twin study of three age groups. Am. J. Hum. Genet. 55, 876-882.
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 876-882
    • Slagboom, P.E.1    Droog, S.2    Boomsma, D.I.3
  • 102
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska, A. and de Lange, T. (2002) Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21, 4338-4348.
    • (2002) EMBO J. , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    De Lange, T.2
  • 103
    • 0033362027 scopus 로고    scopus 로고
    • Accelerated telomere shortening in the human inactive X chromosome
    • Surralles, J., Hande, M. P., Marcos, R., and Lansdorp, P. M. (1999) Accelerated telomere shortening in the human inactive X chromosome. Am. J. Hum. Genet. 65, 1617-1622.
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 1617-1622
    • Surralles, J.1    Hande, M.P.2    Marcos, R.3    Lansdorp, P.M.4
  • 104
    • 0032054313 scopus 로고    scopus 로고
    • Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer
    • Takakura, M., Kyo, S., Kanaya, T., Tanaka, M., and Inoue, M. (1998) Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res. 58, 1558-1561.
    • (1998) Cancer Res. , vol.58 , pp. 1558-1561
    • Takakura, M.1    Kyo, S.2    Kanaya, T.3    Tanaka, M.4    Inoue, M.5
  • 107
    • 0033757350 scopus 로고    scopus 로고
    • Normal telomere lengths found in cloned cattle
    • Tian, X. C., Xu, J., and Yang, X. (2000) Normal telomere lengths found in cloned cattle. Nat. Genet. 26, 272-273.
    • (2000) Nat. Genet. , vol.26 , pp. 272-273
    • Tian, X.C.1    Xu, J.2    Yang, X.3
  • 111
    • 0034966374 scopus 로고    scopus 로고
    • Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita
    • Vulliamy, T. J., Knight, S. W., Mason, P. J., and Dokal, I. (2001a) Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita. Blood Cells Mol. Dis. 27, 353-357.
    • (2001) Blood Cells Mol. Dis. , vol.27 , pp. 353-357
    • Vulliamy, T.J.1    Knight, S.W.2    Mason, P.J.3    Dokal, I.4
  • 112
    • 0035960043 scopus 로고    scopus 로고
    • The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
    • Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., and Dokal, I. (2001b) The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413, 432-435.
    • (2001) Nature , vol.413 , pp. 432-435
    • Vulliamy, T.1    Marrone, A.2    Goldman, F.3    Dearlove, A.4    Bessler, M.5    Mason, P.J.6    Dokal, I.7
  • 113
    • 0037157582 scopus 로고    scopus 로고
    • Association between aplastic anaemia and mutations in telomerase RNA
    • Vulliamy, T., Marrone, A., Dokal, I., and Mason, P. J. (2002) Association between aplastic anaemia and mutations in telomerase RNA. Lancet 359, 2168-2170.
    • (2002) Lancet , vol.359 , pp. 2168-2170
    • Vulliamy, T.1    Marrone, A.2    Dokal, I.3    Mason, P.J.4
  • 115
    • 0030961087 scopus 로고    scopus 로고
    • Telomere lengthening and telomerase activation during human B cell differentiation
    • Weng, N. P., Granger, L., and Hodes, R. J. (1997) Telomere lengthening and telomerase activation during human B cell differentiation. Proc. Natl. Acad. Sci. USA 94, 10827-10832.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10827-10832
    • Weng, N.P.1    Granger, L.2    Hodes, R.J.3
  • 117
    • 0033543120 scopus 로고    scopus 로고
    • Normal telomere lengths in naïve and memory CD4+ T cells in HIV type 1 infection: A mathematical interpretation
    • Wolthers, K. C., Noest, A. J., Otto, S. A., Miedema, F., and De Boer, R. J. (1999) Normal telomere lengths in naïve and memory CD4+ T cells in HIV type 1 infection: a mathematical interpretation. AIDS Res. Hum. Retroviruses 15, 1053-1062.
    • (1999) AIDS Res. Hum. Retroviruses , vol.15 , pp. 1053-1062
    • Wolthers, K.C.1    Noest, A.J.2    Otto, S.A.3    Miedema, F.4    De Boer, R.J.5
  • 118
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • Wong, K. K., Maser, R. S., Bachoo, R. M., Menon, J., Carrasco, D. R., Gu, Y., Alt, F. W., and DePinho, R. A. (2003) Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421, 643-648.
    • (2003) Nature , vol.421 , pp. 643-648
    • Wong, K.K.1    Maser, R.S.2    Bachoo, R.M.3    Menon, J.4    Carrasco, D.R.5    Gu, Y.6    Alt, F.W.7    DePinho, R.A.8
  • 119
    • 0026680249 scopus 로고
    • The two stage mechanism controlling cellular senescence and immortalization
    • Wright, W. E. and Shay, J. W. (1992) The two stage mechanism controlling cellular senescence and immortalization. Exp. Gerontol. 27, 389.
    • (1992) Exp. Gerontol. , vol.27 , pp. 389
    • Wright, W.E.1    Shay, J.W.2
  • 120
    • 0035253719 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-protection mechanism: The essential role of counting
    • Wright, W. E. and Shay, J. W. (2001) Cellular senescence as a tumor-protection mechanism: the essential role of counting. Crit. Opin. Genet. Dev. 11, 98-103.
    • (2001) Crit. Opin. Genet. Dev. , vol.11 , pp. 98-103
    • Wright, W.E.1    Shay, J.W.2
  • 121
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissue and cells
    • Wright, W. E., Piatyszek, M. A., Rainey, W. E., Byrd, W., and Shay, J. W. (1996) Telomerase activity in human germline and embryonic tissue and cells. Dev. Genet. 18, 173-179.
    • (1996) Dev. Genet. , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 123
    • 0035853524 scopus 로고    scopus 로고
    • Molecular biology: Enhanced: DNA ends ReQ-uire attention
    • Wu, L. and Hickson, I. D. (2001) Molecular biology: enhanced: DNA ends ReQ-uire attention. Science 292, 229-230.
    • (2001) Science , vol.292 , pp. 229-230
    • Wu, L.1    Hickson, I.D.2
  • 125
    • 0031697244 scopus 로고    scopus 로고
    • Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia
    • Xu, D., Gruber, A., Peterson, C., and Pisa, P. (1998) Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia. Br. J. Haematol. 102, 1367-1375.
    • (1998) Br. J. Haematol. , vol.102 , pp. 1367-1375
    • Xu, D.1    Gruber, A.2    Peterson, C.3    Pisa, P.4
  • 127
    • 0034846018 scopus 로고    scopus 로고
    • Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells
    • Yang, L., Suwa, T., Wright, W. E., Shay, J. W., and Hornsby, P. J. (2001) Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells. Mech. Ageing Dev. 122, 1685-1694.
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 1685-1694
    • Yang, L.1    Suwa, T.2    Wright, W.E.3    Shay, J.W.4    Hornsby, P.J.5
  • 128


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