Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination

Journal of Neuroscience

Volumn 24, Issue 38, 2004, Pages 8354-8365

  Enwere, Eineka ^a,b   Shingo, Tetsuro ^a,c   Gregg, Christopher ^a   Fujikawa, Hirokazu ^a   Ohta, Shigeki ^a   Weiss, Samuel ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^c OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Aging; EGF receptor; Forebrain SVZ; Neural stem cells; Olfactory discrimination; Olfactory neurogenesis

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FOREBRAIN; IMMUNOHISTOCHEMISTRY; INTERNEURON; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OLFACTORY BULB; OLFACTORY DISCRIMINATION; PRIORITY JOURNAL; WESTERN BLOTTING;

AGING; ANIMALS; CELL COUNT; CELL PROLIFERATION; CELLS, CULTURED; DISCRIMINATION (PSYCHOLOGY); HETEROZYGOTE; INTERNEURONS; LATERAL VENTRICLES; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; OLFACTORY BULB; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CYTOKINE; RECEPTORS, OSM-LIF; SIGNAL TRANSDUCTION; SMELL; STEM CELLS; STIMULATION, CHEMICAL; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 4644294031     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2751-04.2004     Document Type: Article

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