Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

Nature Medicine

Volumn 3, Issue 12, 1997, Pages 1337-1345

  Goodell, Margaret A ^a,f,g   Rosenzweig, Michael ^b   Kim, Hyung ^a   Marks, Douglas F ^b   Demaria, Maryann ^b   Paradis, Glenn ^c   Grupp, Stephen A ^d,g   Sieff, Colin A ^d   Mulligan, Richard C ^a   Johnson, R Paul ^b,e  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

^g The Leukemia & Lymphoma Society   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; DNA BINDING; DRUG TRANSPORT; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031435428     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1297-1337     Document Type: Article

References (31)

1. Metcalf, D. Haemopoietic Cells. p. 550 (North-Holland, Amsterdam, 1971).
2. + cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J. Exp. Med. 175, 175-184 (1992).
3. Spangrude, G.J., Heimfeld, S. & Weissman, I.L. Purification and characterization of mouse hematopoietic stem cells. Science 241, 58-62 (1988).
4. Mulder, A., Bauman, J., Visser, J., Boersma, W. & van, den Engh, G.I. Separation of spleen colony-forming units and prothymocytes by use of a monoclonal antibody detecting an H-2K determinant. Cell. Immunol. 88, 401-410 (1984).
5. Okada, S. et al. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood 80, 3044-3050 (1992).
6. Katayama, N. et al. Stage-specific expression of c-kit protein by murine hematopoietic progenitors. Blood 82, 2353-2360 (1993).
7. Sutherland, H.J., Eaves, C.J., Eaves, A.C., Dragowska, W. & Lansdorp, P.M. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74, 1563-1570 (1989).
8. Sutherland, H.J., Lansdorp, P.M., Henkelman, D.H., Eaves, A.C. & Eaves, C.J. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc. Natl. Acad. Sci. USA 87, 3584-3588 (1990).
9. Baum, C., Weissman, I., Tsukamoto, A., Buckle, A. & Peault, B. Isolation of a candidate human hematopoietic stem-cell population. Proc. Natl. Acad. Sci. USA 89, 2804-2808 (1992).
10. - hematopoietic stem cells. Blood 83, 1515-1526 (1994).
11. Berardi, A., Wang, A., Levine, J., Lopez, P. & Scadden, D. Functional isolation and characterization of human hematopoietic stem cells. Science 267, 104-108 (1995).
12. Petzer, A.L., Hogge, D.E., Landsdorp, P.M., Reid, D.S. & Eaves, C.J. Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc. Natl. Acad. Sci. USA 93, 1470-1474 (1996).
13. Larochelle, A. et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nature Med. 2, 1329-1337 (1996).
14. Hao, Q., Thiemann, F., Petersen, D., Smogorzewska, E. & Crooks, G. Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population. Blood 88, 3306-3313 (1996).
15. Goodell, M., Brose, K., Paradis, G., Conner, A. & Mulligan, R. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 183, 1797-1806 (1996).
16. Krause, D. et al. Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells. Blood 84, 691-701 (1994).
17. Morel, F., Szilvassy, S., Travis, M., Chen, B. & Galy, A. Primitive hematopoietic cells in murine bone marrow express the CD34 antigen. Blood 88, 3774-3784 (1996).
18. Osawa, M., Hanada, K., Hamada, H. & Nakauchi, H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273, 242-245 (1996).
19. Jones, R. et al. Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity. Blood 88, 487-491 (1996).
20. Broxmeyer, H. et al. Human umbilical cord blood: A clinically useful source of transplantable hematopoietic stem/progenitor cells. Int. J. Cell Cloning 8 (Suppl. 1), 76-89; discussion 89-91 (1990).
21. -/lo fetal and adult bone marrow cells. Immunomethods 5, 179-188 (1994).
22. Barcena, A., et al. Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development. Blood 82, 3401-3414 (1993).
23. + progenitor cells. Blood 87, 4040-4048 (1996).
24. Zanjani, E.D., Flake, A.W., Rice, H., Hedrick, M., Tavassoli, M. Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep. J. Clin. Invest. 93, 1051-1055 (1994).
25. Dunbar, C. Gene transfer to hematopoietic stem cells: Implications for gene therapy of human disease. Annu. Rev. Med. 47, 11-20 (1996).
26. + marrow cells in patients with breast cancer or neuroblastoma. Blood 77, 1717-1722 (1991).
27. Civin, C. et al. Highly purified CD34-positive cells reconstitute hematopoiesis. J Clin Oncol. 14, 2224-2233 (1996).
28. Kohn, D. et al. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nature Med. 1, 1017-1023 (1995).
29. Guide for the Care and Use of Laboratory Animals. DHHS Publication No. [NIH] 85-23 (US Dept. of Health and Human Services, Bethesda, MD, 1985).
30. Kawai, T., Wong, J., MacLean, J., Cosimi, A.B., Wee, S. Characterization of a monoclonal antibody (6G12) recognizing the cynomolgus monkey CD3 antigen. Transplant. Proc. 26, 1845-1846 (1994).
31. Sutherland, D.R. & Eaves, C.J. Culture of Hematopoietic Cells. pp. 139-162 (Wiley-Liss, 1994).