Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

Genes and Development

Volumn 23, Issue 17, 2009, Pages 2060-2075

  Martínez, Paula ^a   Thanasoula, Maria ^b   Muñoz, Purificación ^a,c   Liao, Chunyan ^b   Tejera, Agueda ^a   McNees, Carolyn ^a   Flores, Juana M ^d   Fernández Capetillo, Oscar ^a   Tarsounas, Madalena ^b   Blasco, Maria A ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Cancer; Chromosomal instability; Conditional knockout mice; DNA damage; Telomeres; TRF1

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CRE RECOMBINASE; PROTEIN P53; TELOMERIC REPEAT BINDING FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CHROMOSOME; CONTROLLED STUDY; DNA DAMAGE; DYSPLASIA; FIBROBLAST; GENE DELETION; HYPERPIGMENTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID; SQUAMOUS CELL CARCINOMA; TELOMERE;

AGING; ANIMALS; CELL CYCLE; CELL LINE; CHROMOSOME FRAGILITY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; E2F1 TRANSCRIPTION FACTOR; EPIDERMIS; FIBROBLASTS; GENE EXPRESSION REGULATION; HYPERPIGMENTATION; MICE; MICE, KNOCKOUT; MUTATION; NEOPLASM PROTEINS; NEOPLASMS; PROTEIN DEFICIENCY; SKIN DISEASES; SKIN NEOPLASMS; STEM CELLS; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 1; TUMOR SUPPRESSOR PROTEIN P53;

MAMMALIA; MUS;

EID: 69749092744     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.543509     Document Type: Article

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