PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Nature

Volumn 441, Issue 7092, 2006, Pages 518-522

  Zhang, Jiwang ^a   Grindley, Justin C ^a   Yin, Tong ^a   Jayasinghe, Sachintha ^a   He, Xi C ^a   Ross, Jason T ^a   Haug, Jeffrey S ^a   Rupp, Dawn ^a   Porter Westpfahl, Kimberly S ^a   Wiedemann, Leanne M ^a,c   Wu, Hong ^b   Li, Linheng ^a,c  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; DISEASES; ENZYMES; PHOSPHATES; TISSUE;

BONE MARROW NICHE; CELL PROLIFERATION; HAEMATOPOIETIC RECONSTITUTION; MOLECULAR EVENTS;

CELLS;

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; CYCLIN D1;

DISEASE TREATMENT; ENZYME ACTIVITY; HEMATOLOGY; PHOSPHATASE; RODENT;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CANCER PREVENTION; CELL CYCLE REGULATION; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKEMIA; LYMPHOID CELL; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; ANIMAL; CELL COUNT; CELL CYCLE; CYTOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; MUTATION; PATHOLOGY;

ANIMALS; CELL COUNT; CELL CYCLE; CELL LINEAGE; CELL PROLIFERATION; CYCLIN D1; GENE EXPRESSION; HEMATOPOIETIC STEM CELLS; LEUKEMIA; MICE; MUTATION; PTEN PHOSPHOHYDROLASE;

EID: 33646351002     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04747     Document Type: Article

References (30)

1. Li, L. & Xie, T. Stem cell niche: structure and function. Annu. Rev. Cell Dev. Biol. 21, 605-631 (2005).
2. Heissig, B. et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109, 625-637 (2002).
3. Arai, F. et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118, 149-161 (2004).
4. Stiles, B., Groszer, M., Wang, S., Jiao, J. & Wu, H. PTENIess means more. Dev. Biol. 273, 175-184 (2004).
5. Cully, M., You, H., Levine, A. J. & Mak, T. W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nature Rev. Cancer 6, 184-192 (2006).
6. Kogan, S. C. et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 100, 238-245 (2002).
7. Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836-841 (2003).
8. Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
9. Lesche, R. et al. Cre/IoxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis 32, 148-149 (2002).
10. Christensen, J. L. & Weissman, I. L. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl Acad. Sci. USA 98, 14541-14546 (2001).
11. Vazquez, F. et al. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J. Biol. Chem. 276, 48627-48630 (2001).
12. He, X. C. et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling. Nature Genet. 36, 1117-1121 (2004).
13. Calvi, L. M. et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841-846 (2003).
14. Kiel, M. J., Yilmaz, O. H., Iwashita, T., Terhorst, C. & Morrison, S. J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109-1121 (2005).
15. Lapidot, T., Dar, A. & Kollet, O. How do stem cells find their way home? Blood 106, 1901-1910 (2005).
16. Adams, G. B. et al. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 439, 599-603 (2006).
17. van der Loo, J. C. et al. VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin. J. Clin. Invest. 102, 1051-1061 (1998).
18. Passegue, E., Wagers, A. J., Giuriato, S., Anderson, W. C. & Weissman, I. L. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J. Exp. Med. 202, 1599-1611 (2005).
19. Kondo, M., Weissman, I. L. & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661-672 (1997).
20. Akashi, K., Traver, D., Miyamoto, T. & Weissman, I. L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000).
21. Groszer, M. et al. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad. Sci. USA 103, 111-116 (2006).
22. Gregory, M. A., Qi, Y. & Hann, S. R. Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. J. Biol. Chem. 278, 51606-51612 (2003).
23. cip1/waf1. Science 287, 1804-1808 (2000).
24. Wendel, H. G. et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428, 332-337 (2004).
25. Wilson, A. et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. 18, 2747-2763 (2004).
26. + lympho-myeloid stem cells lacking erythro-megakaryocytic potential. A revised road map for adult blood lineage commitment. Cell 121, 295-306 (2005).
27. Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N. & Kincade, P. W. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity 17, 117-130 (2002).
28. Akashi, K., Traver, D. & Zon, L. I. The complex cartography of stem cell commitment. Cell 121, 160-162 (2005).
29. Suzuki, A. et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14, 523-534 (2001).
30. Suzuki, A. et al. Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J. Exp. Med. 197, 657-667 (2003).