How and why we age

Experimental Gerontology

Volumn 33, Issue 7-8, 1998, Pages 639-653

  Hayflick, Leonard ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Cell culture; Cytogerontology; Disease; Evolution; Senescence; Telomerase; Telomere

Indexed keywords

TELOMERASE;

AGING; CELL IMMORTALIZATION; CONFERENCE PAPER; ENZYME ACTIVE SITE; EVOLUTION; GERONTOLOGY; HUMAN; LONGEVITY; NATURAL SELECTION; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; SEXUAL MATURATION; SURVIVAL; TELOMERE;

AGING; ANIMALS; CELL AGING; CELL LINE, TRANSFORMED; DNA REPLICATION; HUMANS; LONGEVITY; TELOMERE;

EID: 0032434055     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(98)00023-0     Document Type: Conference Paper

References (42)

1. Allsopp R.C., Vaziri H., Patterson C., Goldstein S., Younglai E.V., Futcher A.B., Greider C.W., Harley C.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. 89:1992;10114-10118.
2. Blackburn E.H., Gall J.G. A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J. Mol. Biol. 120:1978;33-53.
3. Blackburn, E.H. and Greider, C.W., (Editors). Telomeres, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1995.
4. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C., Morin G.B., Harley C.B., Shay J.W., Lichsteiner S., Wright W.E. Extension of life span by introduction of telomerase into normal human cells. Science. 279:1998;349-352.
5. Chiu C., Harley C.B. Replicative senescence and cell immortality The role of telomeres and telomerase . Proc. Soc. Exp. Biol. Med. 214:1997;99-106.
6. Cooke H.J., Smith B.A. Variability at the telomeres of the human X/Y pseudoautosomal region. Cold Spring Harbor Symp. Quant. Biol. 51:1986;213-219.
7. Counter C.M., Avilon A.A., Lefeuvre C.E., Stewert M.G., Greider C.W., Harley C.B., Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1992;1921-1929.
8. de , Lange, T., Shiue, L., Myers, M.R., Cox, D.R., Naylor, S.L., Killery, A.M., and Varmus, H.E. Structure and variability of human chromosome ends. Mol. Cell Biol.10, 518-527, 1990.
9. Feng, J., Funk, W.D., , Wang, S.-S., et al. The RNA component of human telomerase. Science 269, 1236-1241, 1995.
10. Greider C.W. Telomeres and senescence The history, the experiment, the future . Curr. Biol. 8:1998;178-181.
11. Greider C.W., Blackburn E.H. Identification of a specific telomere terminal transferase enzyme with two kinds of primer specificity. Cell. 51:1985;405-413.
12. Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460.
13. Hastie N.D., Dempster M., Dunlop M.G., Thompson A.M., Green D.K., Allshire R.C. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 346:1990;866-868.
14. Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:1961;585-621.
15. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:1965;614-636.
16. Hayflick L. The cell biology of human aging. Sci. Am. 242:1980;58-66.
17. Hayflick L. Cell aging. Eisdorfer C. Annual Review of Gerontology and Geriatrics. vol. I:1980;26-67 Springer Publishing Co, New York.
18. Hayflick L. The coming of age of WI-38. Advances in Cell Culture. vol. 3:1984;303-316 Academic Press, Orlando, FL.
19. Hayflick, L., How and Why We Age, Ballantine Books, New York City, 1996.
20. Henderson, E., Telomere DNA structure. In: Telomeres, Blackburn, E.H. and Greider, C.W. (Editors), pp. 11-34, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1995.
21. Kipling, D., The Telomere, Oxford University Press, New York, 1995.
22. Levy M.Z., Allsopp R.C., Futcher A.B., Greider C.W., Harley C.B. Telomere end-replication problem and cellular aging. J. Mol. Biol. 225:1992;951-960.
23. Lindsey J., McGill N.I., Lindsey L.A., Green D.K., Cooke H.J. In vivo loss of telomere repeats with age in humans. Mutat. Res. 256:1991;45-48.
24. McClintock, B., The stability of broken ends of chromosomes in Zea mays. Genetics 26, 234-282, 1941.
25. Medvedev, Zh., The Rise and Fall of T.D. Lysenko, Columbia University Press, New York, 1969.
26. Medvedev Zh. Repetition of molecular genetic information as a possible factor in evolutionary changes of life-span. Exp. Gerontol. 7:1972;227-234.
27. Morin G.B. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell. 59:1989;521-529.
28. Moyzis R.K., Buckingham J.M., Cram L.S., Dani M., Deaven L.L., Jones M.D., Meyne J., Ratliff R.L., Wu J.-R. A highly conserved repetitive DNA sequence (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA. 85:1988;6622-6626.
29. , Muggleton-Harris, A.L. and Hayflick, L. Cellular aging studied by the reconstruction of replicating cells from nuclei and cytoplasms isolated from normal human diploid cells. Exp. Cell. Res. 103, 321-330, 1976.
30. Muller H.J. The remaking of chromosomes. Studies of Genetics The selected papers of H.J. Muller . 1962;384-408 Indiana University Press, Bloomington, IL.
31. Nakamura T.M., Morin G.B., Chapman K.B., Weinrich S.L., Andrews W.H., Lingner J., Harley C.B., Cech T.R. Telomerase catalytic subunit homologs from fission yeast and humans. Science. 277:1997;955-959.
32. Norwood T.H., Smith J.R., Stein G.H. Aging at the cellular level The human fibroblastlike cell model . Schneider E.L., Rowe J.W. The Biology of Aging. 1990;131-154 Academic Press, San Diego, CA.
33. Olovnikov A.M. Principles of marginotomy in template synthesis of polynucleotides. Dokl. Akad. Nauk S.S.S.R. 201:1971;1496-1499.
34. Olovnikov A.M. A theory of marginotomy The incomplete copying of template margin in enzyme synthesis of polynucleotides and biological significance of the problem . J. Theoret. Biol. 41:1973;181-190.
35. Olovnikov A.M. Telomeres, telomerase and aging Origin of the theory . Exp. Gerontol. 31:1996;443-448.
36. Shay, J.W., Telomerase in cancer: Diagnostic, prognostic and therapeutic implications. Cancer J. 4(Suppl. 1), S26-S34, 1998.
37. , Shippen-Lentz, D. and Blackburn E.H. Functional evidence for an RNA template in telomerase. Science247, 546-552, 1990.
38. Shock, N., The International Association of Gerontology, A Chronicle - 1950 to 1986, pp. 182-185, Springer Publishing Co., New York, 1988.
39. Vaziri H., Schächter F., Uchida I., Wei L., Zhu X., Effros R., Cohen D., Harley C. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52:1993;661-667.
40. Watson J.D. Origin of concatemeric T7 DNA. Nat. New Biol. 239:1972;197-201.
41. Wright W.E., Hayflick L. Nuclear control of cellular aging demonstrated by hybridization of anucleate and whole cultured normal human fibroblasts. Exp. Cell Res. 96:1975;113-121.
42. Wright W.E., Shay J.W. Telomere positional effect and the regulation of cellular senescence. Trends Genet. 8:1992;193-197.