메뉴 건너뛰기




Volumn 7, Issue 10, 2006, Pages 1037-1047

Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN;

EID: 33748859509     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1387     Document Type: Article
Times cited : (355)

References (59)
  • 1
    • 0028534860 scopus 로고
    • The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
    • Morrison, S.J. & Weissman, I.L. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1, 661-673 (1994).
    • (1994) Immunity , vol.1 , pp. 661-673
    • Morrison, S.J.1    Weissman, I.L.2
  • 2
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya, T. & Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843-850 (2005).
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 3
    • 11244305618 scopus 로고    scopus 로고
    • WNT signalling and haematopoiesis: A WNT-WNT situation
    • Staal, F.J. & Clevers, H.C. WNT signalling and haematopoiesis: A WNT-WNT situation. Nat. Rev. Immunol. 5, 21-30 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 21-30
    • Staal, F.J.1    Clevers, H.C.2
  • 4
    • 0035479835 scopus 로고    scopus 로고
    • New aspects of Wnt signaling pathways in higher vertebrates
    • Huelsken, J. & Birchmeier, W. New aspects of Wnt signaling pathways in higher vertebrates. Curr. Opin. Genet. Dev. 11, 547-553 (2001).
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 547-553
    • Huelsken, J.1    Birchmeier, W.2
  • 5
    • 0031888098 scopus 로고    scopus 로고
    • Beta-catenin: A key mediator of Wnt signaling
    • Willert, K. & Nusse, R. Beta-catenin: A key mediator of Wnt signaling. Curr. Opin. Genet. Dev. 8, 95-102 (1998).
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 95-102
    • Willert, K.1    Nusse, R.2
  • 6
    • 0030978351 scopus 로고    scopus 로고
    • β-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle, H., Bauer, A., Stappert, J., Kispert, A. & Kemler, R. β-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16, 3797-3804 (1997).
    • (1997) EMBO J. , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 7
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with b-catenin, APC, and GSK3b
    • Behrens, J. et al. Functional interaction of an axin homolog, conductin, with b-catenin, APC, and GSK3b. Science 280, 596-599 (1998).
    • (1998) Science , vol.280 , pp. 596-599
    • Behrens, J.1
  • 8
    • 0027070855 scopus 로고
    • Wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
    • Siegfried, E., Chou, T.B. & Perrimon, N. wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell 71, 1167-1179 (1992).
    • (1992) Cell , vol.71 , pp. 1167-1179
    • Siegfried, E.1    Chou, T.B.2    Perrimon, N.3
  • 9
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development
    • Wodarz, A. & Nusse, R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 14, 59-88 (1998).
    • (1998) Annu. Rev. Cell Dev. Biol. , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 10
    • 0034727104 scopus 로고    scopus 로고
    • LDL-receptor-related proteins in Wnt signal transduction
    • Tamai, K. et al. LDL-receptor-related proteins in Wnt signal transduction. Nature 407, 530-535 (2000).
    • (2000) Nature , vol.407 , pp. 530-535
    • Tamai, K.1
  • 11
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of β-catenin with the transcription factor LEF-1
    • Behrens, J. et al. Functional interaction of β-catenin with the transcription factor LEF-1. Nature 382, 638-642 (1996).
    • (1996) Nature , vol.382 , pp. 638-642
    • Behrens, J.1
  • 12
    • 0032941717 scopus 로고    scopus 로고
    • Regulation of LEF-1/TCF transcription factors by Wnt and other signals
    • Eastman, Q. & Grosschedl, R. Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr. Opin. Cell Biol. 11, 233-240 (1999).
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 233-240
    • Eastman, Q.1    Grosschedl, R.2
  • 14
    • 1842535903 scopus 로고    scopus 로고
    • Shutting down Wnt signal-activated cancer
    • Taketo, M.M. Shutting down Wnt signal-activated cancer. Nat. Genet. 36, 320-322 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 320-322
    • Taketo, M.M.1
  • 15
  • 18
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya, T. et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423, 409-414 (2003).
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1
  • 19
    • 0030989287 scopus 로고    scopus 로고
    • A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells
    • Austin, T.W., Solar, G.P., Ziegler, F.C., Liem, L. & Matthews, W. A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells. Blood 89, 3624-3635 (1997).
    • (1997) Blood , vol.89 , pp. 3624-3635
    • Austin, T.W.1    Solar, G.P.2    Ziegler, F.C.3    Liem, L.4    Matthews, W.5
  • 20
    • 0032212190 scopus 로고    scopus 로고
    • Role of members of the Wnt gene family in human hematopoiesis
    • Van Den Berg, D.J., Sharma, A.K., Bruno, E. & Hoffman, R. Role of members of the Wnt gene family in human hematopoiesis. Blood 92, 3189-3202 (1998).
    • (1998) Blood , vol.92 , pp. 3189-3202
    • Van Den Berg, D.J.1    Sharma, A.K.2    Bruno, E.3    Hoffman, R.4
  • 21
    • 0037737726 scopus 로고    scopus 로고
    • Wnt proteins are lipid-modified and can act as stem cell growth factors
    • Willert, K. et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423, 448-452 (2003).
    • (2003) Nature , vol.423 , pp. 448-452
    • Willert, K.1
  • 22
    • 1642499734 scopus 로고    scopus 로고
    • β-catenin is dispensable for hematopoiesis and lymphopoiesis
    • Cobas, M. β-catenin is dispensable for hematopoiesis and lymphopoiesis. J. Exp. Med. 199, 221-229 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 221-229
    • Cobas, M.1
  • 24
    • 0028985161 scopus 로고
    • An HMG-box-containing T-cell factor required for thymocyte differentiation
    • Verbeek, S. et al. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374, 70-74 (1995).
    • (1995) Nature , vol.374 , pp. 70-74
    • Verbeek, S.1
  • 25
    • 0031883962 scopus 로고    scopus 로고
    • Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1
    • Okamura, R.M. et al. Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1. Immunity 8, 11-20 (1998).
    • (1998) Immunity , vol.8 , pp. 11-20
    • Okamura, R.M.1
  • 26
    • 0033711624 scopus 로고    scopus 로고
    • Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
    • Reya, T. et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13, 15-24 (2000).
    • (2000) Immunity , vol.13 , pp. 15-24
    • Reya, T.1
  • 27
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • Jamieson, C.H. et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N. Engl. J. Med. 351, 657-667 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 657-667
    • Jamieson, C.H.1
  • 28
    • 0033230616 scopus 로고    scopus 로고
    • Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    • Harada, N. et al. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 18, 5931-5942 (1999).
    • (1999) EMBO J. , vol.18 , pp. 5931-5942
    • Harada, N.1
  • 29
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 30
    • 0034749999 scopus 로고    scopus 로고
    • + stem cell compartment is accompanied by loss of self-renewal capacity
    • + stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15, 659-669 (2001).
    • (2001) Immunity , vol.15 , pp. 659-669
    • Adolfsson, J.1
  • 31
    • 0035807964 scopus 로고    scopus 로고
    • Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells
    • Christensen, J.L. & Weissman, I.L. Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells. Proc. Natl. Acad. Sci. USA 98, 14541-14546 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14541-14546
    • Christensen, J.L.1    Weissman, I.L.2
  • 32
    • 29244446792 scopus 로고    scopus 로고
    • Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT
    • Almeida, M., Han, L., Bellido, T., Manolagas, S.C. & Kousteni, S. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/ AKT. J. Biol. Chem. 280, 41342-41351 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 41342-41351
    • Almeida, M.1    Han, L.2    Bellido, T.3    Manolagas, S.C.4    Kousteni, S.5
  • 33
    • 0033790502 scopus 로고    scopus 로고
    • Overexpression of β-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators
    • Kim, K., Pang, K.M., Evans, M. & Hay, E.D. Overexpression of β-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol. Biol. Cell 11, 3509-3523 (2000).
    • (2000) Mol. Biol. Cell , vol.11 , pp. 3509-3523
    • Kim, K.1    Pang, K.M.2    Evans, M.3    Hay, E.D.4
  • 34
    • 0034629129 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence maintained by 21cip1/waf1
    • Cheng, T. et al. Hematopoietic stem cell quiescence maintained by 21cip1/ waf1. Science 287, 1804-1808 (2000).
    • (2000) Science , vol.287 , pp. 1804-1808
    • Cheng, T.1
  • 35
    • 0027185511 scopus 로고
    • Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells
    • Fleming, W.H., Alpern, E.J., Uchida, N., Ikuta, K., Spangrude, G.J. & Weissman, I.L. Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. J. Cell Biol. 122, 897-902 (1993).
    • (1993) J. Cell Biol. , vol.122 , pp. 897-902
    • Fleming, W.H.1    Alpern, E.J.2    Uchida, N.3    Ikuta, K.4    Spangrude, G.J.5    Weissman, I.L.6
  • 36
    • 0034663167 scopus 로고    scopus 로고
    • - cells fractionated on the basis of adhesion molecule expression and position in cell cycle
    • - cells fractionated on the basis of adhesion molecule expression and position in cell cycle. Blood 96, 1380-1387 (2000).
    • (2000) Blood , vol.96 , pp. 1380-1387
    • Orschell-Traycoff, C.M.1
  • 37
    • 0032980506 scopus 로고    scopus 로고
    • In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
    • Cheshier, S.H., Morrison, S.J., Liao, X. & Weissman, I.L. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 96, 3120-3125 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3120-3125
    • Cheshier, S.H.1    Morrison, S.J.2    Liao, X.3    Weissman, I.L.4
  • 38
    • 0037944193 scopus 로고    scopus 로고
    • Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit
    • Lambert, J.F.S., Forget, B.G., Weissman, S.M. & Quesenberry, P.J. et al. Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit. J. Exp. Med. 197, 1563-1572 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1563-1572
    • Lambert, J.F.S.1    Forget, B.G.2    Weissman, S.M.3    Quesenberry, P.J.4
  • 39
    • 0036081059 scopus 로고    scopus 로고
    • Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S
    • Na Nakorn, T., Traver, D., Weissman, I.L. & Akashi, K. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J. Clin. Invest. 109, 1579-1585 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 1579-1585
    • Na Nakorn, T.1    Traver, D.2    Weissman, I.L.3    Akashi, K.4
  • 40
    • 0020052387 scopus 로고
    • Transient nature of early haematopoietic spleen colonies
    • Magli, M.C., Iscove, N.N. & Odartchenko, N. Transient nature of early haematopoietic spleen colonies. Nature 295, 527-529 (1982).
    • (1982) Nature , vol.295 , pp. 527-529
    • Magli, M.C.1    Iscove, N.N.2    Odartchenko, N.3
  • 41
    • 0035760889 scopus 로고    scopus 로고
    • -/- mice due to decreased survival of early erythroblasts
    • -/- mice due to decreased survival of early erythroblasts. Blood 98, 3261-3273 (2001).
    • (2001) Blood , vol.98 , pp. 3261-3273
    • Socolovsky, M.1
  • 42
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi, K., Traver, D., Miyamoto, T. & Weissman, I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000).
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 43
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D. & Hayakawa, K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225 (1991).
    • (1991) J. Exp. Med. , vol.173 , pp. 1213-1225
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5
  • 46
    • 20244387299 scopus 로고    scopus 로고
    • + lympho-myeloid stem cells lacking erythromegakaryocytic potential a revised road map for adult blood lineage commitment
    • + lympho-myeloid stem cells lacking erythromegakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121, 295-306 (2005).
    • (2005) Cell , vol.121 , pp. 295-306
    • Adolfsson, J.1
  • 47
    • 8144220648 scopus 로고    scopus 로고
    • Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
    • Zeng, H., Yucel, R., Kosan, C., Klein-Hitpass, L. & Moroy, T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 23, 4116-4125 (2004).
    • (2004) EMBO J. , vol.23 , pp. 4116-4125
    • Zeng, H.1    Yucel, R.2    Kosan, C.3    Klein-Hitpass, L.4    Moroy, T.5
  • 48
    • 0033524834 scopus 로고    scopus 로고
    • Dependence of human stem cell engraftment and repopulation of NOD/ SCID mice on CXCR4
    • Peled, A. et al. Dependence of human stem cell engraftment and repopulation of NOD/ SCID mice on CXCR4. Science 283, 845-848 (1999).
    • (1999) Science , vol.283 , pp. 845-848
    • Peled, A.1
  • 49
    • 0032147025 scopus 로고    scopus 로고
    • Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells
    • Vermeulen, M. et al. Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood 92, 894-900 (1998).
    • (1998) Blood , vol.92 , pp. 894-900
    • Vermeulen, M.1
  • 50
    • 0028971211 scopus 로고
    • The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen
    • Papayannopoulou, T., Craddock, C., Nakamoto, B., Priestley, G.V. & Wolf, N.S. The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc. Natl. Acad. Sci. USA 92, 9647-9651 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9647-9651
    • Papayannopoulou, T.1    Craddock, C.2    Nakamoto, B.3    Priestley, G.V.4    Wolf, N.S.5
  • 51
    • 14344253704 scopus 로고    scopus 로고
    • A regulatory role of Wnt signaling pathway in the hematopoietic differentiation of murine embryonic stem cells
    • Feng, Z., Srivastava, A.S., Mishra, R. & Carrier, E. A regulatory role of Wnt signaling pathway in the hematopoietic differentiation of murine embryonic stem cells. Biochem. Biophys. Res. Commun. 324, 1333-1339 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.324 , pp. 1333-1339
    • Feng, Z.1    Srivastava, A.S.2    Mishra, R.3    Carrier, E.4
  • 53
    • 2542464945 scopus 로고    scopus 로고
    • Wnt signaling in B and T lymphocytes
    • Qiang, Y.W. & Rudikoff, S. Wnt signaling in B and T lymphocytes. Front. Biosci. 9, 1000-1010 (2004).
    • (2004) Front. Biosci. , vol.9 , pp. 1000-1010
    • Qiang, Y.W.1    Rudikoff, S.2
  • 54
    • 0034677173 scopus 로고    scopus 로고
    • The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential
    • Domen, J., Cheshier, S.H. & Weissman, I.L. The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. J. Exp. Med. 191, 253-264 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 253-264
    • Domen, J.1    Cheshier, S.H.2    Weissman, I.L.3
  • 55
    • 0033505949 scopus 로고    scopus 로고
    • Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins
    • Adams, J.M. et al. Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins. Cold Spring Harb. Symp. Quant. Biol. 64, 351-358 (1999).
    • (1999) Cold Spring Harb. Symp. Quant. Biol. , vol.64 , pp. 351-358
    • Adams, J.M.1
  • 56
    • 30044444251 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
    • Trowbridge, J.J., Xenocostas, A., Moon, R.T. & Bhatia, M. Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat. Med. 12, 89-98 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 89-98
    • Trowbridge, J.J.1    Xenocostas, A.2    Moon, R.T.3    Bhatia, M.4
  • 57
    • 0037452998 scopus 로고    scopus 로고
    • Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo
    • Murdoch, B. et al. Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc. Natl. Acad. Sci. USA 100, 3422-3427 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 3422-3427
    • Murdoch, B.1
  • 58
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till, J.E. & Mc, C.E. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14, 213-222 (1961).
    • (1961) Radiat. Res. , vol.14 , pp. 213-222
    • Till, J.E.1    Mc, C.E.2
  • 59
    • 25444437908 scopus 로고    scopus 로고
    • Hematopoietic stem cells, leukemic stem cells and chronic myelogenous leukemia
    • Passegue, E. Hematopoietic stem cells, leukemic stem cells and chronic myelogenous leukemia. Cell Cycle 4, 266-268 (2005).
    • (2005) Cell Cycle , vol.4 , pp. 266-268
    • Passegue, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.