Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 64, Issue 8, 2009, Pages 860-864

  Njajou, Omer T ^a   Hsueh, Wen Chi ^a   Blackburn, Elizabeth H ^b   Newman, Anne B ^c   Wu, Shih Hsuan ^a   Li, Rongling ^d   Simonsick, Eleanor M ^e   Harris, Tamara M ^e   Cummings, Steve R ^f   Cawthon, Richard M ^g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

^f CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^g UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Health status; Life span; Survival; Telomere; Years of healthy life

Indexed keywords

AGED; AGING; ARTICLE; BODY COMPOSITION; CAUSE OF DEATH; COHORT ANALYSIS; DEATH; FEMALE; HEALTH STATUS; HUMAN; INFECTION; LEUKOCYTE; LIFESPAN; LONGEVITY; MALE; NEOPLASM; NORMAL HUMAN; OVERALL SURVIVAL; POPULATION RESEARCH; PRIORITY JOURNAL; TELOMERE; UNITED STATES;

AGED; AGING; BODY COMPOSITION; CAUSE OF DEATH; COHORT STUDIES; FEMALE; HEALTH STATUS; HUMANS; MALE; TELOMERE;

EID: 67650660751     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/glp061     Document Type: Article

References (29)

1. Allsopp RC, Vaziri H, Patterson C, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA. 1992;89:10114-10118.
2. Herbig U, Ferreira M, Condel L, et al. Cellular senescence in aging primates. Science. 2006;311:1257.
3. Blasco MA. Telomere length, stem cells and aging. Nat Chem Biol. 2007;3:640-649.
4. Pignolo RJ, Suda RK, McMillan EA, et al. Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis . Aging Cell. 2008;7:23-31.
5. Choudhury AR, Ju Z, Djojosubroto MW, et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet. 2007;39:99-105.
6. Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007;8:703-713.
7. Chen JH, Hales CN, Ozanne SE. DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res. 2007;35:7417-7428.
8. Bakaysa SL, Mucci LA, Slagboom PE, et al. Telomere length predicts survival independent of genetic influences. Aging Cell. 2007;6:769-774.
9. Cawthon RM, Smith KR, O'Brien E, et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361:393-395.
10. Kimura M, Barbieri M, Gardner JP, et al. Leukocytes of exceptionally old persons display ultra-short telomeres. Am J Physiol Regul Integr Comp Physiol. 2007;293:R2210-R2217.
11. Njajou OT, Cawthon RM, Damcott CM, et al. Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci USA. 2007;104:12135-12139.
12. Bischoff C, Petersen HC, Graakjaer J, et al. No association between telomere length and survival among the elderly and oldest old. Epidemiology . 2006;17:190-194.
13. Martin-Ruiz CM, Gussekloo J, van Heemst D, et al. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell. 2005;4:287-290.
14. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30:e47.
15. Diehr P, Patrick DL. Probabilities of transition among health states for older adults. Qual Life Res. 2001;10:431-442.
16. Diehr P, Patrick DL, Burke GL, et al. Survival versus years of healthy life: which is more powerful as a study outcome? Control Clin Trials. 1999;20:267-279.
17. Diehr P, Patrick DL, Bild DE, et al. Predicting future years of healthy life for older adults. J Clin Epidemiol. 1998;51:343-353.
18. Hastie ND, Dempster M, Dunlop MG, et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 1990;346:866-868.
19. Benetos A, Gardner JP, Zureik M, et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension. 2004;43:182-185.
20. Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol. 2007;165:14-21.
21. Harris SE, Deary IJ, MacIntyre A, et al. The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neurosci Lett. 2006;406:260-264.
22. Ilmonen P, Kotrschal A, Penn DJ. Telomere attrition due to infection. PLoS ONE. 2008;3:e2143.
23. Kimura M, Hjelmborg JV, Gardner JP, et al. Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol . 2008;167:799-806.
24. Honig LS, Schupf N, Lee JH, et al. Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia. Ann Neurol. 2006;60:181-187.
25. Bekaert S, Van Pottelbergh I, De Meyer T, et al. Telomere length versus hormonal and bone mineral status in healthy elderly men. Mech Ageing Dev. 2005;126:1115-1122.
26. Aviv A, Valdes AM, Spector TD. Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol. 2006;35:1424-1429.
27. Faragher RG, Kipling D. How might replicative senescence contribute to human ageing? Bioessays. 1998;20:985-991.
28. Kipling D. Telomeres, replicative senescence and human ageing. Maturitas. 2001;38:25-37; discussion 37-38.
29. Terry DF, Nolan VG, Andersen SL, et al. Association of longer telomeres with better health in centenarians. J Gerontol A Biol Sci Med Sci. 2008;63:809-812.