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Volumn 5, Issue 10, 2009, Pages 1189-1211

Long-term virus-induced alterations of CYP3A-mediated drug metabolism: A look at the virology, immunology and molecular biology of a multi-faceted problem

Author keywords

Adaptive immune response; Cytochrome P450 3A; Drug metabolism; Innate immune response; Integrin receptors; Liver; Virus

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ALPHA INTERFERON; BETA INTERFERON; CCAAT ENHANCER BINDING PROTEIN; CYTOCHROME P450 3A; DEXAMETHASONE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOCORTICOID RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOTOXIN; PARACETAMOL; RANTES; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; RIFAMPICIN; TAMOXIFEN; THEOPHYLLINE; TUMOR NECROSIS FACTOR ALPHA; VIRUS RECEPTOR; VIRUS VECTOR;

EID: 70349397608     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425250903136748     Document Type: Review
Times cited : (16)

References (225)
  • 1
    • 52049089447 scopus 로고    scopus 로고
    • Emerging and reemerging diseases: A historical perspective
    • Snowden FM. Emerging and reemerging diseases: a historical perspective. Immunol Rev 2008;225:9-26
    • (2008) Immunol Rev , vol.225 , pp. 9-26
    • Snowden, F.M.1
  • 4
    • 59649094239 scopus 로고    scopus 로고
    • Human migration and infectious diseases
    • Soto SM. Human migration and infectious diseases. Clin Microbiol Infect 2009;15(Suppl 1):26-28
    • (2009) Clin Microbiol Infect , vol.15 , Issue.SUPPL. 1 , pp. 26-28
    • Soto, S.M.1
  • 5
    • 67349204836 scopus 로고    scopus 로고
    • Biological gene delivery vehicles: Beyond viral vectors
    • Seow Y, Wood MJ. Biological gene delivery vehicles: beyond viral vectors. Mol Ther 2009;17(5):767-777
    • (2009) Mol Ther , vol.17 , Issue.5 , pp. 767-777
    • Seow, Y.1    Wood, M.J.2
  • 6
    • 68549087056 scopus 로고    scopus 로고
    • Viral vectors: From virology to transgene expression
    • Bouard D, Alazard-Dany N, Cosset FL. Viral vectors: from virology to transgene expression. Br J Pharmacol 2009;2157(2):153-165
    • (2009) Br J Pharmacol , vol.2157 , Issue.2 , pp. 153-165
    • Bouard, D.1    Alazard-Dany, N.2    Cosset, F.L.3
  • 8
    • 41749087604 scopus 로고    scopus 로고
    • Infectious agents of bioterrorism: A review for emergency physicians
    • Kman NE, Nelson RN. Infectious agents of bioterrorism: a review for emergency physicians. Emerg Med Clin North Am 2008;26(2):517-547
    • (2008) Emerg Med Clin North Am , vol.26 , Issue.2 , pp. 517-547
    • Kman, N.E.1    Nelson, R.N.2
  • 9
    • 70349398811 scopus 로고
    • Physiopathology of dextoxification of pentobarbital sodium
    • This is the first scientific paper to describe changes in drug metabolism during inflammation
    • Samaras SC, Dietz N. Physiopathology of dextoxification of pentobarbital sodium. Fed Am Soc Exp Biol 1953;12:122-5 •• This is the first scientific paper to describe changes in drug metabolism during inflammation.
    • (1953) Fed Am Soc Exp Biol , vol.12 , pp. 122-125
    • Samaras, S.C.1    Dietz, N.2
  • 10
    • 0008732635 scopus 로고
    • Enhanced phenobarbital induction of liver microsomal drug-metabolizing enzymes in mice infected with murine hepatitus virus
    • This is the first scientific paper to describe changes in drug metabolism during virus infection
    • Kato R, Nakamura Y, Chiesara E. Enhanced phenobarbital induction of liver microsomal drug-metabolizing enzymes in mice infected with murine hepatitus virus. Biochem Pharmacol 1963;12:365-70 •• This is the first scientific paper to describe changes in drug metabolism during virus infection.
    • (1963) Biochem Pharmacol , vol.12 , pp. 365-370
    • Kato, R.1    Nakamura, Y.2    Chiesara, E.3
  • 11
    • 0017079210 scopus 로고
    • Decrease in activity of the drug metabolizing enzymes of the rat following the administration of tilorone hydrochloride
    • This is one of the first scientific papers to correlate changes in drug metabolism during inflammation with changes in hepatic cytochrome P450 enzymes
    • Leeson GA, Biedenback SA, Chan KY, et al. Decrease in activity of the drug metabolizing enzymes of the rat following the administration of tilorone hydrochloride. Drug Metab Dispos 1976;4(3):232-8 •• This is one of the first scientific papers to correlate changes in drug metabolism during inflammation with changes in hepatic cytochrome P450 enzymes.
    • (1976) Drug Metab Dispos , vol.4 , Issue.3 , pp. 232-238
    • Leeson, G.A.1    Biedenback, S.A.2    Chan, K.Y.3
  • 12
    • 0017192259 scopus 로고
    • Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents
    • This is one of the first scientific papers to correlate changes in drug metabolism during inflammation with changes in hepatic cytochrome P450 enzymes
    • Renton KW, Mannering GJ. Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents. Biochem Biophys Res Commun 1976;73(2):343-8 •• This is one of the first scientific papers to correlate changes in drug metabolism during inflammation with changes in hepatic cytochrome P450 enzymes.
    • (1976) Biochem Biophys Res Commun , vol.73 , Issue.2 , pp. 343-348
    • Renton, K.W.1    Mannering, G.J.2
  • 13
    • 0019843503 scopus 로고
    • Interferon-mediated depression of cytochrome P-450-dependent drug biotransformation
    • Singh G, Renton KW. Interferon-mediated depression of cytochrome P-450-dependent drug biotransformation. Mol Pharmacol 1981;20(3):681-684 (Pubitemid 12252294)
    • (1981) Molecular Pharmacology , vol.20 , Issue.3 , pp. 681-684
    • Singh, G.1    Renton, K.W.2
  • 14
    • 0019446311 scopus 로고
    • Depression of hepatic cytochrome P-450-dependent mixed function oxidases during infection with encephalomyocarditis virus
    • Renton KW. Depression of hepatic cytochrome P-450-dependent mixed function oxidases during infection with encephalomyocarditis virus. Biochem Pharmacol 1981;30(16):2333-2336
    • (1981) Biochem Pharmacol , vol.30 , Issue.16 , pp. 2333-2336
    • Renton, K.W.1
  • 15
    • 0031931324 scopus 로고    scopus 로고
    • The effect of chronic retrovirus infection and immune dysfunction on the P-450-mediated activation of acetaminophen in mouse liver microsomes
    • Chow HH, Tang Y, Li P, etal. The effect of chronic retrovirus infection and immune dysfunction on the P-450-mediated activation of acetaminophen in mouse liver microsomes. Biopharm Drug Dispos 1998;19(1):9-15
    • (1998) Biopharm Drug Dispos , vol.19 , Issue.1 , pp. 9-15
    • Chow, H.H.1    Tang, Y.2    Li, P.3
  • 16
    • 0021929410 scopus 로고
    • Effects of influenza virus vaccine on hepatic drug metabolism
    • Meredith CG, Christian CD, Johnson RF, et al. Effects of influenza virus vaccine on hepatic drug metabolism. Clin Pharmacol Ther 1985;37(4):396-401
    • (1985) Clin Pharmacol Ther , vol.37 , Issue.4 , pp. 396-401
    • Meredith, C.G.1    Christian, C.D.2    Johnson, R.F.3
  • 17
    • 0001926035 scopus 로고
    • Relationships between the enzymes of detoxication and host defense mechanisms
    • Caldwell J, Jacoby WB, editors, New York: Academic Press
    • Renton KW. Relationships between the enzymes of detoxication and host defense mechanisms. In: Caldwell J, Jacoby WB, editors, Biological Basis of Detoxication. New York: Academic Press; 1983. p. 307-324
    • (1983) Biological Basis of Detoxication , pp. 307-324
    • Renton, K.W.1
  • 18
    • 0023230059 scopus 로고
    • Inhibition of theophylline metabolism by interferon
    • Williams SJ, Baird-Lambert JA, Farrell GC. Inhibition of theophylline metabolism by interferon. Lancet 1987;2(8565):939-941
    • (1987) Lancet , vol.2 , Issue.8565 , pp. 939-941
    • Williams, S.J.1    Baird-Lambert, J.A.2    Farrell, G.C.3
  • 20
    • 0029970424 scopus 로고    scopus 로고
    • Changes in interleukin-6 concentrations following epilepsy surgery: Potential influence on carbamazepine pharmacokinetics
    • Gidal BE, Reiss WG, Liao JS, Pitterle ME. Changes in interleukin-6 concentrations following epilepsy surgery: potential influence on carbamazepine pharmacokinetics. Ann Pharmacother 1996;30(5):545-546
    • (1996) Ann Pharmacother , vol.30 , Issue.5 , pp. 545-546
    • Gidal, B.E.1    Reiss, W.G.2    Liao, J.S.3    Pitterle, M.E.4
  • 22
    • 0018190964 scopus 로고
    • Altered theophylline pharmacokinetics during acute respiratory viral illness
    • Chang KC, Bell TD, Lauer BA, Chai H. Altered theophylline pharmacokinetics during acute respiratory viral illness. Lancet 1978;1(8074):1132-3 •• This is the first clinical report describing significant changes in drug metabolism during adenovirus infection. (Pubitemid 8356442)
    • (1978) Lancet , vol.1 , Issue.8074 , pp. 1132-1133
    • Chang, K.C.1    Bell, T.D.2    Lauer, B.A.3    Chai, H.4
  • 23
    • 0031966811 scopus 로고    scopus 로고
    • Drug-cytokine interactions: Mechanisms and clinical implications
    • DOI 10.2165/00063030-199809050-00004
    • Reiss WG, Piscitelli SC. Drug-cytokine interactions: mechanisms and clinical implications. Biodrugs 1998;9(5):389-395 (Pubitemid 28216220)
    • (1998) BioDrugs , vol.9 , Issue.5 , pp. 389-395
    • Reiss, W.G.1    Piscitelli, S.C.2
  • 25
    • 80053313530 scopus 로고    scopus 로고
    • Drug Metabolism as Catalyzed by Human Cytochrome P450 Enzymes
    • Sigel A, Sigel H, Siegel RKO, editors, Hoboken, NJ: Wiley
    • Guengerich FP. Drug Metabolism as Catalyzed by Human Cytochrome P450 Enzymes. In: Sigel A, Sigel H, Siegel RKO, editors, The Unbiquitous Roles of Cytochrome P450 Proteins: Metal Ions in Life Sciences. Hoboken, NJ: Wiley; 2007. p. 561-584
    • (2007) The Unbiquitous Roles of Cytochrome P450 Proteins: Metal Ions in Life Sciences , pp. 561-584
    • Guengerich, F.P.1
  • 26
    • 45249121177 scopus 로고    scopus 로고
    • Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
    • Zhou SF. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab 2008;9(4):310-322
    • (2008) Curr Drug Metab , vol.9 , Issue.4 , pp. 310-322
    • Zhou, S.F.1
  • 27
    • 0029584276 scopus 로고
    • Substrates of human hepatic cytochrome P450 3A4
    • DOI 10.1016/0300-483X(95)03155-9
    • Li AP, Kaminski DL, Rasmussen A. Substrates of human hepatic cytochrome P450 3A4. Toxicology 1995;104(1-3):1-8 (Pubitemid 26016371)
    • (1995) Toxicology , vol.104 , Issue.1-3 , pp. 1-8
    • Li, A.P.1    Kaminski, D.L.2    Rasmussen, A.3
  • 28
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994;270(1):414-423 (Pubitemid 24229655)
    • (1994) Journal of Pharmacology and Experimental Therapeutics , vol.270 , Issue.1 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 29
    • 36549059303 scopus 로고    scopus 로고
    • Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring
    • Zhou SF, Xue CC, Yu XQ, etal. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther Drug Monit 2007;29(6):687-710
    • (2007) Ther Drug Monit , vol.29 , Issue.6 , pp. 687-710
    • Zhou, S.F.1    Xue, C.C.2    Yu, X.Q.3
  • 30
    • 56749161252 scopus 로고    scopus 로고
    • Receptor-Mediated Regulation of Cytochrome P450
    • Ioannides C, editor, London: Royal Society of Chemistry; Excellent review of nuclear receptors involved in regulation of cytochrome P450
    • Yoshinari K, Tien E, Negishi M, Honkakoski P. Receptor-Mediated Regulation of Cytochrome P450. In: Ioannides C, editor, Cytochromes P450: Role in the Metabolism and Toxicology of Drugs and Other Xenobiotics. London: Royal Society of Chemistry;2008. p. 418-439 •• Excellent review of nuclear receptors involved in regulation of cytochrome P450.
    • (2008) Cytochromes P450: Role in the Metabolism and Toxicology of Drugs and Other Xenobiotics , pp. 418-439
    • Yoshinari, K.1    Tien, E.2    Negishi, M.3    Honkakoski, P.4
  • 31
    • 33846372558 scopus 로고    scopus 로고
    • The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks
    • DOI 10.1016/j.bbagen.2006.09.024, PII S0304416506002960
    • Plant N. The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks. Biochim Biophys Acta 2007;1770(3):478-88 •• Excellent review of factors involved in regulation of cytochrome P450. (Pubitemid 46136752)
    • (2007) Biochimica et Biophysica Acta - General Subjects , vol.1770 , Issue.3 , pp. 478-488
    • Plant, N.1
  • 32
    • 58149269043 scopus 로고    scopus 로고
    • Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction
    • Lim YP, Kuo SC, Lai ML, Huang JD. Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction. Pharmacogenet Genomics 2009;19(1):11-24
    • (2009) Pharmacogenet Genomics , vol.19 , Issue.1 , pp. 11-24
    • Lim, Y.P.1    Kuo, S.C.2    Lai, M.L.3    Huang, J.D.4
  • 33
    • 33645808917 scopus 로고    scopus 로고
    • Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression
    • Li T, Chiang JY. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression. Drug Metab Dispos 2006;34(5):756-764
    • (2006) Drug Metab Dispos , vol.34 , Issue.5 , pp. 756-764
    • Li, T.1    Chiang, J.Y.2
  • 35
    • 34247349605 scopus 로고    scopus 로고
    • Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for interindividual variability in response to drugs
    • Urquhart BL, Tirona RG, Kim RB. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. J Clin Pharmacol 2007;47(5):566-578
    • (2007) J Clin Pharmacol , vol.47 , Issue.5 , pp. 566-578
    • Urquhart, B.L.1    Tirona, R.G.2    Kim, R.B.3
  • 36
    • 0032702726 scopus 로고    scopus 로고
    • The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
    • Early report describing the distal xenobiotic-responsive enhancer module in the CYP3A4 expression cassette
    • Goodwin B, Hodgson E, Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 1999;56(6):1329-39 •• Early report describing the distal xenobiotic-responsive enhancer module in the CYP3A4 expression cassette.
    • (1999) Mol Pharmacol , vol.56 , Issue.6 , pp. 1329-1339
    • Goodwin, B.1    Hodgson, E.2    Liddle, C.3
  • 37
    • 0034736577 scopus 로고    scopus 로고
    • The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons
    • Finta C, Zaphiropoulos PG. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. Gene 2000;260(1-2):13-23
    • (2000) Gene , vol.260 , Issue.1-2 , pp. 13-23
    • Finta, C.1    Zaphiropoulos, P.G.2
  • 38
    • 21744451043 scopus 로고    scopus 로고
    • Transcriptional regulation of the human hepatic CYP3A4: Identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein)
    • DOI 10.1124/mol.104.008169
    • Martínez-Jiménez CP, Gómez-Lechón MJ, Castell JV, Jover R. Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein). Mol Pharmacol 2005;67(6):2088-101 •• Early report describing an extra distal enhancer module in the CYP3A4 expression cassette. (Pubitemid 41007791)
    • (2005) Molecular Pharmacology , vol.67 , Issue.6 , pp. 2088-2101
    • Martínez-Jiménez, C.P.1    Gómez-Lechón, M.J.2    Castell, J.V.3    Jover, R.4
  • 39
    • 33846864449 scopus 로고    scopus 로고
    • Transcriptional regulation and expression of CYP3A4 in hepatocytes
    • DOI 10.2174/138920007779815986
    • Martínez-Jiménez CP, Jover R, Donato MT, et al. Transcriptional regulation and expression of CYP3A4 in hepatocytes. Curr Drug Metab 2007;8(2):185-94 •• Very comprehensive review describing the transcription factors and promoter/enhancer elements involved in regulation of CYP3A3 expression. (Pubitemid 46218685)
    • (2007) Current Drug Metabolism , vol.8 , Issue.2 , pp. 185-194
    • Martínez-Jiménez, C.P.1    Jover, R.2    Donato, M.T.3    Castell, J.V.4    Gomez-Lechon, M.J.5
  • 43
    • 0037518214 scopus 로고    scopus 로고
    • Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism
    • Westlind-Johnsson A, Malmebo S, Johansson A, etal. Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. Drug Metab Dispos 2003;31(6):755-61.
    • (2003) Drug Metab Dispos , vol.31 , Issue.6 , pp. 755-761
    • Westlind-Johnsson, A.1    Malmebo, S.2    Johansson, A.3
  • 44
    • 0037518214 scopus 로고    scopus 로고
    • Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism
    • Westlind-Johnsson A, Malmebo S, Johansson A, Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. Drug Metab Dispos 2003;31(6):755-761
    • (2003) Drug Metab Dispos , vol.31 , Issue.6 , pp. 755-761
    • Westlind-Johnsson, A.1    Malmebo, S.2    Johansson, A.3
  • 45
    • 0035933511 scopus 로고    scopus 로고
    • The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity
    • Watkins RE, Wisely GB, Moore LB, et al. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 2001;292(5525):2329-2333
    • (2001) Science , vol.292 , Issue.5525 , pp. 2329-2333
    • Watkins, R.E.1    Wisely, G.B.2    Moore, L.B.3
  • 46
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, et al. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 1998;102(5):1016-1023
    • (1998) J Clin Invest , vol.102 , Issue.5 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3
  • 50
    • 8344219885 scopus 로고    scopus 로고
    • Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver
    • DOI 10.1074/jbc.M407281200
    • Squires EJ, Sueyoshi T, Negishi M. Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J Biol Chem 2004;279(47):49307-49314 (Pubitemid 39625817)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.47 , pp. 49307-49314
    • Squires, E.J.1    Sueyoshi, T.2    Negishi, M.3
  • 51
    • 0034035667 scopus 로고    scopus 로고
    • Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver
    • This paper is one of the first to describe how PXR interacts with RXR to drive CYP expression
    • Wan YJ, An D, Cai Y, et al. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 2000;20(12):4436-44 •• This paper is one of the first to describe how PXR interacts with RXR to drive CYP expression.
    • (2000) Mol Cell Biol , vol.20 , Issue.12 , pp. 4436-4444
    • Wan, Y.J.1    An, D.2    Cai, Y.3
  • 52
    • 1642457182 scopus 로고    scopus 로고
    • Identification of a Novel Polymorphic Enhancer of the Human CYP3A4 Gene
    • DOI 10.1124/mol.65.2.326
    • Matsumura K, Saito T, Takahashi Y, et al. Identification of a novel polymorphic enhancer of the human CYP3A4 gene.Mol Pharmacol 2004;65(2):326-3334 •• This paper is one of the first to describe in detail how the RXR:PXR heterodimer interacts with the distal xenobiotic responsive enhancer molecule on the CYP3A promoter. (Pubitemid 38134260)
    • (2004) Molecular Pharmacology , vol.65 , Issue.2 , pp. 326-334
    • Matsumura, K.1    Saito, T.2    Takahashi, Y.3    Ozeki, T.4    Kiyotani, K.5    Fujieda, M.6    Yamazaki, H.7    Kunitoh, H.8    Kamataki, T.9
  • 53
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi JM, Drocourt L, Fabre JM, et al. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol 2000;58(2):361-372 (Pubitemid 30497480)
    • (2000) Molecular Pharmacology , vol.58 , Issue.2 , pp. 361-372
    • Pascussi, J.-M.1    Drocourt, L.2    Fabre, J.-M.3    Maurel, P.4    Vilarem, M.-J.5
  • 54
    • 29944432134 scopus 로고    scopus 로고
    • Transcriptional regulation of the PXR gene: Identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR
    • DOI 10.1124/dmd.105.006064
    • Aouabdi S, Gibson G, Plant N. Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR. Drug Metab Dispos 2006;34(1):138-144 (Pubitemid 43042655)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.1 , pp. 138-144
    • Aouabdi, S.1    Gibson, G.2    Plant, N.3
  • 55
    • 13244291443 scopus 로고    scopus 로고
    • Induction of drug metabolism by forskolin: The role of the pregnane X receptor and the protein kinase a signal transduction pathway
    • DOI 10.1124/jpet.104.076331
    • Ding X, Staudinger JL. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 2005;312(2):849-856 (Pubitemid 40189588)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.2 , pp. 849-856
    • Ding, X.1    Staudinger, J.L.2
  • 56
    • 13844253850 scopus 로고    scopus 로고
    • Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C
    • DOI 10.1016/j.bcp.2004.11.025
    • Ding X, Staudinger JL. Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C. Biochem Pharmacol 2005;69(5):867-873 (Pubitemid 40248628)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.5 , pp. 867-873
    • Ding, X.1    Staudinger, J.L.2
  • 57
    • 57649198455 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells
    • Lin W, Wu J, Dong H, etal. Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem 2008;283(45):30650-30657
    • (2008) J Biol Chem , vol.283 , Issue.45 , pp. 30650-30657
    • Lin, W.1    Wu, J.2    Dong, H.3
  • 58
    • 63849272898 scopus 로고    scopus 로고
    • A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor
    • Pondugula SR, Brimer-Cline C, Wu J, et al. A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor. Drug Metab Dispos 2009;37(4):719-730
    • (2009) Drug Metab Dispos , vol.37 , Issue.4 , pp. 719-730
    • Pondugula, S.R.1    Brimer-Cline, C.2    Wu, J.3
  • 59
    • 44349182094 scopus 로고    scopus 로고
    • Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4
    • This paper is the first to identify a micro-RNA sequence that alters CYP3A4 expression
    • Takagi S, Nakajima M, Mohri T, Yokoi T. Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J Biol Chem 2008;283(15):9674-80 •• This paper is the first to identify a micro-RNA sequence that alters CYP3A4 expression.
    • (2008) J Biol Chem , vol.283 , Issue.15 , pp. 9674-9680
    • Takagi, S.1    Nakajima, M.2    Mohri, T.3    Yokoi, T.4
  • 60
    • 0028210426 scopus 로고
    • A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements
    • Baes M, Gulick T, Choi HS, etal. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol 1994;14(3):1544-52 •• This paper is the first to describe CAR and its interaction with RXR to drive gene expression. (Pubitemid 24074550)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.3 , pp. 1544-1552
    • Baes, M.1    Gulick, T.2    Choi, H.-S.3    Martinolu, M.G.4    Simha, D.5    Moore, D.D.6
  • 62
    • 0034687397 scopus 로고    scopus 로고
    • The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
    • DOI 10.1038/35038112
    • Wei P, Zhang J, Egan-Hafley M, etal. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 2000;407(6806):920-3 •• This paper is the first to describe how CAR influences CYP expression and function. (Pubitemid 30794334)
    • (2000) Nature , vol.407 , Issue.6806 , pp. 920-923
    • Wei, P.1    Zhang, J.2    Egan-Haftey, M.3    Liang, S.4    Moore, D.D.5
  • 64
    • 0042236405 scopus 로고    scopus 로고
    • Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital
    • DOI 10.1016/S0014-5793(03)00720-8
    • Yoshinari K, Kobayashi K, Moore R, et al. Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett 2003;548(1-3):17-20 •• This paper is the first to describe the mechanism by which CAR alters CYP expression and function. (Pubitemid 37281243)
    • (2003) FEBS Letters , vol.548 , Issue.1-3 , pp. 17-20
    • Yoshinari, K.1    Kobayashi, K.2    Moore, R.3    Kawamoto, T.4    Negishi, M.5
  • 65
    • 0142210183 scopus 로고    scopus 로고
    • Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells
    • DOI 10.1124/mol.64.5.1069
    • Kobayashi K, Sueyoshi T, Inoue K, et al. Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol Pharmacol 2003;64(5):1069-1075 (Pubitemid 37310739)
    • (2003) Molecular Pharmacology , vol.64 , Issue.5 , pp. 1069-1075
    • Kobayashi, K.1    Sueyoshi, T.2    Inoue, K.3    Moore, R.4    Negishi, M.5
  • 68
    • 0036765785 scopus 로고    scopus 로고
    • Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
    • DOI 10.1124/mol.62.3.638
    • Maglich JM, Stoltz CM, Goodwin B, et al. Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol 2002;62(3):638-646 (Pubitemid 36329382)
    • (2002) Molecular Pharmacology , vol.62 , Issue.3 , pp. 638-646
    • Maglich, J.M.1    Stoltz, C.M.2    Goodwin, B.3    Hawkins-Brown, D.4    Moore, J.T.5    Kliewer, S.A.6
  • 69
    • 0036367792 scopus 로고    scopus 로고
    • Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response
    • DOI 10.1038/sj.tpj.6500087
    • Wei P, Zhang J, Dowhan DH, et al. Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. Pharmacogenomics J 2002;2(2):117-126 (Pubitemid 34982215)
    • (2002) Pharmacogenomics Journal , vol.2 , Issue.2 , pp. 117-126
    • Wei, P.1    Zhang, J.2    Dowhan, D.H.3    Han, Y.4    Moore, D.D.5
  • 71
    • 34247505536 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear Constitutive Active/androstane Receptor (CAR) in the cytoplasm of mouse primary hepatocytes
    • DOI 10.1124/mol.107.034538
    • Koike C, Moore R, Negishi M. Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes. Mol Pharmacol 2007;71(5):1217-1221 (Pubitemid 46658675)
    • (2007) Molecular Pharmacology , vol.71 , Issue.5 , pp. 1217-1221
    • Koike, C.1    Moore, R.2    Negishi, M.3
  • 72
    • 34250341208 scopus 로고    scopus 로고
    • Genomic profiling in nuclear receptor-mediated toxicity
    • DOI 10.1080/01926230701311351, PII 779478631
    • Woods CG, Heuvel JP, Rusyn I. Genomic profiling in nuclear receptor-mediated toxicity. Toxicol Pathol 2007;35(4):474-494 (Pubitemid 46911892)
    • (2007) Toxicologic Pathology , vol.35 , Issue.4 , pp. 474-494
    • Woods, C.G.1    Heuvel, J.P.V.2    Rusyn, I.3
  • 73
    • 0026597950 scopus 로고
    • Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
    • Mangelsdorf DJ, Borgmeyer U, Heyman RA, etal. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 1992;6(3):329-344
    • (1992) Genes Dev , vol.6 , Issue.3 , pp. 329-344
    • Mangelsdorf, D.J.1    Borgmeyer, U.2    Heyman, R.A.3
  • 74
    • 33947103526 scopus 로고    scopus 로고
    • RXR: From partnership to leadership in metabolic regulations
    • Desvergne B. RXR: from partnership to leadership in metabolic regulations. Vitam Horm 2007;75:1-32
    • (2007) Vitam Horm , vol.75 , pp. 1-32
    • Desvergne, B.1
  • 75
    • 0034721926 scopus 로고    scopus 로고
    • Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway
    • DOI 10.1074/jbc.M002840200
    • Kopf E, Plassat JL, Vivat V, et al. Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway. J Biol Chem 2000;275(43):33280-33288 (Pubitemid 30808534)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.43 , pp. 33280-33288
    • Kopf, E.1    Plassat, J.-L.2    Vivat, V.3    De The, H.4    Chambon, P.5    Rochette-Egly, C.6
  • 76
    • 1542710344 scopus 로고    scopus 로고
    • Nuclear retinoid receptors and the transcription of retinoid-target genes
    • DOI 10.1016/j.gene.2003.12.005, PII S0378111903011296
    • Bastien J, Rochette-Egly C. Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 2004;328:1-16 (Pubitemid 38352876)
    • (2004) Gene , vol.328 , Issue.1-2 , pp. 1-16
    • Bastien, J.1    Rochette-Egly, C.2
  • 77
    • 0142067563 scopus 로고    scopus 로고
    • Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor
    • Usui T, Saitoh Y, Komada F. Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. Biol Pharm Bull 2003;26(4):510-517
    • (2003) Biol Pharm Bull , vol.26 , Issue.4 , pp. 510-517
    • Usui, T.1    Saitoh, Y.2    Komada, F.3
  • 78
    • 0036707623 scopus 로고    scopus 로고
    • Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element
    • DOI 10.1124/dmd.30.9.1029
    • El-Sankary W, Bombail V, Gibson GG, Plant N. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. Drug Metab Dispos 2002;30(9):1029-1034 (Pubitemid 34894656)
    • (2002) Drug Metabolism and Disposition , vol.30 , Issue.9 , pp. 1029-1034
    • El-Sankary, W.1    Bombail, V.2    Gibson, G.G.3    Plant, N.4
  • 79
    • 0035659943 scopus 로고    scopus 로고
    • Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor
    • DOI 10.1046/j.0014-2956.2001.02540.x
    • Pascussi JM, Drocourt L, Gerbal-Chaloin S, et al. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. Eur J Biochem 2001;268(24):6346-6358 (Pubitemid 34014742)
    • (2001) European Journal of Biochemistry , vol.268 , Issue.24 , pp. 6346-6357
    • Pascussi, J.-M.1    Drocourt, L.2    Gerbal-Chaloin, S.3    Fabre, J.-M.4    Maurel, P.5    Vilarem, M.-J.6
  • 80
    • 0037450436 scopus 로고    scopus 로고
    • The expression of CYP2B6, CYP2C9 and CYP3A4 genes: A tangle of networks of nuclear and steroid receptors
    • Pascussi JM, Gerbal-Chaloin S, Drocourt L, et al. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 2003;1619(3):243-253
    • (2003) Biochim Biophys Acta , vol.1619 , Issue.3 , pp. 243-253
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Drocourt, L.3
  • 82
    • 0344736996 scopus 로고    scopus 로고
    • Rapid Transcriptional Suppression of Rat Cytochrome P450 Genes by Endotoxin Treatment and Its Inhibition by Curcumin
    • DOI 10.1124/jpet.103.057174
    • Cheng PY, Wang M, Morgan ET. Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcumin. J Pharmacol Exp Ther 2003;307(3):1205-1212 (Pubitemid 37494243)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.307 , Issue.3 , pp. 1205-1212
    • Cheng, P.-Y.1    Wang, M.2    Morgan, E.T.3
  • 83
    • 2042448417 scopus 로고    scopus 로고
    • Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- And xenobiotic-mediated regulation of the CYP3A4 gene
    • DOI 10.1124/dmd.32.5.525
    • Bombail V, Taylor K, Gibson GG, Plant N. Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene. Drug Metab Dispos 2004;32(5):525-535 (Pubitemid 38535031)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.5 , pp. 525-535
    • Bombail, V.1    Taylor, K.2    Gibson, G.G.3    Plant, N.4
  • 84
    • 0038745433 scopus 로고    scopus 로고
    • Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma
    • Rodríguez-Antona C, Bort R, Jover R, et al. Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma.Mol Pharmacol 2003;63(5):1180-1189
    • (2003) Mol Pharmacol , vol.63 , Issue.5 , pp. 1180-1189
    • Rodríguez-Antona, C.1    Bort, R.2    Jover, R.3
  • 85
    • 70349400498 scopus 로고    scopus 로고
    • Current status and challenges of cytokine pharmacology
    • Zídek Z, Anzenbacher P, Kmonícková E. Current status and challenges of cytokine pharmacology. Br J Pharmacol 2009;157(3):342-361
    • (2009) Br J Pharmacol , vol.157 , Issue.3 , pp. 342-361
    • Zídek, Z.1    Anzenbacher, P.2    Kmonícková, E.3
  • 87
    • 34548090571 scopus 로고    scopus 로고
    • Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes
    • Aitken AE, Morgan ET. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Dispos 2007;35(9):1687-1693
    • (2007) Drug Metab Dispos , vol.35 , Issue.9 , pp. 1687-1693
    • Aitken, A.E.1    Morgan, E.T.2
  • 88
    • 20444467357 scopus 로고    scopus 로고
    • Important role of proinflammatory cytokines/other endogenous substances in drug-induced hepatotoxicity: Depression of drug metabolism during infections/inflammation states, and genetic polymorphisms of drug-metabolizing enzymes/cytokines may markedly contribute to this pathology
    • Prandota J. Important role of proinflammatory cytokines/other endogenous substances in drug-induced hepatotoxicity: depression of drug metabolism during infections/inflammation states, and genetic polymorphisms of drug-metabolizing enzymes/cytokines may markedly contribute to this pathology. Am J Ther 2005;12(3):254-261 (Pubitemid 40825131)
    • (2005) American Journal of Therapeutics , vol.12 , Issue.3 , pp. 254-261
    • Prandota, J.1
  • 89
    • 62649091120 scopus 로고    scopus 로고
    • Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics
    • Excellent review summarizing current research in the area of microbial infection and hepatic drug metabolism
    • Morgan ET. Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics. Clin Pharmacol Ther 2009;85(4):434-8 •• Excellent review summarizing current research in the area of microbial infection and hepatic drug metabolism.
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.4 , pp. 434-438
    • Morgan, E.T.1
  • 91
    • 0036830875 scopus 로고    scopus 로고
    • Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: Molecular mechanism and transcription factors involved
    • Jover R, Bort R, Gómez-Lechón MJ, Castell JV. Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved. FASEB J 2002;16(13):1799-1801
    • (2002) FASEB J , vol.16 , Issue.13 , pp. 1799-1801
    • Jover, R.1    Bort, R.2    Gómez-Lechón, M.J.3    Castell, J.V.4
  • 92
    • 33745805833 scopus 로고    scopus 로고
    • Role of NF-kappaB in regulation of PXR-mediated gene expression: A mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents
    • DOI 10.1074/jbc.M601302200
    • Gu X, Ke S, Liu D, etal. Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. J Biol Chem 2006;281(26):17882-9 •• This is one of the first reports that ties changes in PXR-mediated CYP expression during infection to a major cell signaling pathway. (Pubitemid 44035587)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.26 , pp. 17882-17889
    • Gu, X.1    Ke, S.2    Liu, D.3    Sheng, T.4    Thomas, P.E.5    Rabson, A.B.6    Gallo, M.A.7    Xie, W.8    Tian, Y.9
  • 93
    • 39749189427 scopus 로고    scopus 로고
    • Cell signaling and nuclear receptors: New opportunities for molecular pharmaceuticals in liver disease
    • DOI 10.1021/mp700098c
    • Staudinger JL, Lichti K. Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease. Mol Pharm 2008;5(1):17-34 (Pubitemid 351300031)
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.1 , pp. 17-34
    • Staudinger, J.L.1    Lichti, K.2
  • 95
    • 18144387309 scopus 로고    scopus 로고
    • Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation
    • DOI 10.1186/1478-1336-2-4
    • Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: a novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept 2004;2(1):4 •• This is one of the first reports that describes how RXR is affected by a certain cell signal transduction pathway during infection. (Pubitemid 40617881)
    • (2004) Nuclear Receptor , vol.2 , pp. 4
    • Ghose, R.1    Zimmerman, T.L.2    Thevananther, S.3    Karpen, S.J.4
  • 96
    • 33745529832 scopus 로고    scopus 로고
    • Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-Jun pathway in human liver cells
    • DOI 10.1002/hep.21183
    • Li T, Jahan A, Chiang JY. Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells. Hepatology 2006;43(6):1202-1210 (Pubitemid 43980098)
    • (2006) Hepatology , vol.43 , Issue.6 , pp. 1202-1210
    • Li, T.1    Jahan, A.2    Chiang, J.Y.L.3
  • 97
    • 3042824897 scopus 로고    scopus 로고
    • Signal transduction pathways implicated in the decrease in CYP1A1, 1A2 and 3A6 activity produced by serum from rabbits and humans with an inflammatory reaction
    • DOI 10.1016/j.bcp.2004.04.002, PII S0006295204002333
    • Levitchi M, Fradette C, Bleau AM, et al. Signal transduction pathways implicated in the decrease in CYP1A1, 1A2 and 3A6 activity produced by serum from rabbits and humans with an inflammatory reaction. Biochem Pharmacol 2004;68(3):573-582 (Pubitemid 38887439)
    • (2004) Biochemical Pharmacology , vol.68 , Issue.3 , pp. 573-582
    • Levitchi, M.1    Fradette, C.2    Bleau, A.-M.3    Michaud, D.4    Kourylko, O.5    Arcand, M.6    Du Souich, P.7
  • 98
    • 70349389414 scopus 로고    scopus 로고
    • Bile acids as regulatory molecules
    • [Epub ahead of print]
    • Hylemon PB, Zhou H, Pandak WM, et al. Bile acids as regulatory molecules. J Lipid Res 2006 [Epub ahead of print]
    • (2006) J Lipid Res
    • Hylemon, P.B.1    Zhou, H.2    Pandak, W.M.3
  • 99
    • 37549043182 scopus 로고    scopus 로고
    • Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein
    • This is one of the first reports that ties changes in hepatic CYP expression during infection to a toll-like receptor signaling pathway
    • Ghose R, White D, Guo T, et al. Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos 2008;36(1):95-101 •• This is one of the first reports that ties changes in hepatic CYP expression during infection to a toll-like receptor signaling pathway.
    • (2008) Drug Metab Dispos , vol.36 , Issue.1 , pp. 95-101
    • Ghose, R.1    White, D.2    Guo, T.3
  • 100
    • 65549089505 scopus 로고    scopus 로고
    • Role of NF-kappaB in the regulation of cytochrome p450 enzymes
    • Zordoky BN, El-Kadi AO. Role of NF-kappaB in the regulation of cytochrome p450 enzymes. Curr Drug Metab 2009;10(2):164-178
    • (2009) Curr Drug Metab , vol.10 , Issue.2 , pp. 164-178
    • Zordoky, B.N.1    El-Kadi, A.O.2
  • 102
    • 44249092995 scopus 로고    scopus 로고
    • The nuclear factor-kappa B pathway regulates cytochrome P450 3A4 protein stability
    • DOI 10.1124/mol.107.043976
    • Zangar RC, Bollinger N, Verma S, et al. The nuclear factor-kappa B pathway regulates cytochrome P450 3A4 protein stability. Mol Pharmacol 2008;73(6):1652-1658 (Pubitemid 351724354)
    • (2008) Molecular Pharmacology , vol.73 , Issue.6 , pp. 1652-1658
    • Zangar, R.C.1    Bollinger, N.2    Verma, S.3    Karin, N.J.4    Lu, Y.5
  • 103
    • 39749108827 scopus 로고    scopus 로고
    • Revisiting heme mechanisms. a perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s)
    • Zhu Y, Silverman RB. Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s). Biochemistry 2008;47(8):2231-2243
    • (2008) Biochemistry , vol.47 , Issue.8 , pp. 2231-2243
    • Zhu, Y.1    Silverman, R.B.2
  • 105
    • 63849225881 scopus 로고    scopus 로고
    • Dual mechanisms of CYP3A protein regulation by proinflammatory cytokine stimulation in primary hepatocyte cultures
    • Lee CM, Pohl J, Morgan ET. Dual mechanisms of CYP3A protein regulation by proinflammatory cytokine stimulation in primary hepatocyte cultures. Drug Metab Dispos 2009;37(4):865-872
    • (2009) Drug Metab Dispos , vol.37 , Issue.4 , pp. 865-872
    • Lee, C.M.1    Pohl, J.2    Morgan, E.T.3
  • 106
    • 54949143150 scopus 로고    scopus 로고
    • Phosphorylation of xenobiotic-metabolizing cytochromes P450
    • Oesch-Bartlomowicz B, Oesch F. Phosphorylation of xenobiotic-metabolizing cytochromes P450. Anal Bioanal Chem 2008;392(6):1085-1092
    • (2008) Anal Bioanal Chem , vol.392 , Issue.6 , pp. 1085-1092
    • Oesch-Bartlomowicz, B.1    Oesch, F.2
  • 107
    • 18744393086 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 by posttranslational modification
    • DOI 10.1081/DMR-200046136
    • Aguiar M, Masse R, Gibbs BF. Regulation of cytochrome P450 by posttranslational modification. Drug Metab Rev 2005;37(2):379-404 (Pubitemid 40677509)
    • (2005) Drug Metabolism Reviews , vol.37 , Issue.2 , pp. 379-404
    • Aguiar, M.1    Masse, R.2    Gibbs, B.F.3
  • 108
    • 54949089178 scopus 로고    scopus 로고
    • Intracellular transport and localization of microsomal cytochrome P450
    • Neve EP, Ingelman-Sundberg M. Intracellular transport and localization of microsomal cytochrome P450. Anal Bioanal Chem 2008;392(6):1075-1084
    • (2008) Anal Bioanal Chem , vol.392 , Issue.6 , pp. 1075-1084
    • Neve, E.P.1    Ingelman-Sundberg, M.2
  • 109
    • 13844314200 scopus 로고    scopus 로고
    • Cytochrome P450 ubiquitination: Branding for the proteolytic slaughter?
    • This is the first comprehensive review that discusses the limited number of studies studies that have assessed ubiquitination patterns of hepatic cytochrome P450
    • Correia MA, Sadeghi S, Mundo-Paredes E. Cytochrome P450 ubiquitination: branding for the proteolytic slaughter? Annu Rev Pharmacol Toxicol 2005;45:439-64 •• This is the first comprehensive review that discusses the limited number of studies studies that have assessed ubiquitination patterns of hepatic cytochrome P450.
    • (2005) Annu Rev Pharmacol Toxicol , vol.45 , pp. 439-464
    • Correia, M.A.1    Sadeghi, S.2    Mundo-Paredes, E.3
  • 110
    • 65549106478 scopus 로고    scopus 로고
    • A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation
    • Wang Y, Liao M, Hoe N, etal. A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation. J Biol Chem 2009;284(9):5671-5684
    • (2009) J Biol Chem , vol.284 , Issue.9 , pp. 5671-5684
    • Wang, Y.1    Liao, M.2    Hoe, N.3
  • 111
    • 0035949711 scopus 로고    scopus 로고
    • Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: A mass spectrometric characterization of the phosphorylated peptides
    • DOI 10.1021/bi010690z
    • Wang X, Medzihradszky KF, Maltby D, Correia MA. Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides. Biochemistry 2001;40(38):11318-26 •• This is one of the first studies that describes phosphorylation patterns of hepatic cytochrome P450. (Pubitemid 32911274)
    • (2001) Biochemistry , vol.40 , Issue.38 , pp. 11318-11326
    • Wang, X.1    Medzihradszky, K.F.2    Maltby, D.3    Correia, M.A.4
  • 112
    • 0037228093 scopus 로고    scopus 로고
    • Cytochrome-P450 phosphorylation as a functional switch
    • Oesch-Bartlomowicz B, Oesch F. Cytochrome-P450 phosphorylation as a functional switch. Arch Biochem Biophys 2003;409(1):228-234
    • (2003) Arch Biochem Biophys , vol.409 , Issue.1 , pp. 228-234
    • Oesch-Bartlomowicz, B.1    Oesch, F.2
  • 113
    • 33645109954 scopus 로고    scopus 로고
    • Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor
    • Hosseinpour F, Moore R, Negishi M, Sueyoshi T. Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor. Mol Pharmacol 2006;69(4):1095-1102
    • (2006) Mol Pharmacol , vol.69 , Issue.4 , pp. 1095-1102
    • Hosseinpour, F.1    Moore, R.2    Negishi, M.3    Sueyoshi, T.4
  • 114
    • 34347354365 scopus 로고    scopus 로고
    • Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: A role for the cytosolic AAA ATPase p97?
    • Faouzi S, Medzihradszky KF, Hefner C, et al. Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97? Biochemistry 2007;46(26):7793-7803
    • (2007) Biochemistry , vol.46 , Issue.26 , pp. 7793-7803
    • Faouzi, S.1    Medzihradszky, K.F.2    Hefner, C.3
  • 115
    • 59849092071 scopus 로고    scopus 로고
    • CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
    • Pabarcus MK, Hoe N, Sadeghi S, et al. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. Arch Biochem Biophys 2009;483(1):66-74
    • (2009) Arch Biochem Biophys , vol.483 , Issue.1 , pp. 66-74
    • Pabarcus, M.K.1    Hoe, N.2    Sadeghi, S.3
  • 116
    • 33750959438 scopus 로고    scopus 로고
    • Viral hijacking of cellular ubiquitination pathways as an anti-innate immunity strategy
    • DOI 10.1089/vim.2006.19.349
    • Chen M, Gerlier D. Viral hijacking of cellular ubiquitination pathways as an anti-innate immunity strategy. Viral Immunol 2005;19(3):349-362 (Pubitemid 44735049)
    • (2006) Viral Immunology , vol.19 , Issue.3 , pp. 349-362
    • Chen, M.1    Gerlier, D.2
  • 117
    • 66149114464 scopus 로고    scopus 로고
    • Identification of Integrin {alpha}3 as a New Substrate of the Adenovirus E4orf6/E1B55K E3 Ubiquitin Ligase Complex
    • Dallaire F, Blanchette P, Groitl P, et al. Identification of Integrin {alpha}3 as a New Substrate of the Adenovirus E4orf6/E1B55K E3 Ubiquitin Ligase Complex. J Virol 2009;83(11):5329-5338
    • (2009) J Virol , vol.83 , Issue.11 , pp. 5329-5338
    • Dallaire, F.1    Blanchette, P.2    Groitl, P.3
  • 118
    • 0020481215 scopus 로고
    • The role of the sugar regions of components of the cytochrome P-450-linked mixed-function oxidase (monooxygenase) system of bovine adrenocortical mitochondria
    • Ichikawa Y, Hiwatashi A. The role of the sugar regions of components of the cytochrome P-450-linked mixed-function oxidase (monooxygenase) system of bovine adrenocortical mitochondria. Biochim Biophys Acta 1982;705(1):82-91
    • (1982) Biochim Biophys Acta , vol.705 , Issue.1 , pp. 82-91
    • Ichikawa, Y.1    Hiwatashi, A.2
  • 119
    • 0021111664 scopus 로고
    • On the glycosylation state of five rat hepatic microsomal cytochrome P-450 isozymes
    • This describes the initial work on glycosylation of clinically relevant cytochrome P450 isoforms
    • Armstrong RN, Pinto-Coelho C, Ryan DE, et al. On the glycosylation state of five rat hepatic microsomal cytochrome P-450 isozymes. J Biol Chem 1983;258(4):2106-8 •• This describes the initial work on glycosylation of clinically relevant cytochrome P450 isoforms.
    • (1983) J Biol Chem , vol.258 , Issue.4 , pp. 2106-2108
    • Armstrong, R.N.1    Pinto-Coelho, C.2    De Ryan3
  • 120
    • 23444457486 scopus 로고
    • Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis
    • DOI 10.1210/me.7.12.1617
    • Amarneh B, Corbin CJ, Peterson JA, et al. Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis. Mol Endocrinol 1993;7(12):1617-1624 (Pubitemid 24034244)
    • (1993) Molecular Endocrinology , vol.7 , Issue.12 , pp. 1617-1624
    • Amarneh, B.1    Jo Corbin, C.2    Peterson, J.A.3    Simpson, E.R.4    Graham-Lorence, S.5
  • 121
    • 59349116159 scopus 로고    scopus 로고
    • The Polyomaviridae: Contributions of virus structure to our understanding of virus receptors and infectious entry
    • Neu U, Stehle T, Atwood WJ. The Polyomaviridae: Contributions of virus structure to our understanding of virus receptors and infectious entry. Virology 2009;384(2):389-399
    • (2009) Virology , vol.384 , Issue.2 , pp. 389-399
    • Neu, U.1    Stehle, T.2    Atwood, W.J.3
  • 122
    • 67449164628 scopus 로고    scopus 로고
    • Adenovirus receptors: Implications for tropism, treatment and targeting
    • Arnberg N. Adenovirus receptors: implications for tropism, treatment and targeting. Rev Med Virol 2009;19(3):165-178
    • (2009) Rev Med Virol , vol.19 , Issue.3 , pp. 165-178
    • Arnberg, N.1
  • 125
    • 34548238709 scopus 로고    scopus 로고
    • A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication
    • Netherton C, Moffat K, Brooks E, Wileman T. A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication. Adv Virus Res 2007;70:101-182
    • (2007) Adv Virus Res , vol.70 , pp. 101-182
    • Netherton, C.1    Moffat, K.2    Brooks, E.3    Wileman, T.4
  • 126
    • 70349397393 scopus 로고    scopus 로고
    • Human Immunodeficiency Virus Type I (HIV I) and Related Lentiviruses
    • Malden, MA: Blackwell Publishing
    • Wagner EK, Hewlett MJ, Bloon DC, Carmerini D. Human Immunodeficiency Virus Type I (HIV I) and Related Lentiviruses. Basic Virology. 3 edition. Malden, MA: Blackwell Publishing; 2008. p. 399-413
    • (2008) Basic Virology. 3 Edition , pp. 399-413
    • Wagner, E.K.1    Hewlett, M.J.2    Bloon, D.C.3    Carmerini, D.4
  • 127
    • 43049117085 scopus 로고    scopus 로고
    • Hepatitis B viruses: Reverse transcription a different way
    • Nassal M. Hepatitis B viruses: reverse transcription a different way. Virus Res 2008;134(1-2):235-249
    • (2008) Virus Res , vol.134 , Issue.1-2 , pp. 235-249
    • Nassal, M.1
  • 129
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • DOI 10.1126/science.1068883
    • Medzhitov R, Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science 2002;296(5566):298-300 (Pubitemid 34303673)
    • (2002) Science , vol.296 , Issue.5566 , pp. 298-300
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 130
    • 0037317763 scopus 로고    scopus 로고
    • Innate immune sensing and its roots: The story of endotoxin
    • DOI 10.1038/nri1004
    • Beutler B, Rietschel ET. Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 2003;3(2):169-176 (Pubitemid 37328694)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.2 , pp. 169-176
    • Beutler, B.1    Rietschel, E.T.2
  • 132
    • 23244437654 scopus 로고    scopus 로고
    • Innate immune responses to infection
    • Tosi MF. Innate immune responses to infection. J Allergy Clin Immunol 2005;116(2):241-249
    • (2005) J Allergy Clin Immunol , vol.116 , Issue.2 , pp. 241-249
    • Tosi, M.F.1
  • 133
    • 0035810399 scopus 로고    scopus 로고
    • Complement. First of two parts
    • Walport MJ. Complement. First of two parts. N Engl J Med 2001;344(14):1058-1066
    • (2001) N Engl J Med , vol.344 , Issue.14 , pp. 1058-1066
    • Walport, M.J.1
  • 134
    • 0002472842 scopus 로고    scopus 로고
    • Innate Immunity and Viral Infections
    • Kaufman SHE, Sher A, Ahmed R, editors, Washington, D.C.: ASM Press
    • Biron CA, Dalod M, Salazar-Mather TP. Innate Immunity and Viral Infections. In: Kaufman SHE, Sher A, Ahmed R, editors, Immunology of Infectious Diseases. Washington, D.C.: ASM Press;2002. p. 139-160
    • (2002) Immunology of Infectious Diseases , pp. 139-160
    • Biron, C.A.1    Dalod, M.2    Salazar-Mather, T.P.3
  • 135
    • 51349087106 scopus 로고    scopus 로고
    • Innate immune response to viral infection
    • Koyama S, Ishii KJ, Coban C, Akira S. Innate immune response to viral infection. Cytokine 2008;43(3):336-341
    • (2008) Cytokine , vol.43 , Issue.3 , pp. 336-341
    • Koyama, S.1    Ishii, K.J.2    Coban, C.3    Akira, S.4
  • 136
    • 33847131016 scopus 로고    scopus 로고
    • Virus trafficking - Learning from single-virus tracking
    • DOI 10.1038/nrmicro1615, PII NRMICRO1615
    • Brandenburg B, Zhuang X. Virus trafficking - learning from single-virus tracking. Nat Rev Microbiol 2007;5(3):197-208 (Pubitemid 46291279)
    • (2007) Nature Reviews Microbiology , vol.5 , Issue.3 , pp. 197-208
    • Brandenburg, B.1    Zhuang, X.2
  • 137
    • 34248672889 scopus 로고    scopus 로고
    • Antiviral signaling through pattern recognition receptors
    • Kawai T, Akira S. Antiviral signaling through pattern recognition receptors.J Biochem 2007;141(2):137-145
    • (2007) J Biochem , vol.141 , Issue.2 , pp. 137-145
    • Kawai, T.1    Akira, S.2
  • 138
    • 64049098693 scopus 로고    scopus 로고
    • Innate immune recognition of viruses and viral vectors
    • Huang X, Yang Y. Innate immune recognition of viruses and viral vectors. Hum Gene Ther 2009;20(4):293-301
    • (2009) Hum Gene Ther , vol.20 , Issue.4 , pp. 293-301
    • Huang, X.1    Yang, Y.2
  • 141
    • 22544455673 scopus 로고    scopus 로고
    • Cell type-specific involvement of RIG-I in antiviral response
    • Kato H, Sato S, Yoneyama M, etal. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005;23(1):19-28
    • (2005) Immunity , vol.23 , Issue.1 , pp. 19-28
    • Kato, H.1    Sato, S.2    Yoneyama, M.3
  • 142
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4(7):499-511
    • (2004) Nat Rev Immunol , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 143
    • 33645841633 scopus 로고    scopus 로고
    • IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9
    • Hoshino K, Sugiyama T, Matsumoto M, et al. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 2006;440(7086):949-953
    • (2006) Nature , vol.440 , Issue.7086 , pp. 949-953
    • Hoshino, K.1    Sugiyama, T.2    Matsumoto, M.3
  • 144
    • 34447505084 scopus 로고    scopus 로고
    • Toll-like receptors and Type I interferons
    • Uematsu S, Akira S. Toll-like receptors and Type I interferons. J Biol Chem 2007;282(21):15319-15323
    • (2007) J Biol Chem , vol.282 , Issue.21 , pp. 15319-15323
    • Uematsu, S.1    Akira, S.2
  • 145
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124(4):783-801
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 146
    • 27144440523 scopus 로고    scopus 로고
    • IPS-1, an adaptor triggering RIG-I- And Mda5-mediated type I interferon induction
    • Kawai T, Takahashi K, Sato S, etal. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005;6(10):981-988
    • (2005) Nat Immunol , vol.6 , Issue.10 , pp. 981-988
    • Kawai, T.1    Takahashi, K.2    Sato, S.3
  • 148
    • 33344475548 scopus 로고    scopus 로고
    • Hepatic and renal cytochrome P450 gene regulation during Citrobacter Rodentium infection in wild-type and toll-like receptor 4 mutant mice
    • DOI 10.1124/dmd.105.007393
    • Richardson TA, Sherman M, Antonovic L, et al. Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice. Drug Metab Dispos 2006;34(3):354-60 •• This is one of the first reports that ties changes in hepatic CYP expression during infection to a toll-like receptor signaling pathway. (Pubitemid 43290892)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.3 , pp. 354-360
    • Richardson, T.A.1    Sherman, M.2    Antonovic, L.3    Kardar, S.S.4    Strobel, H.W.5    Kalman, D.6    Morgan, E.T.7
  • 149
    • 57449087449 scopus 로고    scopus 로고
    • Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid
    • Ghose R, Guo T, Haque N. Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. Arch Biochem Biophys 2009;481(1):123-130
    • (2009) Arch Biochem Biophys , vol.481 , Issue.1 , pp. 123-130
    • Ghose, R.1    Guo, T.2    Haque, N.3
  • 150
    • 58249125116 scopus 로고    scopus 로고
    • TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease
    • This is one of the first reports that ties changes in hepatic CYP expression during infection to a toll-like receptor signaling pathway in a clinically relevant disease state
    • Chaluvadi MR, Nyagode BA, Kinloch RD, Morgan ET. TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically
    • (2009) Biochem Pharmacol , vol.77 , Issue.3 , pp. 464-471
    • Chaluvadi, M.R.1    Nyagode, B.A.2    Kinloch, R.D.3    Morgan, E.T.4
  • 151
    • 0037790710 scopus 로고    scopus 로고
    • Molecular basis of the inflammatory response to adenovirus vectors
    • DOI 10.1038/sj.gt.3302036
    • Liu Q, Muruve DA. Molecular basis of the inflammatory response to adenovirus vectors. Gene Ther 2003;10(11):935-940 (Pubitemid 36722427)
    • (2003) Gene Therapy , vol.10 , Issue.11 SPEC , pp. 935-940
    • Liu, Q.1    Muruve, D.A.2
  • 152
    • 0036202249 scopus 로고    scopus 로고
    • Adenovirus vector-induced inflammation: Capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B
    • DOI 10.1089/10430340252792503
    • Bowen GP, Borgland SL, Lam M, et al. Adenovirus vector-induced inflammation:capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B. Hum Gene Ther 2002;13(3):367-379 (Pubitemid 34251502)
    • (2002) Human Gene Therapy , vol.13 , Issue.3 , pp. 367-379
    • Bowen, G.P.1    Borgland, S.L.2    Lam, M.3    Libermann, T.A.4    Wong, N.C.W.5    Muruve, D.A.6
  • 153
    • 0031060168 scopus 로고    scopus 로고
    • Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression
    • Bruder JT, Kovesdi I. Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression. J Virol 1997;71(1):398-404 (Pubitemid 26412305)
    • (1997) Journal of Virology , vol.71 , Issue.1 , pp. 398-404
    • Bruder, J.T.1    Kovesdi, I.2
  • 154
    • 33750682048 scopus 로고    scopus 로고
    • Interaction of adenovirus type 5 fiber with the coxsackievirus and adenovirus receptor activates inflammatory response in human respiratory cells
    • DOI 10.1128/JVI.00721-06
    • Tamanini A, Nicolis E, Bonizzato A, et al. Interaction of adenovirus type5 fiber with the coxsackievirus and adenovirus receptor activates inflammatory response in human respiratory cells. J Virol 2006;80(22):11241- 11254 (Pubitemid 44706564)
    • (2006) Journal of Virology , vol.80 , Issue.22 , pp. 11241-11254
    • Tamanini, A.1    Nicolis, E.2    Bonizzato, A.3    Bezzerri, V.4    Melotti, P.5    Assael, B.M.6    Cabrini, G.7
  • 155
    • 0036145860 scopus 로고    scopus 로고
    • Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10
    • Tibbles LA, Spurrell JC, Bowen GP, et al. Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10. J Virol 2002;76(4):1559-1568
    • (2002) J Virol , vol.76 , Issue.4 , pp. 1559-1568
    • Tibbles, L.A.1    Spurrell, J.C.2    Bowen, G.P.3
  • 156
    • 0006186081 scopus 로고    scopus 로고
    • Acquired Immunity Against Viral Infections
    • Kaufman SHE, Sher A, Ahmed R, editor, Washington, D.C.: ASM Press
    • Szomolanyi-Tsuda E, Brehm MA, Welsh RM. Acquired Immunity Against Viral Infections. In: Kaufman SHE, Sher A, Ahmed R, editor, Immunology of Infectious Disease. Washington, D.C.: ASM Press; 2002. p. 247-265
    • (2002) Immunology of Infectious Disease , pp. 247-265
    • Szomolanyi-Tsuda, E.1    Brehm, M.A.2    Welsh, R.M.3
  • 157
    • 0035062597 scopus 로고    scopus 로고
    • Noncytolytic control of viral infections by the innate and adaptive immune response
    • DOI 10.1146/annurev.immunol.19.1.65
    • Guidotti LG, Chisari FV. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 2001;19:65-91 (Pubitemid 32368030)
    • (2001) Annual Review of Immunology , vol.19 , pp. 65-91
    • Guidotti, L.G.1    Chisari, F.V.2
  • 159
    • 0034454016 scopus 로고    scopus 로고
    • Determining the best animal model for human cytochrome P450 activities: A comparison of mouse, rat, rabbit, dog, micropig, monkey and man
    • DOI 10.1080/00498250010021684
    • Bogaards JJ, Bertrand M, Jackson P, et al. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 2000;30(12):1131-1152 (Pubitemid 32368013)
    • (2000) Xenobiotica , vol.30 , Issue.12 , pp. 1131-1152
    • Bogaards, J.J.P.1    Bertrand, M.2    Jackson, P.3    Oudshoorn, M.J.4    Weaver, R.J.5    Van Bladeren, P.J.6    Walther, B.7
  • 160
    • 33845473315 scopus 로고    scopus 로고
    • Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction
    • DOI 10.1517/17425255.2.6.875
    • Martignoni M, Groothuis GM, de Kanter R. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2006;2(6):875-94 •• Comprehensive review describing species differences with respect to CYP-mediated drug metabolism. (Pubitemid 44911538)
    • (2006) Expert Opinion on Drug Metabolism and Toxicology , vol.2 , Issue.6 , pp. 875-894
    • Martignoni, M.1    Groothuis, G.M.M.2    De Kanter, R.3
  • 161
    • 0030735150 scopus 로고    scopus 로고
    • Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species
    • Useful reference that compares species differences of cytochome P450 activity in the context of catalytic activity and selectivity
    • Guengerich FP. Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. Chem Biol Interact 1997;106(3):161-82 •• Useful reference that compares species differences of cytochome P450 activity in the context of catalytic activity and selectivity.
    • (1997) Chem Biol Interact , vol.106 , Issue.3 , pp. 161-182
    • Guengerich, F.P.1
  • 162
    • 43949122957 scopus 로고    scopus 로고
    • Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism
    • DOI 10.1038/clpt.2008.50, PII CLPT200850
    • Muruganandan S, Sinal CJ. Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism. Clin Pharmacol Ther 2008;83(6):818-28 •• Comprehensive review of mouse models currently used in drug metabolism research. (Pubitemid 351704925)
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.6 , pp. 818-828
    • Muruganandan, S.1    Sinal, C.J.2
  • 163
    • 35648976075 scopus 로고    scopus 로고
    • Induction of hepatic cytochrome P450 enzymes: Methods, mechanisms, recommendations, and invitro-invivo correlations
    • Hewitt NJ, Lecluyse EL, Ferguson SS. Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and invitro-invivo correlations. Xenobiotica 2007;37(10-11):1196-1224
    • (2007) Xenobiotica , vol.37 , Issue.10-11 , pp. 1196-1224
    • Hewitt, N.J.1    Lecluyse, E.L.2    Ferguson, S.S.3
  • 164
    • 0024564718 scopus 로고
    • The new mouse genetics: Altering the genome by gene targeting
    • Capecchi MR. The new mouse genetics: altering the genome by gene targeting. Trends Genet 1989;5(3):70-76
    • (1989) Trends Genet , vol.5 , Issue.3 , pp. 70-76
    • Capecchi, M.R.1
  • 166
    • 54349128898 scopus 로고    scopus 로고
    • Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment
    • Excellent summary of humanized mouse models for drug metabolism research
    • Cheung C, Gonzalez FJ. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. J Pharmacol Exp Ther 2008;327(2):288-99 •• Excellent summary of humanized mouse models for drug metabolism research.
    • (2008) J Pharmacol Exp Ther , vol.327 , Issue.2 , pp. 288-299
    • Cheung, C.1    Gonzalez, F.J.2
  • 167
    • 51349112400 scopus 로고    scopus 로고
    • A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
    • Scheer N, Ross J, Rode A, etal. A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest 2008;118(9):3228-3239
    • (2008) J Clin Invest , vol.118 , Issue.9 , pp. 3228-3239
    • Scheer, N.1    Ross, J.2    Rode, A.3
  • 168
    • 38749088304 scopus 로고    scopus 로고
    • Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice
    • Felmlee MA, Lon HK, Gonzalez FJ, Yu AM. Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug Metab Dispos 2008;36(2):435-441
    • (2008) Drug Metab Dispos , vol.36 , Issue.2 , pp. 435-441
    • Felmlee, M.A.1    Lon, H.K.2    Gonzalez, F.J.3    Yu, A.M.4
  • 169
    • 57349179929 scopus 로고    scopus 로고
    • A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4
    • Ma X, Cheung C, Krausz KW, etal. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug Metab Dispos 2008;36(12):2506-2512
    • (2008) Drug Metab Dispos , vol.36 , Issue.12 , pp. 2506-2512
    • Ma, X.1    Cheung, C.2    Krausz, K.W.3
  • 174
    • 53849093733 scopus 로고    scopus 로고
    • Current industrial practices in assessing CYP450 enzyme induction: Preclinical and clinical
    • Sinz M, Wallace G, Sahi J. Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical. AAPS J 2008;10(2):391-400
    • (2008) AAPS J , vol.10 , Issue.2 , pp. 391-400
    • Sinz, M.1    Wallace, G.2    Sahi, J.3
  • 175
  • 176
    • 33847018050 scopus 로고    scopus 로고
    • Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
    • Very complete review describing in vitro metabolism studies using primary hepatocytes
    • Hewitt NJ, Lechón MJ, Houston JB, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev 2007;39(1):159-234 •• Very complete review describing in vitro metabolism studies using primary hepatocytes.
    • (2007) Drug Metab Rev , vol.39 , Issue.1 , pp. 159-234
    • Hewitt, N.J.1    Lechón, M.J.2    Houston, J.B.3
  • 177
    • 34848828243 scopus 로고    scopus 로고
    • Broad but distinct role of pregnane X receptor on the expression of individual cytochrome p450s in human hepatocytes
    • Kojima K, Nagata K, Matsubara T, Yamazoe Y. Broad but distinct role of pregnane X receptor on the expression of individual cytochrome p450s in human hepatocytes. Drug Metab Pharmacokinet 2007;22(4):276-286
    • (2007) Drug Metab Pharmacokinet , vol.22 , Issue.4 , pp. 276-286
    • Kojima, K.1    Nagata, K.2    Matsubara, T.3    Yamazoe, Y.4
  • 179
    • 1842627852 scopus 로고    scopus 로고
    • Phase I and II enzyme characterization of two sources of HepG2 cell lines
    • DOI 10.1080/00498250310001657568
    • Hewitt NJ, Hewitt P. PhaseI and II enzyme characterization of two sources of HepG2 cell lines. Xenobiotica 2004;34(3):243-256 (Pubitemid 38478893)
    • (2004) Xenobiotica , vol.34 , Issue.3 , pp. 243-256
    • Hewitt, N.J.1    Hewitt, P.2
  • 180
    • 0036301269 scopus 로고    scopus 로고
    • Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: Molecular mechanisms that determine lower expression in cultured cells
    • DOI 10.1080/00498250210128675
    • Rodríguez-Antona C, Donato MT, Boobis A, et al. Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. Xenobiotica 2002;32(6):505-20 •• This is one of the first manuscripts that describes the disparity between the expression and function patterns of cytochrome P450 in cell culture with respect to that observed in vivo. (Pubitemid 34743622)
    • (2002) Xenobiotica , vol.32 , Issue.6 , pp. 505-520
    • Rodriguez-Antona, C.1    Donato, M.T.2    Boobis, A.3    Edwards, R.J.4    Watts, P.S.5    Castell, J.V.6    Gomez-Lechon, M.-J.7
  • 181
    • 15644384598 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line
    • DOI 10.1074/jbc.M412711200
    • Rencurel F, Stenhouse A, Hawley SA, et al. AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. J Biol Chem 2005;280(6):4367-4373 (Pubitemid 41741356)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.6 , pp. 4367-4373
    • Rencurel, F.1    Stenhouse, A.2    Hawley, S.A.3    Friedberg, T.4    Hardie, D.G.5    Sutherland, C.6    Wolf, C.R.7
  • 183
    • 34247517355 scopus 로고    scopus 로고
    • The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
    • Guillouzo A, Corlu A, Aninat C, etal. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 2007;168(1):66-73
    • (2007) Chem Biol Interact , vol.168 , Issue.1 , pp. 66-73
    • Guillouzo, A.1    Corlu, A.2    Aninat, C.3
  • 184
    • 66649089506 scopus 로고    scopus 로고
    • Evaluation of multiple invitro systems for assessment of CYP3A4 Induction in Drug Discovery: Human hepatocytes, PXR reporter gene, Fa2N-4 and HepaRG cells
    • [Epub ahead of print]
    • McGinnity DF, Zhang G, Kenny J, et al. Evaluation of multiple invitro systems for assessment of CYP3A4 Induction in Drug Discovery: human hepatocytes, PXR reporter gene, Fa2N-4 and HepaRG cells. Drug Metab Dispos 2009. [Epub ahead of print]
    • (2009) Drug Metab Dispos
    • McGinnity, D.F.1    Zhang, G.2    Kenny, J.3
  • 185
    • 33244490008 scopus 로고    scopus 로고
    • Generation of human hepatocytes by stem cell technology: Definition of the hepatocyte
    • Hengstler JG, Brulport M, Schormann W, et al. Generation of human hepatocytes by stem cell technology: definition of the hepatocyte. Expert Opin Drug Metab Toxicol 2005;1(1):61-74
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , Issue.1 , pp. 61-74
    • Hengstler, J.G.1    Brulport, M.2    Schormann, W.3
  • 188
    • 50049112412 scopus 로고    scopus 로고
    • Blood monocyte-derived neohepatocytes as invitro test system for drug metabolism
    • Ehnert S, Nussler AK, Lehmann A, Dooley S. Blood monocyte-derived neohepatocytes as invitro test system for drug metabolism. Drug Metab Dispos 2008;36(9):1922-1929
    • (2008) Drug Metab Dispos , vol.36 , Issue.9 , pp. 1922-1929
    • Ehnert, S.1    Nussler, A.K.2    Lehmann, A.3    Dooley, S.4
  • 189
    • 49649089503 scopus 로고    scopus 로고
    • Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism
    • Tuschl G, Lauer B, Mueller SO. Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism. Expert Opin Drug Metab Toxicol 2008;4(7):855-870
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.7 , pp. 855-870
    • Tuschl, G.1    Lauer, B.2    Mueller, S.O.3
  • 190
    • 34247505574 scopus 로고    scopus 로고
    • Human hepatocytes: Isolation, cryopreservation and applications in drug development
    • Li AP. Human hepatocytes: isolation, cryopreservation and applications in drug development. Chem Biol Interact 2007;168(1):16-29
    • (2007) Chem Biol Interact , vol.168 , Issue.1 , pp. 16-29
    • Li, A.P.1
  • 193
    • 84934443240 scopus 로고    scopus 로고
    • Invitro assays for induction of drug metabolism
    • Excellent review for the novice that is considering using cell culture models for mechanistic study of drug metabolism
    • Lake BG, Price RJ, Giddings AM, Walters DG. Invitro assays for induction of drug metabolism. Methods Mol Biol 2009;481:47-58 •• Excellent review for the novice that is considering using cell culture models for mechanistic study of drug metabolism.
    • (2009) Methods Mol Biol , vol.481 , pp. 47-58
    • Lake, B.G.1    Price, R.J.2    Giddings, A.M.3    Walters, D.G.4
  • 194
  • 195
    • 33645848942 scopus 로고    scopus 로고
    • Regulation of hepatocyte cell cycle progression and differentiation by type I collagen structure
    • Hansen LK, Wilhelm J, Fassett JT. Regulation of hepatocyte cell cycle progression and differentiation by type I collagen structure. Curr Top Dev Biol 2006;72:205-236
    • (2006) Curr Top Dev Biol , vol.72 , pp. 205-236
    • Hansen, L.K.1    Wilhelm, J.2    Fassett, J.T.3
  • 197
    • 0033047434 scopus 로고    scopus 로고
    • Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes
    • DOI 10.1016/S0014-2999(98)00988-1, PII S0014299998009881
    • Milosevic N, Schawalder H, Maier P. Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes. Eur J Pharmacol 1999;368:75-87 (Pubitemid 29106417)
    • (1999) European Journal of Pharmacology , vol.368 , Issue.1 , pp. 75-87
    • Milosevic, N.1    Schawalder, H.2    Maier, P.3
  • 198
    • 0022416353 scopus 로고
    • Preparation of pure hepatocytes and reticuloendothelial cells in high yield from a single rat liver by means of Percoll centrifugation and selective adherence
    • Smedsrod B, Pertoft H. Preparation of pure hepatocytes and reticuloendothelial cells in high yield from a single rat liver by means of Percoll centrifugation and selective adherence. J Leukoc Biol 1985;38(2):213-230 (Pubitemid 15243425)
    • (1985) Journal of Leukocyte Biology , vol.38 , Issue.2 , pp. 213-230
    • Smedsrod, B.1    Pertoft, H.2
  • 200
    • 32244447844 scopus 로고    scopus 로고
    • Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans
    • DOI 10.1007/s11095-005-8812-5
    • Persson KP, Ekehed S, Otter C, et al. Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs invivo in humans. Pharm Res 2006;23(1):56-69 (Pubitemid 43214661)
    • (2006) Pharmaceutical Research , vol.23 , Issue.1 , pp. 56-69
    • Persson, K.P.1    Ekehed, S.2    Otter, C.3    Lutz, E.S.M.4    McPheat, J.5    Masimirembwa, C.M.6    Andersson, T.B.7
  • 201
    • 67349105004 scopus 로고    scopus 로고
    • Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: A key role for the pregnane X receptor
    • Harmsen S, Meijerman I, Beijnen JH, Schellens JH. Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. Cancer Chemother Pharmacol 2009;64(1):35-43
    • (2009) Cancer Chemother Pharmacol , vol.64 , Issue.1 , pp. 35-43
    • Harmsen, S.1    Meijerman, I.2    Beijnen, J.H.3    Schellens, J.H.4
  • 202
    • 66649134127 scopus 로고    scopus 로고
    • Quantitative prediction of invivo profiles of CYP3A4 induction in humans from in vitro results with reporter gene assay
    • Kozawa M, Honma M, Suzuki H. Quantitative prediction of invivo profiles of CYP3A4 induction in humans from in vitro results with reporter gene assay. Drug Metab Dispos 2009;37(6):1234-1241
    • (2009) Drug Metab Dispos , vol.37 , Issue.6 , pp. 1234-1241
    • Kozawa, M.1    Honma, M.2    Suzuki, H.3
  • 203
  • 204
  • 205
    • 45449114994 scopus 로고    scopus 로고
    • Reprogrammed viruses as cancer therapeutics: Targeted, armed and shielded
    • DOI 10.1038/nrmicro1927, PII NRMICRO1927
    • Cattaneo R, Miest T, Shashkova EV, Barry MA. Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded. Nat Rev Microbiol 2008;6(7):529-540 (Pubitemid 351850977)
    • (2008) Nature Reviews Microbiology , vol.6 , Issue.7 , pp. 529-540
    • Cattaneo, R.1    Miest, T.2    Shashkova, E.V.3    Barry, M.A.4
  • 206
    • 0037362028 scopus 로고    scopus 로고
    • Viral infections in obstructive airway diseases
    • Seemungal TA, Wedzicha JA. Viral infections in obstructive airway diseases. Curr Opin Pulm Med 2003;9(2):111-116
    • (2003) Curr Opin Pulm Med , vol.9 , Issue.2 , pp. 111-116
    • Seemungal, T.A.1    Wedzicha, J.A.2
  • 207
    • 33746390422 scopus 로고    scopus 로고
    • Reactivation of viruses in solid organ transplant patients receiving cytomegalovirus prophylaxis
    • DOI 10.1097/01.tp.0000230432.39447.8b, PII 0000789020060727100004
    • Humar A. Reactivation of viruses in solid organ transplant patients receiving cytomegalovirus prophylaxis. Transplantation 2006;82(2S):S9-14 (Pubitemid 44126860)
    • (2006) Transplantation , vol.82 , Issue.SUPPL. 2
    • Humar, A.1
  • 208
    • 13244260822 scopus 로고    scopus 로고
    • Considerations for use of recombinant adenoviral vectors: Dose effect on hepatic cytochromes P450
    • DOI 10.1124/jpet.104.075374
    • Callahan SM, Ming X, Lu SK, et al. Considerations for use of recombinant adenoviral vectors: dose effect on hepatic cytochromes P450. J Pharmacol Exp Ther 2005;312(2):492-501 •• The first scientific paper describing a dose effect for a recombinant virus with respect to hepatic cytochrome P450 expression and function. (Pubitemid 40189545)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.2 , pp. 492-501
    • Callahan, S.M.1    Ming, X.2    Lu, S.K.3    Brunner, L.J.4    Croyle, M.A.5
  • 209
    • 53749084130 scopus 로고    scopus 로고
    • Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection
    • The first scientific paper that suggests that attenuation of the virus-induced immune response does not provide a similar change in drug metabolism patterns commonly seen during infection
    • Callahan SM, Wonganan P, Croyle MA. Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection. Virol J 2008;5:111 •• The first scientific paper that suggests that attenuation of the virus-induced immune response does not provide a similar change in drug metabolism patterns commonly seen during infection.
    • (2008) Virol J , vol.5 , pp. 111
    • Callahan, S.M.1    Wonganan, P.2    Croyle, M.A.3
  • 210
    • 0036412085 scopus 로고    scopus 로고
    • PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver
    • DOI 10.1089/104303402760372972
    • Croyle MA, Chirmule N, Zhang Y, Wilson JM. PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver. Hum Gene Ther 2002;13(15):1887-1900 (Pubitemid 35292683)
    • (2002) Human Gene Therapy , vol.13 , Issue.15 , pp. 1887-1900
    • Croyle, M.A.1    Chirmule, N.2    Zhang, Y.3    Wilson, J.M.4
  • 211
    • 0035033758 scopus 로고    scopus 로고
    • "Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung
    • DOI 10.1128/JVI.75.10.4792-4801.2001
    • Croyle MA, Chirmule N, Zhang Y, Wilson JM. "Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung. J Virol 2001;75(10):4792-4801 (Pubitemid 32381522)
    • (2001) Journal of Virology , vol.75 , Issue.10 , pp. 4792-4801
    • Croyle, M.A.1    Chirmule, N.2    Zhang, Y.3    Wilson, J.M.4
  • 212
    • 34848904829 scopus 로고    scopus 로고
    • Adenoviral vectors for gene therapy
    • Douglas JT. Adenoviral vectors for gene therapy. Mol Biotechnol 2007;36(1):71-80
    • (2007) Mol Biotechnol , vol.36 , Issue.1 , pp. 71-80
    • Douglas, J.T.1
  • 213
    • 33750981542 scopus 로고    scopus 로고
    • Renal pathophysiology after systemic administration of recombinant adenovirus: Changes in renal cytochromes P450 based on vector dose
    • The first scientific paper describing a dose effect for a recombinant virus with respect to renal cytochrome P450 expression and function
    • Le HT, Boquet MP, Clark EA, etal. Renal pathophysiology after systemic administration of recombinant adenovirus: changes in renal cytochromes P450 based on vector dose. Hum Gene Ther 2006;17(11):1095-111 •• The first scientific paper describing a dose effect for a recombinant virus with respect to renal cytochrome P450 expression and function.
    • (2006) Hum Gene Ther , vol.17 , Issue.11 , pp. 1095-1111
    • Le, H.T.1    Boquet, M.P.2    Clark, E.A.3
  • 214
    • 33744782825 scopus 로고    scopus 로고
    • Impact of transgene expression on drug metabolism following systemic adenoviral vector administration
    • DOI 10.1002/jgm.884
    • Callahan SM, Boquet MP, Ming X, et al. Impact of transgene expression on drug metabolism following systemic adenoviral vector administration. J Gene Med 2006;8(5):566-576 (Pubitemid 43827250)
    • (2006) Journal of Gene Medicine , vol.8 , Issue.5 , pp. 566-576
    • Callahan, S.M.1    Boquet, M.P.2    Ming, X.3    Brunner, L.J.4    Croyle, M.A.5
  • 215
    • 65049085743 scopus 로고    scopus 로고
    • Drug-virus interaction: Effect of administration of recombinant adenoviruses on the pharmacokinetics of docetaxel in a rat model
    • Wonganan P, Zamboni WC, Strychor S, et al. Drug-virus interaction: effect of administration of recombinant adenoviruses on the pharmacokinetics of docetaxel in a rat model. Cancer Gene Ther 2009;16(5):405-414
    • (2009) Cancer Gene Ther , vol.16 , Issue.5 , pp. 405-414
    • Wonganan, P.1    Zamboni, W.C.2    Strychor, S.3
  • 216
    • 0035868714 scopus 로고    scopus 로고
    • Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus
    • DOI 10.1093/emboj/20.6.1310
    • Suomalainen M, Nakano MY, Boucke K, et al. Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus. EMBO J 2001;20(6):1310-1319 (Pubitemid 32233971)
    • (2001) EMBO Journal , vol.20 , Issue.6 , pp. 1310-1319
    • Suomalainen, M.1    Nakano, M.Y.2    Boucke, K.3    Keller, S.4    Greber, U.F.5
  • 217
    • 0042668823 scopus 로고    scopus 로고
    • Adenovirus endocytosis
    • Meier O, Greber U. Adenovirus endocytosis. J Gene Med 2003;5(6):451-462
    • (2003) J Gene Med , vol.5 , Issue.6 , pp. 451-462
    • Meier, O.1    Greber, U.2
  • 219
    • 38949207486 scopus 로고    scopus 로고
    • Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications
    • DOI 10.1016/j.virusres.2007.10.005, PII S0168170207003668
    • Hartman ZC, Appledorn DM, Amalfitano A. Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. Virus Res 2008;132(1-2):1-14 (Pubitemid 351232078)
    • (2008) Virus Research , vol.132 , Issue.1-2 , pp. 1-14
    • Hartman, Z.C.1    Appledorn, D.M.2    Amalfitano, A.3
  • 220
    • 46749138342 scopus 로고    scopus 로고
    • Integrin-dependent phagocytosis - Spreading from microadhesion to new concepts
    • DOI 10.1242/jcs.018036
    • Dupuy AG, Caron E. Integrin-dependent phagocytosis: spreading from microadhesion to new concepts. J Cell Sci 2008;121(Pt 11):1173-1183 (Pubitemid 351943370)
    • (2008) Journal of Cell Science , vol.121 , Issue.11 , pp. 1773-1783
    • Dupuy, A.G.1    Caron, E.2
  • 221
    • 0036233715 scopus 로고    scopus 로고
    • Signalling in viral entry
    • Greber UF. Signalling in viral entry. Cell Mol Life Sci 2002;59(4):608-626
    • (2002) Cell Mol Life Sci , vol.59 , Issue.4 , pp. 608-626
    • Greber, U.F.1
  • 222
    • 61949195236 scopus 로고    scopus 로고
    • Integrins in immunity
    • Evans R, Patzak I, Svensson L, et al. Integrins in immunity. J Cell Sci 2009;122(Pt 2):212-225
    • (2009) J Cell Sci , vol.122 , Issue.PART 2 , pp. 212-225
    • Evans, R.1    Patzak, I.2    Svensson, L.3
  • 223
    • 33744783122 scopus 로고    scopus 로고
    • The hepatocyte integrin system and cell volume sensing
    • DOI 10.1111/j.1748-1716.2006.01542.x
    • Haüussinger D, Reinehr R, Schliess F. The hepatocyte integrin system and cell volume sensing. Acta Physiol 2006;187(1-2):249-255 (Pubitemid 43828783)
    • (2006) Acta Physiologica , vol.187 , Issue.1-2 , pp. 249-255
    • Häussinger, D.1    Reinehr, R.2    Schliess, F.3
  • 224
    • 65649146880 scopus 로고    scopus 로고
    • Integrin signalling at a glance
    • Harburger DS, Calderwood DA. Integrin signalling at a glance. J Cell Sci 2009;122(Pt 2):159-163
    • (2009) J Cell Sci , vol.122 , Issue.PART 2 , pp. 159-163
    • Harburger, D.S.1    Calderwood, D.A.2
  • 225
    • 62149091091 scopus 로고    scopus 로고
    • Signal co-operation between integrins and other receptor systems
    • Streuli CH, Akhtar N. Signal co-operation between integrins and other receptor systems. Biochem J 2009;418(3):491-506
    • (2009) Biochem J , vol.418 , Issue.3 , pp. 491-506
    • Streuli, C.H.1    Akhtar, N.2


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