Near completely humanized liver in mice shows human-type metabolic responses to drugs

American Journal of Pathology

Volumn 165, Issue 3, 2004, Pages 901-912

  Tateno, Chise ^a,b   Yoshizane, Yasumi ^a,b,c   Saito, Naomi ^b   Kataoka, Miho ^a,b   Utoh, Rie ^a   Yamasaki, Chihiro ^a,b   Tachibana, Asato ^a,c   Soeno, Yoshinori ^a,d   Asahina, Kinji ^b   Hino, Hiroshi ^b,f   Asahara, Toshimasa ^f   Yokoi, Tsuyoshi ^h   Furukawa, Toshinori ^g   Yoshizato, Katsutoshi ^a,b,e,i  

^a National Institute of Advanced Industrial Science and Technology   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c PhoenixBio USA Corporation

^d Chugai Technos Company Limited

^e HIROSHIMA UNIVERSITY   (Japan)

^f Grad School of Biomedical Sciences

^g HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^h KANAZAWA UNIVERSITY   (Japan)

ⁱ HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; GENOMIC DNA; HUMAN ALBUMIN; MESSENGER RNA; RIFAMPICIN; UROKINASE;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHILD; CHIMERA; COMPLEMENT FACTOR; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER CELL; LIVER FAILURE; LIVER METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; TRANSGENIC MOUSE;

EID: 4344574035     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63352-4     Document Type: Article

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