"Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung

Journal of Virology

Volumn 75, Issue 10, 2001, Pages 4792-4801

  Croyle, M A ^a   Chirmule, N ^a   Zhang, Y ^a   Wilson, J M ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; MACROGOL; NEUTRALIZING ANTIBODY; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOTOXIC T LYMPHOCYTE; GENE DELETION; GENE EXPRESSION; GENE THERAPY; HUMORAL IMMUNITY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; TRANSGENE; VIRUS CAPSID;

ADENOVIRUSES, HUMAN; ANIMALS; ANTIBODIES, VIRAL; ANTIBODY FORMATION; BETA-GALACTOSIDASE; CELL LINE; GENE EXPRESSION; GENES, REPORTER; GENETIC VECTORS; HUMANS; IMMUNITY, CELLULAR; IMMUNOCOMPETENCE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; LUNG; MICE; MICE, INBRED C57BL; POLYETHYLENE GLYCOLS; SUCCINIMIDES; SULFONES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035033758     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.10.4792-4801.2001     Document Type: Article

References (61)

1. Effect of the E4 region on the persistence of transgene expression from adenovirus vectors
2. Aerosol administration of a recombinant adenovirus expressing CFTR to cystic fibrosis patients: A phase I clinical trial
3. Adenovirus vectors for gene delivery
4. IgG antibody response to polyethylene glycol-modified adenosine deaminase in patients with adenosine deaminase deficiency
5. Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and reduce immunogenicity
6. Role of E4 in eliciting CD4 T-cell and B-cell responses to adenovirus vectors delivered to murine and nonhuman primate lungs
7. Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with a non-depleting CD4 antibody
8. Development of a rapid method for the PEGylation of adenoviruses with enhanced transduction and improved stability under harsh storage conditions
9. Classification of chemical allergens according to cytokine secretion profiles of murine lymph node cells
10. Coupling of poly (ethylene glycol) to albumin under very mild conditions by activation with tresyl chloride: Characterization of the conjugate by partitioning in aqueous two-phase systems
11. Chemical modification of enzymes for enhanced functionality
12. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a
13. Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis
14. PEGylation of cytokines and other therapeutic proteins and peptides: The importance of biological optimisation of coupling techniques
15. A new technique for the assay of infectivity of human adenovirus 5 DNA
16. In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes
17. Enzyme replacement therapy of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase (PEGADA)
18. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression
19. Biomedical and biotechnological applications of PEG- and PM-modified proteins
20. Synthesis, isolation, and characterization of conjugates of ovalbumin with monomethoxypolyethylene glycol using cyanuric chloride as the coupling agent
21. Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver
22. Blunting of immune responses to adenoviral vectors in mouse liver and lung with CTLA4Ig
23. Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung
24. Circumventing the immune response to adenovirus-mediated gene therapy
25. Transient immunomodulation with anti-CD40 ligans antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver
26. Characterization of a polyethylene glycol conjugate of recombinant human interferon-gamma
27. Safety of airway gene transfer with Ad2/CFTR2: Aerosol administration in the nonhuman primate
28. Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector
29. High doses of a helper-dependent adenoviral vector yield supra-physiological levels of alphal-antitrypsin with negligible toxicity
30. Stealth cells: Prevention of major histocompatibility complex class II-mediated T-cell activation by cell surface modification
31. Gene transfer into the liver of non-human primates with E1-deleted recombinant adenoviral vectors: Safety of readministration
32. PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo
33. Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses
34. Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors
35. Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration
36. Is DNA destiny? A cure for cystic fibrosis
37. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
38. Tolerogenic capacity of poly(ethylene glycol) (PEG)-modified ovalbumins in relation to their immunoreactivity towards anti-ovalbumin antibody
39. Antibody to CD40 ligand inhibits both humoral and cellular immune responses to adenoviral vectors and facilitates repeated administration to mouse airway
40. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
41. Cellular camouflage: Fooling the immune system with polymers
42. Carl Prausnitz Memorial Lecture: Suppression of antibody responses by chemically modified antigens
43. Reduced immunogenicity of monomethoxypolyethylene glycol-modified lysozyme for activation of T cells
44. The molecular weight ratio of monomethoxypolyethylene glycol (mPEG) to protein determines the immunotolerogenicity of mPEG proteins
45. Effects of macrophage depletion and anti-CD40 ligand on transgene expression and redosing with recombinant adenovirus
46. Gene therapy for malignant pleural mesothelioma
47. Viral vectors for gene delivery and gene therapy within the endocrine system
48. Studies on antigenicity of the polyethylene glycol (PEG)-modified uricase
49. Surface modification of proteins: Activation of monomethoxy-polyethylene glycols by phenylchloroformates and modification of ribonuclease and superoxide dismutase
50. 5 promote adenovirus internalization but not virus attachment
51. Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration
52. Adenoviruses as gene-delivery vehicles
53. Immune responses to adenoviruses: Viral evasion mechanisms and their implications for the clinic
54. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vino
55. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
56. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
57. An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer
58. Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues
59. Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs
60. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung
61. A phase I study of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator gene to a lung segment of individuals with cystic fibrosis