Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells

Journal of Biological Chemistry

Volumn 283, Issue 45, 2008, Pages 30650-30657

  Lin, Wenwei ^a   Wu, Jing ^a   Dong, Hanqing ^a   Bouck, David ^a   Zeng, Fu Yue ^a   Chen, Taosheng ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOCHEMISTRY; CATALYSTS; CHEMICAL REACTIONS; DNA SEQUENCES; ENZYMES; GENE EXPRESSION; LIVER; METABOLISM; PHOSPHORYLATION; PROTEINS; TRANSCRIPTION FACTORS;

CARCINOMA CELLS; CELL CYCLES; CELLULAR SIGNALING PATHWAYS; DRUG METABOLISMS; HEPATOCYTES; HUMAN LIVERS; IN VITRO KINASE ASSAYS; LIVER DEVELOPMENTS; LUCIFERASE REPORTERS; NUCLEAR RECEPTORS; PHOSPHORYLATION SITES; ROSCOVITINE; S-PHASE; SMALL MOLECULES;

ANIMAL CELL CULTURE;

CELL NUCLEUS RECEPTOR; CYCLIN DEPENDENT KINASE 2; CYTOCHROME P450 3A4; KENPAULLONE; PREGNANE X RECEPTOR; ROSCOVITINE;

ARTICLE; CANCER CELL; CELL CYCLE; CYP3A4 GENE; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME INHIBITION; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; LIVER CARCINOMA; LIVER CELL CULTURE; LIVER DEVELOPMENT; LIVER REGENERATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

BENZAZEPINES; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 2; CYTOCHROME P-450 CYP3A; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; HUMANS; INDOLES; LIVER NEOPLASMS; MUTATION; PHOSPHORYLATION; RECEPTORS, STEROID; REGENERATION; SIGNAL TRANSDUCTION;

EID: 57649198455     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806132200     Document Type: Article

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