SCOPUS 정보 검색 플랫폼

Metal Ions in Life Sciences

Volumn 3, Issue , 2007, Pages 561-589

Drug metabolism as catalyzed by human cytochrome P450 systems

(1) Guengerich, F Peter a

a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80053313530 PISSN: 15590836 EISSN: None Source Type: Book Series
DOI: 10.1002/9780470028155.ch16 Document Type: Article

Times cited : (6)

References (147)

1
- 0004946256
- F. P. Guengerich, ed., Elsevier Science, Oxford
- F. P. Guengerich, in Biotransformation Vol. 3 Comprehensive Toxicology, (F. P. Guengerich, ed.), Elsevier Science, Oxford, 1997, pp. 1-6.
- (1997) Biotransformation Vol. 3 Comprehensive Toxicology , pp. 1-6
- Guengerich, F.P.¹

2
- 0004260431
- John Wiley & Sons, Inc. New York
- R. T. Williams, Detoxication Mechanisms, John Wiley & Sons, Inc., New York, 1947.
- (1947) Detoxication Mechanisms
- Williams, R.T.¹

3
- 0004260431
- John Wiley & Sons, Inc., New York
- R. T. Williams, Detoxication Mechanisms, John Wiley & Sons, Inc., New York, 1959.
- (1959) Detoxication Mechanisms
- Williams, R.T.¹

4
- 34250951164
- Naunyn-schmiedeberg's arch
- H. Remmer, Naunyn-Schmiedeberg's Arch. Exp. Pathol Pharmakol., 237, 296-307 (1957).
- (1957) Exp. Pathol Pharmakol. , vol.237 , pp. 296-307
- Remmer, H.¹

5
- 84930288145
- A. H. Conney, E. C. Miller, and J. A. Miller, Cancer Res., 16, 450-459 (1956).
- (1956) Cancer Res. , vol.16 , pp. 450-459
- Conney, A.H.¹ Miller, E.C.² Miller, J.A.³

6
- 0001477544
- G. C. Mueller and J. A. Miller, J. Biol. Chem., 202, 579-587 (1953).
- (1953) J. Biol. Chem. , vol.202 , pp. 579-587
- Mueller, G.C.¹ Miller, J.A.²

7
- 0000759380
- B. B. Brodie, J. R. Gillette, and B. N. La Du, Annu. Rev. Biochem., 27, 427-454 (1958).
- (1958) Annu. Rev. Biochem. , vol.27 , pp. 427-454
- Brodie, B.B.¹ Gillette, J.R.² La Du, B.N.³

8
- 0042484474
- W. B. Saunders, Philadelphia
- W. Kalow, Pharmacogenetics, W. B. Saunders, Philadelphia, 1962.
- (1962) Pharmacogenetics
- Kalow, W.¹

9
- 0014429295
- A. Y. H. Lu and M. J. Coon, J. Biol. Chem., 243, 1331-1332 (1968).
- (1968) J. Biol. Chem. , vol.243 , pp. 1331-1332
- Lu, A.Y.H.¹ Coon, M.J.²

10
- 0018877218
- P. Wang, P. S. Mason, and F. P. Guengerich, Arch. Biochem. Biophys., 199, 206-219 (1980).
- (1980) Arch. Biochem. Biophys. , vol.199 , pp. 206-219
- Wang, P.¹ Mason, P.S.² Guengerich, F.P.³

11
- 0001786847
- F. P. Guengerich, ed., CRC Press, Boca Raton, Florida
- L. M. Distlerath and F. P. Guengerich, in Mammalian Cytochromes P-450, Vol. 1 (F. P. Guengerich, ed.), CRC Press, Boca Raton, Florida, 1987, pp. 133- 198.
- (1987) Mammalian Cytochromes P-450 , vol.1 , pp. 133-198
- Distlerath, L.M.¹ Guengerich, F.P.²

12
- 0024236331
- F. J. Gonzalez, Pharmacol. Rev., 40, 243-288 (1989).
- (1989) Pharmacol. Rev. , vol.40 , pp. 243-288
- Gonzalez, F.J.¹

13
- 17044392310
- F. P. Guengerich, Int. J. Toxicol., 24, 5-21 (2005).
- (2005) Int. J. Toxicol. , vol.24 , pp. 5-21
- Guengerich, F.P.¹

14
- 0015712923
- D. W. Nebert, J. K. Heidema, H. W. Strobe, and M. J. Coon, J. Biol. Chem., 248, 7631-7636 (1973).
- (1973) J. Biol. Chem. , vol.248 , pp. 7631-7636
- Nebert, D.W.¹ Heidema, J.K.² Strobe, H.W.³ Coon, M.J.⁴

15
- 0037225752
- F. J. Gonzalez and S. Kimura, Arch. Biochem. Biophys., 409, 153-158 (2003).
- (2003) Arch. Biochem. Biophys. , vol.409 , pp. 153-158
- Gonzalez, F.J.¹ Kimura, S.²

16
- 1942497956
- F. P. Guengerich, Mol. Interventions, 3, 194-204 (2003).
- (2003) Mol. Interventions , vol.3 , pp. 194-204
- Guengerich, F.P.¹

17
- 18944401259
- D. C. Liebler and F. P. Guengerich, Nature Rev. Drug Discov., 4, 410-420 (2005).
- (2005) Nature Rev. Drug Discov. , vol.4 , pp. 410-420
- Liebler, D.C.¹ Guengerich, F.P.²

18
- 0027468346
- P. K. Honig, D. C. Wortham, K. Zamani, D. P. Conner, J. C. Mullin, and L. R. Cantilena, J. Am. Med. Assoc., 269, 1513-1518 (1993).
- (1993) J. Am. Med. Assoc. , vol.269 , pp. 1513-1518
- Honig, P.K.¹ Wortham, D.C.² Zamani, K.³ Conner, D.P.⁴ Mullin, J.C.⁵ Cantilena, L.R.⁶

19
- 0027168405
- C.-H. Yun, R. A. Okerholm, and F. P. Guengerich, Drug Metab. Dispos., 21, 403-409 (1993).
- (1993) Drug Metab. Dispos. , vol.21 , pp. 403-409
- Yun, C.-H.¹ Okerholm, R.A.² Guengerich, F.P.³

20
- 0025992864
- F. P. Guengerich and T. Shimada, Chem. Res. Toxicol., 4, 391-407 (1991).
- (1991) Chem. Res. Toxicol. , vol.4 , pp. 391-407
- Guengerich, F.P.¹ Shimada, T.²

21
- 14844363304
- P. R. Ortiz de Montellano, ed., 3rd edn, Kluwer Academic/Plenum Press, New York
- F. P. Guengerich, in Cytochrome P450: Structure, Mechanism, & Biochemistry (P. R. Ortiz de Montellano, ed.), 3rd edn, Kluwer Academic/Plenum Press, New York, 2005, pp. 377-530.
- (2005) Cytochrome P450: Structure, Mechanism, & Biochemistry , pp. 377-530
- Guengerich, F.P.¹

22
- 0022357068
- M. D. Burke, S. Thompson, C. R. Elcombe, J. Halpert, T. Haaparanta, and R. T. Mayer, Biochem. Pharmacol., 34, 3337-3345 (1985).
- (1985) Biochem. Pharmacol. , vol.34 , pp. 3337-3345
- Burke, M.D.¹ Thompson, S.² Elcombe, C.R.³ Halpert, J.⁴ Haaparanta, T.⁵ Mayer, R.T.⁶

23
- 0031570357
- C. L. Crespi, V. P. Miller, and B. W. Penman, Anal. Biochem., 248, 188-190 (1997).
- (1997) Anal. Biochem. , vol.248 , pp. 188-190
- Crespi, C.L.¹ Miller, V.P.² Penman, B.W.³

24
- 0027193265
- A. K. Daly, S. Cholerton, W. Gregory, and J. R. Idle, Pharmacol. Therapeut., 57, 129-160(1993).
- (1993) Pharmacol. Therapeut. , vol.57 , pp. 129-160
- Daly, A.K.¹ Cholerton, S.² Gregory, W.³ Idle, J.R.⁴

25
- 0031884233
- E. U. Griese, U. M. Zanger, U. Brudermanns, A. Gaedigk, G. Mikus, K. Morike, T. Stuven, and M. Eichelbaum, Pharmacogenetics, 8, 15-26 (1998).
- (1998) Pharmacogenetics , vol.8 , pp. 15-26
- Griese, E.U.¹ Zanger, U.M.² Brudermanns, U.³ Gaedigk, A.⁴ Mikus, G.⁵ Morike, K.⁶ Stuven, T.⁷ Eichelbaum, M.⁸

26
- 0030904031
- J. A. Goldstein, T. Ishizaki, K. Chiba, S. M. F. de Morais, D. Bell, P. M. Krahn, and D. A. P. Evans, Pharmacogenetics, 7, 59-64 (1997).
- (1997) Pharmacogenetics , vol.7 , pp. 59-64
- Goldstein, J.A.¹ Ishizaki, T.² Chiba, K.³ Morais, S.M.F.D.⁴ Bell, D.⁵ Krahn, P.M.⁶ Evans, D.A.P.⁷

27
- 0028590127
- J. A. Goldstein and S. M. F. Demorais, Pharmacogenetics, 4, 285-299 (1994).
- (1994) Pharmacogenetics , vol.4 , pp. 285-299
- Goldstein, J.A.¹ Demorais, S.M.F.²

28
- 0034921210
- L. J. Dickmann, A. E. Rettie, M. B. Kneller, R. B. Kim, A. J. Wood, C. M. Stein, G. R. Wilkinson, and U. I. Schwarz, Mol. Pharmacol., 60, 382-387 (2001).
- (2001) Mol. Pharmacol. , vol.60 , pp. 382-387
- Dickmann, L.J.¹ Rettie, A.E.² Kneller, M.B.³ Kim, R.B.⁴ Wood, A.J.⁵ Stein, C.M.⁶ Wilkinson, G.R.⁷ Schwarz, U.I.⁸

29
- 33645911192
- Z. Jiang, N. Dragin, L. F. Jorge-Nebert, M. V. Martin, F. P. Guengerich, E. Aklillu, M. Ingelman-Sundberg, G. J. Hammons, B. D. Lyn-Cook, F. F. Kadlubar, S. N. Saldana, M. Sorter, A. A. Vinks, N. Nassr, O.von Richter, L. Jin, and D. W. Nebert, Pharmacogenetics Genomics, 16, 359-367 (2006).
- (2006) Pharmacogenetics Genomics , vol.16 , pp. 359-367
- Jiang, Z.¹ Dragin, N.² Jorge-Nebert, L.F.³ Martin, M.V.⁴ Guengerich, F.P.⁵ Aklillu, E.⁶ Ingelman-Sundberg, M.⁷ Hammons, G.J.⁸ Lyn-Cook, B.D.⁹ Kadlubar, F.F.¹⁰ Saldana, S.N.¹¹ Sorter, M.¹² Vinks, A.A.¹³ Nassr, N.¹⁴ Richter, O.Von.¹⁵ Jin, L.¹⁶ Nebert, D.W.¹⁷

30
- 0037131879
- J. K. Lamba, Y. S. Lin, E. G. Schuetz, and K. E. Thummel, Adv. Drug Deliv. Rev., 54, 1271-1294(2002).
- (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1271-1294
- Lamba, J.K.¹ Lin, Y.S.² Schuetz, E.G.³ Thummel, K.E.⁴

31
- 0037155271
- A. L. Shen, K. A. O'Leary, and C. B. Kasper, J. Biol. Chem., 277, 6536- 6541 (2002).
- (2002) J. Biol. Chem. , vol.277 , pp. 6536-6541
- Shen, A.L.¹ O'Leary, K.A.² Kasper, C.B.³

32
- 0037790603
- C. J. Henderson, D. M. Otto, D. Carrie, M. A. McGnuson, A. W. McLaren, I. Rosewell, and C. R. Wolf, J. Biol. Chem., 278, 13480-13486 (2003).
- (2003) J. Biol. Chem. , vol.278 , pp. 13480-13486
- Henderson, C.J.¹ Otto, D.M.² Carrie, D.³ McGnuson, M.A.⁴ McLaren, A.W.⁵ Rosewell, I.⁶ Wolf, C.R.⁷

33
- 0038507099
- J. Gu, Y. Weng, Q. Y. Zhang, H. Cui, M. Behr, L. Wu, W. Yang, L. Zhang, and X. Ding, J. Biol. Chem., 278, 25895-25901 (2003).
- (2003) J. Biol. Chem. , vol.278 , pp. 25895-25901
- Gu, J.¹ Weng, Y.² Zhang, Q.Y.³ Cui, H.⁴ Behr, M.⁵ Wu, L.⁶ Yang, W.⁷ Zhang, L.⁸ Ding, X.⁹

34
- 19944426178
- L. Wu, J. Gu, H. Cui, Q. Y. Zhang, M. Behr, C. Fang, Y. Weng, K. Kluetzman, P. J. Swiatek, W. Yang, L. Kaminsky, and X. Ding, J. Pharmacol. Exp. Ther., 312, 35-43 (2005).
- (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 35-43
- Wu, L.¹ Gu, J.² Cui, H.³ Zhang, Q.Y.⁴ Behr, M.⁵ Fang, C.⁶ Weng, Y.⁷ Kluetzman, K.⁸ Swiatek, P.J.⁹ Yang, W.¹⁰ Kaminsky, L.¹¹ Ding, X.¹²

35
- 24744466284
- Y. Weng, C. C. Di Russo, A. A. Reilly, P. N. Black, and X. Ding, J. Biol. Chem., 280, 31686-31698 (2005).
- (2005) J. Biol. Chem. , vol.280 , pp. 31686-31698
- Weng, Y.¹ Di Russo, C.C.² Reilly, A.A.³ Black, P.N.⁴ Ding, X.⁵

36
- 0028343838
- C. L. Meschter, B. A. Mico, M. Mortillo, D. Feldman, W. A. Garland, J. A. Riley, and L. S. Kaufman, Fund. Appl. Toxicol, 22, 369-381 (1994).
- (1994) Fund. Appl. Toxicol , vol.22 , pp. 369-381
- Meschter, C.L.¹ Mico, B.A.² Mortillo, M.³ Feldman, D.⁴ Garland, W.A.⁵ Riley, J.A.⁶ Kaufman, L.S.⁷

37
- 2642544107
- A. Galijatovic, D. Beaton, N. Nguyen, S. Chen, J. Bonzo, R. Johnson, S. Maeda, M. Karin, F. P. Guengerich, and R. H. Tukey, J. Biol. Chem., 279, 23969- 23976 (2004).
- (2004) J. Biol. Chem. , vol.279 , pp. 23969-23976
- Galijatovic, A.¹ Beaton, D.² Nguyen, N.³ Chen, S.⁴ Bonzo, J.⁵ Johnson, R.⁶ Maeda, S.⁷ Karin, M.⁸ Guengerich, F.P.⁹ Tukey, R.H.¹⁰

38
- 22144438011
- A. M. Yu, K. Fukamachi, K. W. Krausz, C. Cheung, and F. J. Gonzalez, Endocrinology, 146, 2911-2919 (2005).
- (2005) Endocrinology , vol.146 , pp. 2911-2919
- Yu, A.M.¹ Fukamachi, K.² Krausz, K.W.³ Cheung, C.⁴ Gonzalez, F.J.⁵

39
- 14044254162
- C. Cheung, A. M. Yu, J. M. Ward, K. W. Krausz, T. E. Akiyama, L. Feigenbaum, and F. J. Gonzalez, Drug Metah. Dispos., 33, 449-457 (2005).
- (2005) Drug Metah. Dispos. , vol.33 , pp. 449-457
- Cheung, C.¹ Yu, A.M.² Ward, J.M.³ Krausz, K.W.⁴ Akiyama, T.E.⁵ Feigenbaum, L.⁶ Gonzalez, F.J.⁷

40
- 27544495165
- F. P. Guengerich, Z.-L. Wu, and C. J. Bartleson, Biochem. Biophys. Res. Commun., 338, 465-469 (2005).
- (2005) Biochem. Biophys. Res. Commun. , vol.338 , pp. 465-469
- Guengerich, F.P.¹ Wu, Z.-L.² Bartleson, C.J.³

41
- 0037068964
- D. W. Nebert and D. W. Russell, Lancet, 360, 1155-1162 (2002).
- (2002) Lancet , vol.360 , pp. 1155-1162
- Nebert, D.W.¹ Russell, D.W.²

42
- 0018751330
- J. R. Idle and R. L. Smith, Drug Metab. Rev., 9, 301-317 (1979).
- (1979) Drug Metab. Rev. , vol.9 , pp. 301-317
- Idle, J.R.¹ Smith, R.L.²

43
- 84892335196
- P. R. Ortiz de Montellano, ed., 3rd edn., Kluwer Academic/Plenum Press, New York
- J. H. Capdevila, V. R. Holla, and J. R. Falck, in Cytochrome P450: Structure, Mechanism, and Biochemistry (P. R. Ortiz de Montellano, ed.), 3rd edn., Kluwer Academic/Plenum Press, New York, 2005, pp. 531-551.
- (2005) Cytochrome P450: Structure, Mechanism, and Biochemistry , pp. 531-551
- Capdevila, J.H.¹ Holla, V.R.² Falck, J.R.³

44
- 6944221357
- J. A. Williams, R. Hyland, B. C. Jones, D. A. Smith, S. Hurst, T. C. Goosen, V. Peterkin, J. R. Koup, and S. E. Ball, Drug Metab. Dispos., 32, 1201- 1208 (2004).
- (2004) Drug Metab. Dispos. , vol.32 , pp. 1201-1208
- Williams, J.A.¹ Hyland, R.² Jones, B.C.³ Smith, D.A.⁴ Hurst, S.⁵ Goosen, T.C.⁶ Peterkin, V.⁷ Koup, J.R.⁸ Ball, S.E.⁹

45
- 27644596457
- L. C. Wienkers and T. G. Heath, Nature Rev. Drug Discov., 4, 825-833 (2005).
- (2005) Nature Rev. Drug Discov. , vol.4 , pp. 825-833
- Wienkers, L.C.¹ Heath, T.G.²

46
- 6944221357
- J. A. Williams, R. Hyland, B. C. Jones, D. A. Smith, S. Hurst, T. C. Goosen, V. Peterkin, J. R. Koup, and S. E. Ball, Drug Metab. Dispos., 32, 1201-1208 (2004).
- (2004) Drug Metab. Dispos. , vol.32 , pp. 1201-1208
- Williams, J.A.¹ Hyland, R.² Jones, B.C.³ Smith, D.A.⁴ Hurst, S.⁵ Goosen, T.C.⁶ Peterkin, V.⁷ Koup, J.R.⁸ Ball, S.E.⁹

47
- 0036786382
- I. Koch, R. Weil, R. Wolbold, J. Brockmoller, E. Hustert, O. Burk, A. Nuessler, P. Neuhaus, M. Eichelbaum, U. Zanger, and L. Wojnowski, Drug Metab. Dispos., 30, 1108-1114 (2002).
- (2002) Drug Metab. Dispos. , vol.30 , pp. 1108-1114
- Koch, I.¹ Weil, R.² Wolbold, R.³ Brockmoller, J.⁴ Hustert, E.⁵ Burk, O.⁶ Nuessler, A.⁷ Neuhaus, P.⁸ Eichelbaum, M.⁹ Zanger, U.¹⁰ Wojnowski, L.¹¹

48
- 9444228347
- W. Huang, Y. S. Lin, D. J. McConn 2nd, J. C. Calamia, R. A. Totah, N. Isoherranen, M. Glodowski, and K. E. Thummel, Drug Metab. Dispos., 32, 1434- 1445 (2004).
- (2004) Drug Metab. Dispos. , vol.32 , pp. 1434-1445
- Huang, W.¹ Lin, Y.S.² McConn II, D.J.³ Calamia, J.C.⁴ Totah, R.A.⁵ Isoherranen, N.⁶ Glodowski, M.⁷ Thummel, K.E.⁸

49
- 0036223831
- S. Rendic, Drug Metab. Rev., 34, 83-148 (2002).
- (2002) Drug Metab. Rev. , vol.34 , pp. 83-148
- Rendic, S.¹

50
- 0022263133
- L. M. Distlerath, P. E. B. Reilly, M. V. Martin, G. G. Davis, G. R. Wilkinson, and F. P. Guengerich, J. Biol Chem., 260, 9057-9067 (1985).
- (1985) J. Biol Chem. , vol.260 , pp. 9057-9067
- Distlerath, L.M.¹ Reilly, P.E.B.² Martin, M.V.³ Davis, G.G.⁴ Wilkinson, G.R.⁵ Guengerich, F.P.⁶

51
- 0028318179
- L. C. Quattrochi, T. Vu, and R. H. Tukey, J. Biol. Chem., 269, 6949-6954 (1994).
- (1994) J. Biol. Chem. , vol.269 , pp. 6949-6954
- Quattrochi, L.C.¹ Vu, T.² Tukey, R.H.³

52
- 0015983638
- E. J. Pantuck, K.-C. Hsiao, A. McGgio, K. Nakamura, R. Kuntzman, and A. H. Conney, Clin. Pharmacol. Ther., 15, 9-17 (1974).
- (1974) Clin. Pharmacol. Ther. , vol.15 , pp. 9-17
- Pantuck, E.J.¹ Hsiao, K.-C.² McGgio, A.³ Nakamura, K.⁴ Kuntzman, R.⁵ Conney, A.H.⁶

53
- 0024362285
- L. C. Quattrochi and R. H. Tukey, Mol. Pharmacol, 36, 66-71 (1989).
- (1989) Mol. Pharmacol , vol.36 , pp. 66-71
- Quattrochi, L.C.¹ Tukey, R.H.²

54
- 0024343858
- M. A. Butler, M. Iwasaki, F. P. Guengerich, and F. F. Kadlubar, Proc. Natl. Acad. Sci. USA, 86, 7696-7700 (1989).
- (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7696-7700
- Butler, M.A.¹ Iwasaki, M.² Guengerich, F.P.³ Kadlubar, F.F.⁴

55
- 0026879487
- M. A. Butler, N. P. Lang, J. F. Young, N. E. Caporaso, P. Vineis, R. B. Hayes, H. Teitel, J. P. Massengill, M. F. Lawsen, and F. F. Kadlubar, Pharmacogenetics, 2, 116-127 (1992).
- (1992) Pharmacogenetics , vol.2 , pp. 116-127
- Butler, M.A.¹ Lang, N.P.² Young, J.F.³ Caporaso, N.E.⁴ Vineis, P.⁵ Hayes, R.B.⁶ Teitel, H.⁷ Massengill, J.P.⁸ Lawsen, M.F.⁹ Kadlubar, F.F.¹⁰

56
- 0033608962
- A. Parikh, P. D. Josephy, and F. P. Guengerich, Biochemistry, 38, 5283-5289 (1999).
- (1999) Biochemistry , vol.38 , pp. 5283-5289
- Parikh, A.¹ Josephy, P.D.² Guengerich, F.P.³

57
- 0346690115
- H. Zhou, P. D. Josephy, D. Kim, and F. P. Guengerich, Arch. Biochem. Biophys., 422, 23-30 (2004).
- (2004) Arch. Biochem. Biophys. , vol.422 , pp. 23-30
- Zhou, H.¹ Josephy, P.D.² Kim, D.³ Guengerich, F.P.⁴

58
- 0942301388
- D. Kim and F. P. Guengerich, Biochemistry, 43, 981-988 (2004).
- (2004) Biochemistry , vol.43 , pp. 981-988
- Kim, D.¹ Guengerich, F.P.²

59
- 0032722410
- D. F. V. Lewis, B. G. Lake, S. G. George, M. Dickins, P. J. Eddershaw, M. H. Tarbit, A. P. Beresford, P. S. Goldfarb, and F. P. Guengerich, Toxicology, 139, 53-79 (1999).
- (1999) Toxicology , vol.139 , pp. 53-79
- Lewis, D.F.V.¹ Lake, B.G.² George, S.G.³ Dickins, M.⁴ Eddershaw, P.J.⁵ Tarbit, M.H.⁶ Beresford, A.P.⁷ Goldfarb, P.S.⁸ Guengerich, F.P.⁹

60
- 7044239768
- D. Kim and F. P. Guengerich, Arch. Biochem. Biophys., 432, 102-108 (2004).
- (2004) Arch. Biochem. Biophys. , vol.432 , pp. 102-108
- Kim, D.¹ Guengerich, F.P.²

61
- 0025294782
- D. Sesardic, A. Boobis, B. Murray, S. Murray, J. Segura, R. De La Torre, and A. Davies, Brit. J. Clin. Pharmacol., 29, 651-663 (1990).
- (1990) Brit. J. Clin. Pharmacol. , vol.29 , pp. 651-663
- Sesardic, D.¹ Boobis, A.² Murray, B.³ Murray, S.⁴ Segura, J.⁵ De La Torre, R.⁶ Davies, A.⁷

62
- 0023121619
- D. R. Umbenhauer, M. V. Martin, R. S. Lloyd, and F. P. Guengerich, Biochemistry, 26, 1094-1099 (1987).
- (1987) Biochemistry , vol.26 , pp. 1094-1099
- Umbenhauer, D.R.¹ Martin, M.V.² Lloyd, R.S.³ Guengerich, F.P.⁴

63
- 0037223832
- Y. Yamamoto, T. Kawamoto, and M. Negishi, Arch. Biochem. Biophys., 409, 207-211 (2003).
- (2003) Arch. Biochem. Biophys. , vol.409 , pp. 207-211
- Yamamoto, Y.¹ Kawamoto, T.² Negishi, M.³

64
- 0033816613
- G. P. Aithal, C. P. Day, J. B. Leathart, and A. K. Daly, Pharmacogenetics, 10, 511-518 (2000).
- (2000) Pharmacogenetics , vol.10 , pp. 511-518
- Aithal, G.P.¹ Day, C.P.² Leathart, J.B.³ Daly, A.K.⁴

65
- 0025264682
- M. E. Veronese, J. O. Miners, D. Randies, D. Gregov, and D. J. Birkett, Clin. Pharmacol. Ther., 47, 403-411 (1990).
- (1990) Clin. Pharmacol. Ther. , vol.47 , pp. 403-411
- Veronese, M.E.¹ Miners, J.O.² Randies, D.³ Gregov, D.⁴ Birkett, D.J.⁵

66
- 0242668517
- P. Beaune, P. M. Dansette, D. Mansuy, L. Kiffel, M. Finck, C. Amar, J. P. Leroux, and J. C. Homberg, Proc. Natl. Acad. Sci. USA, 84, 551-555 (1987).
- (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 551-555
- Beaune, P.¹ Dansette, P.M.² Mansuy, D.³ Kiffel, L.⁴ Finck, M.⁵ Amar, C.⁶ Leroux, J.P.⁷ Homberg, J.C.⁸

67
- 0028693737
- P. Beaune, D. Pessayre, P. Dansette, D. Mansuy, and M. Manns, Adv. Pharmacol., 30, 199-245 (1994).
- (1994) Adv. Pharmacol. , vol.30 , pp. 199-245
- Beaune, P.¹ Pessayre, D.² Dansette, P.³ Mansuy, D.⁴ Manns, M.⁵

68
- 0042265520
- P. A. Williams, J. Cosme, A. Ward, H. C. Angove, D. Matak Vinkovic, and H. Jhoti, Nature, 424, 464-68 (2003).
- (2003) Nature , vol.424 , pp. 464-468
- Williams, P.A.¹ Cosme, J.² Ward, A.³ Angove, H.C.⁴ Vinkovic, D.M.⁵ Jhoti, H.⁶

69
- 4143143372
- M. R. Wester, J. K. Yano, G. A. Schoch, C. Yang, K. J. Griffin, C. D. Stout, and F. Johnson, J. Biol. Chem., 279, 35630-35637 (2004).
- (2004) J. Biol. Chem. , vol.279 , pp. 35630-35637
- Wester, M.R.¹ Yano, J.K.² Schoch, G.A.³ Yang, C.⁴ Griffin, K.J.⁵ Stout, C.D.⁶ Johnson, F.⁷

70
- 0021684926
- P. J. Wedlund, W. S. Aslanian, C. B. McAllister, G. R. Wilkinson, and R. A. Branch, Clin. Pharmacol. Ther., 36, 773-780 (1984).
- (1984) Clin. Pharmacol. Ther. , vol.36 , pp. 773-780
- Wedlund, P.J.¹ Aslanian, W.S.² McAllister, C.B.³ Wilkinson, G.R.⁴ Branch, R.A.⁵

71
- 0028279041
- J. A. Goldstein, M. B. Faletto, M. Romkes-Sparks, T. Sullivan, S. Kitareewan, J. L. Raucy, J. M. Lasker, and B. I. Ghanayem, Biochemistry, 33, 1743- 1752(1994).
- (1994) Biochemistry , vol.33 , pp. 1743-1752
- Goldstein, J.A.¹ Faletto, M.B.² Romkes-Sparks, M.³ Sullivan, T.⁴ Kitareewan, S.⁵ Raucy, J.L.⁶ Lasker, J.M.⁷ Ghanayem, B.I.⁸

72
- 0028260641
- S. M. F. de Morais, G. R. Wilkinson, J. Blaisdell, K. Nakamura, U. A. Meyer, and J. A. Goldstein, J. Biol. Chem., 269, 15419-15422 (1994).
- (1994) J. Biol. Chem. , vol.269 , pp. 15419-15422
- Morais, S.M.F.D.¹ Wilkinson, G.R.² Blaisdell, J.³ Nakamura, K.⁴ Meyer, U.A.⁵ Goldstein, J.A.⁶

73
- 0024959582
- H. H. Zhou, R. P. Koshakji, D. J. Silberstein, G. R. Wilkinson, and A. J. J. Wood, New Engl. J. Med., 320, 565-570 (1989).
- (1989) New Engl. J. Med. , vol.320 , pp. 565-570
- Zhou, H.H.¹ Koshakji, R.P.² Silberstein, D.J.³ Wilkinson, G.R.⁴ Wood, A.J.J.⁵

74
- 0035916224
- C. C. Tsao, M. R. Wester, B. Ghanayem, S. J. Coulter, B. Chanas, E. F. Johnson, and J. A. Goldstein, Biochemistry, 40, 1937-1944 (2001).
- (2001) Biochemistry , vol.40 , pp. 1937-1944
- Tsao, C.C.¹ Wester, M.R.² Ghanayem, B.³ Coulter, S.J.⁴ Chanas, B.⁵ Johnson, E.F.⁶ Goldstein, J.A.⁷

75
- 0017695082
- A. Mahgoub, J. R. Idle, L. G. Dring, R. Lancaster, and R. L. Smith, Lancet, 2, 584-586 (1977).
- (1977) Lancet , vol.2 , pp. 584-586
- Mahgoub, A.¹ Idle, J.R.² Dring, L.G.³ Lancaster, R.⁴ Smith, R.L.⁵

76
- 0018615011
- M. Eichelbaum, N. Spannbrucker, B. Steincke, and H. J. Dengler, Eur. J. Clin. Pharmacol., 16, 183-187 (1979).
- (1979) Eur. J. Clin. Pharmacol. , vol.16 , pp. 183-187
- Eichelbaum, M.¹ Spannbrucker, N.² Steincke, B.³ Dengler, H.J.⁴

77
- 0242427839
- M. S. Lennard, J. H. Silas, S. Freestone, G. T. Tucker, L. E. Ramsay, and H. F. Woods, Brit. J. Pharmacol., 16, 572P-573P (1982).
- (1982) Brit. J. Pharmacol. , vol.16 , pp. 572-573
- Lennard, M.S.¹ Silas, J.H.² Freestone, S.³ Tucker, G.T.⁴ Ramsay, L.E.⁵ Woods, H.F.⁶

78
- 0022916809
- J. Gut, U. T. Meier, T. Catin, and U. A. Meyer, Biochim. Biophys. Acta, 884, 435-447 (1986).
- (1986) Biochim. Biophys. Acta , vol.884 , pp. 435-447
- Gut, J.¹ Meier, U.T.² Catin, T.³ Meyer, U.A.⁴

79
- 0023854270
- F. J. Gonzalez, R. C. Skoda, S. Kimura, M. Umeno, U. M. Zanger, D. W. Nebert, H. V. Gelboin, J. P. Hardwick, and U. A. Meyer, Nature, 331, 442-46 (1988).
- (1988) Nature , vol.331 , pp. 442-446
- Gonzalez, F.J.¹ Skoda, R.C.² Kimura, S.³ Umeno, M.⁴ Zanger, U.M.⁵ Nebert, D.W.⁶ Gelboin, H.V.⁷ Hardwick, J.P.⁸ Meyer, U.A.⁹

80
- 0030995879
- U. A. Meyer and U. M. Zanger, Annu. Rev. Pharmacol. Toxicol., 37, 269- 296(1997).
- (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 269-296
- Meyer, U.A.¹ Zanger, U.M.²

81
- 0021884394
- T. Wolff, L. M. Distlerath, M. T. Worthington, J. D. Groopman, G. J. Hammons, F. F. Kadlubar, R. A. Prough, M. V. Martin, and F. P. Guengerich, Cancer Res., 45, 2116-2122 (1985).
- (1985) Cancer Res. , vol.45 , pp. 2116-2122
- Wolff, T.¹ Distlerath, L.M.² Worthington, M.T.³ Groopman, J.D.⁴ Hammons, G.J.⁵ Kadlubar, F.F.⁶ Prough, R.A.⁷ Martin, M.V.⁸ Guengerich, F.P.⁹

82
- 0036712187
- F. P. Guengerich, G. P. Miller, I. H. Hanna, M. V. Martin, S. Leger, C. Black, N. Chauret, J. M. Silva, L. Trimble, J. A. Jergey, and D. A. Nicoll-Griffith, Biochemistry, 41, 11025-11034 (2002).
- (2002) Biochemistry , vol.41 , pp. 11025-11034
- Guengerich, F.P.¹ Miller, G.P.² Hanna, I.H.³ Martin, M.V.⁴ Leger, S.⁵ Black, C.⁶ Chauret, N.⁷ Silva, J.M.⁸ Trimble, L.⁹ Jergey, J.A.¹⁰ Nicoll-Griffith, D.A.¹¹

83
- 0035883891
- I. H. Hanna, M.-S. Kim, and F. P. Guengerich, Arch. Biochem. Biophys., 393, 255-261 (2001).
- (2001) Arch. Biochem. Biophys. , vol.393 , pp. 255-261
- Hanna, I.H.¹ Kim, M.-S.² Guengerich, F.P.³

84
- 84893097461
- in press
- P. Rowland, F. E. Blaney, M. G. Smyth, J. J. Jones, V. R. Leydon, A. K. Oxbrow, J. Lewis, M. G. Tennant, S. Modi, D. S. Eggleston, R. J. Chenery, and A. M. Bridges, J. Biol. Chem., 281, in press (2006).
- (2006) J. Biol. Chem. , vol.281
- Rowland, P.¹ Blaney, F.E.² Smyth, M.G.³ Jones, J.J.⁴ Leydon, V.R.⁵ Oxbrow, A.K.⁶ Lewis, J.⁷ Tennant, M.G.⁸ Modi, S.⁹ Eggleston, D.S.¹⁰ Chenery, R.J.¹¹ Bridges, A.M.¹²

85
- 0021098075
- P. P. Wang, P. Beaune, L. S. Kaminsky, G. A. Dannan, F. F. Kadlubar, D. Larrey, and F. P. Guengerich, Biochemistry, 22, 5375-5383 (1983).
- (1983) Biochemistry , vol.22 , pp. 5375-5383
- Wang, P.P.¹ Beaune, P.² Kaminsky, L.S.³ Dannan, G.A.⁴ Kadlubar, F.F.⁵ Larrey, D.⁶ Guengerich, F.P.⁷

86
- 0041301863
- P. B. Watkins, S. A. Wrighton, P. Maurel, E. G. Schuetz, G. Mendez-Picon, G. A. Parker, and P. S. Guzelian, Proc. Natl. Acad. Sci. USA, 82, 6310-6314 (1985).
- (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 6310-6314
- Watkins, P.B.¹ Wrighton, S.A.² Maurel, P.³ Schuetz, E.G.⁴ Mendez-Picon, G.⁵ Parker, G.A.⁶ Guzelian, P.S.⁷

87
- 0022998708
- F. P. Guengerich, M. V. Martin, P. H. Beaune, P. Kremers, T. Wolff, and D. J. Waxman, J. Biol. Chem., 261, 5051-5060 (1986).
- (1986) J. Biol. Chem. , vol.261 , pp. 5051-5060
- Guengerich, F.P.¹ Martin, M.V.² Beaune, P.H.³ Kremers, P.⁴ Wolff, T.⁵ Waxman, D.J.⁶

88
- 0023929834
- D. J. Waxman, C. Attisano, F. P. Guengerich, and D. P. Lapenson, Arch. Biochem. Biophys., 263, 424-436 (1988).
- (1988) Arch. Biochem. Biophys. , vol.263 , pp. 424-436
- Waxman, D.J.¹ Attisano, C.² Guengerich, F.P.³ Lapenson, D.P.⁴

89
- 0022550688
- R. H. Bocker and F. P. Guengerich, J. Med. Chem., 29, 1596-1603 (1986).
- (1986) J. Med. Chem. , vol.29 , pp. 1596-1603
- Bocker, R.H.¹ Guengerich, F.P.²

90
- 0025646757
- W. R. Brian, M.-A. Sari, M. Iwasaki, T. Shimada, L. S. Kaminsky, and F. P. Guengerich, Biochemistry, 29, 11280-11292 (1990).
- (1990) Biochemistry , vol.29 , pp. 11280-11292
- Brian, W.R.¹ Sari, M.-A.² Iwasaki, M.³ Shimada, T.⁴ Kaminsky, L.S.⁵ Guengerich, F.P.⁶

91
- 0026654417
- S. Imaoka, Y. Imai, T. Shimada, and Y. Funae, Biochemistry, 31, 6063- 6069 (1992).
- (1992) Biochemistry , vol.31 , pp. 6063-6069
- Imaoka, S.¹ Imai, Y.² Shimada, T.³ Funae, Y.⁴

92
- 0027223881
- E. M. J. Gillam, T. Baba, B.-R. Kim, S. Ohmori, and F. P. Guengerich, Arch. Biochem. Biophys., 305, 123-131 (1993).
- (1993) Arch. Biochem. Biophys. , vol.305 , pp. 123-131
- Gillam, E.M.J.¹ Baba, T.² Kim, B.-R.³ Ohmori, S.⁴ Guengerich, F.P.⁵

93
- 0032524690
- N. A. Hosea and F. P. Guengerich, Arch. Biochem. Biophys., 353, 365-373 (1998).
- (1998) Arch. Biochem. Biophys. , vol.353 , pp. 365-373
- Hosea, N.A.¹ Guengerich, F.P.²

94
- 0024588897
- R. W. Bork, T. Muto, P. H. Beaune, P. K. Srivastava, R. S. Lloyd, and F. P. Guengerich, J. Biol. Chem., 264, 910-919 (1989).
- (1989) J. Biol. Chem. , vol.264 , pp. 910-919
- Bork, R.W.¹ Muto, T.² Beaune, P.H.³ Srivastava, P.K.⁴ Lloyd, R.S.⁵ Guengerich, F.P.⁶

95
- 0023883363
- F. P. Guengerich, Mol. Pharmacol., 33, 500-508 (1988).
- (1988) Mol. Pharmacol. , vol.33 , pp. 500-508
- Guengerich, F.P.¹

96
- 0032498303
- S. A. Kliewer, J. T. Moore, L. Wade, J. L. Staudinger, M. A. Watson, S. A. Jones, D. McKee, B. B. Oliver, T. M. Wilson, R. H. Zetterstorm, T. Perlmann, and J. M. Lehmann, Cell, 92, 73-82 (1998).
- (1998) Cell , vol.92 , pp. 73-82
- Kliewer, S.A.¹ Moore, J.T.² Wade, L.³ Staudinger, J.L.⁴ Watson, M.A.⁵ Jones, S.A.⁶ McKee, D.⁷ Oliver, B.B.⁸ Wilson, T.M.⁹ Zetterstorm, R.H.¹⁰ Perlmann, T.¹¹ Lehmann, J.M.¹²

97
- 0031914323
- C. Calleja, J. M. Pascussi, J. C. Mani, P. Maurel, and M. J. Vilarem, Nature Med., 4, 92-96 (1998).
- (1998) Nature Med. , vol.4 , pp. 92-96
- Calleja, C.¹ Pascussi, J.M.² Mani, J.C.³ Maurel, P.⁴ Vilarem, M.J.⁵

98
- 0037450436
- J. M. Pascussi, S. Gerbal-Chaloin, L. Drocourt, P. Maurel, and M. J. Vilarem, Biochim. Biophys. Acta, 1619, 243-253 (2003).
- (2003) Biochim. Biophys. Acta , vol.1619 , pp. 243-253
- Pascussi, J.M.¹ Gerbal-Chaloin, S.² Drocourt, L.³ Maurel, P.⁴ Vilarem, M.J.⁵

99
- 0036784516
- K. Yasuda, L. B. Lan, D. Sanglard, K. Furuya, J. D. Schuetz, and E. G. Schuetz, J. Pharmacol. Exp. Ther., 303, 323-332 (2002).
- (2002) J. Pharmacol. Exp. Ther. , vol.303 , pp. 323-332
- Yasuda, K.¹ Lan, L.B.² Sanglard, D.³ Furuya, K.⁴ Schuetz, J.D.⁵ Schuetz, E.G.⁶

100
- 0030059953
- E. G. Schuetz, W. T. Beck, and J. D. Schuetz, Mol. Pharmacol., 49, 311- 318 (1996).
- (1996) Mol. Pharmacol. , vol.49 , pp. 311-318
- Schuetz, E.G.¹ Beck, W.T.² Schuetz, J.D.³

101
- 0000950252
- T. F. Woolf, ed., Marcel Dekker, New York
- F. P. Guengerich, in Handbook of Drug Metabolism (T. F. Woolf, ed.), Marcel Dekker, New York, 1999, pp. 203-227.
- (1999) Handbook of Drug Metabolism , pp. 203-227
- Guengerich, F.P.¹

102
- 0026099498
- D. G. Bailey, J. D. Spence, C. Munoz, and J. M. O. Arnold, Lancet, 337, 268- 269 (1991).
- (1991) Lancet , vol.337 , pp. 268-269
- Bailey, D.G.¹ Spence, J.D.² Munoz, C.³ Arnold, J.M.O.⁴

103
- 0030897505
- S. E. Rau, J. R. Bend, J. M. O. Arnold, L. T. Tran, J. D. Spence, and D. G. Bailey, Clin. Pharmacol. Ther., 61, 401-409 (1997).
- (1997) Clin. Pharmacol. Ther. , vol.61 , pp. 401-409
- Rau, S.E.¹ Bend, J.R.² Arnold, J.M.O.³ Tran, L.T.⁴ Spence, J.D.⁵ Bailey, D.G.⁶

104
- 10044240240
- T. C. Goosen, D. Cillie, D. G. Bailey, C. Yu, K. He, P. F. Hollenberg, P. M. Woster, L. Cohen, J. A. Williams, M. Rheeders, and H. P. Dijkstra, Clin. Pharm acol. Ther., 76, 607-617 (2004).
- (2004) Clin. Pharm Acol. Ther. , vol.76 , pp. 607-617
- Goosen, T.C.¹ Cillie, D.² Bailey, D.G.³ Yu, C.⁴ He, K.⁵ Hollenberg, P.F.⁶ Woster, P.M.⁷ Cohen, L.⁸ Williams, J.A.⁹ Rheeders, M.¹⁰ Dijkstra, H.P.¹¹

105
- 4644301430
- J. K. Yano, M. R. Wester, G. A. Schoch, K. J. Griffin, C. D. Stout, and E. F. Johnson, J. Biol. Chem., 38091-38094 (2004).
- (2004) J. Biol. Chem. , pp. 38091-38094
- Yano, J.K.¹ Wester, M.R.² Schoch, G.A.³ Griffin, K.J.⁴ Stout, C.D.⁵ Johnson, E.F.⁶

106
- 3442896773
- P. A. Williams, J. Cosme, D. M. Vinkovic, A. Ward, H. C. Angove, P. J. Day, C. Vonrhein, I. J. Tickle, and H. Jhoti, Science, 305, 683-686 (2004).
- (2004) Science , vol.305 , pp. 683-686
- Williams, P.A.¹ Cosme, J.² Vinkovic, D.M.³ Ward, A.⁴ Angove, H.C.⁵ Day, P.J.⁶ Vonrhein, C.⁷ Tickle, I.J.⁸ Jhoti, H.⁹

107
- 0004114084
- CRC Press, Boca Raton, FL
- S. A. Kuby, A Study of Enzymes, Enzyme Catalysis, Kinetics, and Substrate Binding. CRC Press, Boca Raton, FL, 1991.
- (1991) A Study of Enzymes, Enzyme Catalysis, Kinetics, and Substrate Binding
- Kuby, S.A.¹

108
- 33646942269
- E. M. Isin and F. P. Guengerich, J. Biol. Chem., 281, 9127-9136 (2006).
- (2006) J. Biol. Chem. , vol.281 , pp. 9127-9136
- Isin, E.M.¹ Guengerich, F.P.²

109
- 1542364450
- G. A. Schoch, J. K. Yano, M. R. Wester, K. J. Griffin, C. D. Stout, and E. F. Johnson, J. Biol. Chem., 279, 9497-9503 (2004).
- (2004) J. Biol. Chem. , vol.279 , pp. 9497-9503
- Schoch, G.A.¹ Yano, J.K.² Wester, M.R.³ Griffin, K.J.⁴ Stout, C.D.⁵ Johnson, E.F.⁶

110
- 0026459382
- D. A. Smith and B. C. Jones, Biochem. Pharmacol., 44, 2089-2098 (1992).
- (1992) Biochem. Pharmacol. , vol.44 , pp. 2089-2098
- Smith, D.A.¹ Jones, B.C.²

111
- 0037431382
- S. B. Singh, L. Q. Shen, M. J. Walker, and R. P. Sheridan, J. Med. Chem., 46, 1330-1336(2003).
- (2003) J. Med. Chem. , vol.46 , pp. 1330-1336
- Singh, S.B.¹ Shen, L.Q.² Walker, M.J.³ Sheridan, R.P.⁴

112
- 21244497304
- J. A. Krauser and F. P. Guengerich, J. Biol. Chem., 280, 19496-19506 (2005).
- (2005) J. Biol. Chem. , vol.280 , pp. 19496-19506
- Krauser, J.A.¹ Guengerich, F.P.²

113
- 0034902923
- L. C. Wienkers, J. Pharmacol. Toxicol. Methods, 45, 79-84 (2001).
- (2001) Toxicol. Methods , vol.45 , pp. 79-84
- Wienkers, L.C.¹ Pharmacol, J.²

114
- 0029798503
- K. Nakamura, T. Yokoi, K. Inoue, N. Shimada, N. Ohashi, T. Kume, and T. Kamataki, Pharmacogenetics, 6, 449-457 (1996).
- (1996) Pharmacogenetics , vol.6 , pp. 449-457
- Nakamura, K.¹ Yokoi, T.² Inoue, K.³ Shimada, N.⁴ Ohashi, N.⁵ Kume, T.⁶ Kamataki, T.⁷

115
- 0028227627
- E. D. Kharasch, K. E. Thummel, D. Mautz, and S. Bosse, Clin. Pharmacol. Ther., 55, 434-440 (1994).
- (1994) Clin. Pharmacol. Ther. , vol.55 , pp. 434-440
- Kharasch, E.D.¹ Thummel, K.E.² Mautz, D.³ Bosse, S.⁴

116
- 26944462419
- J. K. Yano, M. H. Hsu, K. J. Griffin, C. D. Stout, and E. F. Johnson, Nat. Struct. Biol., 12, 822-823 (2005).
- (2005) Nat. Struct. Biol. , vol.12 , pp. 822-823
- Yano, J.K.¹ Hsu, M.H.² Griffin, K.J.³ Stout, C.D.⁴ Johnson, E.F.⁵

117
- 0037371329
- J. Hakkola, Y. Hu, and M. Ingelman-Sundberg, J. Pharmacol. Exp. Ther., 304, 1048-1054 (2003).
- (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1048-1054
- Hakkola, J.¹ Hu, Y.² Ingelman-Sundberg, M.³

118
- 0028036727
- A. Rahman, K. R. Korzekwa, J. Grogan, F. J. Gonzalez, and J. W. Harris, Cancer Res., 54, 5543-5546 (1994).
- (1994) Cancer Res. , vol.54 , pp. 5543-5546
- Rahman, A.¹ Korzekwa, K.R.² Grogan, J.³ Gonzalez, F.J.⁴ Harris, J.W.⁵

119
- 0028234586
- J. C. Gorski, S. D. Hall, D. R. Jones, M. Van den Branden, and S. A. Wrighton, Biochem. Pharmacol., 47, 1643-1653 (1994).
- (1994) Biochem. Pharmacol. , vol.47 , pp. 1643-1653
- Gorski, J.C.¹ Hall, S.D.² Jones, D.R.³ Van Den Branden, M.⁴ Wrighton, S.A.⁵

120
- 32644474169
- A. M. Larson, J. Poison, R. J. Fontana, T. J. Davern, E. Lalani, L. S. Hynan, J. S. Reisch, F. V. Schiodt, G. Ostapowicz, A. O. Shakil, and W. M. Lee, Hepatology, 42, 1364-1372 (2005).
- (2005) Hepatology , vol.42 , pp. 1364-1372
- Larson, A.M.¹ Poison, J.² Fontana, R.J.³ Davern, T.J.⁴ Lalani, E.⁵ Hynan, L.S.⁶ Reisch, J.S.⁷ Schiodt, F.V.⁸ Ostapowicz, G.⁹ Shakil, A.O.¹⁰ Lee, W.M.¹¹

121
- 32944472713
- J. G. O'Grady, Hepatology, 42, 1252-1254 (2005).
- (2005) Hepatology , vol.42 , pp. 1252-1254
- O'Grady, J.G.¹

122
- 0027304762
- C. J. Patten, P. E. Thomas, R. L. Guy, M. Lee, F. J. Gonzalez, F. P. Guengerich, and C. S. Yang, Chem. Res. Toxicol., 6, 511-518 (1993).
- (1993) Chem. Res. Toxicol. , vol.6 , pp. 511-518
- Patten, C.J.¹ Thomas, P.E.² Guy, R.L.³ Lee, M.⁴ Gonzalez, F.J.⁵ Guengerich, F.P.⁶ Yang, C.S.⁷

123
- 15844419997
- S. S. T. Lee, J. T. M. Buters, T. Pineau, P. Fernandez-Salguero, and F. J. Gonzalez, J. Biol. Chem., 271, 12063-12067 (1996).
- (1996) J. Biol. Chem. , vol.271 , pp. 12063-12067
- Lee, S.S.T.¹ Buters, J.T.M.² Pineau, T.³ Fernandez-Salguero, P.⁴ Gonzalez, F.J.⁵

124
- 0015754446
- D. J. Jollow, J. R. Mitchell, W. Z. Potter, D. C. Davis, J. R. Gillette, and B. B. Brodie, J. Pharmacol. Exp. Ther., 187, 195-202 (1973).
- (1973) J. Pharmacol. Exp. Ther. , vol.187 , pp. 195-202
- Jollow, D.J.¹ Mitchell, J.R.² Potter, W.Z.³ Davis, D.C.⁴ Gillette, J.R.⁵ Brodie, B.B.⁶

125
- 0015733053
- J. R. Mitchell, D. J. Jollow, W. Z. Potter, J. R. Gillette, and B. B. Brodie, J. Pharmacol. Exp. Ther., 187, 211-217 (1973).
- (1973) J. Pharmacol. Exp. Ther. , vol.187 , pp. 211-217
- Mitchell, J.R.¹ Jollow, D.J.² Potter, W.Z.³ Gillette, J.R.⁴ Brodie, B.B.⁵

126
- 0027474601
- R. L. Woosley, Y. Chen, J. P. Freiman, and R. A. Gillis, J. Am. Med. Assoc., 269, 1532-1536 (1993).
- (1993) J. Am. Med. Assoc. , vol.269 , pp. 1532-1536
- Woosley, R.L.¹ Chen, Y.² Freiman, J.P.³ Gillis, R.A.⁴

127
- 4244171512
- S. C. Stinson, Chem. Eng. News, 75, 43-5 (1997).
- (1997) Chem. Eng. News , vol.75 , pp. 43-45
- Stinson, S.C.¹

128
- 0015062805
- D. Reimers and A. Jezek, Prax. Pneumol., 25, 255-262 (1971).
- (1971) Prax. Pneumol. , vol.25 , pp. 255-262
- Reimers, D.¹ Jezek, A.²

129
- 0015787943
- L. Nocke-Finck, H. Breuer, and D. Reimers, Deutsch. Med. Wochenschr., 98, 1521-1523 (1973).
- (1973) Deutsch. Med. Wochenschr. , vol.98 , pp. 1521-1523
- Nocke-Finck, L.¹ Breuer, H.² Reimers, D.³

130
- 0016075464
- D. Janz and D. Schmidt, Lancet, 1113 (1974).
- (1974) Lancet , pp. 1113
- Janz, D.¹ Schmidt, D.²

131
- 0017601139
- H. M. Bolt, M. Bolt, and H. Kappus, Acta Endocrinol., 85, 189-197 (1977).
- (1977) Acta Endocrinol. , vol.85 , pp. 189-197
- Bolt, H.M.¹ Bolt, M.² Kappus, H.³

132
- 0025184340
- F. P. Guengerich, Chem. Res. Toxicol, 3, 363-371 (1990).
- (1990) Chem. Res. Toxicol , vol.3 , pp. 363-371
- Guengerich, F.P.¹

133
- 0025367754
- F. Morel, P. H. Beaune, D. Ratanasavanh, J.-P. Flinois, C.-S. Yang, F. P. Guengerich, and A. Guillouzo, Eur. J. Biochem., 191, 437-444 (1990).
- (1990) Eur. J. Biochem. , vol.191 , pp. 437-444
- Morel, F.¹ Beaune, P.H.² Ratanasavanh, D.³ Flinois, J.-P.⁴ Yang, C.-S.⁵ Guengerich, F.P.⁶ Guillouzo, A.⁷

134
- 0034095323
- K. Wilbur and M. H. Ensom, Clin. Pharmacokinet., 38, 355-365 (2000).
- (2000) Clin. Pharmacokinet. , vol.38 , pp. 355-365
- Wilbur, K.¹ Ensom, M.H.²

135
- 19444379050
- P. A. Murphy, S. E. Kern, F. Z. Stanczyk, and C. L. Westhoff, Contraception, 71, 402-408 (2005).
- (2005) Contraception , vol.71 , pp. 402-408
- Murphy, P.A.¹ Kern, S.E.² Stanczyk, F.Z.³ Westhoff, C.L.⁴

136
- 0021235725
- V. Ravindranath, L. T. Burka, and M. R. Boyd, Science, 224, 884-886 (1984).
- (1984) Science , vol.224 , pp. 884-886
- Ravindranath, V.¹ Burka, L.T.² Boyd, M.R.³

137
- 0026989166
- P. M. Dansette, D. C. Thang, H. El-Amri, and D. Mansuy, Biochem. Biophys. Res. Commun., 186, 1624-1630(1992).
- (1992) Biochem. Biophys. Res. Commun. , vol.186 , pp. 1624-1630
- Dansette, P.M.¹ Thang, D.C.² El-Amri, H.³ Mansuy, D.⁴

138
- 27544482086
- P. M. Dansette, G. Bertho, and D. Mansuy, Biochem. Biophys. Res. Commun., 338, 450-455 (2005).
- (2005) Biochem. Biophys. Res. Commun. , vol.338 , pp. 450-455
- Dansette, P.M.¹ Bertho, G.² Mansuy, D.³

139
- 0025341427
- M. Bourdi, D. Larrey, J. Nataf, J. Berunau, D. Pessayre, M. Iwasaki, F. P. Guengerich, and P. H. Beaune, J. Clin. Invest., 85, 1967-1973 (1990).
- (1990) J. Clin. Invest. , vol.85 , pp. 1967-1973
- Bourdi, M.¹ Larrey, D.² Nataf, J.³ Berunau, J.⁴ Pessayre, D.⁵ Iwasaki, M.⁶ Guengerich, F.P.⁷ Beaune, P.H.⁸

140
- 2042546756
- O. Beck, N. Stephanson, R. G. Morris, B. C. Sallustio, and P. Hjemdahl, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 805, 87-91 (2004).
- (2004) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.805 , pp. 87-91
- Beck, O.¹ Stephanson, N.² Morris, R.G.³ Sallustio, B.C.⁴ Hjemdahl, P.⁵

141
- 0019838792
- R. K. Roberts, D. Cohn, V. Petroff, and B. Seneviratne, Med. J. Aust., 2, 553- 554(1981).
- (1981) Med. J. Aust. , vol.2 , pp. 553-554
- Roberts, R.K.¹ Cohn, D.² Petroff, V.³ Seneviratne, B.⁴

142
- 0020075333
- R. R. Shah, N. S. Oates, J. R. Idle, R. L. Smith, and J. D. Lockhart, Br. Med. J. Clin. Res. Ed., 284, 295-299 (1982).
- (1982) Br. Med. J. Clin. Res. Ed. , vol.284 , pp. 295-299
- Shah, R.R.¹ Oates, N.S.² Idle, J.R.³ Smith, R.L.⁴ Lockhart, J.D.⁵

143
- 0021146282
- M. Y. Morgan, R. Reshef, R. R. Shah, N. S. Oates, R. L. Smith, and S. Sherlock, Gut, 25, 1057-1064(1984).
- (1984) Gut , vol.25 , pp. 1057-1064
- Morgan, M.Y.¹ Reshef, R.² Shah, R.R.³ Oates, N.S.⁴ Smith, R.L.⁵ Sherlock, S.⁶

144
- 0038804137
- L. B. Sorensen, R. N. Sorensen, J. O. Miners, A. A. Somogyi, N. Grgurinovich, and D. J. Birkett, Br. J. Clin. Pharmacol., 55, 635-638 (2003).
- (2003) Br. J. Clin. Pharmacol. , vol.55 , pp. 635-638
- Sorensen, L.B.¹ Sorensen, R.N.² Miners, J.O.³ Somogyi, A.A.⁴ Grgurinovich, N.⁵ Birkett, D.J.⁶

145
- 0020666214
- R. R. Shah, N. S. Oates, J. R. Idle, R. L. Smith, and J. D. Lockhart, Am. Heart J., 105, 159-161 (1983).
- (1983) Am. Heart J. , vol.105 , pp. 159-161
- Shah, R.R.¹ Oates, N.S.² Idle, J.R.³ Smith, R.L.⁴ Lockhart, J.D.⁵

146
- 0142188770
- M. L. Barclay, S. M. Sawyers, E. J. Begg, M. Zhang, R. L. Roberts, M. A. Kennedy, and J. M. Elliott, Pharmacogenetics, 13, 627-632 (2003).
- (2003) Pharmacogenetics , vol.13 , pp. 627-632
- Barclay, M.L.¹ Sawyers, S.M.² Begg, E.J.³ Zhang, M.⁴ Roberts, R.L.⁵ Kennedy, M.A.⁶ Elliott, J.M.⁷

147
- 0035188837
- R. Hussein, B. G. Charles, R. G. Morris, and R. L. Rasiah, Ther. Drug Monit., 23, 636-643 (2001).
- (2001) Ther. Drug Monit. , vol.23 , pp. 636-643
- Hussein, R.¹ Charles, B.G.² Morris, R.G.³ Rasiah, R.L.⁴

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