Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells

Journal of Clinical Investigation

Volumn 109, Issue 10, 2002, Pages 1291-1302

  Schwartz, Robert E ^a   Reyes, Morayma ^a   Koodie, Lisa ^a   Jiang, Yuehua ^a   Blackstad, Mark ^a   Lund, Troy ^a   Lenvik, Todd ^a   Johnson, Sandra ^a   Hu, Wei Shou ^b   Verfaillie, Catherine M ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CYTOCHROME P450; CYTOKERATIN 18; CYTOKERATIN 19; FIBROBLAST GROWTH FACTOR 4; GLYCOGEN; HEPATOCYTE NUCLEAR FACTOR 3; HEPATOCYTE NUCLEAR FACTOR 4; LOW DENSITY LIPOPROTEIN; NUCLEAR FACTOR I; PHENOBARBITAL; PREALBUMIN; SCATTER FACTOR; TRANSCRIPTION FACTOR GATA 4; UREA;

ANIMAL CELL; ARTICLE; BIOARTIFICIAL ORGAN; BONE MARROW; CELL DIFFERENTIATION; CELL STRUCTURE; EPITHELIOID CELL; HUMAN; HUMAN CELL; LIVER CELL; LIVER DISEASE; MESODERM; MOUSE; NEUROECTODERM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STEM CELL;

EID: 0036106054     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215182     Document Type: Article

References (45)

1. Hepatocyte differentiation: From the endoderm and beyond
2. Signals for tissue induction and organ formation in vertebrate embryos
3. Vertebrate endoderm development
4. Liver specification and early morphogenesis
5. Hepatic "stem" cells: Coming full circle
6. The canals of Hering and hepatic stem cells in humans
7. Extracellular matrix remodeling at the early stages of liver regeneration in the rat
8. Bone marrow as a potential source of hepatic oval cells
9. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation
10. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
11. Multilineage potential of adult human mesenchymal stem cells
12. Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells
13. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
14. Molecular basis of trans-differentiation of pancreas to liver
15. Hepatic maturation in differentiating embryonic stem cells in vitro
16. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
17. Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells
18. Preparation of isolated rat liver cells
19. Probing enhanced cytochrome P450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy
20. The role of actin filaments and microtubules in hepatocyte spheroid self-assembly
21. Kinetics of hepatocyte spheroid formation
22. Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells
23. Early mouse endoderm is patterned by soluble factors from adjacent germ layers
24. Role of oncostatin M in hematopoiesis and liver development
25. Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
26. Expression and localization of hepatocyte domain-specific plasma membrane proteins in hepatoma x fibroblast hybrids and in hepatoma dedifferentiated variants
27. A novel cellular phenotype for familial hypercholesterolemia due to a defect in polarized targeting of LDL receptor
28. Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro
29. Development of a non-transformed human liver cell line with differentiated-hepatocyte and urea-synthetic functions: Applicable for bioartificial liver
30. Growth and differentiation of cultured fetal hepatocytes isolated various developmental stages
31. Phenobarbital suppresses growth and accelerates restoration of differentiation markers of primary culture rat hepatocytes in the chemically defined hepatocyte growth medium containing hepatocyte growth factor and epidermal growth factor
32. Cytoskeletal filament assembly and the control of cell spreading and function by extracellular matrix
33. Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture
34. Long-term in vitro Function of adult hepatocytes in a collagen sandwich configuration
35. Cytochrome P450 in the brain; a review
36. Different regulation of the expression of mouse hepatic cytochrome P450 2B enzymes by glucocorticoid and phenobarbital
37. Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice
38. Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes
39. The endothelium and lipoproteins: Insights from recent cell biology and animal studies
40. Control of vesicle traffic in hepatocytes
41. Formation of plasma membrane domains in rat hepatocytes and hepatoma cell lines in culture
42. Development and maintenance of bile canaliculi in vitro and in vivo
43. Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells
44. Viable offspring derived from fetal and adult mammalian cells
45. Generation of mice from wild-type and targeted ES cells by nuclear cloning