Hepatitis C virus replication in mice with chimeric human livers

Nature Medicine

Volumn 7, Issue 8, 2001, Pages 927-933

  Mercer, David F ^a   Schiller, Daniel E ^a   Elliott, John F ^a   Douglas, Donna N ^a   Hao, Chunhai ^a   Rinfret, Aline ^b   Addison, William R ^a   Fischer, Karl P ^a   Churchill, Thomas A ^a   Lakey, Jonathan R T ^a   Tyrrell, David L J ^a   Kneteman, Norman M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMINOGEN ACTIVATOR; VIRUS PROTEIN; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; CHIMERA; GENOTYPE; GRAFT SURVIVAL; HEPATITIS C VIRUS; HOMOZYGOSITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SCID MOUSE; TRANSGENE; VIRUS LOAD; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS TITRATION;

ANIMALS; CELL TRANSPLANTATION; CHIMERA; HEPACIVIRUS; HOMOZYGOTE; HUMANS; LIVER; MICE; MICE, SCID; RNA, VIRAL; TRANSGENES; VIRUS REPLICATION;

EID: 17944379233     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/90968     Document Type: Article

References (22)

1. Hepatitis C: An update on the silent epidemic
2. Isolation of a cDNA clone derived from a blood borne non-A non-B viral hepatitis genome
3. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator
4. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
5. Replacement of diseased mouse liver by hepatic cell transplantation
6. Liver repopulation with xenogeneic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma
7. A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2 deficient mice
8. Hepatocytes isolated from the adult human liver can repopulate the liver of uPA/Rag-2 mice and support hepatitis B virus infection and replication
9. Long-term co-cultures of adult human hepatocytes with rat liver epithelial cells: Modulation of albumin secretion and accumulation of extracellular material
10. Complete reconstitution of mouse liver with xenogeneic hepatocytes
11. Alu: Structure, origin, evolution, significance, and function of one-tenth of human DNA
12. Nucleotide sequence of the genome of a murine sarcoma virus
13. Low level or absent in vivo replication of hepatitis C virus and hepatitis G virus/GB virus C in peripheral blood mononuclear cells
14. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly-specific rTth reverse transcriptase PCR
15. Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR
16. Immunohistochemical detection of hepatitis C antigen by monoclonal antibody TORDJI-22 compared with PCR viral detection
17. Isolation, culture and characterization of adult human hepatocytes from surgical liver biopsies
18. A new technique for isolating and culturing human hepatocytes from whole or split livers not used for transplantation
19. Preparation of isolated rat liver cells
20. Isolation and long-term culture of human hepatocytes
21. Linkage mapping by simultaneous screening of multiple polymorphic loci using Alu oligonucleotide-directed PCR
22. Use of the 5′ noncoding region for genotyping hepatitis C virus