Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4α interaction

Pharmacogenetics and Genomics

Volumn 19, Issue 1, 2009, Pages 11-24

  Lim, Yun Ping ^a   Kuo, Sheng Chun ^a   Lai, Ming Liang ^a   Huang, Jin Ding ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Hepatocyte nuclear factor 4 ; Ketoconazole; Pregnane X receptor; Rifampin; Steroid receptor coactivator 1

Indexed keywords

CYTOCHROME P450 3A4; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; KETOCONAZOLE; PREGNANE X RECEPTOR; RIFAMPICIN; STEROID RECEPTOR COACTIVATOR 1;

ARTICLE; DRUG RECEPTOR BINDING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RNA INTERFERENCE; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM;

ANTIFUNGAL AGENTS; BASE SEQUENCE; CELL LINE; CYTOCHROME P-450 CYP3A; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HISTONE ACETYLTRANSFERASES; HUMANS; KETOCONAZOLE; LIGANDS; PHARMACOGENETICS; PROMOTER REGIONS, GENETIC; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, STEROID; RECOMBINANT PROTEINS; RIFAMPIN; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 58149269043     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32831665ea     Document Type: Article

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