-
1
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S., and Takeda, K. (2004). Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511.
-
(2004)
Nat. Rev. Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
2
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira, S., Uematsu, S., and Takeuchi, O. (2006). Pathogen recognition and innate immunity. Cell 124, 783-801.
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
4
-
-
33751225361
-
-a production
-
-a production. J. Gene Med. 8, 1300-1306.
-
(2006)
J. Gene Med
, vol.8
, pp. 1300-1306
-
-
Basner-Tschakarjan, E.1
Gaffal, E.2
O'Keeffe, M.3
Tormo, D.4
Limmer, A.5
Wagner, H.6
Hochrein, H.7
Tuting, T.8
-
5
-
-
0033861419
-
The interleukin-1 receptor/Toll-like receptor superfamily: Signal generators for proinflammatory interleukins and microbial products
-
Bowie, A., and O'Neill, L.A. (2000). The interleukin-1 receptor/Toll-like receptor superfamily: Signal generators for proinflammatory interleukins and microbial products. J. Leukoc. Biol. 67, 508-514.
-
(2000)
J. Leukoc. Biol
, vol.67
, pp. 508-514
-
-
Bowie, A.1
O'Neill, L.A.2
-
6
-
-
33847131016
-
Virus trafficking: Learning from single-virus tracking
-
Brandenburg, B., and Zhuang, X. (2007). Virus trafficking: Learning from single-virus tracking. Nat. Rev. Microbiol. 5, 197-208.
-
(2007)
Nat. Rev. Microbiol
, vol.5
, pp. 197-208
-
-
Brandenburg, B.1
Zhuang, X.2
-
7
-
-
34247484007
-
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
-
Brinkmann, M.M., Spooner, E., Hoebe, K., Beutler, B., Ploegh, H.L., and Kim, Y.M. (2007). The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J. Cell Biol. 177, 265-275.
-
(2007)
J. Cell Biol
, vol.177
, pp. 265-275
-
-
Brinkmann, M.M.1
Spooner, E.2
Hoebe, K.3
Beutler, B.4
Ploegh, H.L.5
Kim, Y.M.6
-
8
-
-
0742307422
-
Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates
-
Brunetti-Pierri, N., Palmer, D.J., Beaudet, A.L., Carey, K.D., Finegold, M., and Ng, P. (2004). Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates. Hum. Gene Ther. 15, 35-46.
-
(2004)
Hum. Gene Ther
, vol.15
, pp. 35-46
-
-
Brunetti-Pierri, N.1
Palmer, D.J.2
Beaudet, A.L.3
Carey, K.D.4
Finegold, M.5
Ng, P.6
-
9
-
-
33846309241
-
Toll-like receptor 9 triggers an innate immune response to helperdependent adenoviral vectors
-
Cerullo, V., Seiler, M.P., Mane, V., Brunetti-Pierri, N., Clarke, C., Bertin, T.K., Rodgers, J.R., and LEE, B. (2007). Toll-like receptor 9 triggers an innate immune response to helperdependent adenoviral vectors. Mol. Ther. 15, 378-385.
-
(2007)
Mol. Ther
, vol.15
, pp. 378-385
-
-
Cerullo, V.1
Seiler, M.P.2
Mane, V.3
Brunetti-Pierri, N.4
Clarke, C.5
Bertin, T.K.6
Rodgers, J.R.7
LEE, B.8
-
10
-
-
0033977047
-
Humoral immunity to adeno-associated virus type 2 vectors following administration to murine and nonhuman primate muscle
-
Chirmule, N., Xiao, W., Truneh, A., Schnell, M.A., Hughes, J.V., Zoltick, P., and Wilson, J.M. (2000). Humoral immunity to adeno-associated virus type 2 vectors following administration to murine and nonhuman primate muscle. J. Virol. 74, 2420-2425.
-
(2000)
J. Virol
, vol.74
, pp. 2420-2425
-
-
Chirmule, N.1
Xiao, W.2
Truneh, A.3
Schnell, M.A.4
Hughes, J.V.5
Zoltick, P.6
Wilson, J.M.7
-
11
-
-
0345505220
-
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2
-
Compton, T., Kurt-Jones, E.A., Boehme, K.W., Belko, J., Latz, E., Golenbock, D.T., and Finberg, R.W. (2003). Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J. Virol. 77, 4588-4596.
-
(2003)
J. Virol
, vol.77
, pp. 4588-4596
-
-
Compton, T.1
Kurt-Jones, E.A.2
Boehme, K.W.3
Belko, J.4
Latz, E.5
Golenbock, D.T.6
Finberg, R.W.7
-
12
-
-
0033583516
-
Two roads diverged: Interferon α/β -and interleukin 12-mediated pathways in promoting T cell interferon y responses during viral infection
-
Cousens, L.P., Peterson, R., Hsu, S., Dorner, A., Altman, J.D., Ahmed, R., and Biron, C.A. (1999). Two roads diverged: Interferon α/β -and interleukin 12-mediated pathways in promoting T cell interferon y responses during viral infection. J. Exp. Med. 189, 1315-1328.
-
(1999)
J. Exp. Med
, vol.189
, pp. 1315-1328
-
-
Cousens, L.P.1
Peterson, R.2
Hsu, S.3
Dorner, A.4
Altman, J.D.5
Ahmed, R.6
Biron, C.A.7
-
13
-
-
2342623292
-
TLR7: A new sensor of viral infection
-
Crozat, K., and Beutler, B. (2004). TLR7: A new sensor of viral infection. Proc. Natl. Acad. Sci. U.S.A. 101, 6835-6836.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 6835-6836
-
-
Crozat, K.1
Beutler, B.2
-
14
-
-
0028934815
-
Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression.Proc
-
Dai, Y., Schwarz, E.M., Gu, D., Zhang, W.W., Sarvetnick, N., and Verma, I.M. (1995). Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression.Proc. Natl. Acad. Sci. U.S.A. 92, 1401-1405.
-
(1995)
Natl. Acad. Sci. U.S.A
, vol.92
, pp. 1401-1405
-
-
Dai, Y.1
Schwarz, E.M.2
Gu, D.3
Zhang, W.W.4
Sarvetnick, N.5
Verma, I.M.6
-
15
-
-
0042307304
-
Viral infection switches nonplasmacytoid dendritic cells into high interferon producers
-
Diebold, S.S., Montoya, M., Unger, H., Alexopoulou, L., Roy, P., Haswell, L.E., Al-Shamkhani, A., Flavell, R., Borrow, P., and Reis E Sousa, C. (2003). Viral infection switches nonplasmacytoid dendritic cells into high interferon producers. Nature 424, 324-328.
-
(2003)
Nature
, vol.424
, pp. 324-328
-
-
Diebold, S.S.1
Montoya, M.2
Unger, H.3
Alexopoulou, L.4
Roy, P.5
Haswell, L.E.6
Al-Shamkhani, A.7
Flavell, R.8
Borrow, P.9
Reis, E.10
Sousa, C.11
-
16
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
Diebold, S.S., Kaisho, T.,Hemmi,H., Akira, S., and Reis E Sousa,C. (2004). Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531.
-
(2004)
Science
, vol.303
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis, E.5
Sousa, C.6
-
17
-
-
0031058024
-
Recombinant adeno-associated virus for muscle directed gene therapy
-
Fisher, K.J., Jooss, K., Alston, J., Yang, Y., Haecker, S.E., High, K., Pathak, R., Raper, S.E., and Wilson, J.M. (1997). Recombinant adeno-associated virus for muscle directed gene therapy. Nat. Med. 3, 306-312.
-
(1997)
Nat. Med
, vol.3
, pp. 306-312
-
-
Fisher, K.J.1
Jooss, K.2
Alston, J.3
Yang, Y.4
Haecker, S.E.5
High, K.6
Pathak, R.7
Raper, S.E.8
Wilson, J.M.9
-
18
-
-
0027484584
-
Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector
-
Flotte, T.R., Afione, S.A., Conrad, C., McGrath, S.A., Solow, R., Oka, H., Zeitlin, P.L., Guggino, W.B., and Carter, B.J. (1993). Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc. Natl. Acad. Sci. U.S.A. 90, 10613-10617.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A
, vol.90
, pp. 10613-10617
-
-
Flotte, T.R.1
Afione, S.A.2
Conrad, C.3
McGrath, S.A.4
Solow, R.5
Oka, H.6
Zeitlin, P.L.7
Guggino, W.B.8
Carter, B.J.9
-
19
-
-
34247341367
-
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
-
Gack, M.U., Shin, Y.C., Joo, C.H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., and Jung, J.U. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916-920.
-
(2007)
Nature
, vol.446
, pp. 916-920
-
-
Gack, M.U.1
Shin, Y.C.2
Joo, C.H.3
Urano, T.4
Liang, C.5
Sun, L.6
Takeuchi, O.7
Akira, S.8
Chen, Z.9
Inoue, S.10
Jung, J.U.11
-
20
-
-
33646555810
-
Type 1 interferons and the virus-host relationship: A lesson in de'tente
-
Garcia-Sastre, A., and Biron, C.A. (2006). Type 1 interferons and the virus-host relationship: A lesson in de'tente. Science 312, 879-882.
-
(2006)
Science
, vol.312
, pp. 879-882
-
-
Garcia-Sastre, A.1
Biron, C.A.2
-
21
-
-
0032907636
-
Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector
-
Greelish, J.P., Su, L.T., Lankford, E.B., Burkman, J.M., Chen, H., Konig, S.K., Mercier, I.M., Desjardins, P.R., Mitchell, M.A., Zheng, X.G., Leferovich, J., Gao, G.P., Balice-Gordon, R.J., Wilson, J.M., and Stedman, H.H. (1999). Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector. Nat. Med. 5, 439-443.
-
(1999)
Nat. Med
, vol.5
, pp. 439-443
-
-
Greelish, J.P.1
Su, L.T.2
Lankford, E.B.3
Burkman, J.M.4
Chen, H.5
Konig, S.K.6
Mercier, I.M.7
Desjardins, P.R.8
Mitchell, M.A.9
Zheng, X.G.10
Leferovich, J.11
Gao, G.P.12
Balice-Gordon, R.J.13
Wilson, J.M.14
Stedman, H.H.15
-
22
-
-
33745894322
-
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice
-
Gregorevic, P., Allen, J.M., Minami, E., Blankinship, M.J., Haraguchi, M., Meuse, L., Finn, E., Adams, M.E., Froehner, S.C.,Murry, C.E., and Chamberlain, J.S. (2006). rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice. Nat. Med. 12, 787-789.
-
(2006)
Nat. Med
, vol.12
, pp. 787-789
-
-
Gregorevic, P.1
Allen, J.M.2
Minami, E.3
Blankinship, M.J.4
Haraguchi, M.5
Meuse, L.6
Finn, E.7
Adams, M.E.8
Froehner, S.C.9
Murry, C.E.10
Chamberlain, J.S.11
-
23
-
-
33746884630
-
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
-
Guiducci, C., Ott, G., Chan, J.H., Damon, E., Calacsan, C., Matray, T., Lee, K.D., Coffman, R.L., and Barrat, F.J. (2006). Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203, 1999-2008.
-
(2006)
J. Exp. Med
, vol.203
, pp. 1999-2008
-
-
Guiducci, C.1
Ott, G.2
Chan, J.H.3
Damon, E.4
Calacsan, C.5
Matray, T.6
Lee, K.D.7
Coffman, R.L.8
Barrat, F.J.9
-
24
-
-
33846799474
-
Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo
-
Hartman, Z.C., Kiang, A., Everett, R.S., Serra, D., Yang, X.Y., Clay, T.M., and Amalfitano, A. (2007). Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. J. Virol. 81, 1796-1812.
-
(2007)
J. Virol
, vol.81
, pp. 1796-1812
-
-
Hartman, Z.C.1
Kiang, A.2
Everett, R.S.3
Serra, D.4
Yang, X.Y.5
Clay, T.M.6
Amalfitano, A.7
-
25
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via Tolllike receptor 7 and 8
-
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., and Bauer, S. (2004). Species-specific recognition of single-stranded RNA via Tolllike receptor 7 and 8. Science 303, 1526-1529.
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
Akira, S.6
Lipford, G.7
Wagner, H.8
Bauer, S.9
-
26
-
-
27144508046
-
+ T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors
-
+ T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors. J. Immunol. 175, 6032-6041.
-
(2005)
J. Immunol
, vol.175
, pp. 6032-6041
-
-
Hensley, S.E.1
Giles-Davis, W.2
McCoy, K.C.3
Weninger, W.4
Ertl, H.C.5
-
27
-
-
0030902985
-
Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus
-
Herzog, R.W., Hagstrom, J.N., Kung, S.H., Tai, S.J., Wilson, J.M., Fisher, K.J., and High, K.A. (1997). Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc. Natl. Acad. Sci. U.S.A. 94, 5804-5809.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A
, vol.94
, pp. 5804-5809
-
-
Herzog, R.W.1
Hagstrom, J.N.2
Kung, S.H.3
Tai, S.J.4
Wilson, J.M.5
Fisher, K.J.6
High, K.A.7
-
28
-
-
17444387438
-
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
-
Herzog, R.W., Yang, E.Y., Couto, L.B., Hagstrom, J.N., Elwell, D., Fields, P.A., Burton, M., Bellinger, D.A., Read, M.S., Brinkhous, K.M., Podsakoff, G.M., Nichols, T.C., Kurtzman, G.J., and High, K.A. (1999). Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nat. Med. 5, 56-63.
-
(1999)
Nat. Med
, vol.5
, pp. 56-63
-
-
Herzog, R.W.1
Yang, E.Y.2
Couto, L.B.3
Hagstrom, J.N.4
Elwell, D.5
Fields, P.A.6
Burton, M.7
Bellinger, D.A.8
Read, M.S.9
Brinkhous, K.M.10
Podsakoff, G.M.11
Nichols, T.C.12
Kurtzman, G.J.13
High, K.A.14
-
29
-
-
3843103508
-
Herpes simplex virus type-1 induces IFN-a production via Toll-like receptor 9-dependent and -independent pathways
-
Hochrein, H., Schlatter, B., O'Keeffe, M., Wagner, C., Schmitz, F., Schiemann, M., Bauer, S., Suter, M., and Wagner, H. (2004). Herpes simplex virus type-1 induces IFN-a production via Toll-like receptor 9-dependent and -independent pathways. Proc. Natl. Acad. Sci. U.S.A. 101, 11416-11421.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 11416-11421
-
-
Hochrein, H.1
Schlatter, B.2
O'Keeffe, M.3
Wagner, C.4
Schmitz, F.5
Schiemann, M.6
Bauer, S.7
Suter, M.8
Wagner, H.9
-
30
-
-
0347146027
-
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trifindependent pathways
-
Hoebe, K., Janssen, E.M., Kim, S.O., Alexopoulou, L., Flavell, R.A., Han, J., and Beutler, B. (2003). Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trifindependent pathways. Nat. Immunol. 4, 1223-1229.
-
(2003)
Nat. Immunol
, vol.4
, pp. 1223-1229
-
-
Hoebe, K.1
Janssen, E.M.2
Kim, S.O.3
Alexopoulou, L.4
Flavell, R.A.5
Han, J.6
Beutler, B.7
-
31
-
-
0033591428
-
Phylogenetic perspectives in innate immunity
-
Hoffmann, J.A., Kafatos, F.C., Janeway, C.A., and Ezekowitz, R.A. (1999). Phylogenetic perspectives in innate immunity. Science 284, 1313-1318.
-
(1999)
Science
, vol.284
, pp. 1313-1318
-
-
Hoffmann, J.A.1
Kafatos, F.C.2
Janeway, C.A.3
Ezekowitz, R.A.4
-
32
-
-
0141703238
-
Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
-
Honda, K., Sakaguchi, S., Nakajima, C., Watanabe, A., Yanai, H., Matsumoto, M., Ohteki, T., Kaisho, T., Takaoka, A., Akira, S., Seya, T., and Taniguchi, T. (2003). Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl. Acad. Sci. U.S.A. 100, 10872-10877.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 10872-10877
-
-
Honda, K.1
Sakaguchi, S.2
Nakajima, C.3
Watanabe, A.4
Yanai, H.5
Matsumoto, M.6
Ohteki, T.7
Kaisho, T.8
Takaoka, A.9
Akira, S.10
Seya, T.11
Taniguchi, T.12
-
33
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
-
Honda, K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C., and Taniguchi, T. (2005). Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434, 1035-1040.
-
(2005)
Nature
, vol.434
, pp. 1035-1040
-
-
Honda, K.1
Ohba, Y.2
Yanai, H.3
Negishi, H.4
Mizutani, T.5
Takaoka, A.6
Taya, C.7
Taniguchi, T.8
-
34
-
-
33750976374
-
50-Triphosphate RNA is the ligand for RIG-I
-
Hornung, V., Ellegast, J., KIM, S., Brzozka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.K., Schlee, M., Endres, S., and Hartmann, G. (2006). 50-Triphosphate RNA is the ligand for RIG-I. Science 314, 994-997.
-
(2006)
Science
, vol.314
, pp. 994-997
-
-
Hornung, V.1
Ellegast, J.2
KIM, S.3
Brzozka, K.4
Jung, A.5
Kato, H.6
Poeck, H.7
Akira, S.8
Conzelmann, K.K.9
Schlee, M.10
Endres, S.11
Hartmann, G.12
-
35
-
-
33645841633
-
kB kinase-α is critical for interferon-α production induced by Tolllike receptors 7 and 9
-
kB kinase-α is critical for interferon-α production induced by Tolllike receptors 7 and 9. Nature 440, 949-953.
-
(2006)
Nature
, vol.440
, pp. 949-953
-
-
Hoshino, K.1
Sugiyama, T.2
Matsumoto, M.3
Tanaka, T.4
Saito, M.5
Hemmi, H.6
Ohara, O.7
Akira, S.8
Kaisho, T.9
-
36
-
-
33846532947
-
Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses
-
Iacobelli-Martinez, M., and Nemerow, G.R. (2007). Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses. J. Virol. 81, 1305-1312.
-
(2007)
J. Virol
, vol.81
, pp. 1305-1312
-
-
Iacobelli-Martinez, M.1
Nemerow, G.R.2
-
37
-
-
29244471275
-
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
-
Ishii, K.J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H., Sutter, G., Suzuki, K., Hemmi, H., Sato, S., Yamamoto, M., Uematsu, S., Kawai, T., Takeuchi, O., and Akira, S. (2006). A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7, 40-48.
-
(2006)
Nat. Immunol
, vol.7
, pp. 40-48
-
-
Ishii, K.J.1
Coban, C.2
Kato, H.3
Takahashi, K.4
Torii, Y.5
Takeshita, F.6
Ludwig, H.7
Sutter, G.8
Suzuki, K.9
Hemmi, H.10
Sato, S.11
Yamamoto, M.12
Uematsu, S.13
Kawai, T.14
Takeuchi, O.15
Akira, S.16
-
38
-
-
38949093002
-
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
-
Ishii, K.J., Kawagoe, T., Koyama, S., Matsui, K., Kumar, H., Kawai, T., Uematsu, S., Takeuchi, O., Takeshita, F., Coban, C., and Akira, S. (2008). TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451, 725-729.
-
(2008)
Nature
, vol.451
, pp. 725-729
-
-
Ishii, K.J.1
Kawagoe, T.2
Koyama, S.3
Matsui, K.4
Kumar, H.5
Kawai, T.6
Uematsu, S.7
Takeuchi, O.8
Takeshita, F.9
Coban, C.10
Akira, S.11
-
39
-
-
5444262511
-
Toll-like receptor control of the adaptive immune responses
-
Iwasaki, A., and Medzhitov, R. (2004). Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5, 987-995.
-
(2004)
Nat. Immunol
, vol.5
, pp. 987-995
-
-
Iwasaki, A.1
Medzhitov, R.2
-
40
-
-
9144234252
-
-α expression in human plasmacytoid and monocyte-derived dendritic cells
-
-α expression in human plasmacytoid and monocyte-derived dendritic cells. J. Leukoc. Biol. 74, 1125-1138.
-
(2003)
J. Leukoc. Biol
, vol.74
, pp. 1125-1138
-
-
Izaguirre, A.1
Barnes, B.J.2
Amrute, S.3
Yeow, W.S.4
Megjugorac, N.5
Dai, J.6
Feng, D.7
Chung, E.8
Pitha, P.M.9
Fitzgerald- Bocarsly, P.10
-
41
-
-
0030585155
-
When two strands are better than one: The mediators and modulators of the cellular responses to double-stranded RNA
-
Jacobs, B.L., and Langland, J.O. (1996). When two strands are better than one: The mediators and modulators of the cellular responses to double-stranded RNA. Virology 219, 339-349.
-
(1996)
Virology
, vol.219
, pp. 339-349
-
-
Jacobs, B.L.1
Langland, J.O.2
-
42
-
-
20644469429
-
CD14 is required for MyD88 - independent LPS signaling
-
Jiang, Z., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., Freudenberg, M., and Beutler, B. (2005). CD14 is required for MyD88 - independent LPS signaling. Nat. Immunol. 6, 565-570.
-
(2005)
Nat. Immunol
, vol.6
, pp. 565-570
-
-
Jiang, Z.1
Georgel, P.2
Du, X.3
Shamel, L.4
Sovath, S.5
Mudd, S.6
Huber, M.7
Kalis, C.8
Keck, S.9
Galanos, C.10
Freudenberg, M.11
Beutler, B.12
-
43
-
-
22544455673
-
Cell type-specific involvement of RIG-I in antiviral response
-
Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., and Akira, S. (2005). Cell type-specific involvement of RIG-I in antiviral response. Immunity 23, 19-28.
-
(2005)
Immunity
, vol.23
, pp. 19-28
-
-
Kato, H.1
Sato, S.2
Yoneyama, M.3
Yamamoto, M.4
Uematsu, S.5
Matsui, K.6
Tsujimura, T.7
Takeda, K.8
Fujita, T.9
Takeuchi, O.10
Akira, S.11
-
44
-
-
31344461659
-
Innate immune recognition of viral infection
-
Kawai, T., and Akira, S. (2006). Innate immune recognition of viral infection. Nat. Immunol. 7, 131-137.
-
(2006)
Nat. Immunol
, vol.7
, pp. 131-137
-
-
Kawai, T.1
Akira, S.2
-
45
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
-
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K.J., Takeuchi, O., and Akira, S. (2005). IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6, 981-988.
-
(2005)
Nat. Immunol
, vol.6
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
Kumar, H.5
Kato, H.6
Ishii, K.J.7
Takeuchi, O.8
Akira, S.9
-
46
-
-
0029113869
-
Long-term hepatic adenovirus- mediated gene expression in mice following CTLA4Ig administration
-
Kay, M.A., Holterman, A.X., Meuse, L., Gown, A., Ochs, H.D., Linsley, P.S., and Wilson, C.B. (1995). Long-term hepatic adenovirus- mediated gene expression in mice following CTLA4Ig administration. Nat. Genet. 11, 191-197.
-
(1995)
Nat. Genet
, vol.11
, pp. 191-197
-
-
Kay, M.A.1
Holterman, A.X.2
Meuse, L.3
Gown, A.4
Ochs, H.D.5
Linsley, P.S.6
Wilson, C.B.7
-
47
-
-
0036219195
-
CpG motifs in bacterial DNA and their immune effects
-
Krieg, A.M. (2002). CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760.
-
(2002)
Annu. Rev. Immunol
, vol.20
, pp. 709-760
-
-
Krieg, A.M.1
-
48
-
-
3142683548
-
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
-
Krug, A., French, A.R., Barchet, W., Fischer, J.A., Dzionek, A., Pingel, J.T., Orihuela, M.M., Akira, S., Yokoyama, W.M., and Colonna, M. (2004). TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21, 107-119.
-
(2004)
Immunity
, vol.21
, pp. 107-119
-
-
Krug, A.1
French, A.R.2
Barchet, W.3
Fischer, J.A.4
Dzionek, A.5
Pingel, J.T.6
Orihuela, M.M.7
Akira, S.8
Yokoyama, W.M.9
Colonna, M.10
-
49
-
-
5944261457
-
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
-
Kurt-Jones, E.A., Popova, L., Kwinn, L., Haynes, L.M., Jones, L.P., Tripp, R.A., Walsh, E.E., Freeman, M.W., Golenbock, D.T., Anderson, L.J., and Finberg, R.W. (2000). Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1, 398-401.
-
(2000)
Nat. Immunol
, vol.1
, pp. 398-401
-
-
Kurt-Jones, E.A.1
Popova, L.2
Kwinn, L.3
Haynes, L.M.4
Jones, L.P.5
Tripp, R.A.6
Walsh, E.E.7
Freeman, M.W.8
Golenbock, D.T.9
Anderson, L.J.10
Finberg, R.W.11
-
50
-
-
0842342607
-
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis
-
Kurt-Jones, E.A., Chan, M., Zhou, S., Wang, J., Reed, G., Bronson, R., Arnold, M.M., Knipe, D.M., and Finberg, R.W. (2004). Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc. Natl. Acad. Sci. U.S.A. 101, 1315-1320.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 1315-1320
-
-
Kurt-Jones, E.A.1
Chan, M.2
Zhou, S.3
Wang, J.4
Reed, G.5
Bronson, R.6
Arnold, M.M.7
Knipe, D.M.8
Finberg, R.W.9
-
51
-
-
34250698370
-
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
-
Latz, E., Verma, A., Visintin, A., Gong, M., Sirois, C.M., Klein, D.C., Monks, B.G., McKnight, C.J., Lamphier, M.S., Duprex, W.P., Espevik, T., and Golenbock, D.T. (2007). Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat. Immunol. 8, 772-779.
-
(2007)
Nat. Immunol
, vol.8
, pp. 772-779
-
-
Latz, E.1
Verma, A.2
Visintin, A.3
Gong, M.4
Sirois, C.M.5
Klein, D.C.6
Monks, B.G.7
McKnight, C.J.8
Lamphier, M.S.9
Duprex, W.P.10
Espevik, T.11
Golenbock, D.T.12
-
52
-
-
0142092614
-
+ T cells stimulated by virus-induced type I interferon
-
+ T cells stimulated by virus-induced type I interferon. Nat. Immunol. 4, 1009-1015.
-
(2003)
Nat. Immunol
, vol.4
, pp. 1009-1015
-
-
Le Bon, A.1
Etchart, N.2
Rossmann, C.3
Ashton, M.4
Hou, S.5
Gewert, D.6
Borrow, P.7
Tough, D.F.8
-
53
-
-
32244432768
-
Double-stranded RNA-mediated TLR3 activation is enhanced by CD14
-
Lee, H.K., Dunzendorfer, S., Soldau, K., and Tobias, P.S. (2006). Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Immunity 24, 153-163.
-
(2006)
Immunity
, vol.24
, pp. 153-163
-
-
Lee, H.K.1
Dunzendorfer, S.2
Soldau, K.3
Tobias, P.S.4
-
54
-
-
33947134377
-
Autophagy-dependent viral recognition by plasmacytoid dendritic cells
-
Lee, H.K., Lund, J.M., Ramanathan, B., Mizushima, N., and Iwasaki, A. (2007). Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315, 1398-1401.
-
(2007)
Science
, vol.315
, pp. 1398-1401
-
-
Lee, H.K.1
Lund, J.M.2
Ramanathan, B.3
Mizushima, N.4
Iwasaki, A.5
-
55
-
-
0042123694
-
Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells
-
Lund, J., Sato, A., Akira, S., Medzhitov, R., and Iwasaki, A. (2003). Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198, 513-520.
-
(2003)
J. Exp. Med
, vol.198
, pp. 513-520
-
-
Lund, J.1
Sato, A.2
Akira, S.3
Medzhitov, R.4
Iwasaki, A.5
-
56
-
-
1842631428
-
Recognition of single-stranded RNA viruses by Toll-like receptor 7
-
Lund, J.M., Alexopoulou, L., Sato, A., Karow, M., Adams, N.C., Gale, N.W., Iwasaki, A., and Flavell, R.A. (2004). Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. U.S.A. 101, 5598-5603.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 5598-5603
-
-
Lund, J.M.1
Alexopoulou, L.2
Sato, A.3
Karow, M.4
Adams, N.C.5
Gale, N.W.6
Iwasaki, A.7
Flavell, R.A.8
-
57
-
-
33644820684
-
-
Manno, C.S., Pierce, G.F., Arruda, V.R., Glader, B., Ragni, M., Rasko, J.J., Ozelo, M.C., Hoots, K., Blatt, P., Konkle, B., Dake, M., Kaye, R., Razavi, M., Zajko, A., Zehnder, J., Rustagi, P.K., Nakai, H., Chew, A., Leonard, D., Wright, J.F., Lessard, R.R., Sommer, J.M., Tigges, M., Sabatino, D., Luk, A., Jiang, H., Mingozzi, F., Couto, L., Ertl, H.C., High, K.A., and Kay, M.A. (2006). Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 12, 342-347.
-
Manno, C.S., Pierce, G.F., Arruda, V.R., Glader, B., Ragni, M., Rasko, J.J., Ozelo, M.C., Hoots, K., Blatt, P., Konkle, B., Dake, M., Kaye, R., Razavi, M., Zajko, A., Zehnder, J., Rustagi, P.K., Nakai, H., Chew, A., Leonard, D., Wright, J.F., Lessard, R.R., Sommer, J.M., Tigges, M., Sabatino, D., Luk, A., Jiang, H., Mingozzi, F., Couto, L., Ertl, H.C., High, K.A., and Kay, M.A. (2006). Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 12, 342-347.
-
-
-
-
58
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
-
Martinon, F., Burns, K., and Tschopp, J. (2002). The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417-426.
-
(2002)
Mol. Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
59
-
-
42549161844
-
The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver
-
McCaffrey, A.P., Fawcett, P., Nakai, H., McCaffrey, R.L., Ehrhardt, A., Pham, T.T., Pandey, K., Xu, H., Feuss, S., Storm, T.A., and Kay, M.A. (2008). The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Mol. Ther. 16, 931-941.
-
(2008)
Mol. Ther
, vol.16
, pp. 931-941
-
-
McCaffrey, A.P.1
Fawcett, P.2
Nakai, H.3
McCaffrey, R.L.4
Ehrhardt, A.5
Pham, T.T.6
Pandey, K.7
Xu, H.8
Feuss, S.9
Storm, T.A.10
Kay, M.A.11
-
60
-
-
27144440476
-
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
-
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., and Tschopp, J. (2005). Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167-1172.
-
(2005)
Nature
, vol.437
, pp. 1167-1172
-
-
Meylan, E.1
Curran, J.2
Hofmann, K.3
Moradpour, D.4
Binder, M.5
Bartenschlager, R.6
Tschopp, J.7
-
61
-
-
2442638935
-
Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo
-
Muruve, D.A., Cotter, M.J., Zaiss, A.K., White, L.R., Liu, Q., Chan, T., Clark, S.A., Ross, P.J., Meulenbroek, R.A., Maelandsmo, G.M., and Parks, R.J. (2004). Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. J. Virol. 78, 5966-5972.
-
(2004)
J. Virol
, vol.78
, pp. 5966-5972
-
-
Muruve, D.A.1
Cotter, M.J.2
Zaiss, A.K.3
White, L.R.4
Liu, Q.5
Chan, T.6
Clark, S.A.7
Ross, P.J.8
Meulenbroek, R.A.9
Maelandsmo, G.M.10
Parks, R.J.11
-
62
-
-
40449097257
-
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
-
Muruve, D.A., Petrilli, V., Zaiss, A.K., White, L.R., Clark, S.A., Ross, P.J., Parks, R.J., and Tschopp, J. (2008). The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452, 103-107.
-
(2008)
Nature
, vol.452
, pp. 103-107
-
-
Muruve, D.A.1
Petrilli, V.2
Zaiss, A.K.3
White, L.R.4
Clark, S.A.5
Ross, P.J.6
Parks, R.J.7
Tschopp, J.8
-
63
-
-
0034123135
-
Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
-
Muzio, M., Bosisio, D., Polentarutti, N., D'Amico, G., Stoppacciaro, A., Mancinelli, R., Van't Veer, C., Penton-Rol, G., Ruco, L.P., Allavena, P., and Mantovani, A. (2000). Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells.J. Immunol. 164, 5998-6004.
-
(2000)
J. Immunol
, vol.164
, pp. 5998-6004
-
-
Muzio, M.1
Bosisio, D.2
Polentarutti, N.3
D'Amico, G.4
Stoppacciaro, A.5
Mancinelli, R.6
Van't Veer, C.7
Penton-Rol, G.8
Ruco, L.P.9
Allavena, P.10
Mantovani, A.11
-
64
-
-
0037144547
-
Critical role for STAT4 activation by type 1 interferons in the interferon-y response to viral infection
-
Nguyen, K.B., Watford, W.T., Salomon, R., Hofmann, S.R., Pien, G.C., Morinobu, A., Gadina, M., O'Shea, J.J., and Biron, C.A. (2002). Critical role for STAT4 activation by type 1 interferons in the interferon-y response to viral infection. Science 297, 2063-2066.
-
(2002)
Science
, vol.297
, pp. 2063-2066
-
-
Nguyen, K.B.1
Watford, W.T.2
Salomon, R.3
Hofmann, S.R.4
Pien, G.C.5
Morinobu, A.6
Gadina, M.7
O'Shea, J.J.8
Biron, C.A.9
-
65
-
-
34247116994
-
Sensing infection by adenovirus: Toll-like receptorindependent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator
-
Nociari, M., Ocheretina, O., Schoggins, J.W., and Falck-Pedersen, E. (2007). Sensing infection by adenovirus: Toll-like receptorindependent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. J. Virol. 81, 4145-4157.
-
(2007)
J. Virol
, vol.81
, pp. 4145-4157
-
-
Nociari, M.1
Ocheretina, O.2
Schoggins, J.W.3
Falck-Pedersen, E.4
-
66
-
-
0030462599
-
A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
-
Parks, R.J., Chen, L., Anton, M., Sankar, U., Rudnicki, M.A., and Graham, F.L. (1996). A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Natl. Acad. Sci. U.S.A. 93, 13565-13570.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A
, vol.93
, pp. 13565-13570
-
-
Parks, R.J.1
Chen, L.2
Anton, M.3
Sankar, U.4
Rudnicki, M.A.5
Graham, F.L.6
-
67
-
-
2642537522
-
Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain
-
Peden, C.S., Burger, C., Muzyczka, N., and Mandel, R.J. (2004). Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. J. Virol. 78, 6344-6359.
-
(2004)
J. Virol
, vol.78
, pp. 6344-6359
-
-
Peden, C.S.1
Burger, C.2
Muzyczka, N.3
Mandel, R.J.4
-
68
-
-
1942533432
-
Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-α induction pathway
-
Philpott, N.J., Nociari, M., Elkon, K.B., and Falck-Pedersen, E. (2004). Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-α induction pathway. Proc. Natl. Acad. Sci. U.S.A. 101, 6200-6205.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 6200-6205
-
-
Philpott, N.J.1
Nociari, M.2
Elkon, K.B.3
Falck-Pedersen, E.4
-
69
-
-
34548694962
-
-
Pichlmair, A., and Reis e Sousa, C. (2007). Innate recognition of viruses. Immunity 27, 370-383.
-
Pichlmair, A., and Reis e Sousa, C. (2007). Innate recognition of viruses. Immunity 27, 370-383.
-
-
-
-
70
-
-
32944478316
-
Translating innate immunity into immunological memory: Implications for vaccine development
-
Pulendran, B., and Ahmed, R. (2006). Translating innate immunity into immunological memory: Implications for vaccine development. Cell 124, 849-863.
-
(2006)
Cell
, vol.124
, pp. 849-863
-
-
Pulendran, B.1
Ahmed, R.2
-
71
-
-
42149149899
-
STAT1 Signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo
-
Quigley, M., Huang, X., and Yang, Y. (2008). STAT1 Signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo. J. Immunol. 180, 2158-2164.
-
(2008)
J. Immunol
, vol.180
, pp. 2158-2164
-
-
Quigley, M.1
Huang, X.2
Yang, Y.3
-
72
-
-
0142089747
-
Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
-
Raper, S.E., Chirmule, N., Lee, F.S., Wivel, N.A., Bagg, A., Gao, G.P., Wilson, J.M., and Batshaw, M.L. (2003). Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol. Genet. Metab. 80, 148-158.
-
(2003)
Mol. Genet. Metab
, vol.80
, pp. 148-158
-
-
Raper, S.E.1
Chirmule, N.2
Lee, F.S.3
Wivel, N.A.4
Bagg, A.5
Gao, G.P.6
Wilson, J.M.7
Batshaw, M.L.8
-
73
-
-
0037133308
-
Murine retroviruses activate B cells via interaction with Toll-like receptor 4
-
Rassa, J.C., Meyers, J.L., Zhang, Y., Kudaravalli, R., and Ross, S.R. (2002). Murine retroviruses activate B cells via interaction with Toll-like receptor 4. Proc. Natl. Acad. Sci. U.S.A. 99, 2281-2286.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A
, vol.99
, pp. 2281-2286
-
-
Rassa, J.C.1
Meyers, J.L.2
Zhang, Y.3
Kudaravalli, R.4
Ross, S.R.5
-
74
-
-
26844503987
-
The RNA helicase Lgp2 inhibits TLRindependent sensing of viral replication by retinoic acidinducible gene-I
-
Rothenfusser, S., Goutagny, N., Diperna, G., Gong, M., Monks, B.G., Schoenemeyer, A., Yamamoto, M., Akira, S., and Fitzgerald, K.A. (2005). The RNA helicase Lgp2 inhibits TLRindependent sensing of viral replication by retinoic acidinducible gene-I. J. Immunol. 175, 5260-5268.
-
(2005)
J. Immunol
, vol.175
, pp. 5260-5268
-
-
Rothenfusser, S.1
Goutagny, N.2
Diperna, G.3
Gong, M.4
Monks, B.G.5
Schoenemeyer, A.6
Yamamoto, M.7
Akira, S.8
Fitzgerald, K.A.9
-
75
-
-
33846307026
-
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
-
Saito, T., Hirai, R., Loo, Y.M., Owen, D., Johnson, C.L., Sinha, S.C., Akira, S., Fujita, T., and Gale, M., Jr. (2007). Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl. Acad. Sci. U.S.A. 104, 582-587.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A
, vol.104
, pp. 582-587
-
-
Saito, T.1
Hirai, R.2
Loo, Y.M.3
Owen, D.4
Johnson, C.L.5
Sinha, S.C.6
Akira, S.7
Fujita, T.8
Gale Jr., M.9
-
76
-
-
0033680737
-
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction
-
Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., and Taniguchi, T. (2000). Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction. Immunity 13, 539-548.
-
(2000)
Immunity
, vol.13
, pp. 539-548
-
-
Sato, M.1
Suemori, H.2
Hata, N.3
Asagiri, M.4
Ogasawara, K.5
Nakao, K.6
Nakaya, T.7
Katsuki, M.8
Noguchi, S.9
Tanaka, N.10
Taniguchi, T.11
-
77
-
-
33344466244
-
Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice
-
Scallan, C.D., Jiang, H., Liu, T., Patarroyo-White, S., Sommer, J.M., Zhou, S., Couto, L.B., and Pierce, G.F. (2006). Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice. Blood 107, 1810-1817.
-
(2006)
Blood
, vol.107
, pp. 1810-1817
-
-
Scallan, C.D.1
Jiang, H.2
Liu, T.3
Patarroyo-White, S.4
Sommer, J.M.5
Zhou, S.6
Couto, L.B.7
Pierce, G.F.8
-
78
-
-
17844393413
-
Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors
-
Schnell, M.A., Zhang, Y., Tazelaar, J., Gao, G.P., Yu, Q.C., Qian, R., Chen, S.J., Varnavski, A.N., Leclair, C., Raper, S.E., and Wilson, J.M. (2001). Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol. Ther. 3, 708-722.
-
(2001)
Mol. Ther
, vol.3
, pp. 708-722
-
-
Schnell, M.A.1
Zhang, Y.2
Tazelaar, J.3
Gao, G.P.4
Yu, Q.C.5
Qian, R.6
Chen, S.J.7
Varnavski, A.N.8
Leclair, C.9
Raper, S.E.10
Wilson, J.M.11
-
79
-
-
20044382430
-
-
Schulz, O., Diebold, S.S., Chen, M., Naslund, T.I., Nolte, M.A., Alexopoulou, L., Azuma, Y.T., Flavell, R.A., Liljestrom, P., and Reis e Sousa, C. (2005). Toll-like receptor 3 promotes crosspriming to virus-infected cells. Nature 433, 887-892.
-
Schulz, O., Diebold, S.S., Chen, M., Naslund, T.I., Nolte, M.A., Alexopoulou, L., Azuma, Y.T., Flavell, R.A., Liljestrom, P., and Reis e Sousa, C. (2005). Toll-like receptor 3 promotes crosspriming to virus-infected cells. Nature 433, 887-892.
-
-
-
-
80
-
-
24144461689
-
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kB and IRF 3
-
Seth, R.B., Sun, L., Ea, C.K., and Chen, Z.J. (2005). Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kB and IRF 3. Cell 122, 669-682.
-
(2005)
Cell
, vol.122
, pp. 669-682
-
-
Seth, R.B.1
Sun, L.2
Ea, C.K.3
Chen, Z.J.4
-
81
-
-
33645963170
-
Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells
-
Shinohara, M.L., Lu, L., Bu, J., Werneck, M.B., Kobayashi, K.S., Glimcher, L.H., and Cantor, H. (2006). Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells. Nat. Immunol. 7, 498-506.
-
(2006)
Nat. Immunol
, vol.7
, pp. 498-506
-
-
Shinohara, M.L.1
Lu, L.2
Bu, J.3
Werneck, M.B.4
Kobayashi, K.S.5
Glimcher, L.H.6
Cantor, H.7
-
82
-
-
17444372024
-
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors
-
Snyder, R.O., Miao, C., Meuse, L., Tubb, J., Donahue, B.A., Lin, H.F., Stafford, D.W., Patel, S., Thompson,A.R., Nichols, T.,Read, M.S., Bellinger, D.A., Brinkhous, K.M., and Kay, M.A. (1999). Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors. Nat. Med. 5, 64-70.
-
(1999)
Nat. Med
, vol.5
, pp. 64-70
-
-
Snyder, R.O.1
Miao, C.2
Meuse, L.3
Tubb, J.4
Donahue, B.A.5
Lin, H.F.6
Stafford, D.W.7
Patel, S.8
Thompson, A.R.9
Nichols, T.10
Read, M.S.11
Bellinger, D.A.12
Brinkhous, K.M.13
Kay, M.A.14
-
83
-
-
13144305062
-
Sustained secretion of human α-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors
-
Song, S., Morgan, M., Ellis, T., Poirier, A., Chesnut, K., Wang, J., Brantly, M., Muzyczka, N., Byrne, B.J., Atkinson, M., and Flotte, T.R. (1998). Sustained secretion of human α-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors. Proc. Natl. Acad. Sci. U.S.A. 95, 14384-14388.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A
, vol.95
, pp. 14384-14388
-
-
Song, S.1
Morgan, M.2
Ellis, T.3
Poirier, A.4
Chesnut, K.5
Wang, J.6
Brantly, M.7
Muzyczka, N.8
Byrne, B.J.9
Atkinson, M.10
Flotte, T.R.11
-
84
-
-
30444450839
-
-
Stetson, D.B., and Medzhitov, R. (2006). Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.Immunity 24, 93-103.
-
Stetson, D.B., and Medzhitov, R. (2006). Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.Immunity 24, 93-103.
-
-
-
-
85
-
-
1642525192
-
Role of viral vectors and virion shells in cellular gene expression
-
Stilwell, J.L., and Samulski, R.J. (2004). Role of viral vectors and virion shells in cellular gene expression. Mol. Ther. 9, 337-346.
-
(2004)
Mol. Ther
, vol.9
, pp. 337-346
-
-
Stilwell, J.L.1
Samulski, R.J.2
-
86
-
-
31344466165
-
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
-
Tabeta, K., Hoebe, K., Janssen, E.M., DU, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A.A., Portnoy, D.A., Cooke, M., Tarantino, L.M., Wiltshire, T., Steinberg, B.E., Grinstein, S., and Beutler, B. (2006). The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7, 156-164.
-
(2006)
Nat. Immunol
, vol.7
, pp. 156-164
-
-
Tabeta, K.1
Hoebe, K.2
Janssen, E.M.3
DU, X.4
Georgel, P.5
Crozat, K.6
Mudd, S.7
Mann, N.8
Sovath, S.9
Goode, J.10
Shamel, L.11
Herskovits, A.A.12
Portnoy, D.A.13
Cooke, M.14
Tarantino, L.M.15
Wiltshire, T.16
Steinberg, B.E.17
Grinstein, S.18
Beutler, B.19
-
87
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka, A., Wang, Z., Choi, M.K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., Ohba, Y., and Taniguchi, T. (2007). DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448, 501-505.
-
(2007)
Nature
, vol.448
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
Yanai, H.4
Negishi, H.5
Ban, T.6
Lu, Y.7
Miyagishi, M.8
Kodama, T.9
Honda, K.10
Ohba, Y.11
Taniguchi, T.12
-
88
-
-
0034857262
-
DExD/H box RNA helicases: From generic motors to specific dissociation functions
-
Tanner, N.K., and Linder, P. (2001). DExD/H box RNA helicases: From generic motors to specific dissociation functions. Mol. Cell 8, 251-262.
-
(2001)
Mol. Cell
, vol.8
, pp. 251-262
-
-
Tanner, N.K.1
Linder, P.2
-
89
-
-
17644402442
-
Type I interferons (α/β) in immunity and autoimmunity
-
Theofilopoulos, A.N., Baccala, R., Beutler, B., and Kono, D.H. (2005). Type I interferons (α/β) in immunity and autoimmunity. Annu. Rev. Immunol. 23, 307-336.
-
(2005)
Annu. Rev. Immunol
, vol.23
, pp. 307-336
-
-
Theofilopoulos, A.N.1
Baccala, R.2
Beutler, B.3
Kono, D.H.4
-
90
-
-
34447505084
-
Toll-like receptors and type I interferons
-
Uematsu, S., and Akira, S. (2007). Toll-like receptors and type I interferons. J. Biol. Chem. 282, 15319-15323.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 15319-15323
-
-
Uematsu, S.1
Akira, S.2
-
92
-
-
33947258375
-
Cutting edge: Antibody-mediated TLR7 - dependent recognition of viral RNA
-
Wang, J.P., Asher, D.R., Chan, M., Kurt-Jones, E.A., and Finberg, R.W. (2007). Cutting edge: Antibody-mediated TLR7 - dependent recognition of viral RNA. J. Immunol. 178, 3363-3367.
-
(2007)
J. Immunol
, vol.178
, pp. 3363-3367
-
-
Wang, J.P.1
Asher, D.R.2
Chan, M.3
Kurt-Jones, E.A.4
Finberg, R.W.5
-
93
-
-
0033616680
-
Sustained correction of bleeding disorder in hemophilia B mice by gene therapy
-
Wang, L., Takabe, K., Bidlingmaier, S.M., Ill, C.R., and Verma, I.M. (1999). Sustained correction of bleeding disorder in hemophilia B mice by gene therapy. Proc. Natl. Acad. Sci. U.S.A. 96, 3906-3910.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A
, vol.96
, pp. 3906-3910
-
-
Wang, L.1
Takabe, K.2
Bidlingmaier, S.M.3
Ill, C.R.4
Verma, I.M.5
-
94
-
-
0031034030
-
Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration
-
Worgall, S., Wolff, G., Falck-Pedersen, E., and Crystal, R.G. (1997). Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum. Gene Ther. 8, 37-44.
-
(1997)
Hum. Gene Ther
, vol.8
, pp. 37-44
-
-
Worgall, S.1
Wolff, G.2
Falck-Pedersen, E.3
Crystal, R.G.4
-
95
-
-
24944538819
-
VISA is an adapter protein required for virus-triggered IFN-β signaling
-
Xu, L.G., Wang, Y.Y., Han, K.J., Li, L.Y., Zhai, Z., and Shu, H.B. (2005). VISA is an adapter protein required for virus-triggered IFN-β signaling. Mol. Cell 19, 727-740.
-
(2005)
Mol. Cell
, vol.19
, pp. 727-740
-
-
Xu, L.G.1
Wang, Y.Y.2
Han, K.J.3
Li, L.Y.4
Zhai, Z.5
Shu, H.B.6
-
96
-
-
0028484704
-
MHC class Irestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
-
Yang, Y., Ertl, H.C., and Wilson, J.M. (1994a). MHC class Irestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1, 433-442.
-
(1994)
Immunity
, vol.1
, pp. 433-442
-
-
Yang, Y.1
Ertl, H.C.2
Wilson, J.M.3
-
97
-
-
0028328261
-
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
-
Yang, Y., Nunes, F.A., Berencsi, K., Furth, E.E., Gonczol, E., and Wilson, J.M. (1994b). Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. U.S.A. 91, 4407-4411.
-
(1994)
Proc. Natl. Acad. Sci. U.S.A
, vol.91
, pp. 4407-4411
-
-
Yang, Y.1
Nunes, F.A.2
Berencsi, K.3
Furth, E.E.4
Gonczol, E.5
Wilson, J.M.6
-
98
-
-
0029944988
-
Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver
-
Yang, Y., Greenough, K., and Wilson, J.M. (1996a). Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Ther. 3, 412-420.
-
(1996)
Gene Ther
, vol.3
, pp. 412-420
-
-
Yang, Y.1
Greenough, K.2
Wilson, J.M.3
-
99
-
-
9244220682
-
Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
-
Yang, Y., Jooss, K.U., Su, Q., Ertl, H.C., and Wilson, J.M. (1996b). Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther. 3, 137-144.
-
(1996)
Gene Ther
, vol.3
, pp. 137-144
-
-
Yang, Y.1
Jooss, K.U.2
Su, Q.3
Ertl, H.C.4
Wilson, J.M.5
-
100
-
-
3242813113
-
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
-
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., and Fujita, T. (2004). The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730-737.
-
(2004)
Nat. Immunol
, vol.5
, pp. 730-737
-
-
Yoneyama, M.1
Kikuchi, M.2
Natsukawa, T.3
Shinobu, N.4
Imaizumi, T.5
Miyagishi, M.6
Taira, K.7
Akira, S.8
Fujita, T.9
-
101
-
-
23844438864
-
Shared and unique functions of the DExD=H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
-
Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E., Loo, Y.M., Gale, M., Jr., Akira, S., Yonehara, S., Kato, A., and Fujita, T. (2005). Shared and unique functions of the DExD=H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 175, 2851-2858.
-
(2005)
J. Immunol
, vol.175
, pp. 2851-2858
-
-
Yoneyama, M.1
Kikuchi, M.2
Matsumoto, K.3
Imaizumi, T.4
Miyagishi, M.5
Taira, K.6
Foy, E.7
Loo, Y.M.8
Gale Jr., M.9
Akira, S.10
Yonehara, S.11
Kato, A.12
Fujita, T.13
-
102
-
-
21244441929
-
Immune responses to adeno-associated virus vectors
-
Zaiss, A.K., and Muruve, D.A. (2005). Immune responses to adeno-associated virus vectors. Curr. Gene Ther. 5, 323-331.
-
(2005)
Curr. Gene Ther
, vol.5
, pp. 323-331
-
-
Zaiss, A.K.1
Muruve, D.A.2
-
103
-
-
0036227449
-
Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors
-
Zaiss, A.K., Liu, Q., Bowen, G.P., Wong, N.C., Bartlett, J.S., and Muruve, D.A. (2002). Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors. J. Virol. 76, 4580-4590.
-
(2002)
J. Virol
, vol.76
, pp. 4580-4590
-
-
Zaiss, A.K.1
Liu, Q.2
Bowen, G.P.3
Wong, N.C.4
Bartlett, J.S.5
Muruve, D.A.6
-
104
-
-
0033816530
-
An RNA helicase, RHIV-1, induced by porcine reproductive and respiratory syndrome virus (PRRSV) is mapped on porcine chromosome 10q13
-
Zhang, X., Wang, C., Schook, L.B., Hawken, R.J., and Rutherford, M.S. (2000). An RNA helicase, RHIV-1, induced by porcine reproductive and respiratory syndrome virus (PRRSV) is mapped on porcine chromosome 10q13. Microb. Pathog. 28, 267-278.
-
(2000)
Microb. Pathog
, vol.28
, pp. 267-278
-
-
Zhang, X.1
Wang, C.2
Schook, L.B.3
Hawken, R.J.4
Rutherford, M.S.5
-
105
-
-
0034986416
-
Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages
-
Zhang, Y., Chirmule, N., Gao, G.P., Qian, R., Croyle, M., Joshi, B., Tazelaar, J., and Wilson, J.M. (2001). Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages. Mol. Ther. 3, 697-707.
-
(2001)
Mol. Ther
, vol.3
, pp. 697-707
-
-
Zhang, Y.1
Chirmule, N.2
Gao, G.P.3
Qian, R.4
Croyle, M.5
Joshi, B.6
Tazelaar, J.7
Wilson, J.M.8
-
106
-
-
33947396347
-
Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways
-
Zhu, J., Huang, X., and Yang, Y. (2007a). Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways. J. Virol. 81, 3170-3180.
-
(2007)
J. Virol
, vol.81
, pp. 3170-3180
-
-
Zhu, J.1
Huang, X.2
Yang, Y.3
-
107
-
-
33947236749
-
Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus
-
Zhu, J., Huang, X., and Yang, Y. (2007b). Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus. J. Immunol. 178, 3505-3510.
-
(2007)
J. Immunol
, vol.178
, pp. 3505-3510
-
-
Zhu, J.1
Huang, X.2
Yang, Y.3
-
108
-
-
33846232145
-
Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-β
-
Zhu, J., Martinez, J., Huang, X., and Yang, Y. (2007c). Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-β. Blood 109, 619-625.
-
(2007)
Blood
, vol.109
, pp. 619-625
-
-
Zhu, J.1
Martinez, J.2
Huang, X.3
Yang, Y.4
-
109
-
-
45749110171
-
A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo
-
Zhu, J., Huang, X., and Yang, Y. (2008). A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. Mol. Ther. 16, 1300-1307.
-
(2008)
Mol. Ther
, vol.16
, pp. 1300-1307
-
-
Zhu, J.1
Huang, X.2
Yang, Y.3
|