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Volumn 2, Issue , 2004, Pages

Endotoxin leads to rapid subcellular re-localization of hepatic RXRα: A novel mechanism for reduced hepatic gene expression in inflammation

Author keywords

Endotoxin; Inflammation; JNK; Liver; Nuclear export; Nuclear receptor; RXR

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CELL EXTRACT; ENDOTOXIN; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA; SODIUM CHLORIDE; STRESS ACTIVATED PROTEIN KINASE;

EID: 18144387309     PISSN: 14781336     EISSN: None     Source Type: Journal    
DOI: 10.1186/1478-1336-2-4     Document Type: Article
Times cited : (125)

References (42)
  • 1
    • 0028965644 scopus 로고
    • Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
    • Ulevitch RJ, Tobias PS: Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995, 13:437-457.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 437-457
    • Ulevitch, R.J.1    Tobias, P.S.2
  • 3
    • 0031835596 scopus 로고    scopus 로고
    • Clinicopathology conferences: Inflammation-induced cholestasis
    • Crawford JM, Boyer JL: Clinicopathology conferences: inflammation-induced cholestasis. Hepatology 1998, 28: 253-260.
    • (1998) Hepatology , vol.28 , pp. 253-260
    • Crawford, J.M.1    Boyer, J.L.2
  • 4
    • 37949057149 scopus 로고    scopus 로고
    • Transcriptional Regulation of Hepatobiliary Transporters
    • Karpen SJ: Transcriptional Regulation of Hepatobiliary Transporters. In 2003:96-111.
    • (2003) , pp. 96-111
    • Karpen, S.J.1
  • 5
    • 0031013566 scopus 로고    scopus 로고
    • Hepatocyte transport of bile acids and organic anions in endotoxemic rats: Impaired uptake and secretion
    • Bolder U, Ton-Nu HT, Schteingart CD, Frick E, Hofmann AF: Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology 1997, 112:214-225.
    • (1997) Gastroenterology , vol.112 , pp. 214-225
    • Bolder, U.1    Ton-Nu, H.T.2    Schteingart, C.D.3    Frick, E.4    Hofmann, A.F.5
  • 6
    • 0032524012 scopus 로고    scopus 로고
    • Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
    • Trauner M, Arrese M, Lee H, Boyer JL, Karpen SJ: Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest 1998, 101:2092-2100.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2092-2100
    • Trauner, M.1    Arrese, M.2    Lee, H.3    Boyer, J.L.4    Karpen, S.J.5
  • 8
    • 0037200089 scopus 로고    scopus 로고
    • Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent
    • Li D, Zimmerman TL, Thevananther S, Lee HY, Kurie JM, Karpen SJ: Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. J Biol Chem 2002, 277:31416-31422.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31416-31422
    • Li, D.1    Zimmerman, T.L.2    Thevananther, S.3    Lee, H.Y.4    Kurie, J.M.5    Karpen, S.J.6
  • 9
    • 0035844156 scopus 로고    scopus 로고
    • Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway
    • Gupta S, Stravitz RT, Dent P, Hylemon PB: Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J Biol Chem 2001, 276:15816-15822.
    • (2001) J. Biol. Chem. , vol.276 , pp. 15816-15822
    • Gupta, S.1    Stravitz, R.T.2    Dent, P.3    Hylemon, P.B.4
  • 12
    • 0032740993 scopus 로고    scopus 로고
    • Modulating nuclear receptor function: May the phos be with you
    • Shao D, Lazar MA: Modulating nuclear receptor function: may the phos be with you. J Clin Invest 1999, 103: 1617-1618.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1617-1618
    • Shao, D.1    Lazar, M.A.2
  • 13
    • 0029855010 scopus 로고    scopus 로고
    • Steroid hormone receptors and their regulation by phosphorylation
    • Weigel NL: Steroid hormone receptors and their regulation by phosphorylation. Biochem J 1996, 319(Pt 3):657-667.
    • (1996) Biochem. J. , vol.319 , Issue.PART 3 , pp. 657-667
    • Weigel, N.L.1
  • 14
    • 0141706670 scopus 로고    scopus 로고
    • The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers
    • Gianni M, Tarrade A, Nigro EA, Garattini E, Rochette-Egly C: The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers. J Biol Chem 2003, 278:34458-34466.
    • (2003) J. Biol. Chem. , vol.278 , pp. 34458-34466
    • Gianni, M.1    Tarrade, A.2    Nigro, E.A.3    Garattini, E.4    Rochette-Egly, C.5
  • 15
    • 0034721926 scopus 로고    scopus 로고
    • Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway
    • Kopf E, Plassat JL, Vivat V, de The H, Chambon P, Rochette-Egly C: Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway. J Biol Chem 2000, 275:33280-33288.
    • (2000) J. Biol. Chem. , vol.275 , pp. 33280-33288
    • Kopf, E.1    Plassat, J.L.2    Vivat, V.3    de The, H.4    Chambon, P.5    Rochette-Egly, C.6
  • 16
    • 0033516462 scopus 로고    scopus 로고
    • Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases
    • Adam-Stitah S, Penna L, Chambon P, Rochette-Egly C: Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases. J Biol Chem 1999, 274:18932-18941.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18932-18941
    • Adam-Stitah, S.1    Penna, L.2    Chambon, P.3    Rochette-Egly, C.4
  • 18
    • 0036794281 scopus 로고    scopus 로고
    • Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation
    • Itoh M, Adachi M, Yasui H, Takekawa M, Tanaka H, Imai K: Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation. Mol Endocrinol 2002, 16:2382-2392.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 2382-2392
    • Itoh, M.1    Adachi, M.2    Yasui, H.3    Takekawa, M.4    Tanaka, H.5    Imai, K.6
  • 19
    • 0032766430 scopus 로고    scopus 로고
    • Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
    • Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, Negishi M: Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 1999, 19: 6318-6322.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 6318-6322
    • Kawamoto, T.1    Sueyoshi, T.2    Zelko, I.3    Moore, R.4    Washburn, K.5    Negishi, M.6
  • 21
    • 0031041904 scopus 로고    scopus 로고
    • Subcellular distribution of normal and mutant vitamin D receptors in living cells. Studies with a novel fluorescent ligand
    • Barsony J, Renyi I, McKoy W: Subcellular distribution of normal and mutant vitamin D receptors in living cells. Studies with a novel fluorescent ligand. J Biol Chem 1997, 272:5774-5782.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5774-5782
    • Barsony, J.1    Renyi, I.2    McKoy, W.3
  • 22
    • 0036329226 scopus 로고    scopus 로고
    • Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis
    • Denson LA, Bohan A, Held MA, Boyer JL: Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis. Gastroenterology 2002, 123:599-607.
    • (2002) Gastroenterology , vol.123 , pp. 599-607
    • Denson, L.A.1    Bohan, A.2    Held, M.A.3    Boyer, J.L.4
  • 23
    • 0028609209 scopus 로고
    • JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
    • Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G, Davis R, Karin M: JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 1994, 8:2996-3007.
    • (1994) Genes Dev. , vol.8 , pp. 2996-3007
    • Kallunki, T.1    Su, B.2    Tsigelny, I.3    Sluss, H.K.4    Derijard, B.5    Moore, G.6    Davis, R.7    Karin, M.8
  • 24
    • 0034717067 scopus 로고    scopus 로고
    • The acute phase response is associated with retinoid X receptor repression in rodent liver
    • Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR: The acute phase response is associated with retinoid X receptor repression in rodent liver. J Biol Chem 2000, 275: 16390-16399.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16390-16399
    • Beigneux, A.P.1    Moser, A.H.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 25
    • 0036623233 scopus 로고    scopus 로고
    • Nuclear receptor regulation of hepatic function
    • Karpen SJ: Nuclear receptor regulation of hepatic function. J Hepatol 2002, 36:832-850.
    • (2002) J. Hepatol. , vol.36 , pp. 832-850
    • Karpen, S.J.1
  • 26
    • 0036296149 scopus 로고    scopus 로고
    • Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
    • Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR: Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem Biophys Res Commun 2002, 293:145-149.
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 145-149
    • Beigneux, A.P.1    Moser, A.H.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 27
    • 0037523216 scopus 로고    scopus 로고
    • Hepatic expression of PPARalpha, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner
    • Tai ES, bin Ali A, Zhang Q, Loh LM, Tan CE, Retnam L, El Oakley RM, Lim SK: Hepatic expression of PPARalpha, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner. FEBS Lett 2003, 546:237-240.
    • (2003) FEBS Lett. , vol.546 , pp. 237-240
    • Tai, E.S.1    bin Ali, A.2    Zhang, Q.3    Loh, L.M.4    Tan, C.E.5    Retnam, L.6    El Oakley, R.M.7    Lim, S.K.8
  • 29
    • 0037450436 scopus 로고    scopus 로고
    • The expression of CYP2B6, CYP2C9 and CYP3A4 genes: A tangle of networks of nuclear and steroid receptors
    • Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ: The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 2003, 1619:243-253.
    • (2003) Biochim. Biophys. Acta , vol.1619 , pp. 243-253
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Drocourt, L.3    Maurel, P.4    Vilarem, M.J.5
  • 31
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf DJ, Evans RM: The RXR heterodimers and orphan receptors. Cell 1995, 83:841-850.
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 33
    • 0033980287 scopus 로고    scopus 로고
    • Expression of the bile salt export pump is maintained after chronic cholestasis in the rat
    • Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL: Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000, 118: 163-172.
    • (2000) Gastroenterology , vol.118 , pp. 163-172
    • Lee, J.M.1    Trauner, M.2    Soroka, C.J.3    Stieger, B.4    Meier, P.J.5    Boyer, J.L.6
  • 35
    • 0033583034 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
    • Zhang FX, Kirschning CJ, Mancinelli R, Xu XP, Jin Y, Faure E, Mantovani A, Rothe M, Muzio M, Arditi M: Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem 1999, 274:7611-7614.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7611-7614
    • Zhang, F.X.1    Kirschning, C.J.2    Mancinelli, R.3    Xu, X.P.4    Jin, Y.5    Faure, E.6    Mantovani, A.7    Rothe, M.8    Muzio, M.9    Arditi, M.10
  • 36
    • 0344736996 scopus 로고    scopus 로고
    • Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcumin
    • Cheng PY, Wang M, Morgan ET: Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcumin. J Pharmacol Exp Ther 2003, 307: 1205-1212.
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 1205-1212
    • Cheng, P.Y.1    Wang, M.2    Morgan, E.T.3
  • 38
    • 0034731436 scopus 로고    scopus 로고
    • Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting of vitamin D receptors
    • Prufer K, Racz A, Lin GC, Barsony J: Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting of vitamin D receptors. J Biol Chem 2000, 275:41114-41123.
    • (2000) J. Biol. Chem. , vol.275 , pp. 41114-41123
    • Prufer, K.1    Racz, A.2    Lin, G.C.3    Barsony, J.4
  • 39
    • 0029886277 scopus 로고    scopus 로고
    • Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents
    • Green RM, Beier D, Gollan JL: Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 1996, 111:193-198.
    • (1996) Gastroenterology , vol.111 , pp. 193-198
    • Green, R.M.1    Beier, D.2    Gollan, J.L.3
  • 42
    • 0037072809 scopus 로고    scopus 로고
    • Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    • Plosch T, Kok T, Bloks VW, Smit MJ, Havinga R, Chimini G, Groen AK, Kuipers F: Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem 2002, 277:33870-33877.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33870-33877
    • Plosch, T.1    Kok, T.2    Bloks, V.W.3    Smit, M.J.4    Havinga, R.5    Chimini, G.6    Groen, A.K.7    Kuipers, F.8


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