Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2

European Journal of Biochemistry

Volumn 268, Issue 5, 2001, Pages 1448-1459

  Gómez Lechón, María J ^a   Donato, Teresa ^a   Jover, Ramiro ^a   Rodriguez, Cristina ^a   Ponsoda, Xavier ^b   Glaise, Denize ^c   Castell, José V ^a   Guguen Guillouzo, Christiane ^c  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b Facultad de Biológicas   (Spain)

^c PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

Conjugating enzymes; Cytochrome P 450; Differentiation; Hepatoma cell line; Transcription factors

Indexed keywords

3 METHYLCHOLANTHRENE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DEXAMETHASONE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GLYCOGEN; HEPATOCYTE NUCLEAR FACTOR 4; INSULIN; MESSENGER RNA; PHENOBARBITAL; PLASMA PROTEIN; RIFAMPICIN; UREA;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALBUMINS; AMMONIA; BIOTRANSFORMATION; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL SIZE; CYTOCHROME P-450 ENZYME SYSTEM; DNA, NEOPLASM; ENZYME INDUCTION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE; GLYCOGEN; HUMANS; LIVER NEOPLASMS; ORGAN SPECIFICITY; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; UREA;

EID: 0035083477     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02011.x     Document Type: Article

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