Hepatic and renal cytochrome P450 gene regulation during Citrobacter Rodentium infection in wild-type and toll-like receptor 4 mutant mice

Drug Metabolism and Disposition

Volumn 34, Issue 3, 2006, Pages 354-360

  Richardson, Terrilyn A ^a   Sherman, Melanie ^a   Antonovic, Leposava ^b   Kardar, Sean S ^a   Strobel, Henry W ^b   Kalman, Daniel ^a   Morgan, Edward T ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; ALPHA FIBRINOGEN; ANGIOTENSINOGEN; CYTOCHROME; CYTOCHROME P450; CYTOCHROME P450 2A5; CYTOCHROME P450 2C; CYTOCHROME P450 2C29; CYTOCHROME P450 2C9; CYTOCHROME P450 2E; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; CYTOCHROME P450 3A13; CYTOCHROME P450 4A; CYTOCHROME P450 4A10; CYTOCHROME P450 4A14; CYTOCHROME P450 4F14; CYTOCHROME P450 4F15; CYTOCHROME P450 4F16; CYTOCHROME P450 4F18; CYTOCHROME P450 ISOENZYME; CYTOKINE; FIBRINOGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; OROSOMUCOID; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CITROBACTER RODENTIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEEDING; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEPATITIS; KIDNEY INFECTION; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STRAIN DIFFERENCE; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CITROBACTER RODENTIUM; CYTOCHROME P-450 ENZYME SYSTEM; ENTEROBACTERIACEAE INFECTIONS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KIDNEY; LIVER; MICE; MICE, MUTANT STRAINS; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 4;

ANIMALIA; BACTERIA (MICROORGANISMS); CITROBACTER RODENTIUM; ESCHERICHIA COLI; RODENTIA;

EID: 33344475548     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.105.007393     Document Type: Article

References (41)

1. Aliprantis AO, Yang RB, Weiss DS, Godowski P, and Zychlinsky A (2000) The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO (Eur Mol Biol Organ) J 19:3325-3336.
2. Altschul SF, Gish W, Miller W, Myers EW, and Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410.
3. Barclay TB, Peters JM, Sewer MB, Ferrari L, Gonzalez FJ, and Morgan ET (1999) Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-α dependent. J Pharmacol Exp Ther 290:1250-1257.
4. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, and Feingold KR (2000) The acute phase response is associated with retinoid X receptor expression in rodent liver. J Biol Chem 275:16390-16399.
5. Beutler B, Du X, and Poltorak A (2001) Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies. J Endotoxin Res 7:277-280.
6. Biro-Sauveur B, Eeckhoutte C, Baeza E, Boulard C, and Galtier P (1995) Comparison of hepatic and extrahepatic drug-metabolizing enzyme activities in rats given single or multiple challenge infections with Fasciola hepatica. Int J Parasitol 25:1193-1200.
7. Caradonna L, Amati L, Magrone T, Pellegrino NM, Jirillo E, and Caccavo D (2000) Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J Endotoxin Res 6:205-214.
8. Cui X, Kawashima H, Barclay TB, Peters JM, Gonzalez FJ, Morgan ET, and Strobel HW (2001) Molecular cloning and regulation of expression of two novel mouse CYP4F genes: expression in peroxisome proliferator-activated receptor alpha-deficient mice upon lipopolysaccharide and clofibrate challenges. J Pharmacol Exp Ther 296:542-550.
9. Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, and Hacker A (2004) Protective role of arginase in a mouse model of colitis. J Immunol 173:2109-2117.
10. Goncalves NS, Ghaem-Maghami M, Monteleone G, Frankel G, Dougan G, Lewis DJ, Simmons CP, and MacDonald TT (2001) Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis. Infect Immun 69:6651-6659.
11. Goosney DL, Gruenheid S, and Finlay BB (2000) Gut feelings: enteropathogenic E. coli (EPEC) interactions with the host. Annu Rev Cell Dev Biol 16:173-189.
12. Haugen DA and Coon MJ (1976) Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P450. J Biol Chem 251:7929-7939.
13. Heid CA, Stevens J, Livak KJ, and Williams PM (1996) Real time quantitative PCR. Genome Res 6:986-994.
14. Higgins LM, Frankel G, Douce G, Dougan G, and MacDonald TT (1999) Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease. Infect Immun 67:3031-3039.
15. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, and Akira S (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162:3749-3752.
16. Jurjus AR, Khoury NN, and Reimund JM (2004) Animal models of inflammatory bowel disease. J Pharmacol Toxicol Methods 50:81-92.
17. T)) method. Methods 25:402-408.
18. Liu S, Salyapongse AN, Geller DA, Vodovotz Y, and Billiar TR (2000) Hepatocyte toll-like receptor 2 expression in vivo and in vitro: role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide. Shock 14:361-365.
19. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
20. Masubuchi Y and Horie T (2004) Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis. Drug Metab Dispos 32:437-441.
21. Matsumura T, Ito A, Takii T, Hayashi H, and Onozaki K (2000) Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J Interferon Cytokine Res 20:915-921.
22. Mitchell SR, Sewer MB, Kardar SS, and Morgan ET (2001) Characterization of CYP4A induction in rat liver by inflammatory stimuli: dependence on sex, strain and inflammation-evoked hypophagia. Drug Metab Dispos 29:17-22.
23. Montero R, Gentile GJ, Frederick L, McMannis J, Murphy T, Silva G, Blankespoor H, and Gentile JM (1999) Induced expression of CYP2A5 in inflamed trematode-infested mouse liver. Mutagenesis 14:217-220.
24. Morgan ET (2001) Regulation of cytochrome P450 by inflammatory mediators: why and how? Drug Metab Dispos 29:207-212.
25. Nataro JP and Kaper JB (1998) Diarrheagenic Escherichia coli. Clin Microbiol Rev 11:142-201.
26. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, and Nakaya R (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694-702.
27. Overbergh L, Giulietti A, Valckx D, Decallonne R, Bouillon R, and Mathieu C (2003) The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech 14:33-43.
28. Pan J, Xiang Q, and Ball S (2000) Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver. Drug Metab Dispos 28:709-713.
29. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, and Galanos C (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (Wash DC) 282:2085-2088.
30. Renton KW (2004) Cytochrome P450 regulation and drug biotransformation during inflammation and infection. Curr Drug Metab 5:235-243.
31. Richardson TA and Morgan ET (2005) Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice. J Pharmacol Exp Ther 314:703-709.
32. Schauer DB and Falkow S (1993) Attaching and effacing locus of a Citrobacter freundii biotype that causes transmissible murine colonic hyperplasia. Infect Immun 61:2486-2492.
33. Sewer MB, Koop DR, and Morgan ET (1997) Differential inductive and suppressive effects of endotoxin and particulate irritants on hepatic and renal cytochrome P450 expression. J Pharmacol Exp Ther 280:1445-1454.
34. Su T and Ding X (2004) Regulation of the cytochrome P450 2A genes. Toxicol Appl Pharmacol 199:285-294.
35. Vallance BA, Deng W, Jacobson K, and Finlay BB (2003) Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium. Infect Immun 71:3443-3453.
36. Wales AD, Woodward MJ, and Pearson GR (2005) Attaching-effacing bacteria in animals. J Comp Pathol 132:1-26.
37. Weidenbach H, Leiz S, Nussler AK, Dikopoulos N, Bachem M, Buttenschoen K, Reinshagen M, Beger HG, Adler G, and Schmid RM (2000) Disturbed bile secretion and cytochrome P450 function during the acute state of experimental colitis in rats. J Hepatol 32:708-717.
38. Yang RB, Mark MR, Gray A, Huang A, Xie MH, Zhang M, Goddard A, Wood WI, Gurney AL, and Godowski PJ (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature (Lond) 395:284-288.
39. Yang RB, Mark MR, Gurney AL, and Godowski PJ (1999) Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J Immunol 163:639-643.
40. Zhang H, Niesel DW, Peterson JW, and Klimpel GR (1998) Lipoprotein release by bacteria: potential factor in bacterial pathogenesis. Infect Immun 66:5196-5201.
41. Zhang H, Peterson JW, Niesel DW, and Klimpel GR (1997) Bacterial lipoprotein and lipopolysaccharide act synergistically to induce lethal shock and proinflammatory cytokine production. J Immunol 159:4868-4878.