Drug-cytokine interactions: Mechanisms and clinical implications

BioDrugs

Volumn 9, Issue 5, 1998, Pages 389-395

  Reiss, William G ^a   Piscitelli, Stephen C ^b,c  

^a UNIVERSITY OF MARYLAND   (United States)

^b CLINICAL CENTER   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CARBAMAZEPINE; CYCLOSPORIN; CYTOCHROME P450; CYTOKINE; DIDANOSINE; EPIRUBICIN; ERYTHROMYCIN; ETOPOSIDE; HEXOBARBITAL; INFLUENZA VACCINE; INTERLEUKIN 1; INTERLEUKIN 6; MORPHINE DERIVATIVE; OXYGENASE; PHENAZONE; THEOPHYLLINE; TRANSFORMING GROWTH FACTOR BETA; XANTHINE OXIDASE; ZIDOVUDINE;

ANIMAL CELL; ANIMAL TISSUE; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG MECHANISM; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; THEORY; TRANSCRIPTION REGULATION;

EID: 0031966811     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-199809050-00004     Document Type: Review

References (35)

1. Renton KW, Mannering GJ. Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents. Biochem Biophys Res Commun 1976; 73: 343-8
2. Williams JF, Bement WJ, Sinclair JF, et al. Effect of interleukin 6 on phenobarbital induction of cytochrome P-450 in cultured rat hepatocytes. Biochem Biophys Res Commun 1991; 178: 1049-55
3. Barker CW, Fagan JB, Pasco DS. Interleukin-1β suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes. J Biol Chem 1992; 267: 8050-5
4. Abdel-Razzak Z, Loyer P, Fautrel A, et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.
5. Chen JQ, Strom A, Gustafsson JA, et al. Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6. Mol Pharmacol 1995; 47: 940-7
6. Tapner M, Liddle C, Goodwin B, et al. Interferon gamma down-regulates cytochrome P450 3A genes in primary cultures of well-differentiated rat hepatocytes. Hepatology 1996; 24: 367-73
7. Fukuda Y, Sassa S. Suppression of cytochrome P4501A1 by interleukin-6 in human HepG2 hepatoma cells. Biochem Pharmacol 1994; 47: 1187-95
8. Ravishankar H, Padmanaban G. Regulation of cytochrome P-450 gene expression: studies with a cloned probe. J Biol Chem 1985; 260: 1588-92
9. Jayarama BG, Padmanaban G. Heme regulates cytochrome P-450 gene transcription elongation. Biochem Biophys Res Commun 1988; 151: 737-42
10. el Azhary R, Renton KW, Mannering GJ. Effect of interferon inducing agents (polyriboinosinic acid-polyribocytidylic acid and tilorone) on the heme turnover of hepatic cytochrome P-450. Mol Pharmacol 1980; 17: 395-9
11. Singh G, Renton KW. Inhibition of the synthesis of hepatic cytochrome P-450 by the interferon-inducing agent poly rI-rC. Can J Physiol Pharmacol 1984; 62: 379-83
12. Craig PI, Mehta I, Murray M, et al. Interferon down regulates the male-specific cytochrome P450IIIA2 in rat liver. Mol Pharmacol 1990; 38: 313-8
13. Ghezzi P, Bianchi M, Gianera L, et al. Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcystine in mice. Cancer Res 1985; 45: 3444-7
14. Ghezzi P, Saccardo B, Bianchi M. Induction of xanthine oxidase and heme oxygenase and depression of liver drug metabolism by interferon: a study with different recombinant interferons. J Interferon Res 1986; 6: 251-6
15. Paine AJ. Excited states of oxygen in biology: their possible involvement in cytochrome P-450 linked oxidations as well as in the induction of the P-450 system by many diverse compounds. Biochem Pharmacol 1978; 27: 1805-13
16. Mannering GJ, Deloria LB, Abbott V. Role of xanthine oxidase in the interferon-mediated depression of the hepatic cytochrome P-450 system in mice. Cancer Res 1988; 48: 2107-12
17. Reiners JJ, Cantu AR, Rupp TA. Coordinate modulation of murine hepatic xanthine oxidase activity and cytochrome P-450 system by interferons. J Interferon Res 1990; 10: 109-18
18. Ansher SS, Puri RK, Thompson WC, et al. The effects of interleukin 2 and α-interferon administration on hepatic drug metabolism in mice. Cancer Res 1992; 52: 262-6
19. Craig PI, Williams SJ, Cantrill E, et al. Rat but not human interferons suppress hepatic oxidative drug metabolism in rats. Gastroenterology 1989; 97: 999-1004
20. Craig PI, Tapner M, Farrell GC. Interferon suppresses erythromycin metabolism in rats and human subjects. Hepatology 1993; 17: 230-5
21. Chang KC, Lauer BA, Bell TD, et al. Altered theophylline pharmacokinetics during acute respiratory viral illness. Lancet 1978; 1: 1132-3
22. Williams SJ, Baird-Lambert JA, Farrell GC. Inhibition of theophylline metabolism by interferon. Lancet 1987; II: 939-41
23. Israel BC, Blouin RA, McIntyre W, et al. Effects of interferon-α monotherapy on hepatic drug metabolism in cancer patients. Br J Clin Pharmacol 1993; 36: 229-35
24. Okuno H, Takasu M, Kano H, et al. Depression of drug-metabolizing activity in the human liver by interferon-β. Hepatology 1993; 17: 65-9
25. Winstanley PA, Back DJ, Breckenridge AM. Inhibition of theophylline metabolism by interferon. Lancet 1987; II: 1340
26. Hannan SE, May JJ, Pratt DS, et al. The effect of whole virus influenza vaccination on theophylline pharmacokinetics. Am Rev Respir Dis 1988; 137: 903-6
27. Grabowski N, May JJ, Pratt DS, et al. The effect of split virus influenza vaccination on theophylline pharmacokinetics. Am Rev Respir Dis 1985; 131: 934-8
28. Chen YL, Le Vraux V, Leneveu A, et al. Acute phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics. Clin Pharmacol Ther 1994; 55: 649-60
29. Gidal BE, Reiss WG, Liao JS, et al. Changes in interleukin-6 concentrations following epilepsy surgery: potential influence on carbamazepine pharmacokinetics [letter]. Ann Pharmacother 1996; 30: 545-6
30. Shedlofsky SI, Israel BC, McClain CJ, et al. Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J Clin Invest 1994; 94: 2209-14
31. Bortolussi R, Fabiani F, Savron F, et al. Acute morphine intoxication during high dose recombinant interleukin-2 treatment for metastatic renal cell cancer. Eur J Cancer 1994; 30A: 1905-7
32. Bandak S, Czejka M, Schuller J, et al. Pharmacokinetic drug interaction between epirubicin and interferon-α-2b in serum and red blood cells. Arzneimittel Forschung 1995; 45: 212-5
33. Piscitelli SC, Amantea MA, Vogel S, et al. Effects of cytokines on antiviral pharmacokinetics: an alternative approach to assessment of drug interactions using bioequivalence guidelines. Antimicrob Agents Chemother 1996; 40: 161-5
34. Soefie SA, Madden T, Herzog C, et al. The effects of IL-1α on etoposide pharmacokinetics in patients with recurrent metastatic osteosarcoma [abstract]. Pharmacotherapy 1995; 375
35. Williams SJ, Farrell GC. Inhibition of antipyrine metabolism by interferon. Br J Clin Pharmacol 1986; 22: 610-2