Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: A key role for the pregnane X receptor

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 1, 2009, Pages 35-43

  Harmsen, S ^a   Meijerman, I ^a   Beijnen, J H ^a,b   Schellens, J H M ^a,c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Anticancer drugs; CYP3A4; Drug drug interactions; Induction; PXR

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOCHROME P450 3A4; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; ERLOTINIB; ETOPOSIDE; FLUOROURACIL; FLUTAMIDE; IFOSFAMIDE; IMATINIB; IRINOTECAN; MESSENGER RNA; MIDAZOLAM; PACLITAXEL; PREGNANE X RECEPTOR; RIFAMPICIN; TAMOXIFEN; TAMOXIFEN CITRATE; TOPOTECAN; VINBLASTINE; VINCRISTINE;

ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MIDAZOLAM; RECEPTORS, STEROID; RNA, MESSENGER;

EID: 67349105004     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0842-3     Document Type: Article

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