History and development of radiation-protective agents

International Journal of Radiation Biology

Volumn 85, Issue 7, 2009, Pages 539-573

  Weiss, Joseph F ^a   Landauer, Michael R ^b  

^a U S DEPARTMENT OF ENERGY   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Antioxidants; Growth factors; Ionising radiation; Radioprotectors; Radiotherapy

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; 3 (3 METHYLAMINOPROPYLAMINO) 1 PROPANETHIOL; ACETYLCYSTEINE; AMIFOSTINE; CELL DNA; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTEINE; DIETHYLDITHIOCARBAMIC ACID; FERRIC FERROCYANIDE; GLUTAMINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MERCAPTAMINE; MESNA; NITRIC OXIDE; PENTETATE CALCIUM; PENTETATE ZINC; PHOSPHOROTHIOIC ACID S 3 (3 METHYLAMINOPROPYLAMINO)PROPYL ESTER; PHOSPHOROTHIOIC ACID S [2 (3 METHYLAMINOPROPYLAMINO)ETHYL] ESTER; PROTEIN P53; RADIOPROTECTIVE AGENT; RADIOSENSITIZING AGENT; SPERMIDINE; SPERMINE; TIOPRONIN; TRANSCRIPTION FACTOR AP 1; UNINDEXED DRUG;

BYSTANDER EFFECT; CANCER RADIOTHERAPY; DRUG INDICATION; DRUG RESEARCH; HISTORY OF MEDICINE; HUMAN; IONIZING RADIATION; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RADIATION PHYSICS; RADIATION PROTECTION; RADIOBIOLOGY; REVIEW; XEROSTOMIA;

ANIMALS; ANTIOXIDANTS; DRUG DISCOVERY; GLUCANS; HUMANS; PLANT EXTRACTS; RADIATION-PROTECTIVE AGENTS; RADIOACTIVE HAZARD RELEASE;

ANIMALIA;

EID: 67651176009     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000902985144     Document Type: Review

References (416)

1. Aapro M. 2004. Granisetron: An update on its clinical use in the management of nausea and vomiting. Oncologist 9:673-686.
2. Abdelsayed GG. 2007. Management of radiation-induced nausea and vomiting. Experimental Hematology 35:34-36.
3. Abe M, Nishidai T, Yukawa Y, Takahashi M, Ono K, Hiraoka M, Ri N. 1981. Studies on the radioprotective effects of super-oxide dismutase in mice. International Journal of Radiation Oncology, Biology, Physics 7:205-209.
4. Abraham SK, Sarma L, Kesavan PC. 1993. Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage. Mutation Research 303:109-112.
5. Ainsworth EJ. 1988. From endotoxins to newer immunomodula-tors: Survival-promoting effects of microbial polysaccharide complexes in irradiated animals. Pharmacology and Therapeutics 39:223-241.
6. Ainsworth EJ, Hatch MH. 1960. The effect of Proteus morganii endotoxin on radiation mortality in mice. Radiation Research 13:632-638.
7. Åkerfeldt S. 1959. Preparation and determination of sodium hydrogen S-(2-aminoethyl)-phosphorothioate. Acta Chemica Scandinavica 13:1479-1480.
8. Ambrus JL, Ambrus CM, Gahwyler ME, Akhter S, Jankowski A, Lane W. 2004. Studies on the radioprotective effect of etiocholanolone. Journal of Medicine 35:75-86.
9. Anné PR, Machtay M, Rosenthal DI, Brizel DM, Morrison WH, Irwin DH, Chougule PB, Estopinal NC, Berson A, Curran WJ Jr. 2007. A phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics 67:445-452.
10. Ara G, Watkins BA, Zhong H, Hawthorne TR, Karkaria CE, Sonis ST, Larochelle WJ. 2008. Velafermin (rhFGF-20) reduces the severity and duration of hamster cheek pouch mucositis induced by fractionated radiation. International Journal of Radiation Biology 84:401-412.
11. Araujo MC, Dias FL, Takahashi CS. 1999. Potentiation by turmeric and curcumin of gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells. Teratogenesis, Carcinogenesis, and Mutagenesis 19:9-18.
12. Armed Forces Radiobiology Research Institute (AFRRI). 2003. Medical management of radiological casualties. 2nd ed. Bethesda, MD: AFRRI.
13. Arora R, Gupta D, Chawla R, Sagar R, Sharma A, Kumar R, Prasad J, Singh S, Samanta N, Sharma RK. 2005. Radio-protection by plant products: Present status and future prospects. Phytotherapy Research 19:1-22.
14. Azzi A. 2007. Molecular mechanism of alpha-tocopherol action. Free Radicals in Biology and Medicine 43:16-21.
15. Bacq ZM, Herve A, Lecomte J, Fischer P, Blavier J. 1951. Protection contre le rayonnement X par la β-mercapto-ethylamine. Archives Internationales de Physiologie 59: 442-447.
16. Badr FM, El Habit OH, Harraz MM. 1999. Radioprotective effect of melatonin assessed by measuring chromosomal damage in mitotic and meiotic cells. Mutation Research 444:367-372.
17. Bairati I, Meyer F, Gélinas M, Fortin A, Nabid A, Brochet F, Mercier JP, Têtu B, Harel F, Abdous B, Vigneault E, Vass S, Del Vecchio P, Roy J. 2005a. Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients. Journal of Clinical Oncology 23:5805-5813.
18. Bairati I, Meyer F, Gélinas M, Fortin A, Nabid A, Brochet F, Mercier JP, Têtu B, Harel F, Mâsse B, Vigneault E, Vass S, del Vecchio P, Roy J. 2005b. A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. Journal of the National Cancer Institute 97: 481-488.
19. Balcer-Kubiczek EK, Harrison GH, Hill CK, Blakely WF. 1993. Effects of WR-1065 and WR-151326 on survival and neoplastic transformation in C3H/10T1/2 cells exposed to TRIGA or JANUS fission neutrons. International Journal of Radiation Biology 63:37-46.
20. Baranov AE, Selidovkin GD, Butturini A, Gale RP. 1994. Hematopoietic recovery after 10-Gy acute total body radiation. Blood 83:596-599.
21. Bardet E, Martin L, Calais G, Tuchais C, Bourhis J, Rhein B, Feham N, Alphonsi M. 2002. Preliminary data of the GORTEC 2000-02 phase III trial comparing intravenous and subcutaneous administration of amifostine for head and neck tumors treated by external radiotherapy. Seminars in Oncology 29(6 Suppl. 19):57-60.
22. Batra V, Kesavan V, Mishra KP. 2004. Modulation of enzymes involved in folate dependent one-carbon metabolism by gamma-radiation stress in mice. Journal of Radiation Research 45:527-533.
23. Ben-Amotz A, Rachmilevich B, Greenberg S, Sela M, Weshler Z. 1996. Natural beta-carotene and whole body irradiation in rats. Radiation and Environmental Biophysics 35:285-288.
24. Ben-Amotz A, Yatziv S, Sela M, Greenberg S, Rachmilevich B, Shwarzman, M, Weshler Z. 1998. Effect of natural beta-carotene supplementation in children exposed to radiation from the Chernobyl accident. Radiation and Environmental Biophysics 37:187-193.
25. Berger ME, Christensen DM, Lowry PC, Jones OW, Wiley AL. 2006. Medical management of radiation injuries: Current approaches. Occupational Medicine 56:162-172.
26. Bertho JM, Frick J, Prat M, Demarquay C, Dudoignon N, Trompier F, Gorin NC, Thierry D, Gourmelon P. 2005.
27. Comparison of autologous cell therapy and granulocyte-colony stimulating factor (G-CSF) injection vs. G-CSF injection alone for the treatment of acute radiation syndrome in a non-human primate model. International Journal of Radiation Oncology, Biology, Physics 63:911-920.
28. Bertoncello I, Kriegler AB, Woodcock DM, Williams B, Barber L, Nilsson SK. 1995. Haematopoietic radioprotection by Cremophor EL: A polyethoxylated castor oil. International Journal of Radiation Biology 67:57-64.
29. Bhatia M, Davenport V, Cairo MS. 2007. The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes. Leukemia and Lymphoma 48:9-15.
30. Blumenthal RD, Lew W, Reising A, Soyne D, Osorio L, Ying Z, Goldenberg DM. 2000. Anti-oxidant vitamins reduce normal tissue toxicity induced by radio-immunotherapy. International Journal of Cancer 86:276-280.
31. Boerma M, Roberto KA, Hauer-Jensen M. 2008. Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol. International Journal of Radiation Oncology, Biology, Physics 72:170-177.
32. Boerma M, Wang J, Burnett AF, Santin AD, Roman JJ, Hauer-Jensen M. 2007. Local administration of interleukin-11 ameliorates intestinal radiation injury in rats. Cancer Research 67:9501-9506.
33. Bond VP, Cronkite EP. 1957. Effects of radiation on mammals. Annual Review of Physiology 19:299-328.
34. Borek C, Ong A, Mason H, Donahue L, Biaglow JE. 1986. Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms. Proceedings of the National Academy of Sciences of the USA 83:1490-1494.
35. Brach MA, Hass R, Sherman ML, Gunji H, Weichselbaum R, Kufe D. 1991. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. Journal of Clinical Investigation 88:691-695.
36. Breitenstein BD Jr, Fry SA, Lushbaugh CC. 1990. DTPA therapy: The U.S. experience 1958-1987. In: Ricks R, Fry SA, editors. The medical basis of radiation accident preparedness. 2nd ed. New York: Elsevier Science. pp 397-406.
37. Brizel DM, Overgaard J. 2003. Does amifostine have a role in chemoradiation treatment? Lancet Oncology 4:378-381.
38. Brizel DM, Wasserman TH, Henke M, Strnad V, Rudat V, Monnier A, Eschwege F, Zhang J, Russell L, Oster W, Sauer RJ. 2000. Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. Journal of Clinical Oncology 18:3339-3345.
39. Brooks AL. 2005. Paradigm shifts in radiation biology: Their impact on intervention for radiation-induced disease. Radiation Research 164:454-461.
40. Brown DQ, Graham WJ 3rd, MacKenzie LJ, Pittock JW 3rd, Shaw LM. 1988. Can WR-2721 be improved upon? Pharmacology and Therapeutics 39:157-168.
41. Brown DQ, Pittock JW 3rd, Rubinstein JS. 1982. Early results of the screening program for radioprotectors. International Journal of Radiation Oncology, Biology, Physics 8:565-570.
42. Brown JK, Byers T, Doyle C, Coumeya KS, Demark-Wahnefried W, Kushi LH, McTieman A, Rock CL, Aziz N, Bloch AS, Eldridge B, Hamilton K, Katzin C, Koonce A, Main J, Mobley C, Morra ME, Pierce MS, Sawyer KA. 2003. Nutrition and physical activity during and after cancer treatment: An American Cancer Society guide for informed choices. CA: A Cancer Journal for Clinicians 53:268-291.
43. Browne D, Weiss JF, MacVittie TJ, Pillai MV. 1990. Treatment of radiation injuries. New York: Plenum Press.
44. Buc-Calderon P, Defresne MP, Barvais C, Roberfroid M. 1989. N-acyl dehydroalanines protect from radiation toxicity and inhibit radiation carcinogenesis in mice. Carcinogenesis 10: 1641-1644.
45. Buc-Calderon P, Roberfroid M. 1990. Increase in the survival time of mice exposed to ionizing radiation by a new class of free radical scavengers. Experientia 46:708-710.
46. Bump EA, Malaker K. 1998. Radioprotectors: Chemical, biological, and clinical perspectives. Boca Raton, FL: CRC Press.
47. Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, Feinstein E, Gudkov AV. 2008. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. In: Science 320:226-230 and supporting online material. Accessed 1 July 2008 from the website: www.sciencemag.org/cgi/content/full/320/5873/226/ DC1
48. Burlage FR, Roesink JM, Kampinga HH, Coppes RP, Terhaard C, Langendijk JA, van Luijk P, Stokman MA, Vissink A. 2008. Protection of salivary function by concomitant pilocarpine during radiotherapy: A double-blind, randomized, placebo-controlled study. International Journal of Radiation Oncology, Biology, Physics 70:14-22.
49. Burns FJ, Tang MS, Frenkel K, Nádas A, Wu F, Uddin A, Zhang R. 2007. Induction and prevention of carcinogenesis in rat skin exposed to space radiation. Radiation and Environmental Biophysics 46:195-199.
50. Carsten RE, Bachand AM, Bailey SM, Ullrich RL. 2008. Oral resveratrol treatment reduced chromosome aberrations in mouse bone marrow. Radiation Research 169:633-638.
51. Cassatt DR, Kaminski JM, Hatchett RJ, DiCarlo AL, Benjamin JM, Maidment BW. 2008. Meeting Report: Medical countermeasures against nuclear threats: Radionuclide decorporation agents. Radiation Research 170: 540-548.
52. Castillo J, Benavente-Garcia O, Lorente J, Alcaraz M, Redondo, A, Ortuno A, Del Rio JA. 2000. Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (procyanidins) from grape seeds (Vitis vinifera): Comparative study versus other phenolic and organic compounds. Journal of Agricultural and Food Chemistry 48:1738-1745.
53. Cekan E, Slanina P, Pergman K, Tribukait B. 1985a. Effects of dietary supplementation with selenomethionine on the terato-genic effect of ionizing radiation in mice. Acta Radiologica Oncology 24:459-463.
54. Cekan E, Tribukait B, Vokal-Borek H. 1985b. Protective effect of selenium against ionizing radiation-induced malformations in mice. Acta Radiologica Oncology 24:267-271.
55. Chapman WA, Sipe CR, Eltzholtz DC, Cronkite EP, Chambers FW. 1950. Sulfhydryl-containing agents and the effects of ionizing radiations. I. Beneficial effect of glutathione injection on x-ray induced mortality rate and weight loss in mice. Radiology 55:865-873.
56. Charrier S, Michaud A, Badaoui S, Giroux S, Ezan E, Sainteny F, Corvol P, Vainchenker W. 2004. Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells. Blood 104:978-985.
57. Chlebovsky O, Praslicka M. 1984. Modification of radiation response by K and Mg aspartates in continuously irradiated rats and mice. Advances in Space Research 4:257-262.
58. Choi EK, Ji IM, Lee SR, Kook YH, Griffin RJ, Lim BU, Kim JS, Lee DS, Song CW, Park HJ. 2006. Radiosensitization of tumor cells by modulation of ATM kinase. International Journal of Radiation Biology 82:277-283.
59. Chow CK. 1988. Interrelationships of cellular antioxidant defense systems. In: Chow CK, editor. Cellular antioxidant defense mechanisms. Vol. II, Boca Raton, FL: CRC Press. pp 217-237.
60. Chow CK. 2004. Biological functions and metabolic fate of vitamin E revisited. Journal of Biomedical Science 11:295-302.
61. Chung HJ, Yoon SI, Shin SH, Koh YA, Lee SJ, Lee YS, Bae S. 2006. p53-mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression. Journal of Cellular Physiology 209:131-141.
62. Cotrim AP, Hyodo F, Matsumoto K, Sowers AL, Cook JA, Baum BJ, Krishna MC, Mitchell JB. 2007. Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Clinical Cancer Research 13:4928-4933.
63. Dainiak N, Ricks RC. 2005. The evolving role of haematopoietic cell transplantation in radiation injury: Potentials and limitations. British Journal of Radiation (Suppl. 27):169-174.
64. Damron TA, Spadaro JA, Horton JA, Margulies BS, Strauss JA, Farnum CE. 2004. Novel radioprotectant drugs for sparing radiation-induced damage to the physis. International Journal of Radiation Biology 80:217-228.
65. Dauer M, Coon JM. 1952. Failure of rutin and related flavonoids to influence mortality following acute whole body X-irradiation. Proceedings of the Society for Experimental Biology and Medicine 79:702-707.
66. Davidson DE, Grenan MM, Sweeney TR. 1980. Biological characteristics of some improved radioprotectors. In: Brady LW, editor. Radiation sensitizers. Their use in the clinical management of cancer. New York: Masson Publishing. pp 309-320.
67. Davis TA, Clarke TK, Mog SR, Landauer MR. 2007. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. International Journal of Radiation Biology 83: 141-151.
68. Davis TA, Mungunsukh O, Zins S, Day RM, Landauer MR. 2008. Genistein induces radioprotection by hematopoietic stem cell quiescence. International Journal of Radiation Biology 84: 713-726.
69. Day BJ. 2004. Catalytic antioxidants: A radical approach to new therapeutics. Drug Discovery Today 9:557-566.
70. Day RM, Kupper-Barshishat M, Mog SR, McCart EA, Prasanna PGS, Davis TA, Landauer MR. 2008. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. Journal of Radiation Research 49:361-372.
71. Delanian S, Porcher R, Balla-Mekias S, Lefaix JL. 2003. Randomized, placebo-controlled trial of combined pentoxifyl-line and tocopherol for regression of superficial radiation-induced fibrosis. Journal of Clinical Oncology 21:2545-2550.
72. Denekamp J, Rojas A, Stevens G. 1988. Redox competition and radiosensitivity: Implications for testing radioprotective compounds. Pharmacology and Therapeutics 39:59-66.
73. Deng W, Shuyu E, Tsukahara R, Valentine WJ, Durgam G, Gududuru V, Balazs L, Manickam V, Arsura M, VanMiddlesworth L, Johnson LR, Parrill AL, Miller DD, Tigyi G. 2007. The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology 132:1834-1851.
74. Dennert G, Horneber M. 2006. Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients. Cochrane Database of Systematic Reviews 3: CD005037.
75. Diamond AM, Dale P, Murray JL, Grdina DJ. 1996. The inhibition of radiation-induced mutagenesis by the combined effects of selenium and the aminothiol WR-1065. Mutation Research 23:147-154.
76. DiCarlo AL, Hatchett RJ, Kaminski JM, Ledney GD, Pellmar TC, Okunieff P, Ramakrishnan N. 2008. Medical countermeasures for radiation combined injury: Radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26-27, 2007. Radiation Research 169:712-721.
77. Dion MW, Hussey DH, Osborne JW. 1989. The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. International Journal of Radiation Oncology, Biology, Physics 17:101-107.
78. Dittmann K, Toulany M, Classen J, Heinrich V, Milas L, Rodemann HP. 2005. Selective radioprotection of normal tissues by Bowman-Birk proteinase inhibitor (BBI) in mice. Strahlentherapie und Onkologie 181:191-196.
79. Doherty DG, Burnett WT Jr. 1955. Protective effect of S, beta-aminoethylisothiuronium Br-HBr and related compounds against x-radiation death in mice. Proceedings of the Society for Experimental Biology and Medicine 89:312-314.
80. Doherty DG, Burnett WT Jr, Shapira R. 1957. Chemical protection against ionizing radiation. II. Mercaptoalkylamines and related compounds with protective activity. Radiation Research 7:13-21.
81. Donnelly GL, Holman RL. 1942. The stimulating influence of sodium citrate on cellular regeneration and repair in the kidney injured by uranium nitrate. Journal of Pharmacology and Experimental Therapeutics 75:11-17.
82. Drouet M, Delaunay C, Grenier N, Garrigou P, Mayol JF, Hérodin F. 2008. Cytokines in combination to treat radiation-induced myelosuppression: Evaluation of SCF + glycosylated EPO + pegylated G-CSF as an emergency treatment in highly irradiated monkeys. Haematologica 93:465-466.
83. Durbin PW. 2008. Lauriston S. Taylor Lecture: The quest for therapeutic actinide chelators. Health Physics 95:465-492.
84. Emami S, Hosseinimehr SJ, Taghdisi SM, Akhlaghpoor S. 2007. Kojic acid and its manganese and zinc complexes as potential radioprotective agents. Bioorganic and Medicinal Chemistry Letters 17:45-48.
85. Emerit I, Oganesian N, Arutyunyian R, Pogossian A, Sarkisian T, Cernjavski L, Levy A, Feingold J. 1997. Oxidative stress-related clastogenic factors in plasma of Chernobyl liquidators: Protective effects of antioxidant plant phenols, vitamins and oligoelements. Mutation Research 377:239-246.
86. Emerit I, Oganesian N, Sarkisian T, Arutyunyan R, Pogosian A, Asrian K, Levy A, Cernjavski L. 1995. Clastogenic factors in the plasma of Chernobyl accident recovery workers: Anti-clastogenic effect of Ginkgo biloba extract. Radiation Research 144:198-205.
87. Empey LR, Papp JD, Jewell LD, Fedorak RN. 1992. Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis in rats. Digestive Diseases and Sciences 37:205-214.
88. Endoh K, Murakami M, Araki R, Maruyama C, Umegaki K. 2006. Low folate status increases chromosomal damage by X-ray irradiation. International Journal of Radiation Biology 82:223-230.
89. Endoh K, Murakami M, Umegaki K. 2007. Vulnerability of folate in plasma and bone marrow to total body irradiation in mice. International Journal of Radiation Biology 83:65-71.
90. Epperly MW, Bray JA, Krager S, Berry LM, Gooding W, Engelhardt JF, Zwacka R, Travis EL, Greenberger JS. 1999. Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis. International Journal of Radiation Oncology, Biology, Physics 43:169-181.
91. Epperly M, Jin S, Nie S, Cao S, Zhang X, Franicola D, Wang H, Fink MP, Greenberger JS. 2007. Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation. Radiation Research 168:552-559.
92. Erbayraktar S, de Lanerolle N, de Lotbinière A, Knisely JP, Erbayraktar Z, Yilmaz O, Cerami A, Coleman TR, Brines M. 2006. Carbamylated erythropoietin reduces radiosurgically-induced brain injury. Molecular Medicine 12:74-80.
93. Evans RG. 1985. Tumor radiosensitization with concomitant bone marrow radioprotection: A study in mice using
94. diethyldithiocarbamate (DDC) under oxygenated and hypoxic conditions. International Journal of Radiation Oncology, Biology, Physics 11:1163-1169.
95. Farese AM, Hunt P, Grab LB, MacVittie TJ. 1996. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia. Journal of Clinical Investigation 97:2145-2151.
96. Farese AM, Yang BB, Roskos L, Stead RB, MacVittie TJ. 2003. Pegfilgrastim, a sustained-duration form of filgrastim, significantly improves neutrophil recovery after autologous marrow transplantation in rhesus macaques. Bone Marrow Transplantation 32:399-404.
97. Farooqi Z, Kesavan PC. 1992. Radioprotection by caffeine pre-and post-treatment in the bone marrow chromosomes of mice given whole-body gamma-irradiation. Mutation Research 269: 225-230.
98. Farrell CL, Bready JV, Rex KL, Chen JN, DiPalma CR, Whitcomb KL, Yin S, Hill DC, Wiemann B, Starnes CO, Havill AM, Lu ZN, Aukerman SL, Pierce GF, Thomason A, Potten CS, Ulich TR, Lacey DL. 1998. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Research 58: 933-939.
99. Federal Register. 2002. Evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Federal Register (final rule): 67:37988-3799821 CFR 3799314.3799600-3799650 and 3799601. 3799890-3799895.
100. Fehér I, Gidáli J, Sztanyik L. 1968. Study of the radioprotective effect of 5-methoxytryptamine on haemopoietic stem cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 14:257-262.
101. Feuer L, Benkó G. 1981. Effect of glutaurine and its derivatives and their combinations with radiation protective substances upon irradiated mice. Acta Radiologica, Oncology 20: 319-324.
102. Fillmann H, Kretzmann NA, San-Miguel B, Llesuy S, Marroni N, González-Gallego J, Tuñón MJ. 2007. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Toxicology 236:217-226.
103. Finney DJ. 1964. Statistical methods in biological assay. New York: Hafner Publishing Co.
104. Fischer JL, Lancia JK, Mathur A, Smith ML. 2006. Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex. Anticancer Research 26:899-904.
105. Floersheim GL, Bieri A. 1990. Further studies on selective radioprotection by organic zinc salts and synergism of zinc aspartate with WR 2721. British Journal of Radiology 63: 468-475.
106. Floersheim GL, Chiodetti N, Bieri A. 1988. Differential radio-protection of bone marrow and tumour cells by zinc aspartate. British Journal of Radiology 61:501-508.
107. Food and Drug Administration of the United States 2007. Guidance: Emergency Use Authorization of Medical Products. Accessed 20 December 2008 from the website: http://www.fda.gov/oc/guidance/emergencyuse.html
108. Food and Drug Administration of the United States 2008. Drug preparedness and response to bioterrorism: Radiation emergencies. Accessed 20 December 2008 from the website: http://www.fda.gov/cder/drugprepare/default.htm#
109. Foye WO. 1969. Radiation-protective agents in mammals. Journal of Pharmaceutical Sciences 58:283-300.
110. François S, Bensidhoum M, Mouiseddine M, Mazurier C, Allenet B, Semont A, Frick J, Saché A, Bouchet S, Thierry D, Gourmelon P, Gorin NC, Chapel A. 2006. Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: A study of their quantitative distribution after irradiation damage. Stem Cells 24: 1020-1029.
111. Friedenthal E, Mendecki J, Davis L, Seifter E. 1991. The role of vitamin A and analogues in prevention of radiation toxicity during radiotherapy of cancer. In: Jacobs MM, editor. Vitamins and minerals in the prevention and treatment of cancer. Boca Raton, FL: CRC Press. pp 275-278.
112. Fukuda S. 2005. Chelating agents used for plutonium and uranium removal in radiation emergency medicine. Current Medicinal Chemistry 12:2765-2770.
113. Gallo MA. 2001. History and scope of toxicology. In: Klaassen CD, editor. Casarett and Doull's Toxicology: The basic science of poisons. 6th ed. New York: McGraw-Hill. pp 3-10.
114. Gaziev AI, Podlutsky AJ, Panfilov BM, Bradbury R. 1995. Dietary supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice. Mutation Research 338:7786.
115. Gaziev AI, Sologub GR, Fomenko LA, Zaichkina SI, Kosyakova, NI, Bradbury RJ. 1996. Effect of vitamin-antioxidant micro-nutrients on the frequency of spontaneous and in vitro gamma-ray-induced micronuclei in lymphocytes of donors: The age factor. Carcinogenesis 17:493-499.
116. Gehrisch A, Dörr W. 2007. Effects of systemic or topical administration of sodium selenite on early radiation effects in mouse oral mucosa. Strahlentherapie und Onkologie 183: 36-42.
117. George KC, Hebbar SA, Kale SP, Kesavan PC. 1999. Caffeine protects mice against whole-body lethal dose of gamma-irradiation. Journal of Radiological Protection 19:171-176.
118. Gerschman R, Gilbert DL, Nye SW, Dwyer P, Fenn WO. 1954. Oxygen poisoning and x-irradiation: A mechanism in common. Science 119:623-626.
119. Ghose A, Srinivasan MN. 1980. Ineffectiveness of 2- mercaptopropionylglycine in increasing survival of mice after gamma irradiation either alone or in combination with aminoethyl isothiuronium bromide hydrobromide. Journal of Radiation Research 21:197-203.
120. Giriş M, Erbil Y, Epperly S, Olgaç V, Barbaros U, Deveci U, Kirgiz B, Uysal M, Toker GA. 2006 The effect of heme oxygenase-1 induction by glutamine on radiation-induced intestinal damage: The effect of heme oxygenase-1 on radiation enteritis. American Journal of Surgery 191:503-509.
121. Gorbunov NV, Pogue-Geile KL, Epperly MW, Bigbee WL, Draviam R, Day BW, Wald N, Watkins SC, Greenberger JS. 2000. Activation of the nitric oxide synthase 2 pathway in the response of bone marrow stromal cells to high doses of ionizing radiation. Radiation Research 154:73-86.
122. Gorin NC, Fliedner TM, Gourmelon P, Ganser A, Meineke V, Sirohi B, Powles R, Apperley J. 2006. Consensus conference on European preparedness for haematological and other medical management of mass radiation accidents. Annals of Hematology 85:671-679.
123. Gothard L, Cornes P, Earl J, Hall E, MacLaren J, Mortimer P, Peacock J, Peckitt, C, Woods M, Yarnold J. 2004. Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer. Radiotherapy and Oncology 73:133-139.
124. Grachev SA, Sverdlov AG, 1997. Chemical protection against x-ray, gamma, and neutron radiation. Contract Report CR97-1. Bethesda, MD: Armed Forces Radiobiology Research Institute. Accessed 1 August 2008 from the website: http://www.afrri.usuhs.mil/outreach/pdf/CR97-1.pdf
125. Grappin L, Berard P, Menetrier F, Carbone L, Courtay C, Castagnet X, Le Goff JP, Neron MO, Piechowski J. 2007.
126. Treatment of actinide exposures: A review of Ca-DTPA injections inside CEA-COGEMA plants. Radiation Protection Dosimetry 127:435-439.
127. Gray BH, Stull RW. 1983. Radioprotection by polyethylene glycol-protein complexes in mice. Radiation Research 93: 581-587.
128. Grdina DJ, Carnes BA, Grahn D, Sigdestad CP. 1991. Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid. Cancer Research 51:4125-4130.
129. Grdina DJ, Kataoka Y, Basic I, Perrin J. 1992. The radioprotector WR-2721 reduces neutron-induced mutations at the hypox-anthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation. Carcinogenesis 13:811-814.
130. Grdina DJ, Kataoka Y, Murley JS. 2000. Amifostine: Mechanisms of action underlying cytoprotection and chemoprevention. Drug Metabolism and Drug Interactions 16:237-279.
131. Greenberger JS, Epperly MW. 2007. Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization. In Vivo 21:141-146.
132. Greenwald RA. 1990. Superoxide dismutase and catalase as therapeutic agents for human diseases. A critical review. Free Radicals in Biology and Medicine 8:202-209.
133. Gridley DS, Makinde AY, Luo X, Rizvi A, Crapo JD, Dewhirst MW, Moeller BJ, Pearlstein RD, Slater JM. 2007. Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model. Anticancer Research 27:3101-3109.
134. Gudkov SV, Shtarkman IN, Smirnova VS, Chernikov AV, Bruskov VI. 2006. Guanosine and inosine display antioxidant activity, protect DNA in vitro from oxidative damage induced by reactive oxygen species, and serve as radioprotectors in mice. Radiation Research 165:538-545.
135. Guan J, Stewart J, Ware JH, Zhou Z, Donahue JJ, Kennedy AR. 2006. Effects of dietary supplements on the space radiation-induced reduction in total antioxidant status in CBA mice. Radiation Research 165:373-378.
136. Gusev IA, Guskova AK, Mettler FA Jr, editors. 2001. Medical management of radiation accidents. 2nd ed. Boca Raton, FL: CRC Press.
137. Hahn SM, Tochner Z, Krishna CM, Glass J, Wilson L, Samuni A, Sprague M, Venzon D, Glatstein E, Mitchell JB, Russo A. 1992. Tempol, a stable free radical, is a novel murine radiation protector. Cancer Research 52:1750-1753.
138. Hanson WR. 1987. Radiation protection of murine intestine by WR-2721, 16,16-dimethyl prostaglandin E2, and the combination of both agents. Radiation Research 111:361-373.
139. Hanson WR. 1998. Eicosanoid-induced radioprotection and chemoprotection: Laboratory studies and clinical applications. In: Bump EA, Malaker K, editors. Radioprotectors: Chemical, biological, and clinical perspectives. Boca Raton, FL: CRC Press. pp 197-211.
140. Hanson WR, Ainsworth EJ. 1985. 16,16-Dimethyl prostaglandin E2 induces radioprotection in murine intestinal and hematopoietic stem cells. Radiation Research 103:196-203.
141. Hanson WR, DeLaurentiis K. 1987. Comparison of in vivo murine intestinal radiation protection by E-prostaglandins. Prostaglandins 33(Suppl.):93-104.
142. Hanson WR, Marks JE, Reddy SP, Simon S, Mihalo WE, Tova Y. 1995a. Protection from radiation-induced oral mucositis by misoprostol, a prostaglandin E(1) analog: A placebo-controlled, double-blind clinical trial. American Journal of Therapeutics 2:850-857.
143. Hanson WR, Zhen W, Geng L, Hunter N, Milas L. 1995b. The prostaglandin E1 analog, misoprostol, a normal tissue protector, does not protect four murine tumors in vivo from radiation injury. Radiation Research 142:281-287.
144. Hao J, Sun L, Huang H, Xiong G, Liu X, Qiu L, Chen G, Dong B, Li Y, Chen W, Buechler Y, Sun J, Shen C, Luo Q. 2004. Effects of recombinant human interleukin 11 on thrombocytopenia and neutropenia in irradiated rhesus monkeys. Radiation Research 162:157-163.
145. Harapanhalli RS, Yaghmai V, Giuliani D, Howell RW, Rao DV. 1996. Antioxidant effects of vitamin C in mice following x-irradiation. Research Communications in Molecular Pathology and Pharmacology 94:271-287.
146. Hebbar SA, Mitra AK, George KC, Verma NC. 2002. Caffeine ameliorates radiation-induced skin reactions in mice but does not influence tumour radiation response. Journal of Radiological Protection 22:63-69.
147. Held KD, Biaglow JE. 1994. Mechanisms for the oxygen radical-mediated toxicity of various thiol-containing compounds in cultured mammalian cells. Radiation Research 139:15-23.
148. Henke M, Laszig R, Rübe C, Schäfer U, Haase KD, Schilcher B, Mose S, Beer KT, Burger U, Dougherty C, Frommhold H. 2003. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial. The Lancet 362:1255-1260.
149. Hérodin F, Roy L, Grenier N, Delaunay C, Baugé S, Vaurijoux
150. Herve A, Bacq ZM. 1949. Cyanure et dose lethale de rayon X. Comptes rendus des seances de la Societe de biologie et de ses filiales 143:881-883.
151. Hofer M, Pospíšil M. 1997. Glucan as stimulator of hematopoiesis in normal and gamma-irradiated mice. A survey of the authors' results. International Journal of Immunopharmacology 19: 607-609.
152. Hofer M, Pospíšil M. 2006a. Stimulated recovery of perturbed haematopoiesis by inhibition of prostaglandin production - promising therapeutic strategy. Central European Journal of Biology 1:584-593.
153. Hofer M, Pospíšil M. 2006b. Role of adenosine signaling in hematopoiesis - a short review. Medical Hypotheses Research 3:629-635.
154. Hofer M, Pospíšil M, Holá J, Vacek A, Štreitová D, Znojil V. 2008a. Inhibition of cyclooxygenase 2 in mice increases production of G-CSF and induces radioprotection. Radiation Research 170:566-571.
155. Hofer M, Pospíšil M, Pipalová I, Holá J. 1996. Modulation of haemopoietic radiation response of mice by diclofenac in fractionated treatment. Physiological Research 45:213-220.
156. Hofer M, Pospíšil M, Znojil V, Holá J, Vacek A, Streitová D. 2008b. Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy. Physiological Research 57:307-310.
157. Hofer M, Pospíšil M, Znojil V, Holá J, Vacek A, Weiterová L, Streitová D, Kozubík A. 2006. Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice. Radiation Research 166:556-560.
158. Hofer M, Pospíšil M, Znojil V, Vacek A, Weiterova L, Holá J, Vácha J. 2002. Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myelosuppressed mice: Their comparison and joint effects with the granulocyte colony-stimulating factor. European Journal of Haematology 68:4-11.
159. Holwitt EA, Koda E, Swenberg CE. 1990. Enhancement of topoisomerase I-mediated unwinding of supercoiled DNA by the radioprotector WR-33278. Radiation Research 124: 107-109.
160. Hosseinimehr SJ. 2007. Trends in the development of radio-protective agents. Drug Discovery Today 12:794-805.
161. Hosseinimehr SJ, Emami S, Taghdisi SM, Akhlaghpoor S. 2008. 5,7-Dihydroxychromone-2-carboxylic acid and its
162. transition-metal (Mn and Zn) chelates as non-thiol radio-protective agents. European Journal of Medicinal Chemistry 43:557-561.
163. Hosseinimehr SJ, Zakaryaee V, Froughizadeh M. 2006. Oral oxymetholone reduces mortality induced by gamma irradiation in mice through stimulation of hematopoietic cells. Molecular and cellular biochemistry 287:193-199.
164. Houchen CW, Sturmoski MA, Anant S, Breyer RM, Stenson WF. 2003. Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology 284:G490-498.
165. Houdijk AP, Visser JJ, Rijnsburger ER, Teerlink T, van Leeuwen PA. 1998. Dietary glutamine supplementation reduces plasma nitrate levels in rats. Clinical Nutrition 17: 11-14.
166. Huang EY, Leung SW, Wang CJ, Chen HC, Sun LM, Fang FM, Yeh SA, Hsu HC, Hsiung CY. 2000. Oral glutamine to alleviate radiation-induced oral mucositis: A pilot randomized trial. International Journal of Radiation Oncology, Biology, Physics 46:535-539.
167. Inano H, Onoda M. 2002. Radioprotective action of curcumin extracted from Curcuma longa LINN: Inhibitory effect of formation of urinary 8-hydroxy-2′-deoxyguanosine, tumori-genesis, but not mortality, induced by gamma-ray irradiation. International Journal of Radiation Oncology, Biology, Physics 53:735-743.
168. Ishii T, Futami S, Nishida M, Suzuki T, Sakamoto T, Suzuki N, Maekawa K. 2001. Brief note and evaluation of acute-radiation syndrome and treatment of a Tokai-mura criticality accident patient. Journal of Radiation Research 42(Suppl.):S167-182.
169. Jagetia GC. 2007a. Radioprotection and radiosensitization by curcumin. Advances in Experimental Medicine and Biology 595:301-320.
170. Jagetia GC. 2007b. Radioprotective potential of plants and herbs against the effects of ionizing radiation. Journal of Clinical Biochemistry and Nutrition 40:74-81.
171. Jagetia GC, Shirwaikar A, Rao SK, Bhilegaonkar PM. 2003. Evaluation of the radioprotective effect of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation. Journal of Pharmacy and Pharmacology 55: 1151-1158.
172. Jagetia GC, Venkatesh P, Baliga MS. 2004. Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice. International Journal of Radiation Biology 80:281-290.
173. Jaiswal SK, Bordia A. 1996. Radio-protective effect of garlic Allium sativum Linn. in albino rats. Indian Journal of Medical Sciences 50:231-233.
174. Jha MN, Bamburg JR, Bernstein BW, Bedford JS. 2002. Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells. Radiation Research 157: 26-31.
175. Jha MN, Bedford JS, Cole WC, Edwards-Prasad J, Prasad KN. 1999. Vitamin E (d-alpha-tocopheryl succinate) decreases mitotic accumulation in gamma-irradiated human tumor, but not in normal cells. Nutrition and Cancer 35:189-194.
176. Johnstone PA, Niemtzow RC, Riffenburgh RH. 2002. Acupuncture for xerostomia: Clinical update. Cancer 94:1151-1156.
177. Kågerud A, Holm G, Larsson H, Peterson HI. 1978. Tocopherol and local x-ray irradiation of two transplantable rat tumours. Cancer Letters 5:123-129.
178. Kågerud A, Peterson HI. 1981. Tocopherol in irradiation of experimental neoplasms. Influence of dose and administration. Acta Radiologica Oncology 20:97-100.
179. Kang SK, Rabbani ZN, Folz RJ, Golson ML, Huang H, Yu D, Samulski TS, Dewhirst MW, Anscher MS, Vujaskovic Z. 2003. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. International Journal of Radiation Oncology, Biology, Physics 57: 1056-1066.
180. Kennedy AR. 1984. Prevention of radiation transformation in vitro. In: Prasad KN, editor. Vitamins, nutrition and cancer. Basel: Karger. pp 166-179.
181. Kennedy AR, Davis JG, Carlton W, Ware JH. 2008. Effects of dietary antioxidant supplementation on the development of malignant lymphoma and other neoplastic lesions in mice exposed to proton or iron-ion radiation. Radiation Research 169:615-625.
182. Kennedy AR, Ware JH, Guan J, Donahue JJ, Biaglow JE, Zhou Z, Stewart J, Vazquez M, Wan XS. 2004. Selenomethionine protects against adverse biological effects induced by space radiation. Free Radicals in Biology and Medicine 36: 259-266.
183. Kennedy AR, Zhou Z, Donahue JJ, Ware JH. 2006. Protection against adverse biological effects induced by space radiation by the Bowman-Birk inhibitor and antioxidants. Radiation Research 166:327-332.
184. Kennedy M, Bruninga K, Mutlu EA, Losurdo J, Choudhary S, Keshavarzian A. 2001. Successful and sustained treatment of chronic radiation proctitis with antioxidant vitamins E and C. American Journal of Gastroenterology 96:1080-1084.
185. Kesavan PC. 2005. Oxygen effect in radiation biology: Caffeine and serendipity. Current Science 89:318-328.
186. Kesavan PC, Trasi S, Ahmad A. 1973. Modification of barley seed radiosensitivity by post-treatment with caffeine I. Effect of postirradiation heat shock and nature of hydration. International Journal of Radiation Biology 24:581-587.
187. Kim JK, Kim JH, Yoon YD. 2003. Evaluation of caffeine as a radioprotector in whole-body irradiated male mice. In Vivo 17: 197-200.
188. Kimler BF, Leeper DB, Snyder MH, Rowley R, Schneiderman MH. 1982. Modification of radiation-induced division delay by caffeine analogues and dibutyryl cyclic AMP. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 41:47-58.
189. Kiremidjian-Schumacher L, Roy M, Glickman R, Schneider K, Rothstein S, Cooper J, Hochster H, Kim M, Newman R. 2000. Selenium and immunocompetence in patients with head and neck cancer. Biological Trace Element Research 73:97-111.
190. Klayman DL, Copeland ES. 1975. The design of antiradiation agents. In: Ariens EJ, editor. Drug design. New York: Academic Press. pp 81-142.
191. Klimberg VS, Souba WW, Dolson DJ, Salloum RM, Hautamaki RD, Plumley DA, Mendenhall WM, Bova FJ, Khan SR, Hackett RL, Bland KI, Copeland EM. 1990. Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer 66:62-68.
192. Knasmü ller S, de Martin R, Domjan G, Szakmary A. 1989. Studies on the antimutagenic activities of garlic extract. Environmental and Molecular Mutagenesis 13:357-365.
193. Konings AW, Damen J, Trieling WB. 1979. Protection of liposomal lipids against radiation induced oxidative damage. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 35:343-350.
194. Konopacka M, Widel M, Rzeszowska-Wolny J. 1998. Modifying effect of vitamin C, E and beta-carotene against gamma-ray-induced DNA damage in mouse cells. Mutation Research 417: 85-94.
195. Krishna A, Kumar A. 2005. Evaluation of radioprotective effects of Rajgira (Amaranthus paniculatus) extract in Swiss albino mice. Journal of Radiation Research 46:233-239.
196. Kuechler A, Dreidax M, Pigorsch SU, Liehr T, Claussen U, Wendt TG, Dunst J. 2003. Residual chromosomal damage after radiochemotherapy with and without amifostine detected by 24-color FISH. Strahlentherapie und Onkologie 179: 493-498.
197. Kumar KS, Raghavan M, Hieber K, Ege C, Mog S, Parra N, Hildabrand A, Singh V, Srinivasan V, Toles R, Karikari P, Petrovics G, Seed T, Srivastava S, Papas A. 2006. Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant γ-tocotrienol. Life Sciences 78: 2099-2104.
198. Kumar KS, Srinivasan V, Toles R, Jobe L, Seed TM. 2002. Nutritional approaches to radioprotection: Vitamin E. Military Medicine 167(Suppl. 1):57-59.
199. Kumar SS, Devasagayam TP, Jayashree B, Kesavan PC. 2001. Mechanism of protection against radiation-induced DNA damage in plasmid pBR322 by caffeine. International Journal of Radiation Biology 77:617-623.
200. Kuna P. 1983. Duration and degree of radioprotection of WR-2721 in mice following its intraperitoneal, intramuscular and subcutaneous administration. Radiobiologia Radiotherapia 24: 357-364.
201. Kuna P, Vodicka I, Dostál M. 1983. Radioprotective and hemodynamic effects of 5-methoxytryptamine following different route of its administration in rats. Radiobiologia Radio-therapia 24:365-376.
202. Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, Krishnan S. 2008. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-κB-regulated gene products. Clinical Cancer Research 14:2128-2136.
203. Kuter DJ. 2008. New drugs for familiar therapeutic targets: Thrombopoietin receptor agonists and immune thrombocytopenic purpura. European Journal of Haematology Supplementum 69:9-18.
204. Lacassagne M. 1942. Chute de la sensibilite aux rayons X chez la souris nouveau-nu en etat d'asphyxie. Comptes Rendus de L Academie des Sciences (Paris) 616:231-232.
205. LaNasa P, Miller RC, Hanson WR, Hall EJ. 1994. Misoprostol-induced radioprotection of oncogenic transformation. International Journal of Radiation Oncology, Biology, Physics 29: 273-275.
206. Landauer MR, 2008. Radioprotection by the soy isoflavone genistein. In: Arora R, editor. Herbal radiomodulators: Applications in medicine, homeland defence and space. Wallingford, Oxon, UK: CABI Publishing. pp 163-173.
207. Landauer MR, Castro CA, Benson KA, Hogan JB, Weiss JF. 2001. Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR-151327. Journal of Applied Toxicology 21:25-31.
208. Landauer MR, Davis HD, Dominitz JA, Weiss JF. 1988a. Long-term effects of radioprotector WR-2721 on locomotor activity and body weight of mice following exposure to ionizing radiation. Toxicology 49:315-323.
209. Landauer MR, Davis HD, Dominitz JA, Weiss JF. 1988b. Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyl-dithiocarbamate, and N-acetylcysteine. Pharmacology and Therapeutics 39:97-100.
210. Landauer MR, Davis HD, Kumar KS, Weiss JF. 1992. Behavioral toxicity of selected radioprotectors. Advances in Space Research 12:273-283.
211. Landauer MR, Srinivasan V, Seed TM. 2003. Genistein treatment protects mice from ionizing radiation injury. Journal of Applied Toxicology 23:379-385.
212. Landauer MR, Walden TL Jr, Davis HD. 1990. Behavioral effects of radioprotective agents in mice: Combination of WR-2721 and 16,16 dimethyl prostaglandin E2. In: Riklis E, editor. Frontiers of radiation biology. Weinheim, Germany: VCH Publishers. pp 199-207.
213. Lataillade JJ, Doucet C, Bey E, Carsin H, Huet C, Clairand I, Bottollier-Depois JF, Chapel A, Ernou I, Gourven M, Boutin L, Hayden A, Carcamo C, Buglova E, Joussemet M, de Revel T, Gourmelon P. 2007. New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regenerative Medicine 2:785-794.
214. Lee JH, Park JW. 2004. A manganese porphyrin complex is a novel radiation protector. Free Radicals in Biology and Medicine 37:272-283.
215. Lefaix JL, Delanian S, Vozenin MC, Leplat JJ, Tricaud Y, Martin M. 1999. Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and α-tocopherol: An experimental study. International Journal of Radiation Oncology, Biology, Physics 43:839-847.
216. Lehnert S. 1979. Radioprotection of mouse intestine by inhibitors of cyclic AMP phosphodiesterase. International Journal of Radiation Oncology, Biology, Physics 5:825-833.
217. Limoli CL, Giedzinski E, Baure J, Doctrow SR, Rola R, Fike JR. 2006. Using superoxide dismutase/catalase mimetics to manipulate the redox environment of neural precursor cells. Radiation Protection Dosimetry 122:228-236.
218. Limoli CL, Kaplan MI, Giedzinski E, Morgan WF. 2001. Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation. Free Radical Biology and Medicine 31:10-19.
219. Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC. 2007. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. Journal of Biological Chemistry 282:37759-37769.
220. Littlefield LG, Joiner EE, Colyer SP, Sallam F, Frome EL. 1993. Concentration dependent protection against x-ray-induced chromosome aberrations in human lymphocytes by the aminothiol WR-1065. Radiation Research 133:88-93.
221. Liu WC, Wang SC, Tsai ML, Chen MC, Wang YC, Hong JH, McBride WH, Chiang CS. 2006. Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Radiation Research 166: 900-907.
222. Liu Y, Zhang H, Zhang L, Zhou Q, Wang X, Long J, Dong T, Zhao W. 2007. Antioxidant N-acetylcysteine attenuates the acute liver injury caused by x-ray in mice. European Journal of Pharmacology 575:142-148.
223. Machtay M, Scherpereel A, Santiago J, Lee J, McDonough J, Kinniry P, Arguiri E, Shuvaev VV, Sun J, Cengel K, Solomides CC, Christofidou-Solomidou M. 2006. Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse. Radiotherapy and Oncology 81:196-205.
224. MacNaughton WK, Aurora AR, Bhamra J, Sharkey KA, Miller MJ. 1998. Expression, activity and cellular localization of inducible nitric oxide synthase in rat ileum and colon post-irradiation. International Journal of Radiation Biology 74: 255-264.
225. MacVittie TJ, Farese AM, Jackson W. 2005. Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: The effect of supportive care plus administration of G-CSF. Health Physics 89: 546-555.
226. MacVittie TJ, Monroy RL, Patchen ML, Souza LM. 1990. Therapeutic use of recombinant human G-CSF (rhG-CSF) in a canine model of sublethal and lethal whole-body irradiation. International Journal of Radiation Biology 57: 723-736.
227. MacVittie TJ, Monroy R, Vignuelle RM, Zeman GH, Jackson WE. 1991. The relative biological effectiveness of mixed fission-neutron-radiation on the hematopoietic syndrome in the canine: Effect of therapy on survival. Radiation Research 129:529-536.
228. MacVittie TJ, Weiss JF, Browne D, editors. 1996. Advances in the treatment of radiation injury. Oxford: Pergamon Press.
229. Maisin JR. 1998. Bacq and Alexander Award lecture - chemical radioprotection: Past, present, and future prospects. International Journal of Radiation Biology 73:443-450.
230. Maisin JR, Albert C, Henry A. 1993. Reduction of short-term radiation lethality by biological response modifiers given alone or in association with other chemical protectors. Radiation Research 135:332-337.
231. Maisin JR, Declève A, Gerber GB, Mattelin G, Lambiet-Collier M. 1978. Chemical protection against the long-term effects of a single whole-body exposure of mice to ionizing radiation II. Causes of death. Radiation Research 74: 415-435.
232. Maisin J, Dumont P, Dunjic A. 1960. Yeast ribonucleic acid and its nucleotides as recovery factors in rats receiving an acute whole-body dose of x-rays. Nature 186:487-488.
233. Maisin JR, Kondi-Tamba A, Mattelin G. 1986. Polysaccharides induce radioprotection of murine hemopoietic stem cells and increase the LD50/30 days. Radiation Research 105: 276-281.
234. Malick MA, Roy RM, Sternberg J. 1978. Effect of vitamin E on post-irradiation death in mice. Experientia 34:1216-1217.
235. Manda K, Ueno M, Anzai K. 2008. Melatonin mitigates oxidative damage and apoptosis in mouse cerebellum induced by high-LET 56Fe particle irradiation. Journal of Pineal Research 44: 189-196.
236. Mantena SK, Unnikrishnan MK, Joshi R, Radha V, Devi PU, Mukherjee T. 2008. In vivo radioprotection by 5-aminosalicylic acid. Mutation Research 650:63-79.
237. Maqsood DM, Ashikawa JK. 1962. Post-irradiation protection and recovery. I. Effects of lipids on haematopoietic organs of x-irradiated male mice. International Journal of Radiation Biology 4:521-531.
238. Mates JM, Perez-Gomez C, Nunez de Castro I, Asenjo M, Marquez J. 2002. Glutamine and its relationship with intracel-lular redox status, oxidative stress and cell proliferation/death. International Journal of Biochemistry and Cell Biology 34: 439-458.
239. Matsubara J. 1988. Metallothionein induction: A measure of radioprotective action. Health Physics 55:433-436.
240. McClain DE, Kalinich JF, Ramakrishnan N. 1995. Trolox inhibits apoptosis in irradiated MOLT-4 lymphocytes. FASEB Journal 9:1345-1354.
241. McCord JM, Fridovich I. 1969. Superoxide dismutase - an enzymic function for erythrocuprein (hemocuprein). Journal of Biological Chemistry 244:6049-6055.
242. Mewissen DJ, Brucer M. 1957. Late effects of gamma radiation on mice protected with cysteamine or cystamine. Nature 179: 201-202.
243. 137Cs internal contamination involving a Brazilian accident, and the efficacy of Prussian Blue treatment. Health Physics 66: 245-252.
244. Milas L, Hunter N, Stephens LC, Peters LJ. 1984. Inhibition of radiation carcinogenesis in mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid. Cancer Research 44:5567-5569.
245. Miller CP, Hammond CW. 1950. Reduction of mortality from X-radiation by treatment with antibiotics. Science 111: 719-720.
246. Mönig H, Messerschmidt O, Streffer C. 1990. Chemical radio-protection in mammals and in man. In: Scherer E, Streffer C, Trott K-R, editors. Radiation exposure and occupational risks. Berlin: Springer-Verlag. pp 97-143.
247. Monobe M, Hino M, Sumi M, Uzawa A, Hirayama R, Ando K, Kojima S. 2005. Protective effects of melatonin on gamma-ray induced intestinal damage. International Journal of Radiation Biology 81:855-860.
248. Moulder JE, Cohen EP. 2007. Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Seminars in Radiation Oncology 17:141-148.
249. Mouthon MA, Van der Meeren A, Gaugler MH, Visser TP, Squiban C, Gourmelon P, Wagemaker G. 1999. Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation. International Journal of Radiation Oncology, Biology, Physics 43:867-875.
250. 144Ce in dogs. Radiation Research 124:147-155.
251. Murley JS, Kataoka Y, Hallahan DE, Roberts JC, Grdina DJ. 2001. Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radical Biology and Medicine 30: 1426-1439.
252. Murray D, McBride WH. 1996. Radioprotective agents. In: Kirk-Othmer encyclopedia of chemical technology. 4th ed. Vol. 20. New York: Wiley. pp 963-1006.
253. Nagata H, Sugahara T, Tanaka T. 1972. Radiation protection by 2-mercaptopropionylglycine in mice. Journal of Radiation Research 13:163-166.
254. Nash RA, Seidel K, Storb R, Slichter S, Schuening FG, Appelbaum FR, Becker AB, Bolles L, Deeg HJ, Graham T, Hackman RC, Burstein SA. 1995. Effects of rhIL-11 on normal dogs and after sublethal radiation. Experimental Hematology 23:389-396.
255. Nauman J, Wolff J. 1993. Iodide prophylaxis in Poland after the Chernobyl reactor accident: Benefits and risks. American Journal of Medicine 94:524-532.
256. National Council on Radiation Protection and Measurements (NCRP). 2008. Management of persons contaminated with radionuclides. NCRP Report 161. Bethesda, MD: NCRP.
257. Nayak V, Uma Devi P. 2005. Protection of mouse bone marrow against radiation-induced chromosome damage and stem cell death by the Ocimum flavonoids. Radiation Research 163: 165-171.
258. Neal R, Matthews RH, Lutz P, Ercal N. 2003. Antioxidant role of N-acetyl cysteine isomers following high dose irradiation. Free Radical Biology and Medicine 34:689-695.
259. Nénot JC, 1990. Medical and surgical management for localized radiation injuries. International Journal of Radiation Biology 57:783-795.
260. Neta R, 1997. Modulation with cytokines of radiation injury: Suggested mechanisms of action. Environmental Health Perspectives 105(Suppl. 6):1463-1465.
261. Neta R. 1998. Modulation of the radiation response by cytokines. In: Bump EA, Malaker K, editors. Radioprotectors: Chemical, biological, and clinical perspectives. Boca Raton, FL: CRC Press. pp 237-252.
262. Neta R, Douches S, Oppenheim JJ. 1986. Interleukin 1 is a radioprotector. Journal of Immunology 136:2483-2485.
263. Neta R, Oppenheim JJ, Schreiber RD, Chizzonite R, Ledney GD, MacVittie TJ. 1991. Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide-enhanced radioresistance. Journal of Experimental Medicine 173:1177-1182.
264. Nicolatou O, Sotiropoulou-Lontou A, Skarlatos J, Kyprianou K, Kolitsi G, Dardoufas K. 1998. A pilot study of the effect of granulocyte-macrophage colony-stimulating factor on oral mucositis in head and neck cancer patients during x-radiation therapy: A preliminary report. International Journal of Radiation Oncology, Biology, Physics 42:551- 556.
265. Nishiguchi I, Furuta Y, Hunter N, Murray D, Milas L. 1990. Radioprotection of hematopoietic tissues in mice by indo-methacin. Radiation Research 122:188-192.
266. Noaman E, Zahran AM, Kamal AM, Omran MF. 2002. Vitamin E and selenium administration as a modulator of antioxidant defense system: Biochemical assessment and modification. Biological Trace Element Research 86:55-64.
267. North S, El-Ghissassi F, Pluquet O, Verhaegh G, Hainaut P. 2000. The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene 19:1206-1214.
268. Ohta S, Matsuda S, Gunji M, Kamogawa A. 2007. The role of nitric oxide in radiation damage. Biological and Pharmaceutical Bulletin 30:1102-1107.
269. Okunieff P. 1991. Interactions between ascorbic acid and the radiation of bone marrow, skin, and tumor. American Journal of Clinical Nutrition (Suppl. 54):1281S-1283S.
270. Okunieff P, Augustine E, Hicks JE, Cornelison TL, Altemus RM, Naydich BG, Ding I, Huser AK, Abraham EH, Smith JJ, Coleman N, Gerber LH. 2004. Pentoxifylline in the treatment of radiation-induced fibrosis. Journal of Clinical Oncology 22: 2207-2213.
271. Okunieff P, Mester M, Wang J, Maddox T, Gong X, Tang D, Coffee M, Ding I. 1998. In vivo radioprotective effects of angiogenic growth factors on the small bowel of C3H mice. Radiation Research 150:204-211.
272. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. 1996. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 334:1150-1155.
273. Packer JE, Slater TF, Willson RL. 1979. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 278:737-738.
274. Parshad R, Sanford KK, Price FM, Steele VE, Tarone RE, Keloff GJ, Boone CW. 1998. Protective action of plant polyphenols on radiation-induced chromatid breaks in cultured human cells. Anticancer Research 18:3263-3266.
275. Patchen ML. 1998. Immunomodulators and cytokines: Their use in the mitigation of radiation-induced hemopoietic injury. In: Bump EA, Malaker K, editors. Radioprotectors: Chemical, biological, and clinical perspectives. Boca Raton, FL: CRC Press. pp 213-236.
276. Patchen ML, MacVittie TJ. 1985. Stimulated hemopoiesis and enhanced survival following glucan treatment in sublethally and lethally irradiated mice. International Journal of Immunopharmacology 7:923-932.
277. Patchen ML, MacVittie TJ, Jackson WE. 1989. Postirradiation glucan administration enhances the radioprotective effects of WR-2721. Radiation Research 117:59-69.
278. Patchen ML, MacVittie TJ, Solberg BD, Souza LM. 1990. Therapeutic administration of recombinant human granulocyte colony-stimulating factor accelerates hemopoietic regeneration and enhances survival in a murine model of radiation-induced myelosuppression. International Journal of Cell Cloning 8:107-122.
279. Patchen ML, MacVittie TJ, Souza LM. 1992. Postirradiation treatment with granulocyte colony-stimulating factor and preirradiation WR-2721 administration synergize to enhance hemopoietic reconstitution and increase survival. International Journal of Radiation Oncology, Biology, Physics 22:773-779.
280. Patt HM, Straube RL, Tyree EB, Swift MN, Smith DE. 1949a. Influence of estrogens on the acute x-irradiation syndrome. American Journal of Physiology 159:269-280.
281. Patt HM, Tyree EB, Straube RL, Smith DE. 1949b. Cysteine protection against x-irradiation. Science 110:213-214.
282. Pawlik TM, Keyomarsi K. 2004. Role of cell cycle in mediating sensitivity to radiotherapy. International Journal of Radiation Oncology, Biology, Physics 59:928-942.
283. Pellmar TC, Rockwell S, Radiological/Nuclear Threat Countermeasures Working Group. 2005. Priority list of research areas for radiological nuclear threat countermeasures. Radiation Research 163:115-123.
284. Peeters K, Stassen JM, Collen D, Van Geet C, Freson K. 2008. Emerging treatments for thrombocytopenia: Increasing platelet production. Drug Discovery Today 13:798-806.
285. Perez M, Carr Z, editors. 2007. Development of stockpiles for radiation emergencies: Report of the radio-nuclear working group. WHO Headquarters: Geneva, Switzerland. Accessed 20 December 2008 from the website: http://www.who.int/ionizing-radiation/a-e/emergencies/WHO-Stockpile-Report-2007- v2.pdf
286. Peter RU, Gottlober P. 2002. Management of cutaneous radiation injuries: Diagnostic and therapeutic principles of the cutaneous radiation syndrome. Military Medicine. 167:(Suppl 2) 110-112.
287. Petkau A. 1986. Scientific basis for the clinical use of superoxide dismutase. Cancer Treatment Reviews 13:17-44.
288. Petkau A, Chelack WS, Pleskach SD. 1976. Protection of post-irradiated mice by superoxide dismutase. International Journal of Radiation Oncology, Biology, Physics 29:297-299.
289. Phillips TL. 1980. Rationale for initial clinical trials and future development of radioprotectors. Cancer Clinical Trials 3: 165-173.
290. Pihl A, Eldjarn L. 1958. Pharmacological aspects of ionizing radiation and of chemical protection in mammals. Pharmacological Reviews 10:437-474.
291. Pospíšil M, Hofer M, Netíková J, Pipalová I, Vacek A, Bartoníčková A, Volenec K. 1993. Elevation of extracellular adenosine induces radioprotective effects in mice. Radiation Research 134:23-330.
292. Pospíšil M, Hofer M, Znojil V, Vácha J, Netíkova J, Hola J. 1995. Radioprotection of mouse hemopoiesis by dipyridamole and adenosine monophosphate in fractionated treatment. Radiation Research 142:16-22.
293. Pospíšil M, Netíkova J, Pipalová I, Mikeska J. 1980. Effect of K and Mg salts of aspartic acid on haemopoiesis and recovery from radiation damage in mice. Folia Biologica 26: 53-61.
294. Potten CS. 2004. Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine. Radiation Research 161:123-136.
295. Prasad KN, Cole WC, Kumar B, Che Prasad K. 2002. Pros and cons of antioxidant use during radiation therapy. Cancer Treatment Reviews 28:79-91.
296. Prasanna PG, Uma Devi P. 1993. Modification of WR-2721 radiation protection from gastrointestinal injury and death in mice by 2-mercaptopropionylglycine. Radiation Research 133: 111-115.
297. Pratt AG, Emerson RJ, Levin S, Baum SJ. 1973. Granulocytic recovery in the polycythemic dog treated with endotoxin postirradiation. Radiation Research 56:162-170.
298. Rabbani ZN, Salahuddin FK, Yarmolenko P, Batinic-Haberle I, Thrasher BA, Gauter-Fleckenstein B, Dewhirst MW, Anscher MS, Vujaskovic Z. 2007. Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. Free Radical Research 41: 1273-1282.
299. Rades D. 2008. Erythropoietin administration during radiotherapy in anaemic head-and-neck cancer patients: Is it still a reasonable option or too dangerous? Oral Oncology 45:91-93.
300. Rades D, Fehlauer F, Bajrovic A, Mahlmann B, Richter E, Alberti W. 2004. Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients. Radiotherapy and Oncology 70:261-264.
301. Radiation Emergency Assistance Center/Training Site (REAC/ TS). 2008. Accessed 20 December 2008 from the website: http://www.orise.orau.gov/reacts/ guide/care.htm#emergcare
302. Radiation Event Medical Management (REMM). 2008. Accessed 20 December 2008 from the website: http://www.remm.nlm.gov/sns.htm
303. Raffoul JJ, Wang Y, Kucuk O, Forman JD, Sarkar FH, Hillman GG. 2006. Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer 6:107-116.
304. Ramakrishnan N, Wolfe WW, Catravas GN. 1992. Radioprotection of hematopoietic tissues in mice by lipoic acid. Radiation Research 130:360-365.
305. Reagan-Shaw S, Mukhtar H, Ahmad N. 2008. Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells. Photochemistry and Photobiology 84:415-421.
306. Redlich CA, Rockwell S, Chung JS, Sikora AG, Kelley, M, Mayne ST. 1998. Vitamin A inhibits radiation-induced pneumonitis in rats. Journal of Nutrition 128:1661-1664.
307. Rezvani M. 2008. Amelioration of the pathological changes induced by radiotherapy in normal tissues. Journal of Pharmacy and Pharmacology 60:1037-1048.
308. Rich JN. 2007. Cancer stem cells in radiation resistance. Cancer Research 67:8980-8984.
309. Riley PA. 1994. Free radicals in biology: Oxidative stress and the effects of ionizing radiation. International Journal of Radiation Biology 65:27-33.
310. Robbins MEC, Zhao W. 2004. Chronic oxidative stress and radiation-induced late normal tissue injury: A review. International Journal of Radiation Biology 80:251-259.
311. Rodemann HP, Hehr T, Bamberg M. 1999. Radioprotektiven relevanz der wirkung von natriumselenit: praklinische ergebnis. Medizinische Klinik 94(Suppl. 3):39-41.
312. Roy RM, Petrella M, Shateri H. 1988. Effects of administering tocopherol after irradiation on survival and proliferation of murine lymphocytes. Pharmacology and Therapeutics 39: 393-395.
313. Rudat V, Münter M, Rades D, Grötz KA, Bajrovic A, Haberkorn U, Brenner W, Debus J. 2008. The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by
314. Sakamoto K, Sakka M. 1973. Reduced effect of irradiation on normal and malignant cells irradiated in vivo in mice pretreated with vitamin E. British Journal of Radiology 46:538-540.
315. Sandstrom BE, Carlsson J, Marklund SL. 1989. Selenite-induced variation in glutathione peroxidase activity of three mammalian cell lines: No effect on radiation-induced cell killing or DNA strand breakage. Radiation Research 117:318-325.
316. Santoso JT, Lucci JA 3rd, Coleman RL, Hatch S, Wong P, Miller D, Mathis JM. 1998. Does glutamine supplementation increase radioresistance in squamous cell carcinoma of the cervix? Gynecologic Oncology 71:359-363.
317. Sarma L, Kesavan PC. 1993. Protective effects of vitamins C and E against gamma-ray-induced chromosomal damage in mouse. International Journal of Radiation Biology 63:759-764.
318. Satyamitra M, Uma Devi P, Murase H, Kagiya VT. 2003. In vivo postirradiation protection by a vitamin E analog, alpha-TMG. Radiation Research 160:655-661.
319. Savoye C, Swenberg C, Hugot S, Sy D, Sabattier R, Charlier M, Spotheim-Maurizot M. 1997. Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug Ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage. International Journal of Radiation Biology 71:193-202.
320. Schally AV, Paz-Bouza JI, Schlosser JV, Karashima T, Debeljuk L, Gandle B, Sampson M. 1987. Protective effects of analogs of luteinizing hormone-releasing hormone against x-radiation-induced testicular damage in rats. Proceedings of the National Academy of Sciences of the USA 84:851-855.
321. Schubert R, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 2004. Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Human Molecular Genetics 13:1793-1802.
322. Schueller P, Puettmann S, Micke O, Senner V, Schaefer U, Willich N. 2004. Selenium influences the radiation sensitivity of C6 rat glioma cells. Anticancer Research 24:2913-2917.
323. Seed TM. 2005. Radiation protectants: Current status and future prospects. Health Physics 89: 531-545.
324. Seifter E, Mendecki J, Holtzman S, Kanofsky JD, Friedenthal E, Davis L, Weinzweig J. 1988. Role of vitamin A and β carotene in radiation protection: Relation to antioxidant properties. Pharmacology and Therapeutics 39:357-365.
325. Seifter E, Rettura G, Padawer J, Stratford F, Weinzweig J, Demetriou AA, Levenson SM. 1984. Morbidity and mortality reduction by supplemental vitamin A or β carotene in CBA mice given total body gamma-radiation. Journal of the National Cancer Institute 73:1167-1177.
326. Sémont A, François S, Mouiseddine M, François A, Saché A, Frick J, Thierry D, Chapel A. 2006. Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury. Advances in Experimental Biology and Medicine 585:19-30.
327. Serin M, Gülbaş H, Gürses I, Erkal HS, Yücel N. 2007. The histopathological evaluation of the effectiveness of melatonin as a protectant against acute lung injury induced by radiation therapy in a rat model. International Journal of Radiation Biology 83:187-193.
328. Shaeffer J, Schellenberg KA. 1984. Polyethylene glycol as a protector against head and neck irradiation. International Journal of Radiation Oncology, Biology, Physics 10:2329-2333.
329. Sharma M, Kumar M. 2007. Radioprotection of Swiss albino mice by Myristica fragrans houtt. Journal of Radiation Research 48: 135-141.
330. Sharma RA, Steward WP, Gescher AJ. 2007. Pharmacokinetics and pharmacodynamics of curcumin. Advances in Experimental Medicine and Biology 595:453-470.
331. Shen H, Chen ZJ, Zilfou JT, Hopper E, Murphy M, Tew KD. 2001. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. Journal of Pharmacology and Experimental Therapeutics 297: 1067-1073.
332. Shimoi K, Masuda S, Furogori M, Esaki S, Kinae N. 1994. Radioprotective effect of antioxidative flavonoids in gamma-ray irradiated mice. Carcinogenesis 15:2669-2672.
333. Shin SH, Yoon MJ, Kim M, Kim JI, Lee SJ, Lee YS, Bae S. 2007. Enhanced lung cancer cell killing by the combination of selenium and ionizing radiation. Oncology Reports 17: 209-216.
334. Shirazi A, Ghobadi G, Ghazi-Khansari M. 2007. A radiobiological review on melatonin: A novel radioprotector. Journal of Radiation Research 48:263-272.
335. 60Co by WR-2721 and WR-151327. Radiation Research 106: 224-233.
336. Singh SP, Abraham SK, Kesavan PC. 1995. In vivo radioprotection with garlic extract. Mutation Research 345:147-153.
337. Singh VK, Shafran RL, Jackson WE 3rd, Seed TM, Kumar KS. 2006. Induction of cytokines by radioprotective tocopherol analogs. Experimental and Molecular Pathology 8:55-61.
338. Singh VK, Srinivasan V, Seed TM, Jackson WE, Miner VE, Kumar KS. 2005. Radioprotection by N-palmitoylated non-apeptide of human interleukin-1β. Peptides 26:413-418.
339. Sisodia R, Kumari S, Verma RK, Bhatia AL. 2006. Prophylactic role of melatonin against radiation induced damage in mouse cerebellum with special reference to Purkinje cells. Journal of Radiological Protection 26:227-234.
340. Smith TJ, Khatcheressian J, Lyman GH, Ozer H, Armitage JO, Balducci L, Bennett CL, Cantor SB, Crawford J, Cross SJ, Demetri G, Desch CE, Pizzo PA, Schiffer CA, Schwartzberg L, Somerfield MR, Somlo G, Wade JC, Wade JL, Winn RJ, Wozniak AJ, Wolff AC. 2006. 2006 update of recommendations for the use of white blood cell growth factors: An evidence-based clinical practice guideline. Journal of Clinical Oncology 24:3187-3205.
341. Smith WW, Alderman IM, Gillespie RE. 1957. Increased survival in irradiated animals treated with bacterial endotoxins. American Journal of Physiology 191:124-130.
342. Smoluk GD, Fahey RC, Ward JF. 1986. Equilibrium dialysis studies of the binding of radioprotector compounds to DNA. Radiation Research 107:194-204.
343. Snyder SL, Walden TL, Patchen ML, MacVittie TJ, Fuchs P. 1986. Radioprotective properties of detoxified lipid A from Salmonella minnesota R595. Radiation Research 107:107-114.
344. Sölen G. 1993. Radioprotective effect of N-acetylcysteine in vitro using the induction of DNA breaks as end-point. International Journal of Radiation Biology 64:359-366.
345. Sorenson JR. 1992. Essential metalloelement metabolism and radiation protection and recovery. Radiation Research 132: 19-29.
346. Sorenson JR. 2002. Cu, Fe, Mn, and Zn chelates offer a medicinal chemistry approach to overcoming radiation injury. Current Medicinal Chemistry 9:639-662.
347. Souba WW, Klimberg VS, Hautamaki RD, Mendenhall EH, Bova FC, Howard RJ, Bland KI, Copeland EM. 1990. Oral glutamine reduces bacterial translocation following abdominal radiation. Journal of Surgical Research 48:1-5.
348. Spielberger R, Stiff P, Bensinger W, Gentile T, Weisdorf D, Kewalramani T, Shea T, Yanovich S, Hansen K, Noga S, McCarty J, LeMaistre CF, Sung EC, Blazar BR, Elhardt D, Chen MG, Emmanouilides C. 2004. Palifermin for oral mucositis after intensive therapy for hematologic cancers. New England Journal of Medicine 351:2590-2598.
349. Srinivasan V, Doctrow S, Singh VK, Whitnall MH. 2008. Evaluation of EUK-189, a synthetic superoxide dismutase/ catalase mimetic as a radiation countermeasure. Immunopharmacology and Immunotoxicology 30:271-290.
350. Srinivasan V, Dubois A. 1995. Nutritional support of irradiated intestine. In: Dubois A, King GL, Livengood DR, editors. Radiation and the gastrointestinal tract. Boca Raton, FL: CRC Press. pp 201-213.
351. Srinivasan V, Jacobs AJ, Simpson SA, Weiss JF. 1983. Radio-protection by vitamin E: Effects on hepatic enzymes, delayed type hypersensitivity and postirradiation survival of mice. In: Meyskens FL, Prasad KN, editors. Modulation and mediation of cancer by vitamins. Basel: Karger. pp 119-131.
352. Srinivasan V, Weiss JF. 1992. Radioprotection by vitamin E: Injectable vitamin E administered alone or with WR 3689 enhances survival of irradiated mice. International Journal of Radiation Oncology, Biology, Physics 23:841-845.
353. Srinivasan V, Weiss JF, Kumar S. 1997. Radioprotection by misoprostol (PGE1 methyl analog) in combination with vitamin E, selenomethionine and WR-3689. Advances in Experimental Medicine and Biology 400B:791-797.
354. Srivastava M, Chandra D, Kale RK. 2002. Modulation of radiation-induced changes in the xanthine oxidoreductase system in the livers of mice by its inhibitors. Radiation Research 157:290-297.
355. 2. In: Cerutti P. Nygaard OF. Simic MG, editors. Anticarcinogenesis and radiation protection. New York: Plenum. pp. 355-360.
356. Stewart FA, Rojas A, Denekamp J. 1983. Radioprotection of two mouse tumors by WR-2721 in single and fractionated treatments. International Journal of Radiation Oncology, Biology, Physics 9:507-513.
357. Stickney DR, Dowding C, Authier S, Garsd A, Onizuka-Handa N, Reading C, Frincke JM. 2007. 5-Androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression. International Immunopharmacology 7:500-505.
358. Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP, Kolesnick RN, Macvittie TJ, Marks C, McBride WH, Metting N, Pellmar T, Purucker M, Robbins ME, Schiestl RH, Seed TM, Tomaszewski JE, Travis EL, Wallner PE, Wolpert M, Zaharevitz D. 2004. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI workshop, December 3-4, 2003. Radiation Research 162:711-728.
359. Sugahara T, Horikawa M, Hikita M, Nagata H. 1977. Studies on a sulfhydryl radioprotector of low toxicity. Experientia Supplement 27:53-61.
360. Swarup AB, Barrett W, Jazieh AR. 2006. The use of complementary and alternative medicine by cancer patients undergoing radiation therapy. American Journal of Clinical Oncology 29: 468-473.
361. Sweeney TR. 1979. A survey of compounds from the Antiradia-tion Drug Development Program of the U.S. Army Medical Research and Development Command. Washington, DC: Walter Reed Army Institute of Research.
362. Tabata C, Kadokawa Y, Tabata R, Takahashi M, Okoshi K, Sakai Y, Mishima M, Kubo H. 2006. All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine 174:1352-1360.
363. Tanaka Y, Sugahara T. 1970. Chemical radiation protection in man as revealed by chromosome aberrations in peripheral lymphocytes. Journal of Radiation Research 11:166-168.
364. Tanikawa S, Nose M, Aoki Y, Tsuneoka K, Shikita M, Nara N. 1990. Effects of recombinant human granulocyte colony-stimulating factor on the hematologic recovery and survival of irradiated mice. Blood 76:445-449.
365. Thompson CA. 2008. FDA approves thrombopoiesis-stimulating agent. American Journal of Health-System Pharmacy 65:1788.
366. Thompson JF. 1962. Radiation protection in mammals. New York: Reinhold.
367. Thompson JS, Simmons EL, Crawford MK, Severson CD. 1969. Studies on the mechanisms of estradiol-induced radioprotection. Radiation Research 40:70-84.
368. Tiunov LA, Vasil'yev GA, Val'dshteyn EA. 1964. [Antiradiation agents] Russian, Izdatel'stra 'nauka' Moscow. English translation accessed 28 July 2008 from the website: http://handle.dtic.mil/100.2/AD683060
369. Troll W, Wiesner R, Shellabarger CJ, Holtzman S, Stone JP. 1980. Soybean diet lowers breast tumor incidence in irradiated rats. Carcinogenesis 1:469-472.
370. Uma Devi P, Ganasoundari A, Rao BSS, Srinivasan KK. 1999. In vivo radioprotection by Ocimum flavinoids: Survival of mice. Radiation Research 151:74-78.
371. Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. 2000. Radiation protection by the ocimum flavonoids orientin and vicenin: Mechanisms of action. Radiation Research 154:455-460.
372. Uma Devi P, Prasanna PG. 1990. Radioprotective effect of combinations of WR-2721 and mercaptopropionylglycine on mouse bone marrow chromosomes. Radiation Research 124:165-170.
373. Uma Devi P, Satyamitra M. 2004. Protection against prenatal irradiation-induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin. International Journal of Radiation Biology 80:653-662.
374. Umegaki K, Itoh T, Ichikawa T. 1994. Effect of vitamin E on chromosomal damage in bone marrow cells of mice having received low dose of X-ray irradiation. International Journal for Vitamin and Nutrition Research 64:249-252.
375. Urso P, Congdon CC, Doherty DG, Shapira R. 1958. Effect of chemical protection and bone marrow treatment on radiation injury in mice. Blood 7:665-676.
376. U.S. National Academy of Sciences, Food and Nutrition Board, Institute of Medicine. 2000. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academy Press. pp 1-529.
377. Valenzuela MT, Mateos S, Ruiz de Almodóvar JM, McMillan TJ. 2000. Variation in sensitizing effect of caffeine in human tumour cell lines after gamma-irradiation. Radiotherapy and Oncology 54:261-271.
378. van Bekkum D, Vos O. 1961. Treatment of secondary disease in radiation chimaeras. International Journal of Radiation Biology 3:173-181.
379. Vijayalaxmi, Meltz, ML, Reiter RJ, Herman TS, Kumar KS. 1999. Melatonin and protection from whole-body irradiation: survival studies in mice. Mutation Research 425:21-27.
380. Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML. 1996. Melatonin and radioprotection from genetic damage: In vivo/in vitro studies with human volunteers. Mutation Research 371: 221-228.
381. Vijayalaxmi, Reiter RJ, Tan DX, Herman TS, Thomas CR Jr.
382. 2004. Melatonin as a radioprotective agent: A review. International Journal of Radiation Oncology, Biology, Physics 59:639-653.
383. Voevodskaya NV, Vanin AF. 1992. Gamma-irradiation potentiates L-arginine-dependent nitric oxide formation in mice. Biochemical and Biophysical Research Communications 186: 1423-1428.
384. von Deutsch AW, Mitchell CD, Williams CE, Dutt K, Silvestrov NA, Klement BJ, Abukhalaf IK, von Deutsch DA.
385. 2005. Polyamines protect against radiation-induced oxidative stress. Gravitational and Space Biology Bulletin 18: 109-110.
386. Vos O, Roos-Verhey WS. 1988. Radioprotection by glutathione esters and cysteamine in normal and glutathione-depleted mammalian cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 53:273-281.
387. Wambi C, Sanzari J, Wan XS, Nuth M, Davis J, Ko YH, Sayers CM, Baran M, Ware JH, Kennedy AR. 2008. Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiation Research 169: 384-396.
388. Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, Tsu H, Confer DL, Coleman CN, Seed T, Lowry P, Armitage JO, Dainiak N. 2004. Medical management of the acute radiation syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group. Annals of Internal Medicine 140:1037-1051.
389. Wasserman TH, Brizel DM, Henke M, Monnier A, Eschwege F, Sauer R, Strnad V. 2005. Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and-neck cancer: 2-year follow-up of a prospective, randomized, phase III trial. International Journal of Radiation Oncology, Biology, Physics 63:985-990.
390. Weinstock DM, Case C Jr, Bader JL, Chao NJ, Coleman CN, Hatchett RJ, Weisdorf DJ, Confer DL. 2008. Radiologic and nuclear events: Contingency planning for hematologists/ oncologists. Blood 111:5440-5445.
391. Weiss JF, Kumar KS. 1988. Antioxidant mechanisms in radiation injury and radioprotection. In: Chow CK, editor. Cellular antioxidant defense mechanisms. Vol. II. Boca Raton, FL: CRC Press. pp 163-189.
392. Weiss JF, Kumar KS, Walden TL, Neta R, Landauer MR, Clark EP. 1990. Advances in radioprotection through the use of combined agent regimens. International Journal of Radiation Biology 57:709-722.
393. Weiss JF, Landauer MR. 2000. Radioprotection by antioxidants. Annals of the New York Academy of Sciences 899:44-60.
394. Weiss JF, Landauer MR. 2003. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology 189:1-20.
395. Weiss JF, Landauer MR, Hogan JB, Gunter-Smith PJ, Benson KA, Neta R, Hanson WR. 1997. Modification of radiation-induced gastrointestinal and hematopoietic injury in mice by combinations of agents: Effects of indomethacin and caffeine. Advances in Experimental Medicine and Biology 400B:865-872.
396. Weiss JF, Simic MG. editors. 1988. Perspectives in radioprotection. Pharmacology and Therapeutics 39:1-414.
397. Weiss JF, Srinivasan V, Kumar KS, Landauer MR. 1992. Radioprotection by metals: Selenium. Advances in Space Research 12:223-231.
398. Westman NG, Marklund SL. 1987. Inability of polyethyleneglycol substituted copper- and zinc-containing superoxide dismutase to protect mice against radiation lethality. Acta Oncologica 26:483-487.
399. Whanger PD. 2002. Selenocompounds in plants and animals and their biological significance. Journal of the American College of Nutrition 21:223-232.
400. Whitnall MH, Elliott TB, Harding RA, Inal CE, Landauer MR, Wilhelmsen CL, McKinney L, Miner VL, Jackson WE, Loria RM, Ledney GD, Seed TM. 2000. Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice. International Journal of Immunopharmacology 22:1-14.
401. Whitnall MH, Pellmar TC. 2007. New directions in development of pharmacological countermeasures for the acute radiation syndrome. In: Kasid UN, Notario V, Haimovitz-Friedman A, Bar-Eli M, editors. Reviews in cancer biology and therapeutics. Trivandrum, India: Research Signpost. pp 193-209.
402. Wilmore BH, Cassidy PB, Warters RL, Roberts JC. 2001. Thiazolidine prodrugs as protective agents against gamma-radiation-induced toxicity and mutagenesis in V79 cells. Journal of Medicinal Chemistry 44:2661-2666.
403. Withers HR, Elkind MM. 1970. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 17:261-267.
404. Xiao M, Inal CE, Parekh VI, Chang CM, Whitnall MH. 2007. 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-/κB activation and granulocyte colony-stimulating factor expression. Molecular Pharmacology 72: 370-379.
405. Xun C, Shen N, Li B, Zhang Y, Wang F, Yang Y, Shi X, Schafermyer K, Brown SA, Thompson JS. 2008. Radiation mitigation effect of cultured mushroom fungus Hirsutella sinensis (CorImmune) isolated from a Chinese/Tibetan herbal preparation - Cordyceps sinensis. International Journal of Radiation Biology 84:139-149.
406. Xuncla M, Barquinero JF, Caballín MR, Craven-Bartle J, Ribas M, de Vega JM, Barrios L. 2008. Cytogenetic damage induced by radiotherapy. Evaluation of protection by amifostine and analysis of chromosome aberrations persistence. International Journal of Radiation Biology 84:243-251.
407. Yanardag R, Bolkent S, Kizir A. 2001. Protective effects of DL-alpha-tocopherol acetate and sodium selenate on the liver of rats exposed to gamma radiation. Biological Trace Element Research 83:263-273.
408. Yashar CM, Spanos WJ, Taylor DD, Gercel-Taylor C. 2005. Potentiation of the radiation effect with genistein in cervical cancer cells. Gynecologic Oncology 99:199-205.
409. Yavelow J, Finlay TH, Kennedy AR, Troll W. 1983. Bowman-Birk soybean protease inhibitor as an anticarcinogen. Cancer Research 43(Suppl. 5):2454s-2459s.
410. Young RW. 1988. Chernobyl in retrospect. Pharmacology and Therapeutics 39:27-32.
411. Yuhas JM. 1983. Efficacy testing of WR-2721 in Great Britain or everything is black and white at the Gray lab. International Journal of Radiation Oncology, Biology, Physics 9:595-598.
412. Yuhas JM, Storer JB. 1969. Chemoprotection against three modes of radiation death in the mouse. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 15:233-237.
413. Zhang X, Epperly MW, Kay MA, Smith T, Franicola D, Greenberger B, Komanduri P, Greenberger JS. 2008. Radio-protection in vitro and in vivo by mini circle plasmid containing the human manganese superoxide dismutase (MnSOD) transgene. Human Gene Therapy 19:820-826.
414. Zhou Y, Mi MT. 2005. Genistein stimulates hematopoiesis and increases survival in irradiated mice. Journal of Radiation Research 46:425-433.
415. Ziegler DM, Duffel MW, Pulsen LL. 1979. Studies on the nature and regulation of the cellular thio: disulphide potential. Ciba Foundation Symposium 72:191-204.
416. Zinberg N, Kohn A. 1971. Dimethyl sulfoxide protection of bone marrow cells of mice against x-ray damage. Israeli Journal of Medical Science 7:713-718.