메뉴 건너뛰기




Volumn 49, Issue 4, 2008, Pages 361-372

Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation

Author keywords

Genistein; Lung fibrosis; Micronuclei; Pneumonitis; Radioprotection; Total body irradiation

Indexed keywords

AUTOMOBILE BODIES; BIOLOGICAL ORGANS; CELL CULTURE; COLLAGEN; FIBROBLASTS; FLAVONOIDS; IRRADIATION; MAMMALS; RADIATION PROTECTION;

EID: 47749090118     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.07121     Document Type: Article
Times cited : (68)

References (63)
  • 2
    • 1642339513 scopus 로고    scopus 로고
    • Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: A review
    • Moulder, J. E. (2004) Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: A review. Int. J. Radiat. Biol. 80: 3-10.
    • (2004) Int. J. Radiat. Biol , vol.80 , pp. 3-10
    • Moulder, J.E.1
  • 4
    • 9244246263 scopus 로고    scopus 로고
    • Stone, H. B., Moulder, J. E., Coleman, C. N., Ang, K. K., Anscher, M. S., Barcellos-Hoff, M. H., Dynan, W. S., Fike, J. R., Grdina, D. J., Greenberger, J. S., Hauer-Jensen, M., Hill, R. P., Kolesnick, R. N., Macvittie, T. J., Marks, C., McBride, W. H., Metting, N., Pellmar, T., Purucker, M., Robbins, M. E., Schiestl, R. H., Seed, T. M., Tomaszewski, J. E., Travis, E. L., Wallner, P. E., Wolpert, M. and Zaharevitz, D. (2004) Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries report of an NCI workshop, December 3-4, 2003. Radiat. Res. 162: 711-728.
    • Stone, H. B., Moulder, J. E., Coleman, C. N., Ang, K. K., Anscher, M. S., Barcellos-Hoff, M. H., Dynan, W. S., Fike, J. R., Grdina, D. J., Greenberger, J. S., Hauer-Jensen, M., Hill, R. P., Kolesnick, R. N., Macvittie, T. J., Marks, C., McBride, W. H., Metting, N., Pellmar, T., Purucker, M., Robbins, M. E., Schiestl, R. H., Seed, T. M., Tomaszewski, J. E., Travis, E. L., Wallner, P. E., Wolpert, M. and Zaharevitz, D. (2004) Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries report of an NCI workshop, December 3-4, 2003. Radiat. Res. 162: 711-728.
  • 5
    • 19944401152 scopus 로고    scopus 로고
    • Pellmar, T., Rockwell, S. and Group, t. R. N. T. C. W. (2005) Meeting report: Priority list of research areas for radiological nuclear threat countermeasures. Radiat. Res. 163: 115-123.
    • Pellmar, T., Rockwell, S. and Group, t. R. N. T. C. W. (2005) Meeting report: Priority list of research areas for radiological nuclear threat countermeasures. Radiat. Res. 163: 115-123.
  • 6
    • 26844492808 scopus 로고    scopus 로고
    • Radiation protectants: Current status and future prospects
    • Seed, T. M. (2005) Radiation protectants: Current status and future prospects. Health. Phys. 89: 531-545.
    • (2005) Health. Phys , vol.89 , pp. 531-545
    • Seed, T.M.1
  • 7
    • 0038680223 scopus 로고    scopus 로고
    • Protection against ionizing radiation by antioxidant nutrients and phytochemicals
    • Weiss, J. F. and Landauer, M. R. (2003) Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology 189: 1-20.
    • (2003) Toxicology , vol.189 , pp. 1-20
    • Weiss, J.F.1    Landauer, M.R.2
  • 8
    • 47749109936 scopus 로고    scopus 로고
    • Hill, R. P. (2005) Radiation effects on the respiratory system. B. J. R. Suppl. 27: 75-81.
    • Hill, R. P. (2005) Radiation effects on the respiratory system. B. J. R. Suppl. 27: 75-81.
  • 9
    • 0027952656 scopus 로고
    • Hematopoietic recovery after 10-Gy acute total body radiation
    • Baranov, A. E., Selidovkin, G. D., Butturini, A. and Gale, R. P. (1994) Hematopoietic recovery after 10-Gy acute total body radiation. Blood 83: 596-599.
    • (1994) Blood , vol.83 , pp. 596-599
    • Baranov, A.E.1    Selidovkin, G.D.2    Butturini, A.3    Gale, R.P.4
  • 10
    • 47749088693 scopus 로고    scopus 로고
    • Diagnosis and management of pulmonary problems associated with radiation injury. The Medical Basis for Radiation-Accident Preparedness
    • Eds Ricks, R. C, Berger, M. E, O'Hara, F. M. The Parthenon Publishing Group, Boca Ratan
    • Crawford, S. W. (2002) Diagnosis and management of pulmonary problems associated with radiation injury. The Medical Basis for Radiation-Accident Preparedness. The Clinical Care of Victims. 131-138. Eds Ricks, R. C., Berger, M. E., O'Hara, F. M. The Parthenon Publishing Group, Boca Ratan.
    • (2002) The Clinical Care of Victims , pp. 131-138
    • Crawford, S.W.1
  • 11
    • 0028890356 scopus 로고
    • Radiation and the lung: A reevaluation of the mechanisms mediating pulmonary injury
    • Morgan, G. W. and Breit, S. N. (1995) Radiation and the lung: A reevaluation of the mechanisms mediating pulmonary injury. Int. J. Radiat. Oncol. Biol. Phys. 31: 361-369.
    • (1995) Int. J. Radiat. Oncol. Biol. Phys , vol.31 , pp. 361-369
    • Morgan, G.W.1    Breit, S.N.2
  • 12
    • 19244369920 scopus 로고    scopus 로고
    • Brief note and evaluation of acute-radiation syndrome and treatment of a Tokai-mura criticality accident patient
    • Ishii, T., Futami, S., Nishida, M., Suzuki, T., Sakamoto, T., Suzuki, N. and Maekawa, K. (2001) Brief note and evaluation of acute-radiation syndrome and treatment of a Tokai-mura criticality accident patient. J. Radiat. Res. (Tokyo) 42 Suppl: S167-S182.
    • (2001) J. Radiat. Res. (Tokyo) , vol.42 , Issue.SUPPL.
    • Ishii, T.1    Futami, S.2    Nishida, M.3    Suzuki, T.4    Sakamoto, T.5    Suzuki, N.6    Maekawa, K.7
  • 13
    • 47749083992 scopus 로고    scopus 로고
    • Uozaki, H., Fukayama, M., Nakagawa, K., Ishikawa, T., Misawa, S., Doi, M. and Maekawa, K. (2005) The pathology of multi-organ involvement: Two autopsy cases from the Tokai-mura criticality accident. B. J. R. Suppl. 27: 13-16.
    • Uozaki, H., Fukayama, M., Nakagawa, K., Ishikawa, T., Misawa, S., Doi, M. and Maekawa, K. (2005) The pathology of multi-organ involvement: Two autopsy cases from the Tokai-mura criticality accident. B. J. R. Suppl. 27: 13-16.
  • 14
    • 3042751723 scopus 로고    scopus 로고
    • Total body irradiation and pneumonitis risk: A review of outcomes
    • Carruthers, S. A. and Wallington, M. M. (2004) Total body irradiation and pneumonitis risk: A review of outcomes. Br. J. Cancer 90: 2080-2084.
    • (2004) Br. J. Cancer , vol.90 , pp. 2080-2084
    • Carruthers, S.A.1    Wallington, M.M.2
  • 15
    • 17644420314 scopus 로고    scopus 로고
    • Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein
    • Kruk, I., Aboul-Enein, H. Y., Michalska, T., Lichszteld, K. and Kladna, A. (2005) Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein. Luminescence 20: 81-89.
    • (2005) Luminescence , vol.20 , pp. 81-89
    • Kruk, I.1    Aboul-Enein, H.Y.2    Michalska, T.3    Lichszteld, K.4    Kladna, A.5
  • 16
    • 34249815179 scopus 로고    scopus 로고
    • Effects of phytoestrogens and 17beta-estradiol on vasoconstriction elicited by reactive oxygen species
    • Zhang, P., Li, H. F., Tian, Z. F., Qiu, X. Q., Wu, J. X. and Jia, Z. J. (2007) Effects of phytoestrogens and 17beta-estradiol on vasoconstriction elicited by reactive oxygen species. Pharmazie. 62: 378-381.
    • (2007) Pharmazie , vol.62 , pp. 378-381
    • Zhang, P.1    Li, H.F.2    Tian, Z.F.3    Qiu, X.Q.4    Wu, J.X.5    Jia, Z.J.6
  • 18
  • 21
    • 33144477003 scopus 로고    scopus 로고
    • Genistein stimulates hematopoiesis and increases survival in irradiated mice
    • Zhou, Y. and Mi, M. T. (2005) Genistein stimulates hematopoiesis and increases survival in irradiated mice. J. Radiat. Res. (Tokyo) 46: 425-433.
    • (2005) J. Radiat. Res. (Tokyo) , vol.46 , pp. 425-433
    • Zhou, Y.1    Mi, M.T.2
  • 22
    • 0345328280 scopus 로고    scopus 로고
    • Genistein treatment protects mice from ionizing radiation injury
    • Landauer, M., Srinivasan, V. and Seed, T. (2003) Genistein treatment protects mice from ionizing radiation injury. J. Appl. Toxicol. 23: 379-385.
    • (2003) J. Appl. Toxicol , vol.23 , pp. 379-385
    • Landauer, M.1    Srinivasan, V.2    Seed, T.3
  • 23
    • 33847184916 scopus 로고    scopus 로고
    • Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival
    • Davis, T. A., Clarke, T. K., Mog, S. R. and Landauer, M. R. (2007) Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int. J. Radiat. Biol. 83: 141-151.
    • (2007) Int. J. Radiat. Biol , vol.83 , pp. 141-151
    • Davis, T.A.1    Clarke, T.K.2    Mog, S.R.3    Landauer, M.R.4
  • 24
    • 19944382503 scopus 로고    scopus 로고
    • Radiation-induced strain differences in mouse alveolar inflammatory cell apoptosis
    • O'Brien, T. J., Letuve, S. and Haston, C. K. (2005) Radiation-induced strain differences in mouse alveolar inflammatory cell apoptosis. Can. J. Physiol Pharmacol. 83: 117-122.
    • (2005) Can. J. Physiol Pharmacol , vol.83 , pp. 117-122
    • O'Brien, T.J.1    Letuve, S.2    Haston, C.K.3
  • 25
    • 0032605109 scopus 로고    scopus 로고
    • Manganese [correction of magnesium] superoxide dismutase (MNSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-1, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis
    • Epperly, M. W., Travis, E. L., Sikora, C. and Greenberger, J. S. (1999) Manganese [correction of magnesium] superoxide dismutase (MNSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-1, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis. Biol. Blood Marrow Transplant 5: 204-214.
    • (1999) Biol. Blood Marrow Transplant , vol.5 , pp. 204-214
    • Epperly, M.W.1    Travis, E.L.2    Sikora, C.3    Greenberger, J.S.4
  • 26
    • 33947208052 scopus 로고    scopus 로고
    • Pathophysiological principles underlying the blood cell concentration responses used to assess the severity of effect after accidental whole-body radiation exposure: An essential basis for an evidence-based clinical triage
    • Fliedner, T. M., Graessle, D., Meineke, V. and Dorr, H. (2007) Pathophysiological principles underlying the blood cell concentration responses used to assess the severity of effect after accidental whole-body radiation exposure: An essential basis for an evidence-based clinical triage. Exp. Hematol. 35: 8-16.
    • (2007) Exp. Hematol , vol.35 , pp. 8-16
    • Fliedner, T.M.1    Graessle, D.2    Meineke, V.3    Dorr, H.4
  • 28
    • 0348014924 scopus 로고    scopus 로고
    • Inflammatory reaction and changes in expression of coagulation proteins on lung endothelial cells after total-body irradiation in mice
    • Van der Meeren, A., Vandamme, M., Squiban, C., Gaugler, M. H. and Mouthon, M. A. (2003) Inflammatory reaction and changes in expression of coagulation proteins on lung endothelial cells after total-body irradiation in mice. Radiat. Res. 160: 637-646.
    • (2003) Radiat. Res , vol.160 , pp. 637-646
    • Van der Meeren, A.1    Vandamme, M.2    Squiban, C.3    Gaugler, M.H.4    Mouthon, M.A.5
  • 29
    • 0021029043 scopus 로고
    • Radiation injury in rat lung. II. Angiotensin-converting enzyme activity
    • Ward, W. F., Solliday, N. H., Molteni, A. and Port, C. D. (1983) Radiation injury in rat lung. II. Angiotensin-converting enzyme activity. Radiat. Res. 96: 294-300.
    • (1983) Radiat. Res , vol.96 , pp. 294-300
    • Ward, W.F.1    Solliday, N.H.2    Molteni, A.3    Port, C.D.4
  • 30
    • 0032587835 scopus 로고    scopus 로고
    • Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis
    • Ogushi, F., Endo, T., Tani, K., Asada, K., Kawano, T., Tada, H., Maniwa, K. and Sone, S. (1999) Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis. Int. J. Exp. Pathol. 80: 41-49.
    • (1999) Int. J. Exp. Pathol , vol.80 , pp. 41-49
    • Ogushi, F.1    Endo, T.2    Tani, K.3    Asada, K.4    Kawano, T.5    Tada, H.6    Maniwa, K.7    Sone, S.8
  • 31
    • 0036129681 scopus 로고    scopus 로고
    • Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: Correlation with repair and fibrosis
    • Khalil, N., Parekh, T. V., O'Connor, R. N. and Gold, L. I. (2002) Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: Correlation with repair and fibrosis. Exp. Lung Res. 28: 233-250.
    • (2002) Exp. Lung Res , vol.28 , pp. 233-250
    • Khalil, N.1    Parekh, T.V.2    O'Connor, R.N.3    Gold, L.I.4
  • 32
    • 0033795960 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta type I and type II receptors is altered in rat lungs undergoing bleomycin-induced pulmonary fibrosis
    • Zhao, Y. and Shah, D. U. (2000) Expression of transforming growth factor-beta type I and type II receptors is altered in rat lungs undergoing bleomycin-induced pulmonary fibrosis. Exp. Mol. Pathol. 69: 67-78.
    • (2000) Exp. Mol. Pathol , vol.69 , pp. 67-78
    • Zhao, Y.1    Shah, D.U.2
  • 33
    • 0000157434 scopus 로고    scopus 로고
    • McPherson, C. (1963) Reduction of Psuedomonas aeruginosaand coliform bacteria in mouse drinking water following treatment with hyrdochloric acid and chlorine. Lab. Animal Care 13: 737-744.
    • McPherson, C. (1963) Reduction of Psuedomonas aeruginosaand coliform bacteria in mouse drinking water following treatment with hyrdochloric acid and chlorine. Lab. Animal Care 13: 737-744.
  • 34
    • 0035170551 scopus 로고    scopus 로고
    • Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes
    • Kirsch-Volders, M. and Fenech, M. (2001) Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis 16: 51-58.
    • (2001) Mutagenesis , vol.16 , pp. 51-58
    • Kirsch-Volders, M.1    Fenech, M.2
  • 35
    • 34250187067 scopus 로고    scopus 로고
    • Cytokinesis-block micronucleus cytome assay
    • Fenech, M. (2007) Cytokinesis-block micronucleus cytome assay. Nat. Protoc. 2: 1084-1104.
    • (2007) Nat. Protoc , vol.2 , pp. 1084-1104
    • Fenech, M.1
  • 36
    • 12244289275 scopus 로고    scopus 로고
    • Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers
    • Khan, M. A., Van Dyk, J., Yeung, I. W. and Hill, R. P. (2003) Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother. Oncol. 66: 95-102.
    • (2003) Radiother. Oncol , vol.66 , pp. 95-102
    • Khan, M.A.1    Van Dyk, J.2    Yeung, I.W.3    Hill, R.P.4
  • 37
    • 0035065765 scopus 로고    scopus 로고
    • Production of TGF-beta1 in lungs after low-dose whole-body radiation exposure in fibrosing (C57BL/6) and non-fibrosing (C3H/J) mouse strain
    • Olejar, T., Zadinova, M., Hlouskova, D. and Pouckova, P. (2001) Production of TGF-beta1 in lungs after low-dose whole-body radiation exposure in fibrosing (C57BL/6) and non-fibrosing (C3H/J) mouse strain. Folia Biol. (Praha) 47: 55-61.
    • (2001) Folia Biol. (Praha) , vol.47 , pp. 55-61
    • Olejar, T.1    Zadinova, M.2    Hlouskova, D.3    Pouckova, P.4
  • 40
    • 0034054128 scopus 로고    scopus 로고
    • Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker
    • Molteni, A., Moulder, J., Cohen, E., Ward, W., Fish, B., Taylor, J., Wolfe, L., Brizio-Molteni, L. and Veno, P. (2000) Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. Int. J. Radiat. Biol. 76: 523-532.
    • (2000) Int. J. Radiat. Biol , vol.76 , pp. 523-532
    • Molteni, A.1    Moulder, J.2    Cohen, E.3    Ward, W.4    Fish, B.5    Taylor, J.6    Wolfe, L.7    Brizio-Molteni, L.8    Veno, P.9
  • 41
    • 0028924146 scopus 로고
    • Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2
    • Wilborn, J., Crofford, L. J., Burdick, M. D., Kunkel, S. L., Strieter, R. M. and Peters-Golden, M. (1995) Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J. Clin. Invest. 95: 1861-1868.
    • (1995) J. Clin. Invest , vol.95 , pp. 1861-1868
    • Wilborn, J.1    Crofford, L.J.2    Burdick, M.D.3    Kunkel, S.L.4    Strieter, R.M.5    Peters-Golden, M.6
  • 44
    • 0035138909 scopus 로고    scopus 로고
    • Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR-151327
    • Landauer, M. R., Castro, C. A., Benson, K. A., Hogan, J. B. and Weiss, J. F. (2001) Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR-151327. J. Appl. Toxicol. 21: 25-31.
    • (2001) J. Appl. Toxicol , vol.21 , pp. 25-31
    • Landauer, M.R.1    Castro, C.A.2    Benson, K.A.3    Hogan, J.B.4    Weiss, J.F.5
  • 45
    • 0014207383 scopus 로고
    • Radioprotective effects of dimethyl sulfoxide vapor on mice
    • Moos, W. S., LeVan, H. and Mason, H. C. (1967) Radioprotective effects of dimethyl sulfoxide vapor on mice. Experientia 23: 923.
    • (1967) Experientia , vol.23 , pp. 923
    • Moos, W.S.1    LeVan, H.2    Mason, H.C.3
  • 49
    • 25144436299 scopus 로고    scopus 로고
    • Potentiation of the radiation effect with genistein in cervical cancer cells
    • Yashar, C. M., Spanos, W. J., Taylor, D. D. and Gercel-Taylor, C. (2005) Potentiation of the radiation effect with genistein in cervical cancer cells. Gyn. Oncol. 99: 199-205.
    • (2005) Gyn. Oncol , vol.99 , pp. 199-205
    • Yashar, C.M.1    Spanos, W.J.2    Taylor, D.D.3    Gercel-Taylor, C.4
  • 51
    • 33846955072 scopus 로고    scopus 로고
    • Hillman, G. G., Wang, Y., Che, M., Raffoul, J. J., Yudelev, M., Kucuk, O. and Sarkar, F. H. (2007) Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model. B. M. C. Cancer 7: 4.
    • Hillman, G. G., Wang, Y., Che, M., Raffoul, J. J., Yudelev, M., Kucuk, O. and Sarkar, F. H. (2007) Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model. B. M. C. Cancer 7: 4.
  • 52
    • 33646727546 scopus 로고    scopus 로고
    • Raffoul, J. J., Wang, Y., Kucuk, O., Forman, J. D., Sarkar, F. H. and Hillman, G. G. (2006) Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. B. M. C. Cancer 6: 107.
    • Raffoul, J. J., Wang, Y., Kucuk, O., Forman, J. D., Sarkar, F. H. and Hillman, G. G. (2006) Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. B. M. C. Cancer 6: 107.
  • 53
    • 4444237818 scopus 로고    scopus 로고
    • Mohammad, R. M., Al-Katib, A., Aboukameel, A., Doerge, D. R., Sarkar, F. and Kucuk, O. (2003) Genistein sensitizes diffuse large cell lymphoma to chop (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. Mol. Cancer Ther. 2: 1361-1368.
    • Mohammad, R. M., Al-Katib, A., Aboukameel, A., Doerge, D. R., Sarkar, F. and Kucuk, O. (2003) Genistein sensitizes diffuse large cell lymphoma to chop (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. Mol. Cancer Ther. 2: 1361-1368.
  • 54
    • 50249177143 scopus 로고    scopus 로고
    • Li, Z., Li, J., Mo, B., Hu, C., Liu, H., Qi, H., Wang, X. and Xu, J. (2008) Genistein induces G(2)/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells. Cell. Biol. Toxicol., 2008 Jan. 26, Epub; in press.
    • Li, Z., Li, J., Mo, B., Hu, C., Liu, H., Qi, H., Wang, X. and Xu, J. (2008) Genistein induces G(2)/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells. Cell. Biol. Toxicol., 2008 Jan. 26, Epub; in press.
  • 55
    • 33846230598 scopus 로고    scopus 로고
    • Homology-directed repair is required for the development of radioresistance during s phase: Interplay between double-strand break repair and checkpoint response
    • Tamulevicius, P., Wang, M. and Iliakis, G. (2007) Homology-directed repair is required for the development of radioresistance during s phase: Interplay between double-strand break repair and checkpoint response. Radiat. Res. 167: 1-11.
    • (2007) Radiat. Res , vol.167 , pp. 1-11
    • Tamulevicius, P.1    Wang, M.2    Iliakis, G.3
  • 56
    • 1642452767 scopus 로고    scopus 로고
    • The selective effect of genistein on the toxicity of bleomycin in normal lymphocytes and HL-60 cells
    • Lee, R., Kim, Y. J., Lee, Y. J. and Chung, H. W. (2004) The selective effect of genistein on the toxicity of bleomycin in normal lymphocytes and HL-60 cells. Toxicology 195: 87-95.
    • (2004) Toxicology , vol.195 , pp. 87-95
    • Lee, R.1    Kim, Y.J.2    Lee, Y.J.3    Chung, H.W.4
  • 57
    • 0027954494 scopus 로고
    • Free radicals in biology: Oxidative stress and the effects of ionizing radiation
    • Riley, P. A. (1994) Free radicals in biology: Oxidative stress and the effects of ionizing radiation. Int. J. Radiat. Biol. 65: 27-33.
    • (1994) Int. J. Radiat. Biol , vol.65 , pp. 27-33
    • Riley, P.A.1
  • 59
    • 0035186444 scopus 로고    scopus 로고
    • Correlation between lung fibrosis and radiation therapy dose after concurrent radiation therapy and chemotherapy for limited small cell lung cancer
    • Rosen, II, Fischer, T. A., Antolak, J. A., Starkschall, G., Travis, E. L., Tucker, S. L., Hogstrom, K. R., Cox, J. D. and Komaki, R. (2001) Correlation between lung fibrosis and radiation therapy dose after concurrent radiation therapy and chemotherapy for limited small cell lung cancer. Radiology 221: 614-622.
    • (2001) Radiology , vol.221 , pp. 614-622
    • Rosen, I.1    Fischer, T.A.2    Antolak, J.A.3    Starkschall, G.4    Travis, E.L.5    Tucker, S.L.6    Hogstrom, K.R.7    Cox, J.D.8    Komaki, R.9
  • 60
    • 0034961744 scopus 로고    scopus 로고
    • Radiation-induced and chemotherapy-induced pulmonary injury
    • Abid, S. H., Malhotra, V. and Perry, M. C. (2001) Radiation-induced and chemotherapy-induced pulmonary injury. Curr. Opin. Oncol. 13: 242-248.
    • (2001) Curr. Opin. Oncol , vol.13 , pp. 242-248
    • Abid, S.H.1    Malhotra, V.2    Perry, M.C.3
  • 63
    • 5644227426 scopus 로고    scopus 로고
    • Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells
    • Yu, Z., Li, W. and Liu, F. (2004) Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett. 215: 159-166.
    • (2004) Cancer Lett , vol.215 , pp. 159-166
    • Yu, Z.1    Li, W.2    Liu, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.