Inhibition of cyclooxygenase 2 in mice increases production of G-CSF and induces radioprotection

Radiation Research

Volumn 170, Issue 5, 2008, Pages 566-571

  Hofer, M ^a   Pospisil M ^a   Hola J ^a   Vacek, A ^a   Streitova D ^a   Znojil, V ^b  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GRANULOCYTE COLONY STIMULATING FACTOR; MELOXICAM;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; GAMMA IRRADIATION; GRANULOCYTE PRECURSOR; HEMATOPOIESIS; LETHAL DOSE; MALE; MOUSE; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; RADIATION PROTECTION; SINGLE DRUG DOSE; WHOLE BODY RADIATION;

ANIMALS; CYCLOOXYGENASE 2 INHIBITORS; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; MALE; MICE; RADIATION-PROTECTIVE AGENTS; THIAZINES; THIAZOLES;

MUS;

EID: 55549139782     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1387.1     Document Type: Article

References (24)

1. T. C. Pellmar, S. Rockwell and the Radiological/Nuclear Threat Countermeasures Working Group, Priority list of research areas for radiological nuclear threat countermeasures. Radiat. Res. 163, 115-123 (2005).
2. A. D. Augustine, T. Gondré-Lewis, W. McBride, L. Miller, T. C. Pellmar and S. Rockwell, Animal models for radiation injury, protection and therapy. Radiat. Res. 164, 100-109 (2005).
3. M. Pospíšil, J. Netíková and A. Kozubík, Enhancement of hematopoietic recovery by indomethacin after sublethal whole-body gamma irradiation. Acta Radiol. Oncol. 25, 195-198 (1986).
4. B. A. Serushago, K. Tanaka, Y. Koga, K. Taniguchi and K. Nomoto, Positive effects of indomethacin on restoration of splenic nucleated cell populations in mice given sublethal irradiation. Immunopharmacology 14, 21-26 (1987).
5. I. Nishiguchi, Y. Furuta, D. Hunter, D. Murray and L. Milas, Radioprotection of hematopoietic tissues in mice by indomethacin. Radiat. Res. 122, 188-192 (1990).
6. M. Pospíšil, M. Hofer, I. Pipalová, Š. Viklická, J. Netíková and J. Šandula, Enhancement of hematopoietic recovery in gamma-irradiated mice by the joint use of diclofenac, an inhibitor of prostaglandin production, and glucan, a macrophage activator. Exp. Hematol. 20, 891-895 (1992).
7. M. Hofer, M. Pospíšil, Š. Viklická, A. Vacek, I. Pipalová and A. Bartoníčková, Hematopoietic recovery in repeatedly irradiated mice can be enhanced by a repeatedly administered combination of diclofenac and glucan. J. Leukoc. Biol. 53, 185-189 (1993).
8. M. Hofer, M. Pospíšil, I. Pipalová and J. Holá, Modulation of haemopoietic radiation damage by diclofenac in fractionated treatment. Physiol. Res. 45, 213-220 (1996).
9. M. Hofer and M. Pospíšil, Stimulated recovery of perturbed haematopoiesis by inhibition of prostaglandin production - promising therapeutic strategy. Cent. Eur. J. Biol. 1, 584-593 (2006).
10. J. Kurland and M. A. S. Moore, Modulation of hemopoiesis by prostaglandins. Exp. Hematol. 5, 357-373 (1977).
11. J. Fontagné, M. Adolphe, M. Semichon, L. Zizine and P. Lechat, Effect of in vivo treatment with indomethacin on mouse granulocyte-macrophage colony-forming cells in culture (CFUc). Possible role of prostaglandins. Exp. Hematol. 8, 1157-1164 (1980).
12. L. M. Pelus, Modulation of myelopoiesis by prostaglandin E2: demonstration of a novel mechanism of action in vivo. Immunol. Res. 8, 176-184 (1989).
13. G. L. Floersheim, Allopurinol, indomethacin and riboflavin enhance radiation lethality in mice. Radiat. Res. 139, 240-247 (1994).
14. M. Hofer, M. Pospíšil, L. Tkadleček, Š. Viklická, I. Pipalová and J. Holá, Low survival of mice following lethal gamma-irradiation after administration of inhibitors of prostaglandin synthesis. Physiol. Res. 41, 157-161 (1992).
15. G. Engelhardt, D. Homma, K. Schlegel, R. Utzmann and G. Schnitzler, Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance. Inflamm. Res. 44, 423-433 (1995).
16. M. Hofer, M. Pospíšil, V. Znojil, J. Holá, A. Vacek, L. Weiterová, D. Štreitová and A. Kozubík, Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice. Radiat. Res. 166, 556-560 (2006).
17. J. Gosbee and J. Kraicer, Stress-free parenteral injections in the rat. Can. J. Physiol. Pharmacol. 47, 209-210 (1969).
18. A. Munck, P. M. Guyre and N. J. Holbrook, Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocrine Rev. 5, 25-44 (1984).
19. Z. M. Bacq and E. H. Betz, Adaptation reaction to ionizing radiation. In Physiology and Pathology of Adaptation Mechanisms (E. Bajusz, Ed.), pp. 185-203. Pergamon Press, Oxford, 1969.
20. S. Tanikawa, M. Nose, Y. Aoki, K. Tsuneoka, M. Shikita and N. Nara, Effects of recombinant human granulocyte colony-stimulating factor on the hematologic recovery and survival of irradiated mice. Blood 76, 445-449 (1990).
21. M. L. Patchen, T. J. MacVittie and E. W. Jackson, Postirradiation glucan administration enhances the radioprotective effects of WR-2721. Radiat. Res. 117, 59-69 (1989).
22. A. Sureda, A. Valls, E. Kadar, M. Algara, J. Inglés-Esteve, A. Bigas, M. Jaume, M. Lacruz, L. M. Tobajas, M. Rutllant and J. García, A single-dose of granulocyte colony-stimulating factor modifies radiation-induced death in B6D2F1 mice. Exp. Hematol. 21, 1605-1607 (1993).
23. 1 mice. Acta Haematol. 98, 119-124 (1997).
24. T. Kuwabara, S. Kobayashi and Y. Sugiyama, Pharmacokinetics and pharmacodynamics of a recombinant human granulocyte colony-stimulating factor. Drug Metab. Rev. 28, 625-658 (1996).