New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy

Regenerative Medicine

Volumn 2, Issue 5, 2007, Pages 785-794

  Lataillade, J J ^a   Doucet, C ^a   Bey, E ^b   Carsin, H ^b   Huet, C ^c   Clairand, I ^c   Bottollier Depois, J F ^c   Chapel, A ^c   Ernou, I ^a   Gourven, M ^a   Boutin, L ^a   Hayden, A ^d   Carcamo, C ^d   Buglova, E ^e   Joussemet, M ^a   de Revel, T ^b   Gourmelon, P ^c  

^a Centre de Transfusion Sanguine des Armees   (France)

^b PERCY MILITARY HOSPITAL   (France)

^c INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^d Mutual de Seguridad Hospital   (Chile)

^e INTERNATIONAL ATOMIC ENERGY AGENCY   (Austria)

Author keywords

Accidental irradiation; Mesenchymal stem cell; Radiation burn; Tissue regeneration

Indexed keywords

IRIDIUM 192;

ADULT; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BURN; CASE REPORT; CELL LYSATE; COMPUTER ASSISTED SURGERY; DISEASE SEVERITY; DOSIMETRY; FOLLOW UP; GAMMA RADIATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RECURRENT DISEASE; SKIN NECROSIS; SKIN SURFACE; SURGICAL APPROACH; SURGICAL TECHNIQUE; TISSUE REGENERATION; WOUND HEALING;

ACCIDENTS, RADIATION; ADULT; BONE MARROW CELLS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; FOLLOW-UP STUDIES; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; PHANTOMS, IMAGING; RADIATION INJURIES; TIME FACTORS; TREATMENT OUTCOME;

EID: 35048898697     PISSN: 17460751     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460751.2.5.785     Document Type: Article

References (26)

1. Gottlöber P, Bezold G, Weber L et al.: The radiation accident in Georgia: Clinical appearance and diagnosis of cutaneous radiation syndrome. J. Am. Acad. Dermatol. 42, 453-458 (2000).
2. Peter RU, Gottlöber P: Management of cutaneous radiation injuries: diagnostic and therapeutic principles of the cutaneous radiation syndrome. Mil. Med. 167, 110-112 (2002).
3. Peter RU: Cutaneous radiation syndrome in multiorgan failure. Br. J. Radiol. 27 (Suppl.), 180-184 (2005).
4. Zaharia M, Goans RE, Berger ME et al.: Industrial radiography accident at the Yanango hydroelectric power plant. In: The Medical Basis far Radiation-Accident Preparedness. The Parthenon Publishing Group, London, UK, 267-281 (2001).
5. Lefaix JL, Delanian S: Le syndrome cutané radio-induit. In: The terrorist threat NUCLEAR, RADIOLOCICAL, BIOLOGICAL, CHEMICAL - A medical approach. De Revel T, Gourmelon P (Eds), John Libbey Eurotext, Montrouge, France, 87-95 (2005).
6. Stephanazzi J, Bargues L, Curet PM, Lebevert H, Carsin H: Le traitement du syndrome cutané radiologique. In John Libbey Eurotext. The terrorist threat Nuclear, Radiological, Biological, Chemical-A medical approach. De Revel T, Gourmelon P (Eds). 112-122 (2005).
7. Clairand I, Trompier F, Bottollier-Depois JF, Gourmelon P: Ex vivo ESR measurements associated with Monte Carlo calculations for accident dosimetry: application to the 2001 Georgian accident. Radiat. Prot. Dosimetry 119, 500-505 (2006).
8. Bottollier-Depois JF, Gaillard-Lecanu E, Roux A, et al.: New approach for dose reconstruction: application to one case of localized irradiation with radiological burns. Health Phys. 79(3), 251-256 (2000).
9. Lemosquet A, Clairand I, de Carian L, Franck D, Aubineau-Lanièe I, Bottollier-Depois JF: A computational tool based on voxel geometry for dose reconstruction of a radiological accident due to external exposure. Radiat. Prot. Dosimetry 110, 449-454 (2004).
10. Walters LS: MCNPX User's Manual, Version 2.4.0, LA-CP-02-408, Los Alamos National Laboratory, NM, USA (2002).
11. Doucet C, Ernou I, Zhang Y et al.: Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J. Cell. Physiol. 205(2), 228-236 (2005).
12. Lange C, Cakiroglu F, Spiess AN, Cappallo-Obermann H, Dierlamm J, Zander A: Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine. J. Cell. Physiol. 213(1), 18-26 (2007).
13. Kim NW, Piatyszek MA, Prowse KR et al.: Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015 (1994).
14. Bentley SA: Bone marrow connective tissue and the haemopoietic microenvironment. Br. J. Haematol. 50(1), 1-6 (1982).
15. Caplan AI: Mesenchymal stem cells. J. Orthop. Res. 9(5), 641-650 (1991).
16. Ringden O, Uzunel M, Rasmusson I et al.: Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Rrasplantation 81(10), 1390-1397 (2006).
17. Chapel A, Bertho JM, Bensidhoum M et al.: Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multiorgan failure syndrome. J. Gene Med. 5, 1028-1038 (2003).
18. François S, Bensidhoum M, Mouiseddine M et al.: Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: A study of their quantitative distribution after irradiation damages. Stem Cells 24, 1020-1029 (2006).
19. Le Blanc K, Ringden O: Mesenchymal stem cells: properties and role in clinical bone marrow transplantation. Curr. Opin. Immunol. 18(5), 586-591 (2006).
20. Friedenstein AJ, Gorskaja JF, Kulagina NN: Fibroblast precursors in normal and Irradiated mouse hematopoietic organs. Exp. Hematol. 4(5), 267-574 (1976).
21. Koc ON, Gerson SL, Cooper BW et al.: Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J. Clin. Oncol. 18(2), 307-316 (2000).
22. Horwitz EM, Prockop DJ, Fitzpatrick LA, et al.: Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat. Med. 5(3), 309-313 (1999).
23. Le Blanc K, Rasmusson I, Sundberg B et al.: Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363(9419), 1439-1441 (2004).
24. Fouillard L, Bensidhoum M, Bories D et al.: Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma. Leukemia 17(2), 474-476 (2003).
25. François S, Mouiseddine M, Mathieu N et al.: Human mesenchymal stem cells favour heating of the cutaneous radiation syndrome in a xenogenic transplant model. Ann. Hematol. 86, 1-8 (2007).
26. Thierry D, Bertho JM, Chapel A, Gourmelon P: Cell therapy for the treatment of accidental radiation overexposure. Br. J. Radiol. 27(Suppl.), 175-179 (2005).