메뉴 건너뛰기




Volumn 80, Issue SUPPL. 69, 2008, Pages 9-18

New drugs for familiar therapeutic targets: Thrombopoietin receptor agonists and immune thrombocytopenic purpura

Author keywords

Idiopathic; Megakaryocytes; Platelet count; Purpura; Thrombocytopenic; Thrombopoiesis; Thrombopoietin

Indexed keywords

5 OXO 1,5 DIHYDROPYRAZOL 4 YLIDENE HYDRAZINE; AKR 501; ANTINEOPLASTIC AGENT; ELTROMBOPAG; FAB 59; MONOCLONAL ANTIBODY MA01G4G344; MONOCLONAL ANTIBODY VB22B; PEGINTERFERON; PEGYLATED RECOMBINANT HUMAN MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; POLYETHYLENE GLYCOL THROMBOPOIETIN MIMETIC PEPTIDE; RECOMBINANT THROMBOPOIETIN; REMIPLISTIM; RETICULIN; RIBAVIRIN; RITUXIMAB; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; THROMBOPOIETIN RECEPTOR AGONIST; UNCLASSIFIED DRUG; YM 477; BENZOIC ACID DERIVATIVE; CARRIER PROTEIN; FC RECEPTOR; HYDRAZINE DERIVATIVE; MACROGOL DERIVATIVE; MONOCLONAL ANTIBODY; POLYETHYLENE GLYCOL RECOMBINANT HUMAN MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; POLYETHYLENE GLYCOL-RECOMBINANT HUMAN MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; PYRAZOLE DERIVATIVE; RECOMBINANT PROTEIN;

EID: 38649127253     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2007.00999.x     Document Type: Article
Times cited : (39)

References (69)
  • 1
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • Bartley TD, Bogenberger J, Hunt P, et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994 77 : 1117 24.
    • (1994) Cell , vol.77 , pp. 1117-24
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 2
    • 0028117771 scopus 로고
    • The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production
    • Kuter DJ, Beeler DL, Rosenberg RD. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 1994 91 : 11104 8.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11104-8
    • Kuter, D.J.1    Beeler, D.L.2    Rosenberg, R.D.3
  • 3
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
    • Lok S, Kaushansky K, Holly RD, et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994 369 : 565 8.
    • (1994) Nature , vol.369 , pp. 565-8
    • Lok, S.1    Kaushansky, K.2    Holly, R.D.3
  • 4
    • 0028302409 scopus 로고
    • Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
    • de Sauvage FJ, Hass PE, Spencer SD, et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994 369 : 533 8.
    • (1994) Nature , vol.369 , pp. 533-8
    • De Sauvage, F.J.1    Hass, P.E.2    Spencer, S.D.3
  • 5
    • 0029148579 scopus 로고
    • Purification and characterization of thrombopoietin
    • Kato T, Ogami K, Shimada Y, et al. Purification and characterization of thrombopoietin. J Biochem (Tokyo) 1995 118 : 229 36.
    • (1995) J Biochem (Tokyo) , vol.118 , pp. 229-36
    • Kato, T.1    Ogami, K.2    Shimada, Y.3
  • 6
    • 0036530040 scopus 로고    scopus 로고
    • Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
    • Basser RL, O'Flaherty E, Green M, et al. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood 2002 99 : 2599 602.
    • (2002) Blood , vol.99 , pp. 2599-602
    • Basser, R.L.1    O'Flaherty, E.2    Green, M.3
  • 7
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J, Yang C, Xia Y, et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 2001 98 : 3241 8.
    • (2001) Blood , vol.98 , pp. 3241-8
    • Li, J.1    Yang, C.2    Xia, Y.3
  • 8
    • 34249733156 scopus 로고    scopus 로고
    • New thrombopoietic growth factors
    • Kuter DJ. New thrombopoietic growth factors. Blood 2007 109 : 4607 16.
    • (2007) Blood , vol.109 , pp. 4607-16
    • Kuter, D.J.1
  • 9
    • 0034696521 scopus 로고    scopus 로고
    • The glycan domain of thrombopoietin enhances its secretion
    • Linden HM, Kaushansky K. The glycan domain of thrombopoietin enhances its secretion. Biochemistry 2000 39 : 3044 51.
    • (2000) Biochemistry , vol.39 , pp. 3044-51
    • Linden, H.M.1    Kaushansky, K.2
  • 10
    • 0034697362 scopus 로고    scopus 로고
    • Functional analysis of the C-terminal region of recombinant human thrombopoietin. C-terminal region of thrombopoietin is a "shuttle" peptide to help secretion
    • Muto T, Feese MD, Shimada Y, et al. Functional analysis of the C-terminal region of recombinant human thrombopoietin. C-terminal region of thrombopoietin is a "shuttle" peptide to help secretion. J Biol Chem 2000 275 : 12090 4.
    • (2000) J Biol Chem , vol.275 , pp. 12090-4
    • Muto, T.1    Feese, M.D.2    Shimada, Y.3
  • 11
    • 0032126638 scopus 로고    scopus 로고
    • Role of c-Mpl in early hematopoiesis
    • Solar GP, Kerr WG, Zeigler FC, et al. Role of c-Mpl in early hematopoiesis. Blood 1998 92 : 4 10.
    • (1998) Blood , vol.92 , pp. 4-10
    • Solar, G.P.1    Kerr, W.G.2    Zeigler, F.C.3
  • 12
    • 0028985426 scopus 로고
    • The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets
    • Debili N, Wendling F, Cosman D, et al. The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 1995 85 : 391 401.
    • (1995) Blood , vol.85 , pp. 391-401
    • Debili, N.1    Wendling, F.2    Cosman, D.3
  • 13
    • 0029049709 scopus 로고
    • Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation
    • Gurney AL, Wong SC, Henzel WJ, de Sauvage FJ. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc Natl Acad Sci USA 1995 92 : 5292 6.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5292-6
    • Gurney, A.L.1    Wong, S.C.2    Henzel, W.J.3    De Sauvage, F.J.4
  • 14
    • 0029052479 scopus 로고
    • Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of janus kinase 2 and Shc in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, et al. Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of janus kinase 2 and Shc in human blood platelets. Blood 1995 86 : 23 7.
    • (1995) Blood , vol.86 , pp. 23-7
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3
  • 15
    • 0029117375 scopus 로고
    • The thrombopoietin receptor c-Mpl activates Jak2 and Tyk2 tyrosine kinases
    • Sattler M, Durstin MA, Frank DA, et al. The thrombopoietin receptor c-Mpl activates Jak2 and Tyk2 tyrosine kinases. Exp Hematol 1995 23 : 1040 8.
    • (1995) Exp Hematol , vol.23 , pp. 1040-8
    • Sattler, M.1    Durstin, M.A.2    Frank, D.A.3
  • 16
    • 0030871662 scopus 로고    scopus 로고
    • Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway
    • Rouyez MC, Boucheron C, Gisselbrecht S, Dusanter-Fourt I, Porteu F. Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway. Mol Cell Biol 1997 17 : 4991 5000.
    • (1997) Mol Cell Biol , vol.17 , pp. 4991-5000
    • Rouyez, M.C.1    Boucheron, C.2    Gisselbrecht, S.3    Dusanter-Fourt, I.4    Porteu, F.5
  • 17
    • 0031806306 scopus 로고    scopus 로고
    • Involvement of prolonged Ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line
    • Matsumura I, Nakajima K, Wakao H, et al. Involvement of prolonged Ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line. Mol Cell Biol 1998 18 : 4282 90.
    • (1998) Mol Cell Biol , vol.18 , pp. 4282-90
    • Matsumura, I.1    Nakajima, K.2    Wakao, H.3
  • 18
    • 10744223059 scopus 로고    scopus 로고
    • Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
    • Feese MD, Tamada T, Kato Y, et al. Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment. Proc Natl Acad Sci USA 2004 101 : 1816 21.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1816-21
    • Feese, M.D.1    Tamada, T.2    Kato, Y.3
  • 19
    • 0033168819 scopus 로고    scopus 로고
    • Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding
    • Sabath DF, Kaushansky K, Broudy VC. Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding. Blood 1999 94 : 365 7.
    • (1999) Blood , vol.94 , pp. 365-7
    • Sabath, D.F.1    Kaushansky, K.2    Broudy, V.C.3
  • 20
    • 0033548048 scopus 로고    scopus 로고
    • Erythropoietin receptor activation by a ligand-induced conformation change
    • Remy I, Wilson IA, Michnick SW. Erythropoietin receptor activation by a ligand-induced conformation change. Science 1999 283 : 990 3.
    • (1999) Science , vol.283 , pp. 990-3
    • Remy, I.1    Wilson, I.A.2    Michnick, S.W.3
  • 21
    • 0033548259 scopus 로고    scopus 로고
    • Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
    • Livnah O, Stura EA, Middleton SA, et al. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 1999 283 : 987 90.
    • (1999) Science , vol.283 , pp. 987-90
    • Livnah, O.1    Stura, E.A.2    Middleton, S.A.3
  • 22
    • 0030048887 scopus 로고    scopus 로고
    • Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets
    • Stoffel R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 1996 87 : 567 73.
    • (1996) Blood , vol.87 , pp. 567-73
    • Stoffel, R.1    Wiestner, A.2    Skoda, R.C.3
  • 23
    • 0032530534 scopus 로고    scopus 로고
    • Primary role of the liver in thrombopoietin production shown by tissue-specific knockout
    • Qian S, Fu F, Li W, Chen Q, de Sauvage FJ. Primary role of the liver in thrombopoietin production shown by tissue-specific knockout. Blood 1998 92 : 2189 91.
    • (1998) Blood , vol.92 , pp. 2189-91
    • Qian, S.1    Fu, F.2    Li, W.3    Chen, Q.4    De Sauvage, F.J.5
  • 24
    • 0016816633 scopus 로고
    • The effect of massive liver resection on platelet kinetics in the rat
    • Siemensma NP, Bathal PS, Penington DG. The effect of massive liver resection on platelet kinetics in the rat. J Lab Clin Med 1975 86 : 817 33.
    • (1975) J Lab Clin Med , vol.86 , pp. 817-33
    • Siemensma, N.P.1    Bathal, P.S.2    Penington, D.G.3
  • 25
    • 0030737715 scopus 로고    scopus 로고
    • Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver?
    • Peck-Radosavljevic M, Zacherl J, Meng YG, et al. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 1997 27 : 127 31.
    • (1997) J Hepatol , vol.27 , pp. 127-31
    • Peck-Radosavljevic, M.1    Zacherl, J.2    Meng, Y.G.3
  • 26
    • 0034328376 scopus 로고    scopus 로고
    • Thrombocytopenia in liver disease
    • Peck-Radosavljevic M. Thrombocytopenia in liver disease. Can J Gastroenterol 2000 14 (Suppl. D 60D 6D.
    • (2000) Can J Gastroenterol , vol.14 , Issue.500
    • Peck-Radosavljevic, M.1
  • 27
    • 0032899072 scopus 로고    scopus 로고
    • The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat
    • Yang C, Li J, Kuter DJ. The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat. Br J Haematol 1999 105 : 478 85.
    • (1999) Br J Haematol , vol.105 , pp. 478-85
    • Yang, C.1    Li, J.2    Kuter, D.J.3
  • 29
    • 0032842829 scopus 로고    scopus 로고
    • Interaction of thrombopoietin with the platelet c-Mpl receptor in plasma: Binding, internalization, stability and pharmacokinetics
    • Li J, Xia Y, Kuter DJ. Interaction of thrombopoietin with the platelet c-Mpl receptor in plasma: binding, internalization, stability and pharmacokinetics. Br J Haematol 1999 106 : 345 56.
    • (1999) Br J Haematol , vol.106 , pp. 345-56
    • Li, J.1    Xia, Y.2    Kuter, D.J.3
  • 30
    • 0029865443 scopus 로고    scopus 로고
    • Regulation of thrombopoietin levels by c-Mpl-mediated binding to platelets
    • Fielder PJ, Gurney AL, Stefanich E, et al. Regulation of thrombopoietin levels by c-Mpl-mediated binding to platelets. Blood 1996 87 : 2154 61.
    • (1996) Blood , vol.87 , pp. 2154-61
    • Fielder, P.J.1    Gurney, A.L.2    Stefanich, E.3
  • 31
    • 0030901558 scopus 로고    scopus 로고
    • Human platelets as a model for the binding and degradation of thrombopoietin
    • Fielder PJ, Hass P, Nagel M, et al. Human platelets as a model for the binding and degradation of thrombopoietin. Blood 1997 89 : 2782 8.
    • (1997) Blood , vol.89 , pp. 2782-8
    • Fielder, P.J.1    Hass, P.2    Nagel, M.3
  • 32
    • 0028022980 scopus 로고
    • Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit
    • Kuter DJ, Rosenberg RD. Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit. Blood 1994 84 : 1464 72.
    • (1994) Blood , vol.84 , pp. 1464-72
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 33
    • 0002504610 scopus 로고    scopus 로고
    • Serum levels of thrombopoietin in health and disease
    • In: Kuter, D.J., Hunt, P., Sheridan, W., Zucker-Franklin, D., eds. Totowa, NJ: Humana Press Inc
    • Nichol JL. Serum levels of thrombopoietin in health and disease. In : Kuter DJ, Hunt P, Sheridan W, Zucker-Franklin D, eds. Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology. Totowa, NJ : Humana Press Inc, 1996 : 359 75.
    • (1996) Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology. , pp. 359-75
    • Nichol, J.L.1
  • 34
    • 0030307622 scopus 로고    scopus 로고
    • The physiology of platelet production
    • Kuter DJ. The physiology of platelet production. Stem Cells 1996 14 (Suppl. 1 88 101.
    • (1996) Stem Cells , vol.14 , Issue.1 , pp. 88-101
    • Kuter, D.J.1
  • 35
    • 0030966361 scopus 로고    scopus 로고
    • Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer
    • Vadhan-Raj S, Murray LJ, Bueso-Ramos C, et al. Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Ann Intern Med 1997 126 : 673 81.
    • (1997) Ann Intern Med , vol.126 , pp. 673-81
    • Vadhan-Raj, S.1    Murray, L.J.2    Bueso-Ramos, C.3
  • 36
    • 0034050651 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer
    • Vadhan-Raj S, Verschraegen CF, Bueso-Ramos C, et al. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann Intern Med 2000 132 : 364 8.
    • (2000) Ann Intern Med , vol.132 , pp. 364-8
    • Vadhan-Raj, S.1    Verschraegen, C.F.2    Bueso-Ramos, C.3
  • 37
    • 0035469813 scopus 로고    scopus 로고
    • Thrombopoietin therapy increases platelet yields in healthy platelet donors
    • Kuter DJ, Goodnough LT, Romo J, et al. Thrombopoietin therapy increases platelet yields in healthy platelet donors. Blood 2001 98 : 1339 45.
    • (2001) Blood , vol.98 , pp. 1339-45
    • Kuter, D.J.1    Goodnough, L.T.2    Romo, J.3
  • 38
    • 0037100423 scopus 로고    scopus 로고
    • Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
    • Nomura S, Dan K, Hotta T, Fujimura K, Ikeda Y. Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 2002 100 : 728 30.
    • (2002) Blood , vol.100 , pp. 728-30
    • Nomura, S.1    Dan, K.2    Hotta, T.3    Fujimura, K.4    Ikeda, Y.5
  • 39
    • 0034085801 scopus 로고    scopus 로고
    • Future directions with platelet growth factors
    • Kuter DJ. Future directions with platelet growth factors. Semin Hematol 2000 37 : 41 9.
    • (2000) Semin Hematol , vol.37 , pp. 41-9
    • Kuter, D.J.1
  • 40
    • 0030773876 scopus 로고    scopus 로고
    • Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
    • Cwirla SE, Balasubramanian P, Duffin DJ, et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 1997 276 : 1696 9.
    • (1997) Science , vol.276 , pp. 1696-9
    • Cwirla, S.E.1    Balasubramanian, P.2    Duffin, D.J.3
  • 41
    • 33749249751 scopus 로고    scopus 로고
    • A rationally designed agonist antibody fragment that functionally mimics thrombopoietin
    • Frederickson S, Renshaw MW, Lin B, et al. A rationally designed agonist antibody fragment that functionally mimics thrombopoietin. Proc Natl Acad Sci USA 2006 103 : 14307 12.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14307-12
    • Frederickson, S.1    Renshaw, M.W.2    Lin, B.3
  • 42
    • 33746557222 scopus 로고    scopus 로고
    • Stimulation of platelet production in healthy volunteers by a novel pegylated peptide-based thrombopoietin (TPO) receptor agonist
    • Cerneus D, Brown K, Harris R, et al. Stimulation of platelet production in healthy volunteers by a novel pegylated peptide-based thrombopoietin (TPO) receptor agonist. Blood (ASH Annual Meeting Abstracts) 2005 106 : 1249.
    • (2005) Blood (ASH Annual Meeting Abstracts) , vol.106 , pp. 1249
    • Cerneus, D.1    Brown, K.2    Harris, R.3
  • 43
    • 0346881171 scopus 로고    scopus 로고
    • AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl
    • Broudy VC, Lin NL. AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokine 2004 25 : 52 60.
    • (2004) Cytokine , vol.25 , pp. 52-60
    • Broudy, V.C.1    Lin, N.L.2
  • 44
    • 10044296968 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
    • Wang B, Nichol JL, Sullivan JT. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004 76 : 628 38.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 628-38
    • Wang, B.1    Nichol, J.L.2    Sullivan, J.T.3
  • 45
    • 33750035507 scopus 로고    scopus 로고
    • AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
    • Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis- stimulating protein, for chronic ITP. N Engl J Med 2006 355 : 1672 81.
    • (2006) N Engl J Med , vol.355 , pp. 1672-81
    • Bussel, J.B.1    Kuter, D.J.2    George, J.N.3
  • 46
    • 33947096577 scopus 로고    scopus 로고
    • Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update
    • Kuter D, Bussel J, George J, et al. Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update. Blood (ASH Annual Meeting Abstracts) 2006 108 : 476.
    • (2006) Blood (ASH Annual Meeting Abstracts) , vol.108 , pp. 476
    • Kuter, D.1    Bussel, J.2    George, J.3
  • 47
    • 37149046846 scopus 로고    scopus 로고
    • Evaluating safety and efficacy of AMG 531 for the treatment of thrombocytopenic patients with myelodysplastic syndrome (MDS): Preliminary results of a phase 1/2 study
    • Kantarjian HM, Giles FJ, Fenaux P, et al. Evaluating safety and efficacy of AMG 531 for the treatment of thrombocytopenic patients with myelodysplastic syndrome (MDS): preliminary results of a phase 1/2 study. J Clin Oncol (Meeting Abstracts) 2007 25 : 7032.
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , pp. 7032
    • Kantarjian, H.M.1    Giles, F.J.2    Fenaux, P.3
  • 48
    • 0035950101 scopus 로고    scopus 로고
    • Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis
    • Duffy KJ, Darcy MG, Delorme E, et al. Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem 2001 44 : 3730 45.
    • (2001) J Med Chem , vol.44 , pp. 3730-45
    • Duffy, K.J.1    Darcy, M.G.2    Delorme, E.3
  • 50
    • 34648847269 scopus 로고    scopus 로고
    • Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers
    • Desjardins RE, Tempel DL, Lucek R, Kuter DJ. Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers. Blood (ASH Annual Meeting Abstracts) 2006 108 : 477.
    • (2006) Blood (ASH Annual Meeting Abstracts) , vol.108 , pp. 477
    • Desjardins, R.E.1    Tempel, D.L.2    Lucek, R.3    Kuter, D.J.4
  • 52
    • 33746604143 scopus 로고    scopus 로고
    • Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia
    • Luengo JI, Duffy KJ, Shaw AN, et al. Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia. Blood (ASH Annual Meeting Abstracts) 2004 104 : 2910.
    • (2004) Blood (ASH Annual Meeting Abstracts) , vol.104 , pp. 2910
    • Luengo, J.I.1    Duffy, K.J.2    Shaw, A.N.3
  • 53
    • 33749015400 scopus 로고    scopus 로고
    • Biological activity and selectivity for TPO receptor of the orally bioavailable, small molecule TPO receptor agonist, SB-497115
    • Erickson-Miller C, Delorme E, Giampa L, et al. Biological activity and selectivity for TPO receptor of the orally bioavailable, small molecule TPO receptor agonist, SB-497115. Blood (ASH Annual Meeting Abstracts) 2004 104 : 2912.
    • (2004) Blood (ASH Annual Meeting Abstracts) , vol.104 , pp. 2912
    • Erickson-Miller, C.1    Delorme, E.2    Giampa, L.3
  • 54
    • 33744497342 scopus 로고    scopus 로고
    • Species specificity and receptor domain interaction of a small molecule TPO receptor agonist
    • Erickson-Miller CL, Delorme E, Iskander M, et al. Species specificity and receptor domain interaction of a small molecule TPO receptor agonist. Blood (ASH Annual Meeting Abstracts) 2004 104 : 2909.
    • (2004) Blood (ASH Annual Meeting Abstracts) , vol.104 , pp. 2909
    • Erickson-Miller, C.L.1    Delorme, E.2    Iskander, M.3
  • 55
    • 33749024371 scopus 로고    scopus 로고
    • a low molecular weight TPOR agonist, does not induce platelet activation or enhance agonist-induced platelet aggregation in vitro
    • 497115-Gr, a low molecular weight TPOR agonist, does not induce platelet activation or enhance agonist-induced platelet aggregation in vitro.
    • Erhardt J, Erickson-Miller CL, Tapley P. SB 497115-Gr, a low molecular weight TPOR agonist, does not induce platelet activation or enhance agonist-induced platelet aggregation in vitro. Blood (ASH Annual Meeting Abstracts) 2004 104 : 3888.
    • (2004) Blood (ASH Annual Meeting Abstracts) , vol.104 , pp. 3888
    • Erhardt, J.1    Erickson-Miller, C.L.2    Tapley, P.3
  • 56
    • 34249719511 scopus 로고    scopus 로고
    • Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
    • Jenkins JM, Williams D, Deng Y, et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007 109 : 4739 41.
    • (2007) Blood , vol.109 , pp. 4739-41
    • Jenkins, J.M.1    Williams, D.2    Deng, Y.3
  • 57
    • 36549001698 scopus 로고    scopus 로고
    • Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
    • Bussel JB, Provan A, Shamsi T, et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007 357 : 2237 47.
    • (2007) N Engl J Med , vol.357 , pp. 2237-47
    • Bussel, J.B.1    Provan, A.2    Shamsi, T.3
  • 59
    • 36549047972 scopus 로고    scopus 로고
    • Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C
    • McHutchison JG, Dusheiko G, Shiffman ML, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007 357 : 2227 36.
    • (2007) N Engl J Med , vol.357 , pp. 2227-36
    • McHutchison, J.G.1    Dusheiko, G.2    Shiffman, M.L.3
  • 60
    • 19944429567 scopus 로고    scopus 로고
    • A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor
    • Orita T, Tsunoda H, Yabuta N, et al. A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor. Blood 2005 105 : 562 6.
    • (2005) Blood , vol.105 , pp. 562-6
    • Orita, T.1    Tsunoda, H.2    Yabuta, N.3
  • 61
    • 35448952283 scopus 로고    scopus 로고
    • Domain subclass conversion improved activity of anti-Mpl agonist antibodies in the form of whole IgG
    • Kai M, Motoki K, Yoshida H, et al. Domain subclass conversion improved activity of anti-Mpl agonist antibodies in the form of whole IgG. Blood (ASH Annual Meeting Abstracts) 2006 108 : 1134.
    • (2006) Blood (ASH Annual Meeting Abstracts) , vol.108 , pp. 1134
    • Kai, M.1    Motoki, K.2    Yoshida, H.3
  • 62
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucchi M, Glaspy J, Crawford J, et al. Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997 336 : 404 9.
    • (1997) N Engl J Med , vol.336 , pp. 404-9
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 63
    • 0033861984 scopus 로고    scopus 로고
    • Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer
    • Basser RL, Underhill C, Davis I, et al. Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer. J Clin Oncol 2000 18 : 2852 61.
    • (2000) J Clin Oncol , vol.18 , pp. 2852-61
    • Basser, R.L.1    Underhill, C.2    Davis, I.3
  • 64
    • 0029943307 scopus 로고    scopus 로고
    • Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates
    • Harker LA, Marzec UM, Hunt P, et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996 88 : 511 21.
    • (1996) Blood , vol.88 , pp. 511-21
    • Harker, L.A.1    Marzec, U.M.2    Hunt, P.3
  • 65
    • 0029923645 scopus 로고    scopus 로고
    • Relative reactivity of platelets from thrombopoietin- and interleukin-6-treated dogs
    • Peng J, Friese P, Wolf RF, et al. Relative reactivity of platelets from thrombopoietin- and interleukin-6-treated dogs. Blood 1996 87 : 4158 63.
    • (1996) Blood , vol.87 , pp. 4158-63
    • Peng, J.1    Friese, P.2    Wolf, R.F.3
  • 66
    • 34848876335 scopus 로고    scopus 로고
    • Bone marrow fibrosis: Pathophysiology and clinical significance of increased bone marrow stromal fibres
    • Kuter DJ, Bain B, Mufti G, Bagg A, Hasserjian RP. Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres. Br J Haematol 2007 139 : 351 62.
    • (2007) Br J Haematol , vol.139 , pp. 351-62
    • Kuter, D.J.1    Bain, B.2    Mufti, G.3    Bagg, A.4    Hasserjian, R.P.5
  • 67
    • 0029897491 scopus 로고    scopus 로고
    • Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice
    • Ulich TR, del Castillo J, Senaldi G, et al. Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice. Blood 1996 87 : 5006 15.
    • (1996) Blood , vol.87 , pp. 5006-15
    • Ulich, T.R.1    Del Castillo, J.2    Senaldi, G.3
  • 68
    • 6844250789 scopus 로고    scopus 로고
    • The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats
    • Yanagida M, Ide Y, Imai A, et al. The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats. Br J Haematol 1997 99 : 739 45.
    • (1997) Br J Haematol , vol.99 , pp. 739-45
    • Yanagida, M.1    Ide, Y.2    Imai, A.3
  • 69
    • 0036263664 scopus 로고    scopus 로고
    • Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders
    • Douglas VK, Tallman MS, Cripe LD, Peterson LC. Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders. Am J Clin Pathol 2002 117 : 844 50.
    • (2002) Am J Clin Pathol , vol.117 , pp. 844-50
    • Douglas, V.K.1    Tallman, M.S.2    Cripe, L.D.3    Peterson, L.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.