메뉴 건너뛰기




Volumn 122, Issue 1-4, 2006, Pages 228-236

Using superoxide dismutase/catalase mimetics to manipulate the redox environment of neural precursor cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; EUK 163; EUK 172; EUK 189; FLUORESCENT DYE; HYDROGEN PEROXIDE; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); PEROXIDASE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

EID: 34347406350     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/rpd/ncl458     Document Type: Article
Times cited : (29)

References (47)
  • 1
    • 0028895098 scopus 로고
    • FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain
    • Palmer, T. D., Ray, J. and Gage, F. H. FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol. Cell. Neurosci. 6, 474-486 (1995).
    • (1995) Mol. Cell. Neurosci , vol.6 , pp. 474-486
    • Palmer, T.D.1    Ray, J.2    Gage, F.H.3
  • 2
    • 0030438734 scopus 로고    scopus 로고
    • The adult rat hippocampus contains primordial neural stem cells
    • Palmer, T. D., Takahashi, J. and Gage, F. H. The adult rat hippocampus contains primordial neural stem cells. Mol. Cell. Neurosci. 8, 389-404 (1997).
    • (1997) Mol. Cell. Neurosci , vol.8 , pp. 389-404
    • Palmer, T.D.1    Takahashi, J.2    Gage, F.H.3
  • 4
    • 0034718139 scopus 로고    scopus 로고
    • X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats
    • Tada, E., Parent, J. M., Lowenstein, D. H. and Fike, J. R. X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 99, 33-41 (2000).
    • (2000) Neuroscience , vol.99 , pp. 33-41
    • Tada, E.1    Parent, J.M.2    Lowenstein, D.H.3    Fike, J.R.4
  • 5
    • 0041672477 scopus 로고    scopus 로고
    • Extreme sensitivity of adult neurogenesis to low doses of X-irradiation
    • Mizumatsu, S., Monje, M., Morhardt, D., Rola, R., Palmer, T. and Fike, J. Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 63, 4021-4027 (2003).
    • (2003) Cancer Res , vol.63 , pp. 4021-4027
    • Mizumatsu, S.1    Monje, M.2    Morhardt, D.3    Rola, R.4    Palmer, T.5    Fike, J.6
  • 6
    • 3042799716 scopus 로고    scopus 로고
    • Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    • Rola, R., Raber, J., Rizk, A., Otsuka, S., VandenBerg, S., Morhardt, D. and Fike, J. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp. Neurol. 188, 316-330 (2004).
    • (2004) Exp. Neurol , vol.188 , pp. 316-330
    • Rola, R.1    Raber, J.2    Rizk, A.3    Otsuka, S.4    VandenBerg, S.5    Morhardt, D.6    Fike, J.7
  • 7
    • 3843075154 scopus 로고    scopus 로고
    • Radiation-induced cognitive impairments are associated with changes in hippocampal neurogenesis
    • Raber, J., Rola, R., LeFevour, A., Morhardt, D., Curley, J., Mizumatsu, S. and Fike, J. Radiation-induced cognitive impairments are associated with changes in hippocampal neurogenesis. Radiat. Res. 162, 39-47 (2004).
    • (2004) Radiat. Res , vol.162 , pp. 39-47
    • Raber, J.1    Rola, R.2    LeFevour, A.3    Morhardt, D.4    Curley, J.5    Mizumatsu, S.6    Fike, J.7
  • 8
    • 0036735783 scopus 로고    scopus 로고
    • Irradiation induces neural precursor-cell dysfunction
    • Monje, M. L., Mizumatsu, S., Fike, J. R. and Palmer, T. D. Irradiation induces neural precursor-cell dysfunction. Nat. Med. 8 955-962 (2002).
    • (2002) Nat. Med , vol.8 , pp. 955-962
    • Monje, M.L.1    Mizumatsu, S.2    Fike, J.R.3    Palmer, T.D.4
  • 9
    • 0018125603 scopus 로고
    • Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial
    • Walker, M. D. et al. Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J. Neurosurg. 49, 333-343 (1978).
    • (1978) J. Neurosurg , vol.49 , pp. 333-343
    • Walker, M.D.1
  • 10
    • 0018568970 scopus 로고
    • An analysis of dose-effect relationship in the radiotherapy of malignant gliomas
    • Walker, M. D., Strike, T. A. and Sheline, G. E. An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int. J. Radiat. Oncol. Biol. Phys. 5, 1725-1731 (1979).
    • (1979) Int. J. Radiat. Oncol. Biol. Phys , vol.5 , pp. 1725-1731
    • Walker, M.D.1    Strike, T.A.2    Sheline, G.E.3
  • 11
    • 0019142613 scopus 로고
    • Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery
    • Walker, M. D. et al. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N. Engl. J. Med. 303, 1323-1329 (1980).
    • (1980) N. Engl. J. Med , vol.303 , pp. 1323-1329
    • Walker, M.D.1
  • 12
    • 0034852610 scopus 로고    scopus 로고
    • Space radiation research in the new millenium - from where we come and where we go
    • Kiefer, J. Space radiation research in the new millenium - from where we come and where we go. Phys. Med. 17(Suppl. 1), 1-4 (2001).
    • (2001) Phys. Med , vol.17 , Issue.SUPPL. 1 , pp. 1-4
    • Kiefer, J.1
  • 13
    • 0034846376 scopus 로고    scopus 로고
    • Radiation measurements on the International Space Station
    • Badhwar, G. D. Radiation measurements on the International Space Station. Phys. Med. 17(Suppl. 1), 287-291 (2001).
    • (2001) Phys. Med , vol.17 , Issue.SUPPL. 1 , pp. 287-291
    • Badhwar, G.D.1
  • 14
    • 0347995022 scopus 로고    scopus 로고
    • Radiation response of neural precursor cells: Linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress
    • Limoli, C. L., Giedzinski, E., Rola, R., Otsuka, S., Palmer, T. D. and Fike, J. R. Radiation response of neural precursor cells: Linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiat. Res. 161, 17-27 (2004).
    • (2004) Radiat. Res , vol.161 , pp. 17-27
    • Limoli, C.L.1    Giedzinski, E.2    Rola, R.3    Otsuka, S.4    Palmer, T.D.5    Fike, J.R.6
  • 16
    • 25444450749 scopus 로고    scopus 로고
    • Efficient production of reactive oxygen species in neural precursor cells following exposure to 250 MeV protons
    • Giedzinski, E., Rola, R., Fike, J. and Limoli, C. L. Efficient production of reactive oxygen species in neural precursor cells following exposure to 250 MeV protons. Radiat. Res. 164, 540-544 (2005).
    • (2005) Radiat. Res , vol.164 , pp. 540-544
    • Giedzinski, E.1    Rola, R.2    Fike, J.3    Limoli, C.L.4
  • 17
    • 6344259969 scopus 로고    scopus 로고
    • Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dose-dependent manner
    • Rola, R., Otsuka, S., Obenaus, A., Nelson, G. A., Limoli, C. L., VandenBerg, S. R. and Fike, J. R. Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dose-dependent manner. Radiat. Res. 162, 442-446 (2004).
    • (2004) Radiat. Res , vol.162 , pp. 442-446
    • Rola, R.1    Otsuka, S.2    Obenaus, A.3    Nelson, G.A.4    Limoli, C.L.5    VandenBerg, S.R.6    Fike, J.R.7
  • 18
    • 25444483568 scopus 로고    scopus 로고
    • High LET irradiation induced inflammation and persistent changes in markers of hippocampal neurogenesis
    • Rola, R., Sarkissian, V., Obenaus, A., Nelson, G., Otsuka, S., Limoli, C. and Fike J. R. High LET irradiation induced inflammation and persistent changes in markers of hippocampal neurogenesis. Radiat. Res. 164, 556-560 (2005).
    • (2005) Radiat. Res , vol.164 , pp. 556-560
    • Rola, R.1    Sarkissian, V.2    Obenaus, A.3    Nelson, G.4    Otsuka, S.5    Limoli, C.6    Fike, J.R.7
  • 19
    • 0033789565 scopus 로고    scopus 로고
    • Free radical pathways in CNS injury
    • Lewen, A., Matz, P. and Chan, P. H. Free radical pathways in CNS injury. J. Neurotrauma 17, 871-890 (2000).
    • (2000) J. Neurotrauma , vol.17 , pp. 871-890
    • Lewen, A.1    Matz, P.2    Chan, P.H.3
  • 20
    • 0035045079 scopus 로고    scopus 로고
    • Walker-256 tumor growth causes oxidative stress in rat brain
    • Freitas, J. J., Pompeia, C., Miyasaka, C. K. and Curi, R. Walker-256 tumor growth causes oxidative stress in rat brain. J. Neurochem. 77, 655-663 (2001).
    • (2001) J. Neurochem , vol.77 , pp. 655-663
    • Freitas, J.J.1    Pompeia, C.2    Miyasaka, C.K.3    Curi, R.4
  • 21
    • 0343924382 scopus 로고    scopus 로고
    • Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system
    • Peuchen, S., Bolanos, J. P., Heales, S. J., Almeida, A., Duchen, M. R. and Clark, J. B. Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system. Prog. Neurobiol. 52, 261-281 (1997).
    • (1997) Prog. Neurobiol , vol.52 , pp. 261-281
    • Peuchen, S.1    Bolanos, J.P.2    Heales, S.J.3    Almeida, A.4    Duchen, M.R.5    Clark, J.B.6
  • 22
    • 0032950964 scopus 로고    scopus 로고
    • Demyelination: The role of reactive oxygen and nitrogen species
    • Smith, K. J., Kapoor, R. and Felts, P. A. Demyelination: The role of reactive oxygen and nitrogen species. Brain Pathol. 9, 69-92 (1999).
    • (1999) Brain Pathol , vol.9 , pp. 69-92
    • Smith, K.J.1    Kapoor, R.2    Felts, P.A.3
  • 23
    • 0000879568 scopus 로고    scopus 로고
    • Protective action of nitrone-based free radical traps against oxidative damage to the central nervous system
    • Floyd, R. A. Protective action of nitrone-based free radical traps against oxidative damage to the central nervous system. Adv. Pharmacol. 38, 361-378 (1997).
    • (1997) Adv. Pharmacol , vol.38 , pp. 361-378
    • Floyd, R.A.1
  • 24
  • 25
    • 0032924640 scopus 로고    scopus 로고
    • Oxidative stress in brain ischemia
    • Love, S. Oxidative stress in brain ischemia. Brain Pathol. 9 119-131 (1999).
    • (1999) Brain Pathol , vol.9 , pp. 119-131
    • Love, S.1
  • 26
    • 0017348934 scopus 로고
    • Mitochondrial production of superoxide radical and hydrogen peroxide
    • Boveris, A. Mitochondrial production of superoxide radical and hydrogen peroxide. Adv. Exp. Med. Biol. 78, 67-82 (1977).
    • (1977) Adv. Exp. Med. Biol , vol.78 , pp. 67-82
    • Boveris, A.1
  • 27
    • 0002437327 scopus 로고
    • Production of superoxide radicals and hydrogen peroxide in mitochiondria
    • Oberly, L. W, Ed, Boca Raton, FL: CRC Press pp
    • Boveris, A. and Cadenas, E. Production of superoxide radicals and hydrogen peroxide in mitochiondria. In: Superoxide Dismutase. Vol. 2, Oberly, L. W., Ed. (Boca Raton, FL: CRC Press) pp. 15-30 (1982).
    • (1982) Superoxide Dismutase , vol.2 , pp. 15-30
    • Boveris, A.1    Cadenas, E.2
  • 28
    • 0031911994 scopus 로고    scopus 로고
    • Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury
    • Baker, K., Marcus, C. B., Huffman, K., Kruk, H., Malfroy, B. and Doctrow, S. R. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284, 215-221 (1998).
    • (1998) J. Pharmacol. Exp. Ther , vol.284 , pp. 215-221
    • Baker, K.1    Marcus, C.B.2    Huffman, K.3    Kruk, H.4    Malfroy, B.5    Doctrow, S.R.6
  • 29
    • 0037179613 scopus 로고    scopus 로고
    • Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies
    • Doctrow, S. R. et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies. J. Med. Chem. 45, 4549-4558 (2002).
    • (2002) J. Med. Chem , vol.45 , pp. 4549-4558
    • Doctrow, S.R.1
  • 30
    • 0033578309 scopus 로고    scopus 로고
    • EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
    • Rong, Y., Doctrow, S. R., Tocco, G. and Baudry, M. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc. Natl Acad. Sci. USA 96, 9897-9902 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 9897-9902
    • Rong, Y.1    Doctrow, S.R.2    Tocco, G.3    Baudry, M.4
  • 31
    • 0035503501 scopus 로고    scopus 로고
    • Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
    • Melov, S., Doctrow, S. R., Schneider, J. A., Haberson, J., Patel, M., Coskun, P. E., Huffman, K., Wallace, D. C. and Malfroy, B., Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21, 8348-8353 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 8348-8353
    • Melov, S.1    Doctrow, S.R.2    Schneider, J.A.3    Haberson, J.4    Patel, M.5    Coskun, P.E.6    Huffman, K.7    Wallace, D.C.8    Malfroy, B.9
  • 32
    • 0034853453 scopus 로고    scopus 로고
    • Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons
    • Pong, K., Doctrow, S. R., Huffman, K., Adinolfi, C. A. and Baudry, M. Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons. Exp. Neurol. 171, 84-97 (2001).
    • (2001) Exp. Neurol , vol.171 , pp. 84-97
    • Pong, K.1    Doctrow, S.R.2    Huffman, K.3    Adinolfi, C.A.4    Baudry, M.5
  • 33
    • 0035947221 scopus 로고    scopus 로고
    • Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model
    • Jung, C., Rong, Y., Doctrow, S., Baudry, M., Malfroy, B. and Xu, Z. Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model. Neurosci. Lett. 304, 157-160 (2001).
    • (2001) Neurosci. Lett , vol.304 , pp. 157-160
    • Jung, C.1    Rong, Y.2    Doctrow, S.3    Baudry, M.4    Malfroy, B.5    Xu, Z.6
  • 34
    • 0037144177 scopus 로고    scopus 로고
    • Attenuation of zinc-induced intracellular dysfunction and neurotoxicity by a synthetic superoxide dismutase/catalase mimetic, in cultured cortical neurons
    • Pong, K., Rong, Y., Doctrow, S. R. and Baudry, M. Attenuation of zinc-induced intracellular dysfunction and neurotoxicity by a synthetic superoxide dismutase/catalase mimetic, in cultured cortical neurons. Brain Res. 950, 218-230 (2002).
    • (2002) Brain Res , vol.950 , pp. 218-230
    • Pong, K.1    Rong, Y.2    Doctrow, S.R.3    Baudry, M.4
  • 35
    • 9444222523 scopus 로고    scopus 로고
    • Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress
    • Zhang, H. J., Doctrow, S. R., Xu, L., Oberley, L. W., Beecher, B., Morrison, J., Oberley, T. D. and Kregel, K. C. Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. Faseb J. 18, 1547-1549 (2004).
    • (2004) Faseb J , vol.18 , pp. 1547-1549
    • Zhang, H.J.1    Doctrow, S.R.2    Xu, L.3    Oberley, L.W.4    Beecher, B.5    Morrison, J.6    Oberley, T.D.7    Kregel, K.C.8
  • 36
    • 0942298545 scopus 로고    scopus 로고
    • Endogenous mitochondrial oxidative stress: Neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice
    • Hinerfeld, D., Traini, M. D., Weinberger, R. P., Cochran, B., Doctrow, S. R., Harry, J. and Melov, S. Endogenous mitochondrial oxidative stress: Neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J. Neurochem. 88, 657-667 (2004).
    • (2004) J. Neurochem , vol.88 , pp. 657-667
    • Hinerfeld, D.1    Traini, M.D.2    Weinberger, R.P.3    Cochran, B.4    Doctrow, S.R.5    Harry, J.6    Melov, S.7
  • 37
    • 10844277858 scopus 로고    scopus 로고
    • Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment
    • Melov, S., Wolf, N., Strozyk, D., Doctrow, S. R. and Bush, A. I. Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic. Biol. Med. 38, 258-261 (2005).
    • (2005) Free Radic. Biol. Med , vol.38 , pp. 258-261
    • Melov, S.1    Wolf, N.2    Strozyk, D.3    Doctrow, S.R.4    Bush, A.I.5
  • 38
    • 0037196872 scopus 로고    scopus 로고
    • The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis
    • Kee, N., Sivalingam, S., Boonstra, R. and Wojtowicz, J. M. The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis J. Neurosci. Methods 115, 97-105 (2002).
    • (2002) J. Neurosci. Methods , vol.115 , pp. 97-105
    • Kee, N.1    Sivalingam, S.2    Boonstra, R.3    Wojtowicz, J.M.4
  • 39
    • 0036283521 scopus 로고    scopus 로고
    • Doublecortin expression in the adult rat telencephalon
    • Nacher, J., Crespo, C. and McEwen, B. S. Doublecortin expression in the adult rat telencephalon. Eur. J. Neurosci. 14, 629-644 (2001).
    • (2001) Eur. J. Neurosci , vol.14 , pp. 629-644
    • Nacher, J.1    Crespo, C.2    McEwen, B.S.3
  • 40
    • 0041854247 scopus 로고    scopus 로고
    • Induction of chromosomal instability by chronic oxidative stress
    • Limoli, C. L. and Giedzinski, E. Induction of chromosomal instability by chronic oxidative stress. Neoplasia 5, 339-346 (2003).
    • (2003) Neoplasia , vol.5 , pp. 339-346
    • Limoli, C.L.1    Giedzinski, E.2
  • 41
    • 23844483173 scopus 로고    scopus 로고
    • Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: Implications for Parkinson disease
    • Peng, J., Stevenson, F. F., Doctrow, S. R. and Andersen, J. K. Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: Implications for Parkinson disease. J. Biol. Chem. 280, 29194-29198 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 29194-29198
    • Peng, J.1    Stevenson, F.F.2    Doctrow, S.R.3    Andersen, J.K.4
  • 42
    • 0034722098 scopus 로고    scopus 로고
    • Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons
    • Pong, K., Doctrow, S. R. and Baudry, M. Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain Res. 881, 182-189 (2000).
    • (2000) Brain Res , vol.881 , pp. 182-189
    • Pong, K.1    Doctrow, S.R.2    Baudry, M.3
  • 43
    • 4944225788 scopus 로고    scopus 로고
    • SOD2-deficiency anemia: Protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness
    • Friedman, J. S., Lopez, M. F., Fleming, M. D., Rivera, A., Martin, F. M., Welsh, M. L., Boyd, A., Doctrow, S. R. and Burakoff, S. J. SOD2-deficiency anemia: Protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood 104, 2565-2573 (2004).
    • (2004) Blood , vol.104 , pp. 2565-2573
    • Friedman, J.S.1    Lopez, M.F.2    Fleming, M.D.3    Rivera, A.4    Martin, F.M.5    Welsh, M.L.6    Boyd, A.7    Doctrow, S.R.8    Burakoff, S.J.9
  • 44
    • 0029866991 scopus 로고    scopus 로고
    • Beta-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger
    • Bruce, A. J., Malfroy, B. and Baudry, M. Beta-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger. Proc. Natl Acad. Sci. USA 93, 2312-2316 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 2312-2316
    • Bruce, A.J.1    Malfroy, B.2    Baudry, M.3
  • 45
    • 0345700749 scopus 로고    scopus 로고
    • Iron toxicity in organotypic cultures of hippocampal slices: Role of reactive oxygen species
    • Liu, R., Liu, W., Doctrow, S. R. and Baudry, M. Iron toxicity in organotypic cultures of hippocampal slices: Role of reactive oxygen species. J. Neurochem. 85, 492-502 (2003).
    • (2003) J. Neurochem , vol.85 , pp. 492-502
    • Liu, R.1    Liu, W.2    Doctrow, S.R.3    Baudry, M.4
  • 46
    • 0038491473 scopus 로고    scopus 로고
    • Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide distase/catalase mimetics
    • Liu, R., Liu, I. Y., Bi, X., Thompson, R. F., Doctrow, S. R., Malfroy, B. and Baudry, M. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide distase/catalase mimetics. Proc. Natl Acad. Sci. USA 100, 8526-8531 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8526-8531
    • Liu, R.1    Liu, I.Y.2    Bi, X.3    Thompson, R.F.4    Doctrow, S.R.5    Malfroy, B.6    Baudry, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.