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Volumn 168, Issue 5, 2007, Pages 552-559

Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PYRUVIC ACID ETHYL ESTER; RADIOPROTECTIVE AGENT; UNCLASSIFIED DRUG; PYRUVIC ACID DERIVATIVE;

EID: 38449113261     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1009.1     Document Type: Article
Times cited : (34)

References (39)
  • 2
    • 27744473041 scopus 로고    scopus 로고
    • Radioprotective antioxidant gene therapy: Potential mechanisms of action
    • J. S. Greenberger and M. W. Epperly, Radioprotective antioxidant gene therapy: Potential mechanisms of action. Gene Ther. Mol. Biol. 8, 31-44(2004).
    • (2004) Gene Ther. Mol. Biol , vol.8 , pp. 31-44
    • Greenberger, J.S.1    Epperly, M.W.2
  • 3
    • 0036177254 scopus 로고    scopus 로고
    • Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene
    • M. W. Epperly, S. Defilippi, C. Sikora, J. Gretton and J. S. Greenberger, Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene. Mil. Med. 167, 71-73 (2002).
    • (2002) Mil. Med , vol.167 , pp. 71-73
    • Epperly, M.W.1    Defilippi, S.2    Sikora, C.3    Gretton, J.4    Greenberger, J.S.5
  • 4
    • 0348226533 scopus 로고    scopus 로고
    • Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage
    • M. Epperly, J. E. Gretton, M. Bernarding, S. Nie, B. Rasul and J. S. Greenberger, Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage. Radiat. Res. 160, 568-578 (2003).
    • (2003) Radiat. Res , vol.160 , pp. 568-578
    • Epperly, M.1    Gretton, J.E.2    Bernarding, M.3    Nie, S.4    Rasul, B.5    Greenberger, J.S.6
  • 5
    • 17644396168 scopus 로고    scopus 로고
    • Delayed intratracheal injection of manganese superoxide dismutase (MnSOD)-plasmid/liposome provides suboptimal protection against irradiation-induced pulmonary injury compared to treatment before irradiation
    • M. W. Epperly, H. L. Guo, M. Bernarding, J. Gretton, M. Jefferson and J. S. Greenberger, Delayed intratracheal injection of manganese superoxide dismutase (MnSOD)-plasmid/liposome provides suboptimal protection against irradiation-induced pulmonary injury compared to treatment before irradiation. Gene Ther. Mol. Biol. 7, 61-68 (2003).
    • (2003) Gene Ther. Mol. Biol , vol.7 , pp. 61-68
    • Epperly, M.W.1    Guo, H.L.2    Bernarding, M.3    Gretton, J.4    Jefferson, M.5    Greenberger, J.S.6
  • 6
    • 12744269330 scopus 로고    scopus 로고
    • Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis
    • A. Tsung, T. Kaizu, A. Nakao, L. Shao, B. Bucher, M. P. Fink, N. Murase and D. A. Geller, Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis. Transplantation 27, 196-204 (2005).
    • (2005) Transplantation , vol.27 , pp. 196-204
    • Tsung, A.1    Kaizu, T.2    Nakao, A.3    Shao, L.4    Bucher, B.5    Fink, M.P.6    Murase, N.7    Geller, D.A.8
  • 8
    • 0036599639 scopus 로고    scopus 로고
    • Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats
    • Z. S. Tawadrous, R. L. Delude and M. P. Fink, Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats. Shock 17, 473-477 (2002).
    • (2002) Shock , vol.17 , pp. 473-477
    • Tawadrous, Z.S.1    Delude, R.L.2    Fink, M.P.3
  • 11
    • 0037616308 scopus 로고    scopus 로고
    • Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock
    • R. Venkataraman, J. A. Kellum, M. Song and M. P. Fink, Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock. Shock 18, 507-512 (2002).
    • (2002) Shock , vol.18 , pp. 507-512
    • Venkataraman, R.1    Kellum, J.A.2    Song, M.3    Fink, M.P.4
  • 12
    • 0142249406 scopus 로고    scopus 로고
    • Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice
    • T. Miyaji, X. Hu, P. S. T. Yuen, Y. Muramatsu, S. Iyer, S. M. Hewitt and R. A. Star, Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int. 64, 1620-1631 (2003).
    • (2003) Kidney Int , vol.64 , pp. 1620-1631
    • Miyaji, T.1    Hu, X.2    Yuen, P.S.T.3    Muramatsu, Y.4    Iyer, S.5    Hewitt, S.M.6    Star, R.A.7
  • 13
    • 3142759947 scopus 로고    scopus 로고
    • Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis
    • R. Yang, T. Uchiyama, S. M. Alber, X. Han, S. K. Watkins, R. L. Delude and M. P. Fink, Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit. Care Med. 32, 1453-1459 (2004).
    • (2004) Crit. Care Med , vol.32 , pp. 1453-1459
    • Yang, R.1    Uchiyama, T.2    Alber, S.M.3    Han, X.4    Watkins, S.K.5    Delude, R.L.6    Fink, M.P.7
  • 14
    • 7944233880 scopus 로고    scopus 로고
    • Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis
    • R. Yang, T. Uchiyama, S. K. Watkins, X. Han and M. P. Fink, Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis. Shock 22, 369-375 (2004).
    • (2004) Shock , vol.22 , pp. 369-375
    • Yang, R.1    Uchiyama, T.2    Watkins, S.K.3    Han, X.4    Fink, M.P.5
  • 15
    • 0344244898 scopus 로고    scopus 로고
    • Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice
    • R. Yang, X. Han, R. L. Delude and M. P. Fink, Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice. J. Lab. Clin. Med. 142, 322-331 (2003).
    • (2003) J. Lab. Clin. Med , vol.142 , pp. 322-331
    • Yang, R.1    Han, X.2    Delude, R.L.3    Fink, M.P.4
  • 16
    • 31744435952 scopus 로고    scopus 로고
    • Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury
    • Y. Q. Dong, Y. M. Yao, P. Wei, H. Liu, N. Dong, Y. Yu and Z. Y. Sheng, Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury. Chin. Crit. Care 17, 12-15 (2005).
    • (2005) Chin. Crit. Care , vol.17 , pp. 12-15
    • Dong, Y.Q.1    Yao, Y.M.2    Wei, P.3    Liu, H.4    Dong, N.5    Yu, Y.6    Sheng, Z.Y.7
  • 17
    • 0344309146 scopus 로고    scopus 로고
    • Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion
    • T. Uchiyama, R. L. Delude and M. P. Fink, Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. Intensive Care Med. 29, 2050-2058 (2003).
    • (2003) Intensive Care Med , vol.29 , pp. 2050-2058
    • Uchiyama, T.1    Delude, R.L.2    Fink, M.P.3
  • 18
    • 0037213248 scopus 로고    scopus 로고
    • Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated Caco-2 enterocytic monolayers
    • P. L. Sappington, X. Han, R. Yang, R. L. Delude and M. P. Fink, Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated Caco-2 enterocytic monolayers. J. Pharmacol. Exp. Ther. 304, 464-476 (2003).
    • (2003) J. Pharmacol. Exp. Ther , vol.304 , pp. 464-476
    • Sappington, P.L.1    Han, X.2    Yang, R.3    Delude, R.L.4    Fink, M.P.5
  • 19
    • 3042704829 scopus 로고    scopus 로고
    • Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction
    • P. L. Sappington, M. E. Fink, R. Yang, R. L. Delude and M. P. Fink, Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction. Shock 20, 521-528 (2003).
    • (2003) Shock , vol.20 , pp. 521-528
    • Sappington, P.L.1    Fink, M.E.2    Yang, R.3    Delude, R.L.4    Fink, M.P.5
  • 20
    • 0347758406 scopus 로고    scopus 로고
    • Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured LPS-stimulated RAW 264.7 cells
    • M. Song, J. A. Kellum, H. Kaldas and M. P. Fink, Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured LPS-stimulated RAW 264.7 cells. J. Pharmacol. Exp. Ther. 308, 307-316 (2004).
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , pp. 307-316
    • Song, M.1    Kellum, J.A.2    Kaldas, H.3    Fink, M.P.4
  • 21
    • 0023598614 scopus 로고
    • Computer programs for the analysis of cellular survival data
    • N. Albright, Computer programs for the analysis of cellular survival data. Radiat. Res. 112, 331-340 (1987).
    • (1987) Radiat. Res , vol.112 , pp. 331-340
    • Albright, N.1
  • 23
    • 0026326943 scopus 로고
    • Hydrogen peroxide-induced renal injury; A protective role for pyruvate in vitro and in vivo
    • A. K. Salahudeen, E. C. Clark and K. A. Nath, Hydrogen peroxide-induced renal injury; A protective role for pyruvate in vitro and in vivo. J. Clin. Invest. 88, 1886-1893 (1991).
    • (1991) J. Clin. Invest , vol.88 , pp. 1886-1893
    • Salahudeen, A.K.1    Clark, E.C.2    Nath, K.A.3
  • 24
    • 0024600885 scopus 로고
    • Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure
    • R. Bunger, R. T. Mallet and D. A. Hartman, Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure. Eur. J. Biochem. 180, 221-233 (1989).
    • (1989) Eur. J. Biochem , vol.180 , pp. 221-233
    • Bunger, R.1    Mallet, R.T.2    Hartman, D.A.3
  • 25
    • 0030030820 scopus 로고    scopus 로고
    • Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine
    • L. Cicalese, K. Lee, W. Schraut, S. Watkins, A. Borle and R. Stanko, Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine. Am. J. Surg. 171, 97-100 (1999).
    • (1999) Am. J. Surg , vol.171 , pp. 97-100
    • Cicalese, L.1    Lee, K.2    Schraut, W.3    Watkins, S.4    Borle, A.5    Stanko, R.6
  • 28
    • 0034527578 scopus 로고    scopus 로고
    • Diabetes-induced biochemical changes in rat lens: Attenuation of cataractogenesis by pyruvate
    • W. Zhao, P. S. Devamanoharan, M. Henein, A. H. Ali and S. D. Varma, Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate. Diabetes Obes. Metab. 2, 165-174 (2000).
    • (2000) Diabetes Obes. Metab , vol.2 , pp. 165-174
    • Zhao, W.1    Devamanoharan, P.S.2    Henein, M.3    Ali, A.H.4    Varma, S.D.5
  • 29
    • 0035888871 scopus 로고    scopus 로고
    • Protection by pyruvate against transient forebrain ischemia in rats
    • J. Y. Lee, Y. H. Kim and J. Y. Koh, Protection by pyruvate against transient forebrain ischemia in rats. J. Neurosci. 21, 1-6 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 1-6
    • Lee, J.Y.1    Kim, Y.H.2    Koh, J.Y.3
  • 30
    • 0034910965 scopus 로고    scopus 로고
    • Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock
    • P. N. Slovin, C. J. Huang, J. R. Cade, C. E. Wood, O. Nasiroglu, M. Privette, P. Orbach and J. W. Skimming, Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock. Resuscitation 50, 109-115 (2001).
    • (2001) Resuscitation , vol.50 , pp. 109-115
    • Slovin, P.N.1    Huang, C.J.2    Cade, J.R.3    Wood, C.E.4    Nasiroglu, O.5    Privette, M.6    Orbach, P.7    Skimming, J.W.8
  • 32
    • 0034094871 scopus 로고    scopus 로고
    • Fructose induced deactivation of antioxidant enzymes: Preventive effect of pyruvate
    • W. Zhao, P. S. Devamanoharan and S. D. Varma, Fructose induced deactivation of antioxidant enzymes: preventive effect of pyruvate. Free Radic. Res. 33, 23-30 (2000).
    • (2000) Free Radic. Res , vol.33 , pp. 23-30
    • Zhao, W.1    Devamanoharan, P.S.2    Varma, S.D.3
  • 33
    • 0031838461 scopus 로고    scopus 로고
    • Prevention of intracellular oxidative stress to lens by pyruvate and its ester
    • S. D. Varma, P. S. Devamanoharan and A. H. Ali, Prevention of intracellular oxidative stress to lens by pyruvate and its ester. Free Radic. Res. 28, 131-135 (1998).
    • (1998) Free Radic. Res , vol.28 , pp. 131-135
    • Varma, S.D.1    Devamanoharan, P.S.2    Ali, A.H.3
  • 34
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection
    • A. P. Halestrap, S. J. Clarke and S. A. Javadov, Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc. Res. 61, 372-385 (2004).
    • (2004) Cardiovasc. Res , vol.61 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 35
    • 0031013623 scopus 로고    scopus 로고
    • Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
    • A. P. Halestrap, K-Y. Woodfield and C. P. Connern, Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J. Biol. Chem. 272, 3346-3354 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 3346-3354
    • Halestrap, A.P.1    Woodfield, K.-Y.2    Connern, C.P.3
  • 36
    • 0035708661 scopus 로고    scopus 로고
    • Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide
    • L. L. Pearce, M. W. Epperly, J. S. Greenberger, B. R. Pitt and J. Peterson, Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide. Nitric Oxide 5, 128-136 (2001).
    • (2001) Nitric Oxide , vol.5 , pp. 128-136
    • Pearce, L.L.1    Epperly, M.W.2    Greenberger, J.S.3    Pitt, B.R.4    Peterson, J.5
  • 37
    • 0029021013 scopus 로고
    • Inhibition of rat liver mitochondrial permeability transition by respiratory substrates
    • M. P. Rigobello, F. Turcato and A. Bindoli, Inhibition of rat liver mitochondrial permeability transition by respiratory substrates. Arch. Biochem. Biophys. 319, 225-230 (1995).
    • (1995) Arch. Biochem. Biophys , vol.319 , pp. 225-230
    • Rigobello, M.P.1    Turcato, F.2    Bindoli, A.3
  • 38
    • 0030826778 scopus 로고    scopus 로고
    • Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischemia/reperfusion injury
    • A. P. Halestrap, C. P. Connern, E. J. Griffiths and P. M. Kerr, Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischemia/reperfusion injury. Mol. Cell. Biochem. 174, 167-172 (1997).
    • (1997) Mol. Cell. Biochem , vol.174 , pp. 167-172
    • Halestrap, A.P.1    Connern, C.P.2    Griffiths, E.J.3    Kerr, P.M.4


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