Trends in the development of radioprotective agents

Drug Discovery Today

Volumn 12, Issue 19-20, 2007, Pages 794-805

  Hosseinimehr, Seyed Jalal ^a  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; ALPHA TOCOPHEROL; AMIFOSTINE; CAPTOPRIL; CHROMONE DERIVATIVE; CIMETIDINE; CYSTEINE; DIHYDROXYCHROMONE; DILTIAZEM; FAMOTIDINE; GENISTEIN; GERMATHIAZOLIDINE; GLUCAN; HOE 33342; KOJIC ACID; LIV 52; NIMODIPINE; NORPHENAZONE; OLTIPRAZ; OXYMETHOLONE; PHOSPHOROTHIOIC ACID S 3 (3 METHYLAMINOPROPYLAMINO)PROPYL ESTER; RADIOPROTECTIVE AGENT; RANITIDINE; SEROTONIN; TEMPOL; THIAZOLIDINE DERIVATIVE; THIOL DERIVATIVE; TIOPRONIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CLINICAL TRIAL; DRUG APPROVAL; DRUG DELIVERY SYSTEM; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG TOLERABILITY; HUMAN; HYPOTENSION; NAUSEA; NONHUMAN; RADIATION INJURY; RADIATION PROTECTION; REVIEW; SINGLE DRUG DOSE; VOMITING;

ANTIOXIDANTS; CYTOKINES; DRUG DESIGN; FREE RADICAL SCAVENGERS; HUMANS; IMMUNOLOGIC FACTORS; PLANT PREPARATIONS; RADIATION INJURIES; RADIATION, IONIZING; RADIATION-PROTECTIVE AGENTS; RADIOTHERAPY; SUPEROXIDE DISMUTASE;

EID: 35148839942     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2007.07.017     Document Type: Review

References (115)

1. Brown D.Q., et al. Early results of the screening program for radioprotectors. Int. J. Radiat. Oncol. Biol. Phys. 8 (1982) 565-570
2. Cassatt D.R., et al. Preclinical modeling of improved amifostine (ethyol) use in radiation therapy. Semin. Radiat. Oncol. 12 (2002) 97-102
3. Koukourakis M., et al. Subcutaneous administration of amifostine during fractionated radiotherapy: a randomized phase II study. J. Clin. Oncol. 18 (2000) 2226-2233
4. Whitnall M.H., et al. Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice. Int. J. Immunopharmacol. 22 (2000) 1-14
5. Landauer M.R., et al. Genistein treatment protects mice from ionizing radiation injury. J. Appl. Toxicol. 23 (2003) 379-385
6. Karbownik M., and Reiter R.J. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Exp. Biol. Med. 225 (2000) 9-22
7. Prasad K.N. Handbook of Radiobiology (1995), CRC Press
8. Hosseinimehr S.J., et al. Oral oxymetholone reduces mortality induced by gamma irradiation in mice through stimulation of hematopoietic cells. Mol. Cell. Biochem. 287 (2006) 193-199
9. Zhou Y., and Mi M.T. Genistein stimulates hematopoiesis and increases survival in irradiated mice. J. Radiat. Res. 46 (2005) 425-433
10. Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp. Hematol. 30 (2002) 513-528
11. Little J.B. Radiation carcinogenesis. Carcinogenesis 21 (2000) 397-404
12. Maisin J.R. Bacq and Alexander award lecture chemical radioprotection: past, present and future prospects. Int. J. Radiat. Biol. 73 (1998) 443-450
13. Held K.D., and Biaglow J. Mechanisms for the oxygen radical-mediated toxicity of various thiol-containing compounds in cultured mammalian cells. Radiat. Res. 139 (1994) 15-23
14. Drouet M., et al. Single administration of stem cell factor, FLT-3 ligand, megakaryocyte growth and development factor, and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression: long-term follow-up of hematopoiesis. Blood 103 (2004) 878-885
15. Herodin F., et al. Short-term injection of antiapoptotic cytokine combinations soon after lethal γ-irradiation promotes survival. Blood 101 (2003) 2609-2616
16. Whitnall M.H., et al. Radioprotective efficacy and acute toxicity of 5-androstenediol after subcutaneous or oral administration in mice. Immunopharm. Immunotoxicol. 24 (2002) 595-626
17. Weiss J.F., et al. Advances in radioprotection through the use of combined agent regimens. Int. J. Radiat. Biol. 57 (1990) 709-722
18. Holland J. New treatment modulation in radiation therapy. J. Infus. Nurs. 24 (2001) 95-101
19. Mazur L. Radioprotective effects of the thiols GSH and WR-2721 against X-rays-induction of micronuclei in erythroblasts. Mutat. Res. 468 (2000) 27-33
20. Spencer C.M., and Goa K.L. Amifostine, a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential as a radioprotector and cytotoxic chemoprotector. Drugs 50 (1995) 1001-1031
21. Machtay A.P.R., et al. A phase II trial subcutaneous amifostine and radiation therapy in patients with head-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 67 (2007) 445-452
22. Srinivasan V. Radioprotection, pharmacokinetic and behavioural studies in mouse implanted with biodegradable drug (amifostine) pellets. Int. J. Radiat. Biol. 78 (2002) 535-543
23. Ozsahin M., et al. Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy. Arch. Otolaryngol. Head Neck Surg. 132 (2006) 141-145
24. Anne P.R., and Curran W.J. A phase II trial of subcutaneous amifostine and radiation therapy in patients with head and neck cancer. Semin. Radiat. Oncol. 12 (2002) 18-19
25. Maisin J.R., et al. Reduction of short-term radiation lethality by biological response modifiers given alone or in association with other chemical protectors. Radiat. Res. 135 (1993) 332-337
26. Landauer M.R., et al. Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR-151327. J. Appl. Toxicol. 21 (2001) 25-31
27. Seed T.M. Radiation protectants: current status and future prospects. Health Phys. 89 (2005) 531-545
28. Hahn S.M., et al. Evaluation of the hydroxylamine tempol-H as an in vivo radioprotector. Free Radic. Biol. Med. 28 (2000) 953-958
29. Vitolo J.M., et al. The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model. Clin. Cancer Res. 10 (2004) 1807-1812
30. Cortrim A.P., et al. Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin. Cancer Res. 11 (2005) 7564-7568
31. Martin R.F., et al. In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 64 (2004) 1067-1070
32. Celaries B., et al. Synthesis and radioprotective study of new siladithioacetals and germadithioacetals. Appl. Organometal. 17 (2003) 561-569
33. Martin R.F., et al. Radioprotection by DNA ligands. Br. J. Cancer 74 (1996) 99-101
34. Epperly M.W., et al. Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthopedic tumors from irradiation. Gene Ther. 7 (2000) 1011-1018
35. Vujaskovic Z., et al. A small molecular weight catalytic metalloporophyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lung from radiation-induced injury. Free Radic. Biol. Med. 33 (2002) 857-863
36. Guo H., et al. Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat. Res. 159 (2003) 361-370
37. Epperly M.W., et al. Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmide/liposome (SOD2-PL) gene therapy. Radiat. Res. 155 (2001) 2-14
38. Epperly M.W., et al. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. Int. J. Cancer 96 (2001) 221-231
39. Epperly M.W., et al. Intraoral manganeses superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis. In Vivo 18 (2004) 401-410
40. Epperly M.W., et al. Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthopedic tumors. Radiat. Res. 167 (2007) 289-297
41. Somack R., et al. Preparation of long-acting superoxide dismutase using high molecular weight poly-ethylene glycol (41,000-72,000 Daltons). Free Radic. Res. Commun. 12-13 (1991) 553-562
42. Vajragupta O., et al. Manganese-based complexes of radical scavengers as neuroprotective agents. Bioorg. Med. Chem. 11 (2003) 2329-2337
43. Emami S., et al. Kojic acid and its manganese and zinc complexes as potential radioprotective agents. Bioorg. Med. Chem. Lett. 17 (2007) 45-48
44. Sorenson J.R.J. Cu, Fe, Mn, and chelates offer a medicinal chemistry approach to overcoming radiation injury. Curr. Med. Chem. 9 (2002) 639-662
45. Kashiwakura I., et al. Protective effects of thrombopoietin and stem cell factor on x-irradiated CD34+ megakaryocytic progenitor cells from human placental and umbilical cord blood. Radiat. Res. 160 (2003) 210-216
46. Hosseinimehr S.J., et al. Activation of C-kit by stem cell factor induces radioresistance to apoptosis through ERK-dependent expression of survivin in HL60 cells. J. Radiat. Res. 45 (2004) 557-561
47. Herodin F., and Drouet M. Cytokine-based treatment of accidentally irradiated victims and new approaches. Exp. Hematol. 33 (2005) 1071-1080
48. Kim J.Y., et al. Radioprotective effects of various cytokines in peripheral blood mononuclear cells and C3H mice. Oncol. Rep. 13 (2005) 1177-1183
49. Hudak S., et al. Radioprotective effects of flk2/flt3 ligand. Exp. Hematol. 26 (1998) 515-522
50. Legue F., et al. Il-6 key cytokine in vitro and in vivo response of sertoli cells to external gamma irradiation. Cytokine 16 (2001) 232-238
51. Streeter P.R. Activation of the G-CSF and Flt-3 receptors protects hematopoietic stem cells from lethal irradiation. Exp. Hematol. 31 (2003) 1119-1123
52. Neta R., et al. Radioprotection with interleukin-1: comparison with other cytokines. Prog. Immunol. 6 (1986) 900-908
53. Singh V.K., et al. Radioprotection by N-palmitoylated nanopeptide of human interleukin-1β. Peptide 26 (2005) 413-418
54. Patchen M.L., et al. Glucan-induced hematopoietic and immune stimulation: therapeutic effects in sublethally and lethally irradiated mice. Meth. Find. Exp. Clin. Pharmacol. 8 (1986) 151-155
55. Song J.Y., et al. Radioprotective effects of ginsan, an immunomodulator. Radiat. Res. 159 (2003) 768-774
56. Stickney D.R., et al. 5-Androstenediol stimulates multilineage hematopoiesis in rhesus monkeys with radiation-induced myelosuppression. Int. Immunopharmacol. 6 (2006) 1706-1713
57. Stickney D.R., et al. 5-Androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression. Int. Immunopharmacol. 7 (2007) 500-505
58. Safeukui I., et al. Plasmodium bergheri: dehydroepiandrosterone sulfate reverses chloroquino-resistance in experimental malaria infection; correlation with glucose 6-phosphate dehydrogenase and glutathione synthesis pathway. Biochem. Pharmacol. 68 (2004) 1903-1910
59. Weiss J., and Landauer M. Radioprotection by antioxidants. Ann. N.Y. Acad. Sci. 899 (2000) 44-60
60. Kumar S., et al. Nutritional approaches to radiation protection. Mil. Med. 167 (2002) 57-59
61. Seed T., et al. New strategies for the prevention of radiation injury: possible implications for countering radiation hazards of long-term space travel. J. Radiat. Res. 43 (2002) S239-S244
62. Satyamitra M., et al. In vivo radioprotection by α-TMG: preliminary studies. Mutat. Res. 479 (2001) 53-61
63. Satyamitra M., et al. In vivo postirradiation protection by a vitamin E analog, α-TMG. Radiat. Res. 160 (2003) 655-661
64. Singh V.K., et al. Induction of cytokines by radioprotective tocopherol analogs. Exp. Mol. Pathol. 81 (2006) 55-61
65. Keithahn C., and Lerchl A. 5-Hydroxytryptophan is a more potent in vitro hydroxyl radical scavenger than melatonin or vitamin C. J. Pineal. Res. 38 (2005) 62-66
66. Vijayalaxmi, et al. Melatonin as a radioprotective agent: a review. Int. J. Radiat. Oncol. Biol. Phys. 59 (2004) 639-653
67. Koc M., et al. Melatonin protects rat liver against irradiation-induced oxidative injury. J. Radiat. Res. 44 (2003) 211-215
68. Vijayalaxmi, et al. Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers. Mutat. Res. 371 (1996) 221-228
69. Birdsall T.C. The biological effects and clinical uses of the pineal hormone melatonin. Alt. Med. Rev. 1 (1996) 94-102
70. Lusardi P., et al. Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hours study. Br. J. Clin. Pharmacol. 49 (2000) 423-427
71. Hosseinimehr S.J., and Nemati A. Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells. Br. J. Radiol. 79 (2006) 415-418
72. Jagetia G.C., et al. The grapefruit flavonone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. Mutat. Res. 519 (2002) 37-48
73. Devi P., et al. A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors in the mouse. Br. J. Radiol. 71 (1998) 782-784
74. Shimoi K., et al. Radioprotective effects of antioxidative flavonoids in γ-ray. Carcinogenesis 15 (1994) 2669-2672
75. Ganasoundari A., et al. Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum. Mutat. Res. 397 (1998) 303-312
76. Davis T.A., et al. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int. J. Radiat. Biol. 83 (2007) 141-151
77. Hong H., et al. Antibacterial activity of the soy isoflavone genistein. J. Basic Microbiol. 46 (2006) 329-335
78. Hosseinimehr S.J., et al. Radioprotective effects of citrus extract against γ-irradiation in mouse bone marrow cells. J. Radiat. Res. 44 (2003) 237-241
79. Hosseinimehr S.J., et al. Radioprotective effects of hawthorn fruit extract against gamma irradiation in mouse bone marrow cells. J. Radiat. Res. 48 (2007) 63-68
80. Jagetia G.C., et al. Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation. Radiat. Res. 160 (2003) 584-592
81. Sharma A., et al. Zingiber officinale Rosc. Modulates gamma radiation-induced conditioned taste aversion. Pharmacol. Biochem. Behav. 81 (2005) 864-870
82. Jagetia G.C., and Baliga M.S. Influence of the leaf extract of Mentha arvensis Linn. (Mint) on the survival of mice exposed to different doses of gamma radiation. Strahlenther. Onkol. 178 (2002) 91-98
83. Pande S., et al. Evaluation of radiomodifying effects of root extract of panax ginseng. Phytother. Res. 12 (1998) 13-17
84. Samarth R.M., et al. Protection of swiss albino mice against whole-body gamma irradiation by Mentha piperita (Linn.). Phytother. Res. 18 (2004) 546-550
85. Pahadiya S., and Sharma J. Alternative of lethal effects of gamma rays in swiss albino mice by Tinospora cardifolia. Phytother. Res. 17 (2003) 552-554
86. Goel H.C., et al. Radioprotection by a herbal preparation of Hippophae rhamnoides, RH-3, against whole body lethal irradiation in mice. Phytomedicine 9 (2002) 15-25
87. Jagetia G.C., et al. Evaluation of the radioprotective effects of bael leaf (Aegle marmelos) extract in mice. Int. J. Radiat. Biol. 80 (2004) 281-290
88. Maharwal J., et al. Radiomodulatory influence of rajgira (Amaranthus paniculatus) leaf extract in swiss albino mice. Phytother. Res. 17 (2003) 1150-1154
89. Jageta G.C., et al. The evaluation of the radioprotective effects of triphala (an ayurvedic rejuvenating drug) in the mice exposed to γ-radiation. Phytomedicine 9 (2002) 99-108
90. Jagetia G.C., et al. Evaluation of the radioprotective effects of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation. J. Pharm. Pharmacol. 55 (2003) 1151-1158
91. Jagetia G.C., and Baliga M.S. Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study. Phytomedicine 12 (2005) 209-215
92. Freyburger W.A., et al. The pharmacology of 5-hydroxytryptamine (serotonin). J. Pharm. Exp. Ther. 105 (1952) 80-86
93. Otieno M.A., et al. Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo. Free Radic. Biol. Med. 28 (2000) 944-952
94. Kim S.G., et al. In vivo radioprotective effects of oltipraz in γ-irradiated mice. Biochem. Pharmacol. 55 (1998) 1585-1590
95. ®), a clinical drug. J. Radiat. Res. 45 (2004) 319-323
96. Hosseinimehr S.J., et al. Radioprotective effects of 2-imino-3-[(chromone-2-yl)carbonyl] thiazolidines against γ-irradiation in mice. J. Radiat. Res. 43 (2002) 293-300
97. Celaries B., et al. Synthesis and radioprotective action of silathiazolidines and germathiazolidines. Appl. Organometal. Chem. 18 (2004) 291-297
98. Nunia Y., et al. Protection of swiss albino mice against whole-body gamma irradiation by diltiazem. Br. J. Radiol. 80 (2007) 77-84
99. Hosseinimehr, S.J. et al. 5,7-Dihydroxychromone-2-carboxylic acid and it's transitional-metal- (Mn and Zn) chelates as non-thiol radioprotective agents. Eur. J. Med. Chem. (in press)
100. Steel-Goodwin L.J.M., et al. Pathological evaluation of WR-151327 administered orally in irradiated and non-irradiated male mice. Ann. Clin. Lab. Sci. 22 (1992) 182-188
101. Prabhakar K.R., et al. Antioxidant and radioprotective effects of the active fraction Pilea microphylla (L.) ethanolic extract. Chem. Biol. Interact. 165 (2007) 22-32
102. Jagetia G.C., et al. Effect of abana (a herbal preparation) on the radiation-induced mortality in mice. J. Ethnopharmacol. 86 (2003) 159-165
103. Baliga M.S., et al. Radioprotective effect of abana, a polyherbal drug following total body irradiation. Br. J. Radiol. 77 (2007) 1027-1035
104. Jagetia G.C., et al. Evaluation of the radioprotective effect of Liv 52 in mice. Environ. Mol. Mutagen. 47 (2006) 490-502
105. Uma Devi P., et al. In vivo radioprotection by Ocimum flavonoids: survival of mice. Radiat. Res. 151 (1999) 74-78
106. Sharma M., and Kumar M. Radioprotection of swiss albino mice by Myristica fragrans houtt. J. Radiat. Res. 48 (2007) 135-141
107. Singh I., et al. Radioprotection of swiss albino mice by Emblica officinalis. Phytother. Res. 19 (2005) 444-446
108. Jagetia G.C., and Baliga M.S. Polyherbal extract of septilin protects mice against whole body lethal dose of gamma radiation. Phytother. Res. 18 (2004) 619-623
109. Goel H.C., et al. Radioprotective potential of an herbal extract of Tinospora cordifolia. J. Radiat. Res. 45 (2004) 61-68
110. Ivanova T., et al. Antimutagenic effect of polysaccharide ginsan extract from Panax ginseng. Food Chem. Toxicol. 44 (2006) 517-521
111. Hosseinimehr S.J., et al. Captopril protects mice bone marrow cells against genotoxicity induced by gamma irradiation. Cell Biochem. Funct. 25 (2007) 389-394
112. Mozadarni H. Radioprotective properties of histamine H2 receptor antagonist: present and future prospects. J. Radiat. Res. 44 (2003) 145-149
113. Vijayalaxmi, et al. Melatonin: possible mechanisms involved in its radioprotective effect. Mutat. Res. 404 (1998) 187-189
114. Agrawala P.K., and Goel H. Radioprotective effect of RH-3 with special reference to radiation induced micronuclei in mouse bone marrow. Indian J. Exp. Biol. 40 (2002) 525-530
115. Jagetia G.C., and Aruna R. The herbal preparation abana protects against radiation-induced micronuclei in mouse bone marrow. Mutat. Res. 393 (1997) 157-163