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Volumn 162, Issue 6, 2004, Pages 711-728

Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries report of an NCI workshop, December 3-4, 2003

(27)  Stone, Helen B a,o   Moulder, John E b   Coleman, C Norman a   Ang, K Kian c   Anscher, Mitchell S d   Barcellos Hoff, Mary Helen e   Dynan, William S f   Fike, John R g   Grdina, David J h   Greenberger, Joel S i   Hauer Jensen, Martin j   Hill, Richard P k   Kolesnick, Richard N l   MacVittie, Thomas J m,o   Marks, Cheryl a   McBride, William H n,p   Metting, Noelle m,o   Pellmar, Terry n,p   Purucker, Mary q   Robbins, Mike E r   more..


Author keywords

[No Author keywords available]

Indexed keywords

AMIFOSTINE; ANDROSTENEDIOL; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTIOXIDANT; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENEMA; FAS ANTIGEN; FIBROBLAST GROWTH FACTOR; HALOFUGINONE; HEMOPOIETIC GROWTH FACTOR; INTERLEUKIN 11; KERATINOCYTE GROWTH FACTOR; MANGANESE SUPEROXIDE DISMUTASE; MERCAPTAMINE; MISOPROSTOL; OCTREOTIDE; PENTOXIFYLLINE; PRIMROSE OIL; PROTEIN P53; RADIOPROTECTIVE AGENT; SALAZOSULFAPYRIDINE; SHORT CHAIN FATTY ACID; SUCRALFATE; THROMBOMODULIN; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG;

EID: 9244246263     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3276     Document Type: Conference Paper
Times cited : (222)

References (199)
  • 2
    • 0037266986 scopus 로고    scopus 로고
    • Pharmacological intervention to prevent or ameliorate chronic radiation injuries
    • J. E. Moulder, Pharmacological intervention to prevent or ameliorate chronic radiation injuries. Semin. Radiat. Oncol. 13, 73-84 (2003).
    • (2003) Semin. Radiat. Oncol. , vol.13 , pp. 73-84
    • Moulder, J.E.1
  • 3
    • 0037268373 scopus 로고    scopus 로고
    • Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy
    • C. N. Andreassen, C. Grau and J. C. Lindegaard, Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy. Semin. Radiat. Oncol. 13, 62-72 (2003).
    • (2003) Semin. Radiat. Oncol. , vol.13 , pp. 62-72
    • Andreassen, C.N.1    Grau, C.2    Lindegaard, J.C.3
  • 4
    • 0034054128 scopus 로고    scopus 로고
    • Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker
    • A. Molteni, J. E. Moulder, E. P. Cohen, W. F. Ward, B. L. Fish, J. M. Taylor, L. F. Wolfe, L. Brizio-Molteni and P. Veno, Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. Int. J. Radiat. Biol. 76, 523-532 (2000).
    • (2000) Int. J. Radiat. Biol. , vol.76 , pp. 523-532
    • Molteni, A.1    Moulder, J.E.2    Cohen, E.P.3    Ward, W.F.4    Fish, B.L.5    Taylor, J.M.6    Wolfe, L.F.7    Brizio-Molteni, L.8    Veno, P.9
  • 5
    • 0037241228 scopus 로고    scopus 로고
    • ACE inhibitors and AII receptor antagonists in the treatment and prevention of bone marrow transplant nephropathy
    • J. E. Moulder, B. L. Fish and E. P. Cohen, ACE inhibitors and AII receptor antagonists in the treatment and prevention of bone marrow transplant nephropathy. Curr. Pharm. Des. 9, 737-749 (2003).
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 737-749
    • Moulder, J.E.1    Fish, B.L.2    Cohen, E.P.3
  • 6
    • 1642580869 scopus 로고    scopus 로고
    • Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat
    • J. H. Kim, S. L. Brown, A. Kolozsvary, K. A. Jenrow, S. Ryu, M. L. Rosenblum and O. A. Carretero, Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat. Radiat. Res. 161, 137-142 (2004).
    • (2004) Radiat. Res. , vol.161 , pp. 137-142
    • Kim, J.H.1    Brown, S.L.2    Kolozsvary, A.3    Jenrow, K.A.4    Ryu, S.5    Rosenblum, M.L.6    Carretero, O.A.7
  • 7
    • 0033035813 scopus 로고    scopus 로고
    • Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: An experimental study
    • J. L. Lefaix, S. Delanian, M. C. Vozenin, J. J. Leplat, Y. Tricaud and M. Martin, Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: An experimental study. Int. J. Radiat. Oncol. Biol. Phys. 43, 839-847 (1999).
    • (1999) Int. J. Radiat. Oncol. Biol. Phys. , vol.43 , pp. 839-847
    • Lefaix, J.L.1    Delanian, S.2    Vozenin, M.C.3    Leplat, J.J.4    Tricaud, Y.5    Martin, M.6
  • 9
    • 0038302726 scopus 로고    scopus 로고
    • Cytokine-based treatment for acute radiation-induced myelosuppression: Preclinical and clinical perspective
    • R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds., Parthenon Publishing Group, Boca Raton, FL
    • T. J. MacVittie and A. M. Farese, Cytokine-based treatment for acute radiation-induced myelosuppression: Preclinical and clinical perspective. In The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims (R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds.), pp. 53-72. Parthenon Publishing Group, Boca Raton, FL, 2002.
    • (2002) The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims , pp. 53-72
    • MacVittie, T.J.1    Farese, A.M.2
  • 10
    • 0037118277 scopus 로고    scopus 로고
    • Major radiation exposure - What to expect and how to respond
    • F. A. Mettler, Jr. and G. L. Voelz, Major radiation exposure - what to expect and how to respond. N. Engl. J. Med. 346, 1554-1561 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1554-1561
    • Mettler Jr., F.A.1    Voelz, G.L.2
  • 11
    • 0036286183 scopus 로고    scopus 로고
    • Hematologic consequences of exposure to ionizing radiation
    • N. Dainiak, Hematologic consequences of exposure to ionizing radiation. Exp. Hematol. 30, 513-528 (2002).
    • (2002) Exp. Hematol. , vol.30 , pp. 513-528
    • Dainiak, N.1
  • 12
    • 9244236369 scopus 로고    scopus 로고
    • Estimation of exposure using blood markers and clinical indicators
    • Special Publication 98-2, Armed Forces Radiobiology Research Institute, Bethesda, MD
    • T. M. Seed, M. E. Dobson, D. C. Garner, T. B. Kneisler and M. H. Whitnall, Estimation of exposure using blood markers and clinical indicators. In Triage of Irradiated Personnel, pp. 7-13. Special Publication 98-2, Armed Forces Radiobiology Research Institute, Bethesda, MD, 1998.
    • (1998) Triage of Irradiated Personnel , pp. 7-13
    • Seed, T.M.1    Dobson, M.E.2    Garner, D.C.3    Kneisler, T.B.4    Whitnall, M.H.5
  • 13
    • 42149133011 scopus 로고    scopus 로고
    • Alterations of hematological parameters by radiation
    • AFRRI Special Publication 98-2, Armed Forces Radiobiology Research Institute, Bethesda, MD
    • N. Wald, Alterations of hematological parameters by radiation. In Triage of Irradiated Personnel, pp. B-1-B-5. AFRRI Special Publication 98-2, Armed Forces Radiobiology Research Institute, Bethesda, MD, 1998.
    • (1998) Triage of Irradiated Personnel
    • Wald, N.1
  • 14
    • 9244222855 scopus 로고    scopus 로고
    • Prediction of clinical course through serial determinations
    • AFRRI Special Publication 98-2, Armed Forces Radiobiology Research Institute, Bethesda, MD
    • H. Kindler, D. Densow and T. M. Fliedner, Prediction of clinical course through serial determinations. In Triage of Irradiated Personnel pp. B-6-B-9. AFRRI Special Publication 98-2, Armed Forces Radiobiology Research Institute, Bethesda, MD, 1998.
    • (1998) Triage of Irradiated Personnel
    • Kindler, H.1    Densow, D.2    Fliedner, T.M.3
  • 15
    • 0035187563 scopus 로고    scopus 로고
    • Leridistim, a chimeric dual G-CSF and IL-3 receptor agonist, enhances multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression: Effect of schedule, dose, and route of administration
    • A. M. Farese, D. B. Casey, W. G. Smith, R. M. Vigneulle, J. P. McKearn and T. J. MacVittie, Leridistim, a chimeric dual G-CSF and IL-3 receptor agonist, enhances multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression: Effect of schedule, dose, and route of administration. Stem Cells 19, 522-533 (2001).
    • (2001) Stem Cells , vol.19 , pp. 522-533
    • Farese, A.M.1    Casey, D.B.2    Smith, W.G.3    Vigneulle, R.M.4    McKearn, J.P.5    MacVittie, T.J.6
  • 17
    • 0026603428 scopus 로고
    • Acquired radioresistance of hematopoietic progenitors (granulocyte/monocyte colony-forming units) during chronic radiation leukemogenesis
    • T. M. Seed and L. V. Kaspar, Acquired radioresistance of hematopoietic progenitors (granulocyte/monocyte colony-forming units) during chronic radiation leukemogenesis. Cancer Res. 52, 1469-1476 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 1469-1476
    • Seed, T.M.1    Kaspar, L.V.2
  • 18
    • 0029679754 scopus 로고    scopus 로고
    • Hematopoietic tissue repair under chronic low daily dose irradiation
    • T. M. Seed, Hematopoietic tissue repair under chronic low daily dose irradiation. Adv. Space Res. 18, 65-70 (1996).
    • (1996) Adv. Space Res. , vol.18 , pp. 65-70
    • Seed, T.M.1
  • 22
    • 0030710974 scopus 로고    scopus 로고
    • Potential use of hematopoietic stem cells after radiation injury
    • M. R. Bishop, Potential use of hematopoietic stem cells after radiation injury. Stem Cells 15 (Suppl. 2), 305-310 (1997).
    • (1997) Stem Cells , vol.15 , Issue.2 SUPPL. , pp. 305-310
    • Bishop, M.R.1
  • 23
    • 1642370503 scopus 로고    scopus 로고
    • Donor selection and management of hematopoietic cell transplantation
    • R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds., Parthenon Publishing Group, Boca Raton, FL
    • D. L. Confer, Donor selection and management of hematopoietic cell transplantation. In The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims (R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds.), pp. 109-116. Parthenon Publishing Group, Boca Raton, FL, 2002.
    • (2002) The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims , pp. 109-116
    • Confer, D.L.1
  • 24
    • 0036916372 scopus 로고    scopus 로고
    • Radioprotectants: Current status and new directions
    • D. J. Grdina, J. S. Murley and Y. Kataoka, Radioprotectants: Current status and new directions. Oncology 63 (Suppl. 2), 2-10 (2002).
    • (2002) Oncology , vol.63 , Issue.2 SUPPL. , pp. 2-10
    • Grdina, D.J.1    Murley, J.S.2    Kataoka, Y.3
  • 27
    • 0036984321 scopus 로고    scopus 로고
    • Improved tolerability of amifostine with rapid infusion and optimal patient preparation
    • R. Boccia, Improved tolerability of amifostine with rapid infusion and optimal patient preparation. Semin. Oncol. 29, 9-13 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 9-13
    • Boccia, R.1
  • 28
    • 0036274756 scopus 로고    scopus 로고
    • Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: Interactive effect with thrombopoietin
    • A. Van der Meeren, M. A. Mouthon, M. H. Gaugler, M. Vandamme and P. Gourmelon, Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: Interactive effect with thrombopoietin. Radiat. Res. 157, 642-649 (2002).
    • (2002) Radiat. Res. , vol.157 , pp. 642-649
    • Van Der Meeren, A.1    Mouthon, M.A.2    Gaugler, M.H.3    Vandamme, M.4    Gourmelon, P.5
  • 29
    • 17144458848 scopus 로고    scopus 로고
    • Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma-irradiation promotes survival
    • F. Hérodin, P. Bourin, J. F. Mayol, J. J. Lataillade and M. Drouet, Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma-irradiation promotes survival. Blood 101, 2609-2616 (2003).
    • (2003) Blood , vol.101 , pp. 2609-2616
    • Hérodin, F.1    Bourin, P.2    Mayol, J.F.3    Lataillade, J.J.4    Drouet, M.5
  • 31
    • 18744397519 scopus 로고    scopus 로고
    • The effects of ionizing radiation on stem cells and hematopoietic progenitors: The place of apoptosis and the therapeutic potential of anti-apoptosis treatments
    • M. Drouet, F. Mourcin, N. Grenier, J. F. Mayol, V. Leroux, F. Herodin and J. J. Sotto, The effects of ionizing radiation on stem cells and hematopoietic progenitors: The place of apoptosis and the therapeutic potential of anti-apoptosis treatments. Can. J. Physiol. Pharmacol. 80, 700-709 (2002).
    • (2002) Can. J. Physiol. Pharmacol. , vol.80 , pp. 700-709
    • Drouet, M.1    Mourcin, F.2    Grenier, N.3    Mayol, J.F.4    Leroux, V.5    Herodin, F.6    Sotto, J.J.7
  • 32
    • 0030997505 scopus 로고    scopus 로고
    • Radioprotection of bone marrow stem cell subsets by interleukin-1 and kit-ligand: Implications for CFU-S as the responsible target cell population
    • R. van Os, C. Lamont, A. Witsell and P. M. Mauch, Radioprotection of bone marrow stem cell subsets by interleukin-1 and kit-ligand: Implications for CFU-S as the responsible target cell population. Exp. Hematol. 25, 205-210 (1997).
    • (1997) Exp. Hematol. , vol.25 , pp. 205-210
    • Van Os, R.1    Lamont, C.2    Witsell, A.3    Mauch, P.M.4
  • 34
    • 0034798720 scopus 로고    scopus 로고
    • Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma
    • P. Okunieff, M. Li, W. Liu, J. Sun, B. Fenton, L. Zhang and I. Ding, Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma. Am. J. Clin. Oncol. 24, 491-495 (2001).
    • (2001) Am. J. Clin. Oncol. , vol.24 , pp. 491-495
    • Okunieff, P.1    Li, M.2    Liu, W.3    Sun, J.4    Fenton, B.5    Zhang, L.6    Ding, I.7
  • 35
    • 0036240619 scopus 로고    scopus 로고
    • Accelerated recovery from irradiation injury by angiotensin peptides
    • K. E. Rodgers, S. Xiong and G. S. diZerega, Accelerated recovery from irradiation injury by angiotensin peptides. Cancer Chemother. Pharmacol. 49, 403-411 (2002).
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , pp. 403-411
    • Rodgers, K.E.1    Xiong, S.2    Dizerega, G.S.3
  • 36
    • 0027460908 scopus 로고
    • Effect of pelvic irradiation on gastrointestinal function: A prospective longitudinal study
    • E. Yeoh, M. Horowitz, A. Russo, T. Muecke, T. Robb, A. Maddox and B. Chatterton, Effect of pelvic irradiation on gastrointestinal function: a prospective longitudinal study. Am. J. Med. 95, 397-406 (1993).
    • (1993) Am. J. Med. , vol.95 , pp. 397-406
    • Yeoh, E.1    Horowitz, M.2    Russo, A.3    Muecke, T.4    Robb, T.5    Maddox, A.6    Chatterton, B.7
  • 37
    • 0033082302 scopus 로고    scopus 로고
    • Late side effects unchanged 4-8 years after radiotherapy for prostate carcinoma: A comparison with age-matched controls
    • P. Fransson and A. Widmark, Late side effects unchanged 4-8 years after radiotherapy for prostate carcinoma: a comparison with age-matched controls. Cancer 85, 678-688 (1999).
    • (1999) Cancer , vol.85 , pp. 678-688
    • Fransson, P.1    Widmark, A.2
  • 38
    • 1642318509 scopus 로고    scopus 로고
    • Pathophysiology and management of radiation injury to the gastrointestinal tract
    • R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds., Parthenon Publishing Group, Boca Raton, FL
    • A. Fasano, Pathophysiology and management of radiation injury to the gastrointestinal tract. In The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims (R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds.), pp. 149-160. Parthenon Publishing Group, Boca Raton, FL, 2002.
    • (2002) The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims , pp. 149-160
    • Fasano, A.1
  • 39
    • 1642401190 scopus 로고    scopus 로고
    • Radiation injury of the gastrointestinal epithelium: Current research on treatment, management, and prevention
    • R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds., Parthenon Publishing Group, Boca Raton, FL
    • C. S. Potten, Radiation injury of the gastrointestinal epithelium: Current research on treatment, management, and prevention. In The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims (R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds.), pp. 139-148. Parthenon Publishing Group, Boca Raton, FL, 2002.
    • (2002) The Medical Basis for Radiation-Accident Preparedness: The Clinical Care of Victims , pp. 139-148
    • Potten, C.S.1
  • 42
    • 9244234810 scopus 로고    scopus 로고
    • Experimental radiation injuries of the gastrointestinal tract
    • (S. L. Jensen, H. Gregersen, M. H. Shokouh-Amiri and F. G. Moody, Eds.). Harwood Academic Publishers, Amsterdam
    • M. Hauer-Jensen and L. Poulakos, Experimental radiation injuries of the gastrointestinal tract. In Essentials of Experimental Surgery: Gastroenterology (S. L. Jensen, H. Gregersen, M. H. Shokouh-Amiri and F. G. Moody, Eds.). Harwood Academic Publishers, Amsterdam, 1996.
    • (1996) Essentials of Experimental Surgery: Gastroenterology
    • Hauer-Jensen, M.1    Poulakos, L.2
  • 45
    • 0042527679 scopus 로고    scopus 로고
    • Bowel injury: Current and evolving management strategies
    • M. Hauer-Jensen, J. Wang and J. W. Denham, Bowel injury: Current and evolving management strategies. Semin. Radiat. Oncol. 13, 357-371 (2003).
    • (2003) Semin. Radiat. Oncol. , vol.13 , pp. 357-371
    • Hauer-Jensen, M.1    Wang, J.2    Denham, J.W.3
  • 48
    • 0036283219 scopus 로고    scopus 로고
    • The radiotherapeutic injury - A complex 'wound'
    • J. W. Denham and M. Hauer-Jensen, The radiotherapeutic injury - a complex 'wound'. Radiother. Oncol. 63, 129-145 (2002).
    • (2002) Radiother. Oncol. , vol.63 , pp. 129-145
    • Denham, J.W.1    Hauer-Jensen, M.2
  • 49
    • 0036083816 scopus 로고    scopus 로고
    • Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: Possible link between endothelial dysfunction and chronic radiation fibrosis
    • J. Wang, H. Zheng, X. Ou, L. M. Fink and M. Hauer-Jensen, Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: Possible link between endothelial dysfunction and chronic radiation fibrosis. Am. J. Pathol. 160, 2063-2072 (2002).
    • (2002) Am. J. Pathol. , vol.160 , pp. 2063-2072
    • Wang, J.1    Zheng, H.2    Ou, X.3    Fink, L.M.4    Hauer-Jensen, M.5
  • 51
    • 0036718355 scopus 로고    scopus 로고
    • Amelioration of acute oral mucositis by keratinocyte growth factor: Fractionated irradiation
    • W. Dörr, K. Spekl and C. L. Farrell, Amelioration of acute oral mucositis by keratinocyte growth factor: fractionated irradiation. Int. J. Radiat. Oncol. Biol. Phys. 54, 245-251 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 245-251
    • Dörr, W.1    Spekl, K.2    Farrell, C.L.3
  • 52
    • 0029145730 scopus 로고
    • In lethally irradiated mice interleukin-12 protects bone marrow but sensitizes intestinal tract to damage from ionizing radiation
    • R. Neta, S. M. Stiefel and N. Ali, In lethally irradiated mice interleukin-12 protects bone marrow but sensitizes intestinal tract to damage from ionizing radiation. Ann. NY Acad. Sci. 762, 274-281 (1995).
    • (1995) Ann. NY Acad. Sci. , vol.762 , pp. 274-281
    • Neta, R.1    Stiefel, S.M.2    Ali, N.3
  • 56
    • 0027967713 scopus 로고
    • Radioprotection of the rat small intestine with topical WR-2721
    • J. P. Delaney, M. E. Bonsack and I. Felemovicius, Radioprotection of the rat small intestine with topical WR-2721. Cancer 74, 2379-2384 (1994).
    • (1994) Cancer , vol.74 , pp. 2379-2384
    • Delaney, J.P.1    Bonsack, M.E.2    Felemovicius, I.3
  • 60
    • 0022383888 scopus 로고
    • Elemental diet as prophylaxis against radiation injury. Histological and ultrastructural studies
    • A. H. McArdle, C. Wittnich, C. R. Freeman and W. P. Duguid, Elemental diet as prophylaxis against radiation injury. Histological and ultrastructural studies. Arch. Surg. 120, 1026-1032 (1985).
    • (1985) Arch. Surg. , vol.120 , pp. 1026-1032
    • McArdle, A.H.1    Wittnich, C.2    Freeman, C.R.3    Duguid, W.P.4
  • 62
    • 0037317521 scopus 로고    scopus 로고
    • The role of p53 in determining sensitivity to radiotherapy
    • A. V. Gudkov and E. A. Komarova, The role of p53 in determining sensitivity to radiotherapy. Nat. Rev. Cancer 3, 117-129 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 117-129
    • Gudkov, A.V.1    Komarova, E.A.2
  • 63
    • 2442681614 scopus 로고    scopus 로고
    • Dual effect of p53 on radiation sensitivity in vivo: P53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice
    • E. A. Komarova, R. V. Kondratov, K. Wang, K. Christov, T. V. Golovkina, J. R. Goldblum and A. V. Gudkov, Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene 23, 3265-3271 (2004).
    • (2004) Oncogene , vol.23 , pp. 3265-3271
    • Komarova, E.A.1    Kondratov, R.V.2    Wang, K.3    Christov, K.4    Golovkina, T.V.5    Goldblum, J.R.6    Gudkov, A.V.7
  • 66
  • 67
    • 0029947498 scopus 로고    scopus 로고
    • Prognostic value and clinicopathological correlation of thrombomodulin in squamous cell carcinoma of the human lung
    • M. Hamatake, T. Ishida, T. Mitsudomi, K. Akazawa and K. Sugimachi, Prognostic value and clinicopathological correlation of thrombomodulin in squamous cell carcinoma of the human lung. Clin. Cancer Res. 2, 763-766 (1996).
    • (1996) Clin. Cancer Res. , vol.2 , pp. 763-766
    • Hamatake, M.1    Ishida, T.2    Mitsudomi, T.3    Akazawa, K.4    Sugimachi, K.5
  • 69
    • 0031193375 scopus 로고    scopus 로고
    • An immunohistochemical study of thrombomodulin in oral squamous cell carcinoma and its association with invasive and metastatic potential
    • M. Tabata, K. Sugihara, S. Yonezawa, S. Yamashita and I. Maruyama, An immunohistochemical study of thrombomodulin in oral squamous cell carcinoma and its association with invasive and metastatic potential. J. Oral Pathol. Med. 26, 258-264 (1997).
    • (1997) J. Oral Pathol. Med. , vol.26 , pp. 258-264
    • Tabata, M.1    Sugihara, K.2    Yonezawa, S.3    Yamashita, S.4    Maruyama, I.5
  • 72
  • 73
    • 0242392011 scopus 로고    scopus 로고
    • The management of brain metastases
    • R. A. Patchell, The management of brain metastases. Cancer Treat. Rev. 29, 533-540 (2003).
    • (2003) Cancer Treat. Rev. , vol.29 , pp. 533-540
    • Patchell, R.A.1
  • 74
    • 0028356814 scopus 로고
    • Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy
    • J. R. Crossen, D. Garwood, E. Glatstein and E. A. Neuwelt, Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy. J. Clin. Oncol. 12, 627-642 (1994).
    • (1994) J. Clin. Oncol. , vol.12 , pp. 627-642
    • Crossen, J.R.1    Garwood, D.2    Glatstein, E.3    Neuwelt, E.A.4
  • 75
    • 0028914873 scopus 로고
    • Neuropsychological effects of cranial radiation: Current knowledge and future directions
    • D. D. Roman and P. W. Sperduto, Neuropsychological effects of cranial radiation: Current knowledge and future directions. Int. J. Radiat. Oncol. Biol. Phys. 31, 983-998 (1995).
    • (1995) Int. J. Radiat. Oncol. Biol. Phys. , vol.31 , pp. 983-998
    • Roman, D.D.1    Sperduto, P.W.2
  • 76
    • 10344263377 scopus 로고    scopus 로고
    • Pathogenesis of irradiation-induced cognitive dysfunction
    • O. K. Abayomi, Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol. 35, 659-663 (1996).
    • (1996) Acta Oncol. , vol.35 , pp. 659-663
    • Abayomi, O.K.1
  • 77
    • 0027331199 scopus 로고
    • Gamma radiation (5-10 Gy) impairs neuronal function in the guinea pig hippocampus
    • T. C. Pellmar and D. L. Lepinski, Gamma radiation (5-10 Gy) impairs neuronal function in the guinea pig hippocampus. Radiat. Res. 136, 255-261 (1993).
    • (1993) Radiat. Res. , vol.136 , pp. 255-261
    • Pellmar, T.C.1    Lepinski, D.L.2
  • 78
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation
    • H. G. Kuhn, H. Dickinson-Anson and F. H. Gage, Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027-2033 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 80
    • 0034718139 scopus 로고    scopus 로고
    • X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats
    • E. Tada, J. M. Parent, D. H. Lowenstein and J. R. Fike, X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 99, 33-41 (2000).
    • (2000) Neuroscience , vol.99 , pp. 33-41
    • Tada, E.1    Parent, J.M.2    Lowenstein, D.H.3    Fike, J.R.4
  • 82
    • 0036735783 scopus 로고    scopus 로고
    • Irradiation induces neural precursor-cell dysfunction
    • M. L. Monje, S. Mizumatsu, J. R. Fike and T. D. Palmer, Irradiation induces neural precursor-cell dysfunction. Nat. Med. 8, 955-962 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 955-962
    • Monje, M.L.1    Mizumatsu, S.2    Fike, J.R.3    Palmer, T.D.4
  • 83
    • 0038182466 scopus 로고    scopus 로고
    • Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
    • T. M. Madsen, P. E. Kristjansen, T. G. Bolwig and G. Wortwein, Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 119, 635-642 (2003).
    • (2003) Neuroscience , vol.119 , pp. 635-642
    • Madsen, T.M.1    Kristjansen, P.E.2    Bolwig, T.G.3    Wortwein, G.4
  • 84
    • 3843075154 scopus 로고    scopus 로고
    • Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    • R. Rola, J. Raber, A. Rizk, S. Otsuka, S. R. VandenBerg, D. R. Morhardt and J. R. Fike, Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Radiat. Res. 162, 39-47 (2004).
    • (2004) Radiat. Res. , vol.162 , pp. 39-47
    • Rola, R.1    Raber, J.2    Rizk, A.3    Otsuka, S.4    VandenBerg, S.R.5    Morhardt, D.R.6    Fike, J.R.7
  • 85
    • 0023635460 scopus 로고
    • Ionizing radiation alters neuronal excitability in hippocampal slices of the guinea pig
    • J. M. Tolliver and T. C. Pellmar, Ionizing radiation alters neuronal excitability in hippocampal slices of the guinea pig. Radiat. Res. 112, 555-563 (1987).
    • (1987) Radiat. Res. , vol.112 , pp. 555-563
    • Tolliver, J.M.1    Pellmar, T.C.2
  • 86
    • 0025352877 scopus 로고
    • Time- and dose-dependent changes in neuronal activity produced by X radiation in brain slices
    • T. C. Pellmar, D. A. Schauer and G. H. Zeman, Time- and dose-dependent changes in neuronal activity produced by X radiation in brain slices. Radiat. Res. 122, 209-214 (1990).
    • (1990) Radiat. Res. , vol.122 , pp. 209-214
    • Pellmar, T.C.1    Schauer, D.A.2    Zeman, G.H.3
  • 88
    • 0031852587 scopus 로고    scopus 로고
    • Radiation injury to the central nervous system
    • J. W. Hopewell, Radiation injury to the central nervous system. Med. Pediatr. Oncol. (Suppl. 1), 1-9 (1998).
    • (1998) Med. Pediatr. Oncol. Suppl. , vol.1 , pp. 1-9
    • Hopewell, J.W.1
  • 89
    • 0034126973 scopus 로고    scopus 로고
    • The radioresponse of the central nervous system: A dynamic process
    • P. J. Tofilon and J. R. Fike, The radioresponse of the central nervous system: A dynamic process. Radiat. Res. 153, 357-370 (2000).
    • (2000) Radiat. Res. , vol.153 , pp. 357-370
    • Tofilon, P.J.1    Fike, J.R.2
  • 90
    • 4243674932 scopus 로고    scopus 로고
    • Radiobiology of the central nervous system
    • M. Bernstein and M. S. Berger, Eds., Thieme, New York
    • K. K. Ang, Radiobiology of the central nervous system. In Neuro-Oncology: The Essentials (M. Bernstein and M. S. Berger, Eds.), pp. 160-168. Thieme, New York, 2000.
    • (2000) Neuro-Oncology: the Essentials , pp. 160-168
    • Ang, K.K.1
  • 92
    • 0018635197 scopus 로고
    • Experimental delayed radiation necrosis of the brain. Part 1: Effect of early dexamethasone treatment
    • A. N. Martins, R. E. Severance, J. M. Henry and T. F. Doyle, Experimental delayed radiation necrosis of the brain. Part 1: Effect of early dexamethasone treatment. J. Neurosurg. 51, 587-596 (1979).
    • (1979) J. Neurosurg. , vol.51 , pp. 587-596
    • Martins, A.N.1    Severance, R.E.2    Henry, J.M.3    Doyle, T.F.4
  • 93
    • 0030917019 scopus 로고    scopus 로고
    • The protective effect of dexamethasone against radiation damage induced by interstitial irradiation in normal monkey brain
    • E. Tada, K. Matsumoto, K. Kinoshita, T. Furuta and T. Ohmoto, The protective effect of dexamethasone against radiation damage induced by interstitial irradiation in normal monkey brain. Neurosurgery 41, 209-217 (1997).
    • (1997) Neurosurgery , vol.41 , pp. 209-217
    • Tada, E.1    Matsumoto, K.2    Kinoshita, K.3    Furuta, T.4    Ohmoto, T.5
  • 94
    • 0036249803 scopus 로고    scopus 로고
    • Innovative prevention strategies for radiation necrosis of the central nervous system
    • C. Nieder, N. Andratschke, R. E. Price, B. Rivera and K. K. Ang, Innovative prevention strategies for radiation necrosis of the central nervous system. Anticancer Res. 22, 1017-1023 (2002).
    • (2002) Anticancer Res. , vol.22 , pp. 1017-1023
    • Nieder, C.1    Andratschke, N.2    Price, R.E.3    Rivera, B.4    Ang, K.K.5
  • 95
    • 0036185915 scopus 로고    scopus 로고
    • Experimental data for administration of insulin-like growth factor 1 (IGF-1) and basic fibroblast growth factor (bFGF) for prevention of radiation myelopathy
    • C. Nieder, R. E. Price, B. Rivera, N. Andratschke and K. K. Ang, Experimental data for administration of insulin-like growth factor 1 (IGF-1) and basic fibroblast growth factor (bFGF) for prevention of radiation myelopathy. Strahlenther. Onkol. 178, 147-152 (2002).
    • (2002) Strahlenther. Onkol. , vol.178 , pp. 147-152
    • Nieder, C.1    Price, R.E.2    Rivera, B.3    Andratschke, N.4    Ang, K.K.5
  • 96
    • 0035893555 scopus 로고    scopus 로고
    • The role of tumor necrosis factor signaling pathways in the response of murine brain to irradiation
    • J. L. Daigle, J. H. Hong, C. S. Chiang and W. H. McBride, The role of tumor necrosis factor signaling pathways in the response of murine brain to irradiation. Cancer Res. 61, 8859-8865 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 8859-8865
    • Daigle, J.L.1    Hong, J.H.2    Chiang, C.S.3    McBride, W.H.4
  • 98
    • 0037079993 scopus 로고    scopus 로고
    • Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    • L. Vallieres, I. L. Campbell, F. H. Gage and P. E. Sawchenko, Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J. Neurosci. 22, 486-492 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 486-492
    • Vallieres, L.1    Campbell, I.L.2    Gage, F.H.3    Sawchenko, P.E.4
  • 99
    • 0347995022 scopus 로고    scopus 로고
    • Radiation response of neural precursor cells: Linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress
    • C. L. Limoli, E. Giedzinski, R. Rola, S. Otsuka, T. D. Palmer and J. R. Fike, Radiation response of neural precursor cells: Linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiat. Res. 161, 17-27 (2004).
    • (2004) Radiat. Res. , vol.161 , pp. 17-27
    • Limoli, C.L.1    Giedzinski, E.2    Rola, R.3    Otsuka, S.4    Palmer, T.D.5    Fike, J.R.6
  • 100
    • 0001144766 scopus 로고
    • Relative radiosensitivity of the human lung
    • E. L. Travis, Relative radiosensitivity of the human lung. Adv. Radiat. Biol. 12, 205-238 (1987).
    • (1987) Adv. Radiat. Biol. , vol.12 , pp. 205-238
    • Travis, E.L.1
  • 102
    • 0034946073 scopus 로고    scopus 로고
    • Organizational response of normal tissues to irradiation
    • E. L. Travis, Organizational response of normal tissues to irradiation. Semin. Radiat. Oncol. 11, 184-196 (2001).
    • (2001) Semin. Radiat. Oncol. , vol.11 , pp. 184-196
    • Travis, E.L.1
  • 104
    • 0033784887 scopus 로고    scopus 로고
    • The physical parameters and molecular events associated with radiation-induced lung toxicity
    • Z. Vujaskovic, L. B. Marks and M. S. Anscher, The physical parameters and molecular events associated with radiation-induced lung toxicity. Semin. Radiat. Oncol. 10, 296-307 (2000).
    • (2000) Semin. Radiat. Oncol. , vol.10 , pp. 296-307
    • Vujaskovic, Z.1    Marks, L.B.2    Anscher, M.S.3
  • 106
    • 0022512026 scopus 로고
    • The relationship between functional assays of radiation response in the lung and target cell depletion
    • E. L. Travis and S. L. Tucker, The relationship between functional assays of radiation response in the lung and target cell depletion. Br. J. Cancer. 7 (Suppl.), 304-319 (1986).
    • (1986) Br. J. Cancer. , vol.7 , Issue.SUPPL. , pp. 304-319
    • Travis, E.L.1    Tucker, S.L.2
  • 107
    • 0001315714 scopus 로고
    • Radiation pathology and the clinical response of lung and esophagus
    • T. L. Phillips and L. Margolis, Radiation pathology and the clinical response of lung and esophagus. Front. Radiation Ther. Oncol. 6, 254-273 (1972).
    • (1972) Front. Radiation Ther. Oncol. , vol.6 , pp. 254-273
    • Phillips, T.L.1    Margolis, L.2
  • 108
    • 0842278704 scopus 로고    scopus 로고
    • Radiotherapy-induced lung toxicity: Risk factors and prevention strategies
    • C. Nieder, B. Jeremic, S. Astner and M. Molls, Radiotherapy-induced lung toxicity: Risk factors and prevention strategies. Anticancer Res. 23, 4991-4998 (2003).
    • (2003) Anticancer Res. , vol.23 , pp. 4991-4998
    • Nieder, C.1    Jeremic, B.2    Astner, S.3    Molls, M.4
  • 109
    • 0026570555 scopus 로고
    • Effects of dexamethasone on late radiation injury following partial-body and local organ exposures
    • J. P. Geraci, M. S. Mariano, K. L. Jackson, D. A. Taylor and E. R. Still, Effects of dexamethasone on late radiation injury following partial-body and local organ exposures. Radiat. Res. 129, 61-70 (1992).
    • (1992) Radiat. Res. , vol.129 , pp. 61-70
    • Geraci, J.P.1    Mariano, M.S.2    Jackson, K.L.3    Taylor, D.A.4    Still, E.R.5
  • 111
    • 0026554287 scopus 로고
    • Radiation pneumotoxicity in rats: Modification by inhibitors of angiotensin converting enzyme
    • W. F. Ward, A. Molteni, C. H. Ts'ao, Y. T. Kim and J. M. Hinz, Radiation pneumotoxicity in rats: Modification by inhibitors of angiotensin converting enzyme. Int. J. Radiat. Oncol. Biol. Phys. 22, 623-625 (1992).
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.22 , pp. 623-625
    • Ward, W.F.1    Molteni, A.2    Ts'ao, C.H.3    Kim, Y.T.4    Hinz, J.M.5
  • 112
    • 0342369395 scopus 로고    scopus 로고
    • Can angiotensin-converting enzyme inhibitors protect against symptomatic radiation pneumonitis?
    • L. W. Wang, X. L. Fu, R. Clough, G. Sibley, M. Fan, G. C. Bentel, L. B. Marks and M. S. Anscher, Can angiotensin-converting enzyme inhibitors protect against symptomatic radiation pneumonitis? Radiat. Res. 153, 405-410 (2000).
    • (2000) Radiat. Res. , vol.153 , pp. 405-410
    • Wang, L.W.1    Fu, X.L.2    Clough, R.3    Sibley, G.4    Fan, M.5    Bentel, G.C.6    Marks, L.B.7    Anscher, M.S.8
  • 113
    • 0034960535 scopus 로고    scopus 로고
    • Localisation of transforming growth factor 1 and 3 mRNA transcripts in normal and fibrotic human lung
    • R. K. Coker, G. J. Laurent, P. K. Jeffery, R. M. du Bois, C. M. Black and R. J. McAnulty, Localisation of transforming growth factor 1 and 3 mRNA transcripts in normal and fibrotic human lung. Thorax 56, 549-556 (2001).
    • (2001) Thorax , vol.56 , pp. 549-556
    • Coker, R.K.1    Laurent, G.J.2    Jeffery, P.K.3    Du Bois, R.M.4    Black, C.M.5    McAnulty, R.J.6
  • 115
    • 0029851485 scopus 로고    scopus 로고
    • Keratinocyte growth factor ameliorates radiation- And bleomycin-induced lung injury and mortality
    • E. S. Yi, S. T. Williams, H. Lee, D. M. Malicki, E. M. Chin, S. Yin, J. Tarpley and T. R. Ulich, Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am. J. Pathol. 149, 1963-1970 (1996).
    • (1996) Am. J. Pathol. , vol.149 , pp. 1963-1970
    • Yi, E.S.1    Williams, S.T.2    Lee, H.3    Malicki, D.M.4    Chin, E.M.5    Yin, S.6    Tarpley, J.7    Ulich, T.R.8
  • 117
    • 0035921188 scopus 로고    scopus 로고
    • Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophasitis associated with fractionated radiation
    • M. W. Epperly, V. E. Kagan, C. A. Sikora, J. E. Gretton, S. J. Defilippi, D. Bar-Sagi and J. S. Greenberger, Manganese superoxide dismutase-plasmid/ liposome (MnSOD-PL) administration protects mice from esophasitis associated with fractionated radiation. Int. J. Cancer 96, 221-231 (2001).
    • (2001) Int. J. Cancer , vol.96 , pp. 221-231
    • Epperly, M.W.1    Kagan, V.E.2    Sikora, C.A.3    Gretton, J.E.4    Defilippi, S.J.5    Bar-Sagi, D.6    Greenberger, J.S.7
  • 119
    • 0033862252 scopus 로고    scopus 로고
    • Radiation nephropathy after bone marrow transplantation
    • E. P. Cohen, Radiation nephropathy after bone marrow transplantation. Kidney Int. 58, 903-918 (2000).
    • (2000) Kidney Int. , vol.58 , pp. 903-918
    • Cohen, E.P.1
  • 120
    • 0028504786 scopus 로고
    • Prophylaxis of experimental bone marrow transplant nephropathy
    • E. P. Cohen, J. E. Moulder, B. L. Fish and P. Hill, Prophylaxis of experimental bone marrow transplant nephropathy. J. Lab. Clin. Med. 124, 371-380 (1994).
    • (1994) J. Lab. Clin. Med. , vol.124 , pp. 371-380
    • Cohen, E.P.1    Moulder, J.E.2    Fish, B.L.3    Hill, P.4
  • 121
    • 0030061370 scopus 로고    scopus 로고
    • Renal toxicity after allogeneic bone marrow transplantation: The combined effects of total-body irradiation and graft-versus-host disease
    • R. Miralbell, S. Bieri, B. Mermillod, C. Helg, G. Sancho, B. Pastoors, A. Keller, J. M. Kurtz and B. Chapuis, Renal toxicity after allogeneic bone marrow transplantation: The combined effects of total-body irradiation and graft-versus-host disease. J. Clin. Oncol. 14, 579-585 (1996).
    • (1996) J. Clin. Oncol. , vol.14 , pp. 579-585
    • Miralbell, R.1    Bieri, S.2    Mermillod, B.3    Helg, C.4    Sancho, G.5    Pastoors, B.6    Keller, A.7    Kurtz, J.M.8    Chapuis, B.9
  • 122
    • 0343175342 scopus 로고
    • Renal insufficiency after total body irradiation for pediatric bone marrow transplantation
    • N. J. Tarbell, E. C. Guinan, L. Chin, P. Manch and H. J. Weinstein, Renal insufficiency after total body irradiation for pediatric bone marrow transplantation. Radiother. Oncol. 18 (Suppl.), 139-142 (1990).
    • (1990) Radiother. Oncol. , vol.18 , Issue.SUPPL. , pp. 139-142
    • Tarbell, N.J.1    Guinan, E.C.2    Chin, L.3    Manch, P.4    Weinstein, H.J.5
  • 124
    • 0035968599 scopus 로고    scopus 로고
    • Radiation nephropathy caused by yttrium 90
    • E. P. Cohen, J. E. Moulder and M. E. Robbins, Radiation nephropathy caused by yttrium 90. Lancet 358, 1102-1103 (2001).
    • (2001) Lancet , vol.358 , pp. 1102-1103
    • Cohen J E Moulder, E.P.1    Robbins, M.E.2
  • 125
    • 0141593495 scopus 로고    scopus 로고
    • 166Ho-DOTMP plus melphalan followed by peripheral blood stem cell transplantation in patients with multiple myeloma: Results of two phase 1/2 trials
    • S. Giralt, W. Bensinger, M. Goodman, D. Podoloff, J. Eary, R. Wendt, R. Alexanian, D. Weber, D. Maloney and R. Champlin, 166Ho-DOTMP plus melphalan followed by peripheral blood stem cell transplantation in patients with multiple myeloma: Results of two phase 1/2 trials. Blood 102, 2684-2691 (2003).
    • (2003) Blood , vol.102 , pp. 2684-2691
    • Giralt, S.1    Bensinger, W.2    Goodman, M.3    Podoloff, D.4    Eary, J.5    Wendt, R.6    Alexanian, R.7    Weber, D.8    Maloney, D.9    Champlin, R.10
  • 127
    • 0036014817 scopus 로고    scopus 로고
    • The renin-angiotensin system in experimental radiation nephropathy
    • E. P. Cohen, B. L. Fish and J. E. Moulder, The renin-angiotensin system in experimental radiation nephropathy. J. Lab. Clin. Med. 139, 251-257 (2002).
    • (2002) J. Lab. Clin. Med. , vol.139 , pp. 251-257
    • Cohen, E.P.1    Fish, B.L.2    Moulder, J.E.3
  • 128
    • 0027965230 scopus 로고
    • Unilateral nephrectomy 24 hours after bilateral kidney irradiation reduces damage to the function and structure of the remaining kidney
    • Z. X. Liao and E. L. Travis, Unilateral nephrectomy 24 hours after bilateral kidney irradiation reduces damage to the function and structure of the remaining kidney. Radiat. Res. 139, 290-299 (1994).
    • (1994) Radiat. Res. , vol.139 , pp. 290-299
    • Liao, Z.X.1    Travis, E.L.2
  • 129
    • 0037312197 scopus 로고    scopus 로고
    • Proteinuria and vascular changes after renal irradiation: The role of reactive oxygen species (ROS) and vascular endothelial growth factor (Vegf)
    • A. Kuin, J. J. Kruse and F. A. Stewart, Proteinuria and vascular changes after renal irradiation: The role of reactive oxygen species (ROS) and vascular endothelial growth factor (Vegf). Radiat Res. 159, 174-181 (2003).
    • (2003) Radiat Res. , vol.159 , pp. 174-181
    • Kuin, A.1    Kruse, J.J.2    Stewart, F.A.3
  • 130
    • 0026068756 scopus 로고
    • Early detection of damage following bilateral renal irradiation in the mouse
    • G. Stevens, M. Joiner, B. Joiner, H. Johns and J. Denekamp, Early detection of damage following bilateral renal irradiation in the mouse. Radiother. Oncol. 20, 124-131 (1991).
    • (1991) Radiother. Oncol. , vol.20 , pp. 124-131
    • Stevens, G.1    Joiner, M.2    Joiner, B.3    Johns, H.4    Denekamp, J.5
  • 131
    • 0029009140 scopus 로고
    • Amelioration of radiation nephropathy in rats by postirradiation treatment with dexamethasone and/or captopril
    • J. P. Geraci, M. C. Sun and M. S. Mariano, Amelioration of radiation nephropathy in rats by postirradiation treatment with dexamethasone and/or captopril. Radiat. Res. 143, 58-68 (1995).
    • (1995) Radiat. Res. , vol.143 , pp. 58-68
    • Geraci, J.P.1    Sun, M.C.2    Mariano, M.S.3
  • 133
    • 0022399173 scopus 로고
    • The pathogenesis of radiation nephropathy in the dog
    • P. J. Hoopes, E. L. Gillette and S. A. Benjamin. The pathogenesis of radiation nephropathy in the dog. Radiat. Res. 104, 406-419 (1985).
    • (1985) Radiat. Res. , vol.104 , pp. 406-419
    • Hoopes, P.J.1    Gillette, E.L.2    Benjamin, S.A.3
  • 134
    • 0025630565 scopus 로고
    • Modification of radiation damage in the canine kidney by hyperthermia: A histologic and functional study
    • D. M. Prescott, P. J. Hoopes and D. E. Thrall, Modification of radiation damage in the canine kidney by hyperthermia: A histologic and functional study. Radiat. Res. 124, 317-325 (1990).
    • (1990) Radiat. Res. , vol.124 , pp. 317-325
    • Prescott, D.M.1    Hoopes, P.J.2    Thrall, D.E.3
  • 137
    • 0028791425 scopus 로고
    • Radiation nephropathy: A review
    • M. E. Robbins and S. M. Bonsib, Radiation nephropathy: A review. Scanning Microsc. 9, 535-560 (1995).
    • (1995) Scanning Microsc. , vol.9 , pp. 535-560
    • Robbins, M.E.1    Bonsib, S.M.2
  • 138
    • 0031147998 scopus 로고    scopus 로고
    • Successful brief captopril treatment in experimental radiation nephropathy
    • E. P. Cohen, B. L. Fish and J. E. Moulder, Successful brief captopril treatment in experimental radiation nephropathy. J. Lab. Clin. Med. 129, 536-547 (1997).
    • (1997) J. Lab. Clin. Med. , vol.129 , pp. 536-547
    • Cohen, E.P.1    Fish, B.L.2    Moulder, J.E.3
  • 139
  • 140
    • 0347995023 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in mouse kidney after irradiation using microarray analysis
    • J. J. Kruse, J. A. te Poele, A. Velds, R. M. Kerkhoven, L. J. Boersma, N. S. Russell and F. A. Stewart, Identification of differentially expressed genes in mouse kidney after irradiation using microarray analysis. Radiat. Res. 161, 28-38 (2004).
    • (2004) Radiat. Res. , vol.161 , pp. 28-38
    • Kruse, J.J.1    Te Poele, J.A.2    Velds, A.3    Kerkhoven, R.M.4    Boersma, L.J.5    Russell, N.S.6    Stewart, F.A.7
  • 141
    • 0036027887 scopus 로고    scopus 로고
    • Radiation-induced kidney injury: A role for chronic oxidative stress?
    • M. E. Robbins, W. Zhao, C. S. Davis, S. Toyokuni and S. M. Bonsib, Radiation-induced kidney injury: A role for chronic oxidative stress? Micron 33, 133-141 (2002).
    • (2002) Micron , vol.33 , pp. 133-141
    • Robbins, M.E.1    Zhao, W.2    Davis, C.S.3    Toyokuni, S.4    Bonsib, S.M.5
  • 142
    • 0034094763 scopus 로고    scopus 로고
    • Irradiation of rat tubule epithelial cells alters the expression of gene products associated with the synthesis and degradation of extracellular matrix
    • W. Zhao, Y. O'Malley, S. Wei and M. E. Robbins, Irradiation of rat tubule epithelial cells alters the expression of gene products associated with the synthesis and degradation of extracellular matrix. Int. J. Radiat. Biol. 76, 391-402 (2000).
    • (2000) Int. J. Radiat. Biol. , vol.76 , pp. 391-402
    • Zhao, W.1    O'Malley, Y.2    Wei, S.3    Robbins, M.E.4
  • 143
    • 0032838876 scopus 로고    scopus 로고
    • Irradiation of rat mesangial cells alters the expression of gene products associated with the development of renal fibrosis
    • W. Zhao, Y. O'Malley and M. E. Robbins, Irradiation of rat mesangial cells alters the expression of gene products associated with the development of renal fibrosis. Radiat. Res. 152, 160-169 (1999).
    • (1999) Radiat. Res. , vol.152 , pp. 160-169
    • Zhao, W.1    O'Malley, Y.2    Robbins, M.E.3
  • 145
    • 0037216452 scopus 로고    scopus 로고
    • Successful treatment of radiation nephropathy with angiotensin II blockade
    • E. P. Cohen, S. Hussain and J. E. Moulder, Successful treatment of radiation nephropathy with angiotensin II blockade. Int. J. Radiat. Oncol. Biol. Phys. 55, 190-193 (2003).
    • (2003) Int. J. Radiat. Oncol. Biol. Phys. , vol.55 , pp. 190-193
    • Cohen, E.P.1    Hussain, S.2    Moulder, J.E.3
  • 146
    • 0001824278 scopus 로고    scopus 로고
    • Pathogenesis, prevention and management of radiation nephropathy
    • J. S. Tobias and P. R. M. Thomas, Eds., Oxford University Press, New York
    • E. P. Cohen and C. A. Lawton, Pathogenesis, prevention and management of radiation nephropathy. In Current Radiation Oncology (J. S. Tobias and P. R. M. Thomas, Eds.), pp. 94-109. Oxford University Press, New York, 1998.
    • (1998) Current Radiation Oncology , pp. 94-109
    • Cohen, E.P.1    Lawton, C.A.2
  • 147
    • 0010338052 scopus 로고
    • Prevention of renal damage by X rays
    • A. W. Asscher, Prevention of renal damage by X rays. Br. J. Radiol. 38, 533-535 (1965).
    • (1965) Br. J. Radiol. , vol.38 , pp. 533-535
    • Asscher, A.W.1
  • 148
    • 0021066608 scopus 로고
    • Modification of the radiation response of the mouse kidney by misonidazole and WR-2721
    • M. V. Williams and J. Denekamp, Modification of the radiation response of the mouse kidney by misonidazole and WR-2721. Int. J. Radiat. Oncol. Biol. Phys. 9, 1731-1736 (1983).
    • (1983) Int. J. Radiat. Oncol. Biol. Phys. , vol.9 , pp. 1731-1736
    • Williams, M.V.1    Denekamp, J.2
  • 152
    • 0025228531 scopus 로고
    • The skin: Its structure and response to ionizing radiation
    • J. W. Hopewell, The skin: Its structure and response to ionizing radiation. Int. J. Radiat. Biol. 57, 751-773 (1990).
    • (1990) Int. J. Radiat. Biol. , vol.57 , pp. 751-773
    • Hopewell, J.W.1
  • 153
    • 0017140391 scopus 로고
    • The response of human skin to irradiation with x-rays or fast neutrons
    • S. B. Field, R. L. Morgan and R. Morrison, The response of human skin to irradiation with x-rays or fast neutrons. Int. J. Radiat. Oncol. Biol. Phys. 1, 481-486 (1976).
    • (1976) Int. J. Radiat. Oncol. Biol. Phys. , vol.1 , pp. 481-486
    • Field, S.B.1    Morgan, R.L.2    Morrison, R.3
  • 154
    • 0027515643 scopus 로고
    • The effect of local and systemic irradiation on impairment of wound healing in mice
    • V. Vegesna, H. R. Withers, F. E. Holly and W. H. McBride, The effect of local and systemic irradiation on impairment of wound healing in mice. Radiat. Res. 135, 431-433 (1993).
    • (1993) Radiat. Res. , vol.135 , pp. 431-433
    • Vegesna, V.1    Withers, H.R.2    Holly, F.E.3    McBride, W.H.4
  • 155
    • 0021260625 scopus 로고
    • Response of swine skin microvasculature to acute single exposures of X rays: Quantification of endothelial changes
    • J. O. Archambeau, A. Ines and L. F. Fajardo, Response of swine skin microvasculature to acute single exposures of X rays: Quantification of endothelial changes. Radiat. Res. 98, 37-51 (1984).
    • (1984) Radiat. Res. , vol.98 , pp. 37-51
    • Archambeau, J.O.1    Ines, A.2    Fajardo, L.F.3
  • 156
    • 0024366943 scopus 로고
    • The progression rate of late radiation effects in normal tissue and its impact on dose-response relationships
    • I. Turesson, The progression rate of late radiation effects in normal tissue and its impact on dose-response relationships. Radiother. Oncol. 15, 217-226 (1989).
    • (1989) Radiother. Oncol. , vol.15 , pp. 217-226
    • Turesson, I.1
  • 158
    • 0026063762 scopus 로고
    • Effect of fibroblast implants on wound healing of irradiated skin - Assay of wound strength and quantitative immunohistology of collagen
    • R. Gorodetsky, W. H. McBride, H. R. Withers and G. G. Miller, Effect of fibroblast implants on wound healing of irradiated skin - Assay of wound strength and quantitative immunohistology of collagen. Radiat. Res. 125, 181-186 (1991).
    • (1991) Radiat. Res. , vol.125 , pp. 181-186
    • Gorodetsky, R.1    McBride, W.H.2    Withers, H.R.3    Miller, G.G.4
  • 159
    • 0029557229 scopus 로고
    • The effect of interleukin-1 beta or transforming growth factor-beta on radiation-impaired murine skin wound healing
    • V. Vegesna, W. H. McBride, J. M. Taylor and H. R. Withers, The effect of interleukin-1 beta or transforming growth factor-beta on radiation-impaired murine skin wound healing. J. Surg. Res. 59, 699-704 (1995).
    • (1995) J. Surg. Res. , vol.59 , pp. 699-704
    • Vegesna, V.1    McBride, W.H.2    Taylor, J.M.3    Withers, H.R.4
  • 160
    • 0027256061 scopus 로고
    • Temporal modulation of TGF-1 and -actin gene expression in pig skin and muscular fibrosis after ionizing radiation
    • M. Martin, J. L. Lefaix, P. Pinton, F. Crechet and F. Daburon, Temporal modulation of TGF-1 and -actin gene expression in pig skin and muscular fibrosis after ionizing radiation. Radiat. Res. 134, 63-70 (1993).
    • (1993) Radiat. Res. , vol.134 , pp. 63-70
    • Martin, M.1    Lefaix, J.L.2    Pinton, P.3    Crechet, F.4    Daburon, F.5
  • 165
    • 0037999088 scopus 로고    scopus 로고
    • Histochemical and biochemical modifications induced by experimental irradiation of human skin maintained in survival conditions and modulation by application of an emulsion containing trolamine
    • S. Boisnic, M. C. Branchet-Gumila, D. Nizri and L. Ben Slama, Histochemical and biochemical modifications induced by experimental irradiation of human skin maintained in survival conditions and modulation by application of an emulsion containing trolamine. Int. J. Tissue React. 25, 9-18 (2003).
    • (2003) Int. J. Tissue React. , vol.25 , pp. 9-18
    • Boisnic, S.1    Branchet-Gumila, M.C.2    Nizri, D.3    Ben Slama, L.4
  • 167
    • 0031417732 scopus 로고    scopus 로고
    • Modulation of the cell kinetics of pig skin by the topical application of evening primrose oil or Lioxasol
    • G. M. Morris, J. W. Hopewell, M. Harold, G. A. Ross, N. M. Nadejina, I. Gusev and I. Flockhart, Modulation of the cell kinetics of pig skin by the topical application of evening primrose oil or Lioxasol. Cell Prolif. 30, 311-323 (1997).
    • (1997) Cell Prolif. , vol.30 , pp. 311-323
    • Morris, G.M.1    Hopewell, J.W.2    Harold, M.3    Ross, G.A.4    Nadejina, N.M.5    Gusev, I.6    Flockhart, I.7
  • 168
    • 0141990970 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids decrease mucosal/epidermal reactions and enhance antitumour effect of ionising radiation with inhibition of tumour angiogenesis
    • B. Wen, E. Deutsch, P. Opolon, A. Auperin, V. Frascogna, E. Connault and J. Bourhis, n-3 polyunsaturated fatty acids decrease mucosal/epidermal reactions and enhance antitumour effect of ionising radiation with inhibition of tumour angiogenesis. Br. J. Cancer 89, 1102-1107 (2003).
    • (2003) Br. J. Cancer , vol.89 , pp. 1102-1107
    • Wen, B.1    Deutsch, E.2    Opolon, P.3    Auperin, A.4    Frascogna, V.5    Connault, E.6    Bourhis, J.7
  • 169
    • 0042074154 scopus 로고    scopus 로고
    • Celecoxib reduces skin damage after radiation: Selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor
    • L. Liang, D. Hu, W. Liu, J. P. Williams, P. Okunieff and I. Ding, Celecoxib reduces skin damage after radiation: Selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. Am. J. Clin. Oncol. 26, S114-S121 (2003).
    • (2003) Am. J. Clin. Oncol. , vol.26
    • Liang, L.1    Hu, D.2    Liu, W.3    Williams, J.P.4    Okunieff, P.5    Ding, I.6
  • 170
    • 0028066981 scopus 로고
    • Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: Clinical trial
    • S. Delanian, F. Baillet, J. Huart, J. L. Lefaix, C. Maulard and M. Housset, Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: Clinical trial. Radiother. Oncol. 32, 12-20 (1994).
    • (1994) Radiother. Oncol. , vol.32 , pp. 12-20
    • Delanian, S.1    Baillet, F.2    Huart, J.3    Lefaix, J.L.4    Maulard, C.5    Housset, M.6
  • 171
    • 0032886276 scopus 로고    scopus 로고
    • Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol
    • S. Delanian, S. Balla-Mekias and J. L. Lefaix, Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J. Clin. Oncol. 17, 3283-3290 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3283-3290
    • Delanian, S.1    Balla-Mekias, S.2    Lefaix, J.L.3
  • 172
    • 0037453159 scopus 로고    scopus 로고
    • Super models
    • M. M. Barr, Super models. Physiol. Genomics 13, 15-24 (2003).
    • (2003) Physiol. Genomics , vol.13 , pp. 15-24
    • Barr, M.M.1
  • 173
    • 0024025507 scopus 로고
    • Analysis of the mechanism for reversion of a disrupted gene
    • R. H. Schiestl, S. Igarashi and P. J. Hastings, Analysis of the mechanism for reversion of a disrupted gene. Genetics 119, 237-247 (1988).
    • (1988) Genetics , vol.119 , pp. 237-247
    • Schiestl, R.H.1    Igarashi, S.2    Hastings, P.J.3
  • 174
    • 0024973717 scopus 로고
    • Nonmutagenic carcinogens induce intrachromosomal recombination in yeast
    • R. H. Schiestl, Nonmutagenic carcinogens induce intrachromosomal recombination in yeast. Nature 337, 285-288 (1989).
    • (1989) Nature , vol.337 , pp. 285-288
    • Schiestl, R.H.1
  • 175
    • 0034988625 scopus 로고    scopus 로고
    • Persistent genomic instability in the yeast Saccharomyces cerevisiae induced by ionizing radiation and DNA-damaging agents
    • R. J. Brennan and R. H. Schiestl, Persistent genomic instability in the yeast Saccharomyces cerevisiae induced by ionizing radiation and DNA-damaging agents. Radiat. Res. 155, 768-777 (2001).
    • (2001) Radiat. Res. , vol.155 , pp. 768-777
    • Brennan, R.J.1    Schiestl, R.H.2
  • 176
    • 0033981361 scopus 로고    scopus 로고
    • Medical significance of Caenorhabditis elegans
    • A. A. Aboobaker and M. L. Blaxter, Medical significance of Caenorhabditis elegans. Ann. Med. 32, 23-30 (2000).
    • (2000) Ann. Med. , vol.32 , pp. 23-30
    • Aboobaker, A.A.1    Blaxter, M.L.2
  • 177
    • 1642514804 scopus 로고    scopus 로고
    • Death and more: DNA damage response pathways in the nematode C. elegans
    • L. Stergiou and M. O. Hengartner, Death and more: DNA damage response pathways in the nematode C. elegans. Cell Death Differ. 11, 21-28 (2004).
    • (2004) Cell Death Differ. , vol.11 , pp. 21-28
    • Stergiou, L.1    Hengartner, M.O.2
  • 178
    • 0033679966 scopus 로고    scopus 로고
    • A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans
    • A. Gartner, S. Milstein, S. Ahmed, J. Hodgkin and M. O. Hengartner, A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans. Mol. Cell 5, 435-443 (2000).
    • (2000) Mol. Cell , vol.5 , pp. 435-443
    • Gartner, A.1    Milstein, S.2    Ahmed, S.3    Hodgkin, J.4    Hengartner, M.O.5
  • 183
    • 0034816330 scopus 로고    scopus 로고
    • Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of normal human urothelium
    • C. Mothersill, D. Rea, E. G. Wright, S. A. Lorimore, D. Murphy, C. B. Seymour and K. O'Malley, Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of normal human urothelium. Carcinogenesis 22, 1465-1471 (2001).
    • (2001) Carcinogenesis , vol.22 , pp. 1465-1471
    • Mothersill, C.1    Rea, D.2    Wright, E.G.3    Lorimore, S.A.4    Murphy, D.5    Seymour, C.B.6    O'Malley, K.7
  • 185
    • 0031773119 scopus 로고    scopus 로고
    • How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues
    • M. H. Barcellos-Hoff, How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiat. Res. 150 (Suppl.), S109-S120 (1998).
    • (1998) Radiat. Res. , vol.150 , Issue.SUPPL.
    • Barcellos-Hoff, M.H.1
  • 186
    • 0019395368 scopus 로고
    • The differentiated state of normal and malignant cells or how to define a "normal" cell in culture
    • M. J. Bissell, The differentiated state of normal and malignant cells or how to define a "normal" cell in culture. Int. Rev. Cytol. 70, 27-100 (1981).
    • (1981) Int. Rev. Cytol. , vol.70 , pp. 27-100
    • Bissell, M.J.1
  • 187
    • 0036296491 scopus 로고    scopus 로고
    • Molecular signaling in bioengineered tissue microenvironments
    • D. P. Bottaro, A. Liebmann-Vinson and M. A. Heidaran, Molecular signaling in bioengineered tissue microenvironments. Ann. NY Acad. Sci. 961, 143-153 (2002).
    • (2002) Ann. NY Acad. Sci. , vol.961 , pp. 143-153
    • Bottaro, D.P.1    Liebmann-Vinson, A.2    Heidaran, M.A.3
  • 189
    • 2942552909 scopus 로고    scopus 로고
    • Chronic oxidative stress and radiation-induced late normal tissue injury: A review
    • M. E. C. Robbins and W. Zhao, Chronic oxidative stress and radiation-induced late normal tissue injury: A review. Int. J. Radiat. Biol. 80, 251-259 (2004).
    • (2004) Int. J. Radiat. Biol. , vol.80 , pp. 251-259
    • Robbins, M.E.C.1    Zhao, W.2
  • 190
    • 9244262823 scopus 로고    scopus 로고
    • Current Good Manufacturing Practice in manufacturing, processing, packing, or holding of drugs
    • Current Good Manufacturing Practice in manufacturing, processing, packing, or holding of drugs. Title 21 Code of Federal Regulations, part 210, 2002.
    • (2002) Title 21 Code of Federal Regulations , Issue.210 PART
  • 191
    • 0030886937 scopus 로고    scopus 로고
    • Managing the drug discovery/development interface
    • T. Kennedy, Managing the drug discovery/development interface. Drug Discov. Today 10, 436-444 (1997).
    • (1997) Drug Discov. Today , vol.10 , pp. 436-444
    • Kennedy, T.1
  • 193
    • 1942502952 scopus 로고
    • Agent-directed preclinical toxicology for new antineoplastic drugs
    • F. A. Valeriote, T. H. Corbett and L. H. Baker, Eds., Kluwer Academic Publishers, Boston
    • C. K. Grieshaber, Agent-directed preclinical toxicology for new antineoplastic drugs. In Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development (F. A. Valeriote, T. H. Corbett and L. H. Baker, Eds.), pp. 247-260. Kluwer Academic Publishers, Boston, 1992.
    • (1992) Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development , pp. 247-260
    • Grieshaber, C.K.1
  • 194
    • 0000288599 scopus 로고    scopus 로고
    • Safety Testing of Antitumor Agents
    • Chapter 23. P. D. Williams and G. H. Hottendorf, Eds., Elsevier, Oxford
    • J. E. Tomaszewski and A. C. Smith, Chapter 23. Safety Testing of Antitumor Agents. In Comprehensive Toxicology, Toxicity Testing and Evaluation (P. D. Williams and G. H. Hottendorf, Eds.), Vol. 2, pp. 299-309. Elsevier, Oxford, 1997.
    • (1997) Comprehensive Toxicology, Toxicity Testing and Evaluation , vol.2 , pp. 299-309
    • Tomaszewski, J.E.1    Smith, A.C.2
  • 196
    • 0345072162 scopus 로고    scopus 로고
    • Relevance of preclinical pharmacology and toxicology to Phase I trial extrapolation techniques. Relevance of animal toxicology
    • Chapter 17. B. C. Baguley, Ed., Academic Press, San Diego
    • J. E. Tomaszewski, A. C. Smith, J. M. Covey, S. J. Donohue, J. K. Rhie and K. M. Schweikart, Chapter 17. Relevance of preclinical pharmacology and toxicology to Phase I trial extrapolation techniques. Relevance of animal toxicology. In Anticancer Drug Design (B. C. Baguley, Ed.), pp. 301-328. Academic Press, San Diego, 2001.
    • (2001) Anticancer Drug Design , pp. 301-328
    • Tomaszewski, J.E.1    Smith, A.C.2    Covey, J.M.3    Donohue, S.J.4    Rhie, J.K.5    Schweikart, K.M.6
  • 197
    • 10744231168 scopus 로고    scopus 로고
    • Application of the CFU-GM assay to predict acute drug-induced neutropenia: An international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics
    • A. Pessina, B. Albella, M. Bayo, J. Bueren, P. Brantom, S. Casati, C. Croera, G. Gagliardi, P. Foti and L. Gribaldo, Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. Toxicol. Sci. 75, 355-367 (2003).
    • (2003) Toxicol. Sci. , vol.75 , pp. 355-367
    • Pessina, A.1    Albella, B.2    Bayo, M.3    Bueren, J.4    Brantom, P.5    Casati, S.6    Croera, C.7    Gagliardi, G.8    Foti, P.9    Gribaldo, L.10
  • 198
    • 0037205534 scopus 로고    scopus 로고
    • New drug and biological drug products: Evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible
    • New drug and biological drug products: Evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Fed. Regist. 67, 37988-37998 (2002).
    • (2002) Fed. Regist. , vol.67 , pp. 37988-37998
  • 199
    • 84941311792 scopus 로고    scopus 로고
    • Good Laboratory Practice for nonclinical laboratory studies
    • Good Laboratory Practice for nonclinical laboratory studies. Title 21 Code of Federal Regulations, part 58, 2002.
    • (2002) Title 21 Code of Federal Regulations , Issue.58 PART


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