Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy

Physiological Research

Volumn 57, Issue 2, 2008, Pages 307-310

  Hofer, M ^a   Pospisil M ^a   Znojil, V ^b   Hola J ^a   Vacek, A ^a   Streitova D ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Cyclooxygenase 2 inhibition; Granulocyte colony stimulating factor; Hematopoiesis; Meloxicam; Treatment of myelosuppression

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; GRANULOCYTE COLONY STIMULATING FACTOR; MELOXICAM; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD; BONE MARROW; CBA MOUSE; CELL DIFFERENTIATION; CYTOLOGY; DRUG COMBINATION; DRUG EFFECT; DRUG INTERACTION; GRANULOCYTE; HEMATOPOIESIS; LEUKOPENIA; MALE; MOUSE; RADIATION EXPOSURE; WHOLE BODY RADIATION;

ANIMALS; BONE MARROW; CELL DIFFERENTIATION; CYCLOOXYGENASE 2 INHIBITORS; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTES; HEMATOPOIESIS; LEUKOPENIA; MALE; MICE; MICE, INBRED CBA; THIAZINES; THIAZOLES; WHOLE-BODY IRRADIATION;

EID: 45849137510     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. CROFFORD LJ, LIPSKY PE, BROOKS P, ABRAMSON SB, SIMON LS, VAN DE PUTTE LBA: Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. Arthr Rheum 43: 4-13, 2000.
2. FRÖLICH JC: A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol Sci 18: 30-34, 1977.
3. HOFER M, POSPÍŠIL M: Stimulated recovery of perturbed haematopoiesis by inhibition of prostaglandin production - promising therapeutic strategy. Cent Eur J Biol 1: 584-593, 2006.
4. HOFER M, POSPÍŠIL M, ZNOJIL V, HOLÁ J, VACEK A, WEITEROVÁ L, ŠTREITOVÁ D, KOZUBÍK A: Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice. Radiat Res 166: 556-560, 2006.
5. KURLAND J, MOORE MAS: Modulation of hemopoiesis by prostaglandins. Exp Hematol 5: 357-373, 1977.
6. KUWABARA T, KOBAYSHI S, SUGIYAMA Y: Pharmacokinetics and pharmacodynamics of a recombinant human granulocyte colony-stimulating factor. Drug Metab Rev 28: 625-658, 1996.
7. LI W, WANG G, CUI J, XUE L, CAI L: Low dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation. Exp Hematol 32: 1088-1096, 2004.
8. PATCHEN ML, MACVITTIE TJ, SOLBERG BD, SOUZA LM: Therapeutic administration of recombinant human granulocyte colony-stimulating factor accelerates hemopoietic regeneration and enhances survival in a murine model of radiation-induced myelosuppression. Int J Cell Cloning 8: 107-122, 1990.
9. POSPÍŠIL M, HOFER M, ZNOJIL V, VÁCHA J, NETÍKOVÁ J, HOLÁ J: Synergistic effect of granulocyte colony-stimulating factor and drugs elevating extracellular adenosine on neutrophil production in mice. Blood 86: 3692-3697, 1995.
10. ROZENGURT E: Early signals in the mitogenic response. Science 234: 161-166, 1986.
11. WEITEROVÁ L, HOFER M, POSPÍŠIL M, ZNOJIL V, ŠTREITOVÁ D: Drugs elevating extracellular adenosine administered in vivo induce serum colony-stimulating activity and interleukin-6 in mice. Physiol Res 56: 463-473, 2007.
12. WELTE K, GABRILOVE J, BRONCHUD MH, PLATZER E, MORSTYN G: Filgrastim (r-metHuG-CSF): the first 10 years. Blood 88: 1907-1929, 1996.